Prx3 cDNA ORF clone, Drosophila melanogaster(fruit fly)

Gene
Clones
gRNAs

Summary

Gene Symbol	Prx3
Entrez Gene ID	42109
Full Name	Peroxiredoxin 3
Synonyms	CG5826,DPx-5037,DPx5037,Dmel\CG5826,Prx5037,dPrx3,mTPx,mtTPx,peroxiredoxin 5037
General protein information	Preferred Names Peroxiredoxin 3 Names CG5826 gene product from transcript CG5826-RA CG5826-PA Prx3-PA mitochondrial peroxiredoxin peroxiredoxin 3 peroxiredoxin 5037 thioredoxin peroxidase 3 thioredoxin-peroxidase-3
Gene Type	protein-coding
Organism	Drosophila melanogaster(fruit fly)
Genome	Chromosome: 3R Map Location: 90B4-90B4

mRNA and Protein(s)

mRNA	Protein	Name
NM_079663.3	NP_524387.1	peroxiredoxin 3

Pathways from BioSystems

Homologies

Homo sapiens (human)	PRDX3	NP_006784.1
	PRDX3	XP_001097456.1
Bos taurus (cattle)	PRDX3	NP_776857.1
Gallus gallus (chicken)	PRDX3	XP_004942376.1
Kluyveromyces lactis	KLLA0B01628g	XP_451603.1
Anopheles gambiae (African malaria mosquito)	TPX1	XP_310704.3
Caenorhabditis elegans (roundworm)	prdx-3	NP_497892.1
Xenopus tropicalis (tropical clawed frog)	prdx3	NP_001025608.1
Mus musculus (house mouse)	Prdx3	NP_031478.1
Pan troglodytes (chimpanzee)	PRDX3	XP_003951819.1
Canis lupus familiaris (dog)	PRDX3	NP_001243414.1
Rattus norvegicus (Norway rat)	Prdx3	NP_071985.1
Danio rerio (zebrafish)	prdx3	NP_001013478.2
Drosophila melanogaster (fruit fly)	Prx3	NP_524387.1
Saccharomyces cerevisiae (baker's yeast)	TSA2	NP_010741.1
Eremothecium gossypii	AGOS_AER312W	NP_985168.1

Gene Ontology
Bibliography

Related articles in PubMed

Gene Model Annotations for Drosophila melanogaster: Impact of High-Throughput Data.
Matthews BB, Dos Santos G, Crosby MA, Emmert DB, St Pierre SE, Gramates LS, Zhou P, Schroeder AJ, Falls K, Strelets V, Russo SM, Gelbart WM,
G3 (Bethesda, Md.)5(8)1721-36(2015 Jun)

Gene Model Annotations for Drosophila melanogaster: The Rule-Benders.
Crosby MA, Gramates LS, Dos Santos G, Matthews BB, St Pierre SE, Zhou P, Schroeder AJ, Falls K, Emmert DB, Russo SM, Gelbart WM,
G3 (Bethesda, Md.)5(8)1737-49(2015 Jun)

Sequence finishing and mapping of Drosophila melanogaster heterochromatin.
Hoskins RA, Carlson JW, Kennedy C, Acevedo D, Evans-Holm M, Frise E, Wan KH, Park S, Mendez-Lago M, Rossi F, Villasante A, Dimitri P, Karpen GH, Celniker SE
Science (New York, N.Y.)316(5831)1625-8(2007 Jun)

The Release 5.1 annotation of Drosophila melanogaster heterochromatin.
Smith CD, Shu S, Mungall CJ, Karpen GH
Science (New York, N.Y.)316(5831)1586-91(2007 Jun)

Combined evidence annotation of transposable elements in genome sequences.
Quesneville H, Bergman CM, Andrieu O, Autard D, Nouaud D, Ashburner M, Anxolabehere D
PLoS computational biology1(2)166-75(2005 Jul)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Data shows that LRRK2 inhibits PRDX3 in the fly brain.
Title: Thiol peroxidases ameliorate LRRK2 mutant-induced mitochondrial and dopaminergic neuronal degeneration in Drosophila.

