CSN5 cDNA ORF clone, Drosophila melanogaster(fruit fly)

Gene
Clones
gRNAs

Summary

Gene Symbol	CSN5
Entrez Gene ID	42000
Full Name	COP9 signalosome subunit 5
Synonyms	BcDNA.LD14392,BcDNA:LD14392,CG14884,CH5,CSN-5,Csn5,DCH5,Dch5,Dmel\CG14884,JAB1,JAB1/CSN5,Jab1,JadBp,Q9XZ58,csn5,dch5,jab1/csn5,l(3)89Cf,l(3)L4032,l(3)M203,quo
General protein information	Preferred Names COP9 signalosome subunit 5 Names CG14884 gene product from transcript CG14884-RA CG14884-PA CG14884-PB COP9 complex homolog subunit 5 COP9 complex subunit 5 CSN5-PA CSN5-PB JUN activation domain-binding protein-1 Jun activation domain binding protein drosophila COP9 signalosome homolog 5
Gene Type	protein-coding
Organism	Drosophila melanogaster(fruit fly)
Genome	Chromosome: 3R Map Location: 89B17-89B17

mRNA and Protein(s)

mRNA	Protein	Name
NM_001275710.1	NP_001262639.1	COP9 signalosome subunit 5, isoform B
NM_058094.5	NP_477442.1	COP9 signalosome subunit 5, isoform A

Pathways from BioSystems

Homologies

Homo sapiens (human)	COPS5	NP_006828.2
Bos taurus (cattle)	COPS5	NP_001179068.1
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP002880	XP_312032.5
Mus musculus (house mouse)	Cops5	NP_038743.1
Arabidopsis thaliana (thale cress)	CSN5B	NP_177279.1
Oryza sativa (rice)	Os04g0654700	NP_001054112.1
Xenopus tropicalis (tropical clawed frog)	cops5	NP_989109.1
Pan troglodytes (chimpanzee)	COPS5	XP_001162723.1
Canis lupus familiaris (dog)	COPS5	XP_005638087.1
Gallus gallus (chicken)	COPS5	NP_001034400.1
Drosophila melanogaster (fruit fly)	CSN5	NP_477442.1
Caenorhabditis elegans (roundworm)	csn-5	NP_500841.1
Magnaporthe oryzae (rice blast fungus)	MGG_05274	XP_003712833.1
Neurospora crassa	NCU00467	XP_956786.1
	COPS5	XP_001097856.1
Rattus norvegicus (Norway rat)	Cops5	NP_001020866.1
Danio rerio (zebrafish)	cops5	NP_957019.1
Arabidopsis thaliana (thale cress)	CSN5A	NP_173705.1

Gene Ontology
Bibliography

Related articles in PubMed

Gene Model Annotations for Drosophila melanogaster: Impact of High-Throughput Data.
Matthews BB, Dos Santos G, Crosby MA, Emmert DB, St Pierre SE, Gramates LS, Zhou P, Schroeder AJ, Falls K, Strelets V, Russo SM, Gelbart WM,
G3 (Bethesda, Md.)5(8)1721-36(2015 Jun)

Gene Model Annotations for Drosophila melanogaster: The Rule-Benders.
Crosby MA, Gramates LS, Dos Santos G, Matthews BB, St Pierre SE, Zhou P, Schroeder AJ, Falls K, Emmert DB, Russo SM, Gelbart WM,
G3 (Bethesda, Md.)5(8)1737-49(2015 Jun)

Sequence finishing and mapping of Drosophila melanogaster heterochromatin.
Hoskins RA, Carlson JW, Kennedy C, Acevedo D, Evans-Holm M, Frise E, Wan KH, Park S, Mendez-Lago M, Rossi F, Villasante A, Dimitri P, Karpen GH, Celniker SE
Science (New York, N.Y.)316(5831)1625-8(2007 Jun)

The Release 5.1 annotation of Drosophila melanogaster heterochromatin.
Smith CD, Shu S, Mungall CJ, Karpen GH
Science (New York, N.Y.)316(5831)1586-91(2007 Jun)

