aurA cDNA ORF clone, Drosophila melanogaster(fruit fly)

Gene
Clones
gRNAs

Summary

Gene Symbol	aurA
Entrez Gene ID	41446
Full Name	aurora A
Synonyms	87A7-9/2,Aur,Aur-A,AurA,CG3068,Dmel\CG3068,aur,aur-A,ck10,ck[10],l(3)87Ac,l(3)ck10
General protein information	Preferred Names aurora A Names CG3068 gene product from transcript CG3068-RA A-type aurora kinase Aurora-A kinase AuroraA CG3068-PA aurA-PA aurora aurora A kinase aurora kinase aurora-A early-A fruhe2
Gene Type	protein-coding
Organism	Drosophila melanogaster(fruit fly)
Genome	Chromosome: 3R Map Location: 87A3-87A3\|3-53 cM

mRNA and Protein(s)

mRNA	Protein	Name
NM_057401.4	NP_476749.1	aurora A

Pathways from BioSystems

Homologies

Bos taurus (cattle)	AURKA	NP_001033117.1
Danio rerio (zebrafish)	aurka	NP_001003640.1
Gallus gallus (chicken)	AURKA	XP_425725.1
Magnaporthe oryzae (rice blast fungus)	MGG_12408	XP_003715581.1
Arabidopsis thaliana (thale cress)	AUR2	NP_180159.2
Canis lupus familiaris (dog)	AURKA	XP_005635253.1
Rattus norvegicus (Norway rat)	Aurka	NP_695208.2
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP001793	XP_321274.5
Oryza sativa (rice)	Os01g0191800	NP_001042274.1
Xenopus tropicalis (tropical clawed frog)	aurka	NP_001016570.1
Homo sapiens (human)	AURKA	NP_940838.1
Pan troglodytes (chimpanzee)	AURKA	NP_001233545.1
Mus musculus (house mouse)	Aurka	NP_035627.1
Caenorhabditis elegans (roundworm)	air-2	NP_491714.1
	AURKA	XP_002798130.1
Drosophila melanogaster (fruit fly)	aur	NP_476749.1
Arabidopsis thaliana (thale cress)	AUR1	NP_195009.1

Gene Ontology
Bibliography

Related articles in PubMed

Gene Model Annotations for Drosophila melanogaster: Impact of High-Throughput Data.
Matthews BB, Dos Santos G, Crosby MA, Emmert DB, St Pierre SE, Gramates LS, Zhou P, Schroeder AJ, Falls K, Strelets V, Russo SM, Gelbart WM,
G3 (Bethesda, Md.)5(8)1721-36(2015 Jun)

Gene Model Annotations for Drosophila melanogaster: The Rule-Benders.
Crosby MA, Gramates LS, Dos Santos G, Matthews BB, St Pierre SE, Zhou P, Schroeder AJ, Falls K, Emmert DB, Russo SM, Gelbart WM,
G3 (Bethesda, Md.)5(8)1737-49(2015 Jun)

Sequence finishing and mapping of Drosophila melanogaster heterochromatin.
Hoskins RA, Carlson JW, Kennedy C, Acevedo D, Evans-Holm M, Frise E, Wan KH, Park S, Mendez-Lago M, Rossi F, Villasante A, Dimitri P, Karpen GH, Celniker SE
Science (New York, N.Y.)316(5831)1625-8(2007 Jun)

The Release 5.1 annotation of Drosophila melanogaster heterochromatin.
Smith CD, Shu S, Mungall CJ, Karpen GH
Science (New York, N.Y.)316(5831)1586-91(2007 Jun)

Combined evidence annotation of transposable elements in genome sequences.
Quesneville H, Bergman CM, Andrieu O, Autard D, Nouaud D, Ashburner M, Anxolabehere D
PLoS computational biology1(2)166-75(2005 Jul)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

equatorial stimulation is mediated primarily by the delivery of factors to the cortex by noncentrosomal microtubules, as well as a midzone-derived phosphorylation gradient that is amplified by the concerted activities of mABK and a soluble pool of AAK.
Title: Aurora A Kinase Amplifies a Midzone Phosphorylation Gradient to Promote High-Fidelity Cytokinesis.

