HP1c cDNA ORF clone, Drosophila melanogaster(fruit fly)

Gene
Clones
gRNAs

Summary

Gene Symbol	HP1c
Entrez Gene ID	42696
Full Name	Heterochromatin Protein 1c
Synonyms	CG6990,Dmel\CG6990,HP1,HP1C,Hp1c,hp1c
General protein information	Preferred Names Heterochromatin Protein 1c Names CG6990 gene product from transcript CG6990-RA CG6990-PA HP1c-PA heterochromatin protein 1c
Gene Type	protein-coding
Organism	Drosophila melanogaster(fruit fly)
Genome	Chromosome: 3R Map Location: 94C4-94C4

mRNA and Protein(s)

mRNA	Protein	Name
NM_142836.3	NP_651093.1	heterochromatin protein 1c

Pathways from BioSystems
Gene Ontology
Bibliography

Related articles in PubMed

Gene Model Annotations for Drosophila melanogaster: Impact of High-Throughput Data.
Matthews BB, Dos Santos G, Crosby MA, Emmert DB, St Pierre SE, Gramates LS, Zhou P, Schroeder AJ, Falls K, Strelets V, Russo SM, Gelbart WM,
G3 (Bethesda, Md.)5(8)1721-36(2015 Jun)

Gene Model Annotations for Drosophila melanogaster: The Rule-Benders.
Crosby MA, Gramates LS, Dos Santos G, Matthews BB, St Pierre SE, Zhou P, Schroeder AJ, Falls K, Emmert DB, Russo SM, Gelbart WM,
G3 (Bethesda, Md.)5(8)1737-49(2015 Jun)

Sequence finishing and mapping of Drosophila melanogaster heterochromatin.
Hoskins RA, Carlson JW, Kennedy C, Acevedo D, Evans-Holm M, Frise E, Wan KH, Park S, Mendez-Lago M, Rossi F, Villasante A, Dimitri P, Karpen GH, Celniker SE
Science (New York, N.Y.)316(5831)1625-8(2007 Jun)

The Release 5.1 annotation of Drosophila melanogaster heterochromatin.
Smith CD, Shu S, Mungall CJ, Karpen GH
Science (New York, N.Y.)316(5831)1586-91(2007 Jun)

Combined evidence annotation of transposable elements in genome sequences.
Quesneville H, Bergman CM, Andrieu O, Autard D, Nouaud D, Ashburner M, Anxolabehere D
PLoS computational biology1(2)166-75(2005 Jul)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

dDsk2 prevents dUbp8/Nonstop-dependent H2Bub1 deubiquitylation at promoters of dHP1c complex target genes and regulates RNA polymerase II pausing.
Title: dDsk2 regulates H2Bub1 and RNA polymerase II pausing at dHP1c complex target genes.

Data indicate significant similarity and uniqueness in the genes regulated by three HP1 homologs HP1a, HP1b, and HP1c.
Title: DNA microarray profiling of genes differentially regulated by three heterochromatin protein 1 (HP1) homologs in Drosophila.

interaction between HP1c and Woc constitutes a transcriptional feedback loop that operates to balance the concentration of HP1c within the cell
Title: Drosophila HP1c is regulated by an auto-regulatory feedback loop through its binding partner Woc.

HP1c, WOC, and ROW regulate a common gene expression program that, in part, is executed in the context of the nervous system.
Title: Drosophila HP1c isoform interacts with the zinc-finger proteins WOC and Relative-of-WOC to regulate gene expression.

The following HP1c gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the HP1c cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OFa08694	NM_142836.3 Latest version!	Drosophila melanogaster heterochromatin protein 1c (HP1c), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$174.30 $249.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

HP1c ( NM_142836.3 ) cDNA ORF clone, Drosophila melanogaster(fruit fly) -> NP_651093.1 Drosophila melanogaster heterochromatin protein 1c (HP1c), mRNA.

Price & Availability↑

CloneID	OFa08694
Clone ID Related Accession (Same CDS sequence)	NM_142836.3
Accession Version	NM_142836.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 714bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-04-24
Organism	Drosophila melanogaster(fruit fly)
Product	heterochromatin protein 1c
Comment	Comment: REVIEWED REFSEQ: This record has been curated by FlyBase. This record is derived from an annotated genomic sequence (NT_033777). On Jul 15, 2014 this sequence version replaced NM_142836.2. ##Genome-Annotation-Data-START## Annotation Provider :: FlyBase Annotation Status :: Full annotation Annotation Version :: Release 6.26 URL :: http://flybase.org ##Genome-Annotation-Data-END##