Combined evidence annotation of transposable elements in genome sequences.
Quesneville H, Bergman CM, Andrieu O, Autard D, Nouaud D, Ashburner M, Anxolabehere D
PLoS computational biology1(2)166-75(2005 Jul)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

results presented here indicate that CSN5 is a negative regulator of Dorsal subcellular localization, and of hemocyte proliferation and differentiation
Title: COP9 signalosome subunit 5 (CSN5/Jab1) regulates the development of the Drosophila immune system: effects on Cactus, Dorsal and hematopoiesis.

we link the CSN to the degradation of Cyclin E, which promotes the G1-S transition in the cell cycle and then is rapidly degraded by the ubiquitin-proteasome pathway
Title: The COP9 signalosome promotes degradation of Cyclin E during early Drosophila oogenesis.

during oogenesis CSN5/JAB1, one subunit of the CSN, is required for meiotic progression and for establishment of both the AP and DV axes of the Drosophila oocyte
Title: CSN5/Jab1 mutations affect axis formation in the Drosophila oocyte by activating a meiotic checkpoint.

COP9 signalosome subunits 4 and 5 regulate multiple pleiotropic pathways in Drosophila melanogaster.
Title: COP9 signalosome subunits 4 and 5 regulate multiple pleiotropic pathways in Drosophila melanogaster.

The following CSN5 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the CSN5 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OFa05129	NM_058094.5 Latest version!	Drosophila melanogaster COP9 signalosome subunit 5 (CSN5), transcript variant A, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$174.30 $249.00
OFa07931	NM_001275710.1 Latest version!	Drosophila melanogaster COP9 signalosome subunit 5 (CSN5), transcript variant B, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$174.30 $249.00

ORF Online Only Promotion

Next-day Shipping ORF Clones ( in default vector with tag)
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2-4 Clone	40% OFF
5 or more Clone	50% OFF
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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

CSN5 ( NM_058094.5 ) cDNA ORF clone, Drosophila melanogaster(fruit fly) -> NP_477442.1 Drosophila melanogaster COP9 signalosome subunit 5 (CSN5), transcript variant A, mRNA.

Price & Availability↑

CloneID	OFa05129
Clone ID Related Accession (Same CDS sequence)	NM_058094.5
Accession Version	NM_058094.5 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 984bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-04-24
Organism	Drosophila melanogaster(fruit fly)
Product	COP9 signalosome subunit 5, isoform A
Comment	Comment: REVIEWED REFSEQ: This record has been curated by FlyBase. This record is derived from an annotated genomic sequence (NT_033777). On Jan 16, 2013 this sequence version replaced NM_058094.4. ##Genome-Annotation-Data-START## Annotation Provider :: FlyBase Annotation Status :: Full annotation Annotation Version :: Release 6.26 URL :: http://flybase.org ##Genome-Annotation-Data-END##