Disrupting the spindle assembly checkpoint in the aurA mutant does not prevent neuroblast amplification, tumor formation or chromosome segregation.
Title: Spindle assembly checkpoint inactivation fails to suppress neuroblast tumour formation in aurA mutant Drosophila.

Aurora A kinase activity contributes to phosphorylation of kinetochore substrates near poles and its inhibition results in chromosome misalignment and an increased incidence of erroneous kinetochore-MT attachments.
Title: Aurora A Kinase Contributes to a Pole-Based Error Correction Pathway.

Aurora A and B kinases directly phosphorylate Lgl to promote its mitotic relocalization.
Title: Aurora kinases phosphorylate Lgl to induce mitotic spindle orientation in Drosophila epithelia.

AurA and aPKC exert the spatiotemporal control of Lgl distribution to achieve unique cell polarity roles in distinct cell types.
Title: Aurora A triggers Lgl cortical release during symmetric division to control planar spindle orientation.

The following aurA gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the aurA cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OFa04605	NM_057401.4 Latest version!	Drosophila melanogaster aurora A (aurA), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$258.30 $369.00

ORF Online Only Promotion

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

aurA ( NM_057401.4 ) cDNA ORF clone, Drosophila melanogaster(fruit fly) -> NP_476749.1 Drosophila melanogaster aurora A (aurA), mRNA.

Price & Availability↑

CloneID	OFa04605
Clone ID Related Accession (Same CDS sequence)	NM_057401.4
Accession Version	NM_057401.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1236bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-04-24
Organism	Drosophila melanogaster(fruit fly)
Product	aurora A
Comment	Comment: REVIEWED REFSEQ: This record has been curated by FlyBase. This record is derived from an annotated genomic sequence (NT_033777). On Jan 16, 2013 this sequence version replaced NM_057401.3. ##Genome-Annotation-Data-START## Annotation Provider :: FlyBase Annotation Status :: Full annotation Annotation Version :: Release 6.26 URL :: http://flybase.org ##Genome-Annotation-Data-END##

ATGTCCCATC CGTCTGACCA TGTGCTGCGT CCCAAGGAAA ATGCTCCGCA CAGAATGCCA 
GAAAAATCAG CTGCAGTGCA CAATATGCAA AAGAACTTGC TATTGGGAAA GAAGCCCAAC 
AGCGAGAATA TGGCTCCAGC TAGCAAACCC TTGCCAGGAT CCTCTGGCGC TTTGATCAGG 
AAGCCAGGCC TAGGAGGCTC CAATTCCATA GCTTCCTCCG AAGGAAACAA CTTCCAAAAA 
CCCATGGTGC CGTCCGTGAA GAAGACCACA TCAGAGTTTG CTGCTCCGGC TCCAGTAGCA 
CCTATCAAGA AGCCTGAGTC ACTTTCCAAG CAGAAACCCA CTGCTGCGAG CTCTGAATCC 
TCCAAGGAAC TGGGTGCGGC CAGCAGCTCC GCTGAAAAAG AGAAAACCAA GACTGAAACC 
CAGCCCCAGA AGCCGAAGAA GACCTGGGAG CTCAACAACT TTGATATTGG TCGCCTGCTG 
GGACGGGGCA AGTTTGGCAA CGTTTATTTG GCGCGGGAAA AGGAATCCCA GTTCGTGGTG 
GCCCTAAAAG TGCTCTTTAA GCGCCAGATT GGCGAGTCCA ATGTGGAGCA CCAGGTGCGT 
CGTGAGATCG AGATACAATC GCACCTACGT CATCCGCATA TCCTGCGTCT GTATGCCTAC 
TTTCACGACG ACGTGCGCAT ATATCTGATC TTGGAGTATG CGCCACAAGG AACGCTTTTC 
AACGCCTTGC AGGCACAGCC GATGAAACGT TTCGATGAAC GCCAGTCGGC CACCTATATT 
CAGGCGTTGT GCTCGGCGCT GCTCTATCTG CATGAGCGGG ACATCATACA CAGGGACATC 
AAGCCGGAGA ACTTGCTGCT CGGGCACAAG GGCGTCCTGA AGATCGCCGA CTTCGGTTGG 
TCCGTGCACG AGCCGAACTC CATGCGCATG ACACTGTGCG GCACTGTCGA CTACTTGCCA 
CCCGAAATGG TTCAGGGCAA GCCGCACACG AAAAACGTGG ATCTATGGAG CCTGGGTGTG 
CTCTGCTTTG AGCTGCTAGT GGGCCACGCT CCCTTCTACT CGAAGAACTA TGACGAGACC 
TACAAGAAGA TTCTCAAGGT GGACTACAAA CTGCCGGAGC ACATTTCCAA GGCAGCATCC 
CATCTCATTT CCAAGCTGCT GGTCCTTAAT CCGCAGCACC GCCTACCGCT GGATCAGGTG 
ATGGTGCATC CTTGGATCCT GGCGCACACG CAGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_476749.1
CDS	169..1404
Translation	MSHPSDHVLRPKENAPHRMPEKSAAVHNMQKNLLLGKKPNSENMAPASKPLPGSSGALIRKPGLGGSNSIASSEGNNFQKPMVPSVKKTTSEFAAPAPVAPIKKPESLSKQKPTAASSESSKELGAASSSAEKEKTKTETQPQKPKKTWELNNFDIGRLLGRGKFGNVYLAREKESQFVVALKVLFKRQIGESNVEHQVRREIEIQSHLRHPHILRLYAYFHDDVRIYLILEYAPQGTLFNALQAQPMKRFDERQSATYIQALCSALLYLHERDIIHRDIKPENLLLGHKGVLKIADFGWSVHEPNSMRMTLCGTVDYLPPEMVQGKPHTKNVDLWSLGVLCFELLVGHAPFYSKNYDETYKKILKVDYKLPEHISKAASHLISKLLVLNPQHRLPLDQVMVHPWILAHTQ