Prx3 plays an important role in the oxidative stress response and is involved in the age-dependent competence of the oxidative stress response.
Title: Involvement of Prx3, a Drosophila ortholog of the thiol-dependent peroxidase PRDX3, in age-dependent oxidative stress resistance.

flies underexpressing peroxiredoxin 3 and peroxiredoxin 5 showed an 80% reduction in lifespan and a massive induction of apoptosis in the muscle and digestive system tissues.
Title: Mitochondrial peroxiredoxins are critical for the maintenance of redox state and the survival of adult Drosophila.

While the upstream CG7215 gene can be expressed from both mono- and dicistronic mRNAs, the downstream dPrx5 gene is likely to be expressed predominantly from its monocistronic transcripts.
Title: Drosophila peroxiredoxin 5 is the second gene in a dicistronic operon.

The following Prx3 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Prx3 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OFa05237	NM_079663.3 Latest version!	Drosophila melanogaster peroxiredoxin 3 (Prx3), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$174.30 $249.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Prx3 ( NM_079663.3 ) cDNA ORF clone, Drosophila melanogaster(fruit fly) -> NP_524387.1 Drosophila melanogaster peroxiredoxin 3 (Prx3), mRNA.

Price & Availability↑

CloneID	OFa05237
Clone ID Related Accession (Same CDS sequence)	NM_079663.3
Accession Version	NM_079663.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 705bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-04-24
Organism	Drosophila melanogaster(fruit fly)
Product	peroxiredoxin 3
Comment	Comment: REVIEWED REFSEQ: This record has been curated by FlyBase. This record is derived from an annotated genomic sequence (NT_033777). On Jan 16, 2013 this sequence version replaced NM_079663.2. ##Genome-Annotation-Data-START## Annotation Provider :: FlyBase Annotation Status :: Full annotation Annotation Version :: Release 6.26 URL :: http://flybase.org ##Genome-Annotation-Data-END##

ATGTCTTTCG TAGCACGCTC ACTGATTCGC AATGTGCCGC TGATGGGCAA GGCCATCCTG 
AGTCAGCAGA AACAGATTGC CGCCCGCCTC CTGCATCAAA CCGCTCCCCT TGCGGCAGTC 
CGCGTCCAGC AACCTGCTCC CGATTTCAAG GGTCTGGCTG TGGTGGACAA CAGCTTCCAG 
GAGGTTAAGC TGGAAGACTA CAGGGGCAAG TACCTGGTGC TCTTCTTCTA CCCACTAGAT 
TTCACATTCG TTTGCCCCAC CGAAATTGTT GCATTTAGCG AGAGGATCAA GGAGTTCCAT 
GACATTAACA CCGAGGTTCT GGGCGTTTCC GTGGACTCCC ACTTCAGCCA TCTCACCTGG 
TGCAATGTCG ACCGCAAGAA CGGCGGAGTG GGCCAGCTGA AGTACCCGCT CCTCTCCGAT 
TTGACCAAGA AGATCTCTGC CGACTACGAT GTGTTGCTGG ACAAGGAGGG CATCTCGCTG 
CGCGGCACCT TCATCATTGA CCCCAATGGC ATCCTGCGCC AGTACTCCAT TAATGATTTG 
CCCGTGGGCC GATCCGTCGA CGAGGTTCTG CGCCTGATCA AAGCCTTCCA GTTCGTCGAG 
CAGCACGGAG AAGTCTGCCC GGCCAACTGG AATCCCAACT CGAATCCGGC TACCATTAAG 
CCCGATGTGG AGGAGTCCAA GAAGTACTTC AGCAAGCACG GCTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_524387.1
CDS	144..848
Translation	MSFVARSLIRNVPLMGKAILSQQKQIAARLLHQTAPLAAVRVQQPAPDFKGLAVVDNSFQEVKLEDYRGKYLVLFFYPLDFTFVCPTEIVAFSERIKEFHDINTEVLGVSVDSHFSHLTWCNVDRKNGGVGQLKYPLLSDLTKKISADYDVLLDKEGISLRGTFIIDPNGILRQYSINDLPVGRSVDEVLRLIKAFQFVEQHGEVCPANWNPNSNPATIKPDVEESKKYFSKHG