ATGGACTCCG ACGCCGCACA AAAGACCTGG GAGCTGGAGA ACAACATCCA GACGTTGCCC 
AGTTGTGACG AGATCTTTCG CTACGACGCC GAACAGCAGC GGCAGATCAT CGATGCGAAG 
CCCTGGGAGA AAGATCCCCA CTTCTTTAAG GACATTAAGA TCTCGGCTCT GGCGCTCCTA 
AAGATGGTGA TGCACGCTCG CTCTGGCGGT ACTTTGGAGG TGATGGGTCT AATGCTTGGC 
AAGGTAGAGG ACAACACAAT GATTGTCATG GATGCATTTG CACTGCCAGT GGAGGGCACT 
GAAACCCGCG TCAATGCCCA GGCACAAGCG TACGAGTACA TGACCGCCTA CATGGAAGCG 
GCCAAAGAGG TGGGACGCAT GGAACACGCC GTGGGCTGGT ATCACAGCCA TCCCGGTTAC 
GGTTGCTGGT TGTCCGGCAT CGATGTGTCC ACCCAGATGC TCAACCAGAC ATACCAGGAG 
CCATTCGTGG CCATTGTGGT TGATCCGGTG CGCACTGTTT CCGCTGGCAA GGTGTGTCTG 
GGTGCATTCC GCACGTATCC AAAAGGTTAT AAGCCACCAA ACGAGGAGCC CTCGGAGTAT 
CAGACCATCC CGCTGAATAA GATCGAAGAC TTTGGAGTCC ACTGCAAGCA GTACTATCCC 
TTGGAAATTA GCTACTTCAA GTCTGCTCTG GACCGCAGGC TCCTCGACTC TCTGTGGAAC 
AAATACTGGG TAAACACACT GGGCAGCTCG GGTCTGCTCA CCAACACAGA GTACACCACC 
GGTCAGATCA TGGATCTCTC CGAGAAGCTG GAGCAGAGTG AGAACTTTTT AGGTCGCGGA 
ACCGATGTCA ATGAGAAGCG TTCGGAGGAT AAGCTGTCCA AGGCCACCCG AGACTGCAGC 
CGCTCCACCA TTGAACTGAT ACACGGCTTG ATGGCTCAGA TTGTTAAGGA CAAACTTTTC 
AACAAGGTCG GACTGGGCAA ATAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_477442.1
CDS	81..1064
Translation	MDSDAAQKTWELENNIQTLPSCDEIFRYDAEQQRQIIDAKPWEKDPHFFKDIKISALALLKMVMHARSGGTLEVMGLMLGKVEDNTMIVMDAFALPVEGTETRVNAQAQAYEYMTAYMEAAKEVGRMEHAVGWYHSHPGYGCWLSGIDVSTQMLNQTYQEPFVAIVVDPVRTVSAGKVCLGAFRTYPKGYKPPNEEPSEYQTIPLNKIEDFGVHCKQYYPLEISYFKSALDRRLLDSLWNKYWVNTLGSSGLLTNTEYTTGQIMDLSEKLEQSENFLGRGTDVNEKRSEDKLSKATRDCSRSTIELIHGLMAQIVKDKLFNKVGLGK

Target ORF information:

RefSeq Version	NM_058094.5
Organism	Drosophila melanogaster(fruit fly)
Definition	Drosophila melanogaster COP9 signalosome subunit 5 (CSN5), transcript variant A, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_058094.5

ORF Insert Sequence:

ATGGACTCCG ACGCCGCACA AAAGACCTGG GAGCTGGAGA ACAACATCCA GACGTTGCCC 
AGTTGTGACG AGATCTTTCG CTACGACGCC GAACAGCAGC GGCAGATCAT CGATGCGAAG 
CCCTGGGAGA AAGATCCCCA CTTCTTTAAG GACATTAAGA TCTCGGCTCT GGCGCTCCTA 
AAGATGGTGA TGCACGCTCG CTCTGGCGGT ACTTTGGAGG TGATGGGTCT AATGCTTGGC 
AAGGTAGAGG ACAACACAAT GATTGTCATG GATGCATTTG CACTGCCAGT GGAGGGCACT 
GAAACCCGCG TCAATGCCCA GGCACAAGCG TACGAGTACA TGACCGCCTA CATGGAAGCG 
GCCAAAGAGG TGGGACGCAT GGAACACGCC GTGGGCTGGT ATCACAGCCA TCCCGGTTAC 
GGTTGCTGGT TGTCCGGCAT CGATGTGTCC ACCCAGATGC TCAACCAGAC ATACCAGGAG 
CCATTCGTGG CCATTGTGGT TGATCCGGTG CGCACTGTTT CCGCTGGCAA GGTGTGTCTG 
GGTGCATTCC GCACGTATCC AAAAGGTTAT AAGCCACCAA ACGAGGAGCC CTCGGAGTAT 
CAGACCATCC CGCTGAATAA GATCGAAGAC TTTGGAGTCC ACTGCAAGCA GTACTATCCC 
TTGGAAATTA GCTACTTCAA GTCTGCTCTG GACCGCAGGC TCCTCGACTC TCTGTGGAAC 
AAATACTGGG TAAACACACT GGGCAGCTCG GGTCTGCTCA CCAACACAGA GTACACCACC 
GGTCAGATCA TGGATCTCTC CGAGAAGCTG GAGCAGAGTG AGAACTTTTT AGGTCGCGGA 
ACCGATGTCA ATGAGAAGCG TTCGGAGGAT AAGCTGTCCA AGGCCACCCG AGACTGCAGC 
CGCTCCACCA TTGAACTGAT ACACGGCTTG ATGGCTCAGA TTGTTAAGGA CAAACTTTTC 
AACAAGGTCG GACTGGGCAA ATAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

CSN5 ( NM_001275710.1 ) cDNA ORF clone, Drosophila melanogaster(fruit fly) -> NP_001262639.1 Drosophila melanogaster COP9 signalosome subunit 5 (CSN5), transcript variant B, mRNA.