ATGGTTAAAA ACGAGCCCAA CTTCGTGGTG GAGCGCATCA TGGACAAGCG CATTACCAGC 
GAAGGCAAGG TTGAGTACTA CATCAAGTGG CGTGGCTACA CGTCGGCGGA CAACACCTGG 
GAGCCCGAGG AGAACTGCGA TTGCCCGAAT CTCATCCAGA AATTCGAGGA GTCGCGCGCC 
AAGTCCAAGA AGCGCGGCGA GAAGAAACCC AAGTGCGAAG AGATCCAGAA GCTGCGCGGC 
TACGAGCGCG GCTTGGAGCT GGCCGAGATC GTGGGCGCAA CGGATGTGAC GGGCGACATC 
AAGTATCTGG TGCGCTGGCA GTTCTGCGAC GAGTTCGACT TGGTGCCATC GGCACAGATC 
GTGGAGAAGG ATCCGCAAAT GCTGATTGAC TATTTCCAGA AGATGGCACC TTACTCCCGT 
CACATTGCGA TGCGAATGAA GGGCGTGCCG GAGGAGCTGC GTTTGGCGGC CTCGCGCACC 
AGTTATCCGC ACATTAGCAG TGCGCCCGTC GAAGTGCCGC CGGAGGTGGA TCAGTCCGCT 
GAGTTGGCTG GACATCTTGG TGGAATCGCG CCACAGGTGG ACCAGGCGCC GCAGCACCAT 
GCACCCATGG ATCTAGCCAA TGATACCGAC GATTTGGCTA GTGTTTCGTA CTCGATTCCC 
GTGCCCGGCG TTGGCGACAT TGCCATCGAT GTGCCCATGG CGGAAAATCA ATAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_651093.1
CDS	98..811
Translation	MVKNEPNFVVERIMDKRITSEGKVEYYIKWRGYTSADNTWEPEENCDCPNLIQKFEESRAKSKKRGEKKPKCEEIQKLRGYERGLELAEIVGATDVTGDIKYLVRWQFCDEFDLVPSAQIVEKDPQMLIDYFQKMAPYSRHIAMRMKGVPEELRLAASRTSYPHISSAPVEVPPEVDQSAELAGHLGGIAPQVDQAPQHHAPMDLANDTDDLASVSYSIPVPGVGDIAIDVPMAENQ

Target ORF information:

RefSeq Version	NM_142836.3
Organism	Drosophila melanogaster(fruit fly)
Definition	Drosophila melanogaster heterochromatin protein 1c (HP1c), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_142836.3

ORF Insert Sequence:

ATGGTTAAAA ACGAGCCCAA CTTCGTGGTG GAGCGCATCA TGGACAAGCG CATTACCAGC 
GAAGGCAAGG TTGAGTACTA CATCAAGTGG CGTGGCTACA CGTCGGCGGA CAACACCTGG 
GAGCCCGAGG AGAACTGCGA TTGCCCGAAT CTCATCCAGA AATTCGAGGA GTCGCGCGCC 
AAGTCCAAGA AGCGCGGCGA GAAGAAACCC AAGTGCGAAG AGATCCAGAA GCTGCGCGGC 
TACGAGCGCG GCTTGGAGCT GGCCGAGATC GTGGGCGCAA CGGATGTGAC GGGCGACATC 
AAGTATCTGG TGCGCTGGCA GTTCTGCGAC GAGTTCGACT TGGTGCCATC GGCACAGATC 
GTGGAGAAGG ATCCGCAAAT GCTGATTGAC TATTTCCAGA AGATGGCACC TTACTCCCGT 
CACATTGCGA TGCGAATGAA GGGCGTGCCG GAGGAGCTGC GTTTGGCGGC CTCGCGCACC 
AGTTATCCGC ACATTAGCAG TGCGCCCGTC GAAGTGCCGC CGGAGGTGGA TCAGTCCGCT 
GAGTTGGCTG GACATCTTGG TGGAATCGCG CCACAGGTGG ACCAGGCGCC GCAGCACCAT 
GCACCCATGG ATCTAGCCAA TGATACCGAC GATTTGGCTA GTGTTTCGTA CTCGATTCCC 
GTGCCCGGCG TTGGCGACAT TGCCATCGAT GTGCCCATGG CGGAAAATCA ATAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Gene Model Annotations for Drosophila melanogaster: Impact of High-Throughput Data.
G3 (Bethesda, Md.)5(8)1721-36(2015 Jun)
Matthews BB,Dos Santos G,Crosby MA,Emmert DB,St Pierre SE,Gramates LS,Zhou P,Schroeder AJ,Falls K,Strelets V,Russo SM,Gelbart WM,

Gene Model Annotations for Drosophila melanogaster: The Rule-Benders.
G3 (Bethesda, Md.)5(8)1737-49(2015 Jun)
Crosby MA,Gramates LS,Dos Santos G,Matthews BB,St Pierre SE,Zhou P,Schroeder AJ,Falls K,Emmert DB,Russo SM,Gelbart WM,

Sequence finishing and mapping of Drosophila melanogaster heterochromatin.
Science (New York, N.Y.)316(5831)1625-8(2007 Jun)
Hoskins RA,Carlson JW,Kennedy C,Acevedo D,Evans-Holm M,Frise E,Wan KH,Park S,Mendez-Lago M,Rossi F,Villasante A,Dimitri P,Karpen GH,Celniker SE

The Release 5.1 annotation of Drosophila melanogaster heterochromatin.
Science (New York, N.Y.)316(5831)1586-91(2007 Jun)
Smith CD,Shu S,Mungall CJ,Karpen GH

Combined evidence annotation of transposable elements in genome sequences.
PLoS computational biology1(2)166-75(2005 Jul)
Quesneville H,Bergman CM,Andrieu O,Autard D,Nouaud D,Ashburner M,Anxolabehere D

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HP1c cDNA ORF clone, Drosophila melanogaster(fruit fly)

Gene

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Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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