Target ORF information:

RefSeq Version	NM_079663.3
Organism	Drosophila melanogaster(fruit fly)
Definition	Drosophila melanogaster peroxiredoxin 3 (Prx3), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_079663.3

ORF Insert Sequence:

ATGTCTTTCG TAGCACGCTC ACTGATTCGC AATGTGCCGC TGATGGGCAA GGCCATCCTG 
AGTCAGCAGA AACAGATTGC CGCCCGCCTC CTGCATCAAA CCGCTCCCCT TGCGGCAGTC 
CGCGTCCAGC AACCTGCTCC CGATTTCAAG GGTCTGGCTG TGGTGGACAA CAGCTTCCAG 
GAGGTTAAGC TGGAAGACTA CAGGGGCAAG TACCTGGTGC TCTTCTTCTA CCCACTAGAT 
TTCACATTCG TTTGCCCCAC CGAAATTGTT GCATTTAGCG AGAGGATCAA GGAGTTCCAT 
GACATTAACA CCGAGGTTCT GGGCGTTTCC GTGGACTCCC ACTTCAGCCA TCTCACCTGG 
TGCAATGTCG ACCGCAAGAA CGGCGGAGTG GGCCAGCTGA AGTACCCGCT CCTCTCCGAT 
TTGACCAAGA AGATCTCTGC CGACTACGAT GTGTTGCTGG ACAAGGAGGG CATCTCGCTG 
CGCGGCACCT TCATCATTGA CCCCAATGGC ATCCTGCGCC AGTACTCCAT TAATGATTTG 
CCCGTGGGCC GATCCGTCGA CGAGGTTCTG CGCCTGATCA AAGCCTTCCA GTTCGTCGAG 
CAGCACGGAG AAGTCTGCCC GGCCAACTGG AATCCCAACT CGAATCCGGC TACCATTAAG 
CCCGATGTGG AGGAGTCCAA GAAGTACTTC AGCAAGCACG GCTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Gene Model Annotations for Drosophila melanogaster: Impact of High-Throughput Data.
G3 (Bethesda, Md.)5(8)1721-36(2015 Jun)
Matthews BB,Dos Santos G,Crosby MA,Emmert DB,St Pierre SE,Gramates LS,Zhou P,Schroeder AJ,Falls K,Strelets V,Russo SM,Gelbart WM,

Gene Model Annotations for Drosophila melanogaster: The Rule-Benders.
G3 (Bethesda, Md.)5(8)1737-49(2015 Jun)
Crosby MA,Gramates LS,Dos Santos G,Matthews BB,St Pierre SE,Zhou P,Schroeder AJ,Falls K,Emmert DB,Russo SM,Gelbart WM,

Sequence finishing and mapping of Drosophila melanogaster heterochromatin.
Science (New York, N.Y.)316(5831)1625-8(2007 Jun)
Hoskins RA,Carlson JW,Kennedy C,Acevedo D,Evans-Holm M,Frise E,Wan KH,Park S,Mendez-Lago M,Rossi F,Villasante A,Dimitri P,Karpen GH,Celniker SE

The Release 5.1 annotation of Drosophila melanogaster heterochromatin.
Science (New York, N.Y.)316(5831)1586-91(2007 Jun)
Smith CD,Shu S,Mungall CJ,Karpen GH

Combined evidence annotation of transposable elements in genome sequences.
PLoS computational biology1(2)166-75(2005 Jul)
Quesneville H,Bergman CM,Andrieu O,Autard D,Nouaud D,Ashburner M,Anxolabehere D

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Prx3 cDNA ORF clone, Drosophila melanogaster(fruit fly)

Gene

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gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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