Price & Availability↑

CloneID	OFa07931
Clone ID Related Accession (Same CDS sequence)	NM_001275710.1
Accession Version	NM_001275710.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 978bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-04-24
Organism	Drosophila melanogaster(fruit fly)
Product	COP9 signalosome subunit 5, isoform B
Comment	Comment: REVIEWED REFSEQ: This record has been curated by FlyBase. This record is derived from an annotated genomic sequence (NT_033777). ##Genome-Annotation-Data-START## Annotation Provider :: FlyBase Annotation Status :: Full annotation Annotation Version :: Release 6.26 URL :: http://flybase.org ##Genome-Annotation-Data-END##

ATGGACTCCG ACGCCGCACA AAAGACCTGG GAGCTGGAGA ACAACATCCA GACGTTGCCC 
AGTTGTGACG AGATCTTTCG CTACGACGCC GAACAGCAGC GGCAGATCAT CGATGCGAAG 
CCCTGGGAGA AAGATCCCCA CTTCTTTAAG GACATTAAGA TCTCGGCTCT GGCGCTCCTA 
AAGATGGTGA TGCACGCTCG CTCTGGCGGT ACTTTGGAGG TGATGGGTCT AATGCTTGGC 
AAGGTAGAGG ACAACACAAT GATTGTCATG GATGCATTTG CACTGCCAGT GGAGGGCACT 
GAAACCCGCG TCAATGCCCA GGCACAAGCG TACGAGTACA TGACCGCCTA CATGGAAGCG 
GCCAAAGAGG TGGGACGCAT GGAACACGCC GTGGGCTGGT ATCACAGCCA TCCCGGTTAC 
GGTTGCTGGT TGTCCGGCAT CGATGTGTCC ACCCAGATGC TCAACCAGAC ATACCAGGAG 
CCATTCGTGG CCATTGTGGT TGATCCGGTG CGCACTGTTT CCGCTGGCAA GGTGTGTCTG 
GGTGCATTCC GCACGTATCC AAAAGGTTAT AAGCCACCAA ACGAGGAGCC CTCGGAGTAT 
CAGACCATCC CGCTGAATAA GATCGAAGAC TTTGGAGTCC ACTGCAAGCA GTACTATCCC 
TTGGAAATTA GCTACTTCAA GTCTGCTCTG GACCGCAGGC TCCTCGACTC TCTGTGGAAC 
AAATACTGGG TAAACACACT GGGCAGCTCG GGTCTGCTCA CCAACACAGA GTACACCACC 
GGTCAGATCA TGGATCTCTC CGAGAAGCTG GAGCAGAGTG AGAACTTTTT AGGAACCGAT 
GTCAATGAGA AGCGTTCGGA GGATAAGCTG TCCAAGGCCA CCCGAGACTG CAGCCGCTCC 
ACCATTGAAC TGATACACGG CTTGATGGCT CAGATTGTTA AGGACAAACT TTTCAACAAG 
GTCGGACTGG GCAAATAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001262639.1
CDS	81..1058
Translation	MDSDAAQKTWELENNIQTLPSCDEIFRYDAEQQRQIIDAKPWEKDPHFFKDIKISALALLKMVMHARSGGTLEVMGLMLGKVEDNTMIVMDAFALPVEGTETRVNAQAQAYEYMTAYMEAAKEVGRMEHAVGWYHSHPGYGCWLSGIDVSTQMLNQTYQEPFVAIVVDPVRTVSAGKVCLGAFRTYPKGYKPPNEEPSEYQTIPLNKIEDFGVHCKQYYPLEISYFKSALDRRLLDSLWNKYWVNTLGSSGLLTNTEYTTGQIMDLSEKLEQSENFLGTDVNEKRSEDKLSKATRDCSRSTIELIHGLMAQIVKDKLFNKVGLGK

Target ORF information:

RefSeq Version	NM_001275710.1
Organism	Drosophila melanogaster(fruit fly)
Definition	Drosophila melanogaster COP9 signalosome subunit 5 (CSN5), transcript variant B, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001275710.1

ORF Insert Sequence:

ATGGACTCCG ACGCCGCACA AAAGACCTGG GAGCTGGAGA ACAACATCCA GACGTTGCCC 
AGTTGTGACG AGATCTTTCG CTACGACGCC GAACAGCAGC GGCAGATCAT CGATGCGAAG 
CCCTGGGAGA AAGATCCCCA CTTCTTTAAG GACATTAAGA TCTCGGCTCT GGCGCTCCTA 
AAGATGGTGA TGCACGCTCG CTCTGGCGGT ACTTTGGAGG TGATGGGTCT AATGCTTGGC 
AAGGTAGAGG ACAACACAAT GATTGTCATG GATGCATTTG CACTGCCAGT GGAGGGCACT 
GAAACCCGCG TCAATGCCCA GGCACAAGCG TACGAGTACA TGACCGCCTA CATGGAAGCG 
GCCAAAGAGG TGGGACGCAT GGAACACGCC GTGGGCTGGT ATCACAGCCA TCCCGGTTAC 
GGTTGCTGGT TGTCCGGCAT CGATGTGTCC ACCCAGATGC TCAACCAGAC ATACCAGGAG 
CCATTCGTGG CCATTGTGGT TGATCCGGTG CGCACTGTTT CCGCTGGCAA GGTGTGTCTG 
GGTGCATTCC GCACGTATCC AAAAGGTTAT AAGCCACCAA ACGAGGAGCC CTCGGAGTAT 
CAGACCATCC CGCTGAATAA GATCGAAGAC TTTGGAGTCC ACTGCAAGCA GTACTATCCC 
TTGGAAATTA GCTACTTCAA GTCTGCTCTG GACCGCAGGC TCCTCGACTC TCTGTGGAAC 
AAATACTGGG TAAACACACT GGGCAGCTCG GGTCTGCTCA CCAACACAGA GTACACCACC 
GGTCAGATCA TGGATCTCTC CGAGAAGCTG GAGCAGAGTG AGAACTTTTT AGGAACCGAT 
GTCAATGAGA AGCGTTCGGA GGATAAGCTG TCCAAGGCCA CCCGAGACTG CAGCCGCTCC 
ACCATTGAAC TGATACACGG CTTGATGGCT CAGATTGTTA AGGACAAACT TTTCAACAAG 
GTCGGACTGG GCAAATAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Gene Model Annotations for Drosophila melanogaster: Impact of High-Throughput Data.
G3 (Bethesda, Md.)5(8)1721-36(2015 Jun)
Matthews BB,Dos Santos G,Crosby MA,Emmert DB,St Pierre SE,Gramates LS,Zhou P,Schroeder AJ,Falls K,Strelets V,Russo SM,Gelbart WM,

Gene Model Annotations for Drosophila melanogaster: The Rule-Benders.
G3 (Bethesda, Md.)5(8)1737-49(2015 Jun)
Crosby MA,Gramates LS,Dos Santos G,Matthews BB,St Pierre SE,Zhou P,Schroeder AJ,Falls K,Emmert DB,Russo SM,Gelbart WM,

Sequence finishing and mapping of Drosophila melanogaster heterochromatin.
Science (New York, N.Y.)316(5831)1625-8(2007 Jun)
Hoskins RA,Carlson JW,Kennedy C,Acevedo D,Evans-Holm M,Frise E,Wan KH,Park S,Mendez-Lago M,Rossi F,Villasante A,Dimitri P,Karpen GH,Celniker SE

The Release 5.1 annotation of Drosophila melanogaster heterochromatin.
Science (New York, N.Y.)316(5831)1586-91(2007 Jun)
Smith CD,Shu S,Mungall CJ,Karpen GH

Combined evidence annotation of transposable elements in genome sequences.
PLoS computational biology1(2)166-75(2005 Jul)
Quesneville H,Bergman CM,Andrieu O,Autard D,Nouaud D,Ashburner M,Anxolabehere D

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CSN5 cDNA ORF clone, Drosophila melanogaster(fruit fly)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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