Target ORF information:

RefSeq Version	NM_057401.4
Organism	Drosophila melanogaster(fruit fly)
Definition	Drosophila melanogaster aurora A (aurA), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_057401.4

ORF Insert Sequence:

ATGTCCCATC CGTCTGACCA TGTGCTGCGT CCCAAGGAAA ATGCTCCGCA CAGAATGCCA 
GAAAAATCAG CTGCAGTGCA CAATATGCAA AAGAACTTGC TATTGGGAAA GAAGCCCAAC 
AGCGAGAATA TGGCTCCAGC TAGCAAACCC TTGCCAGGAT CCTCTGGCGC TTTGATCAGG 
AAGCCAGGCC TAGGAGGCTC CAATTCCATA GCTTCCTCCG AAGGAAACAA CTTCCAAAAA 
CCCATGGTGC CGTCCGTGAA GAAGACCACA TCAGAGTTTG CTGCTCCGGC TCCAGTAGCA 
CCTATCAAGA AGCCTGAGTC ACTTTCCAAG CAGAAACCCA CTGCTGCGAG CTCTGAATCC 
TCCAAGGAAC TGGGTGCGGC CAGCAGCTCC GCTGAAAAAG AGAAAACCAA GACTGAAACC 
CAGCCCCAGA AGCCGAAGAA GACCTGGGAG CTCAACAACT TTGATATTGG TCGCCTGCTG 
GGACGGGGCA AGTTTGGCAA CGTTTATTTG GCGCGGGAAA AGGAATCCCA GTTCGTGGTG 
GCCCTAAAAG TGCTCTTTAA GCGCCAGATT GGCGAGTCCA ATGTGGAGCA CCAGGTGCGT 
CGTGAGATCG AGATACAATC GCACCTACGT CATCCGCATA TCCTGCGTCT GTATGCCTAC 
TTTCACGACG ACGTGCGCAT ATATCTGATC TTGGAGTATG CGCCACAAGG AACGCTTTTC 
AACGCCTTGC AGGCACAGCC GATGAAACGT TTCGATGAAC GCCAGTCGGC CACCTATATT 
CAGGCGTTGT GCTCGGCGCT GCTCTATCTG CATGAGCGGG ACATCATACA CAGGGACATC 
AAGCCGGAGA ACTTGCTGCT CGGGCACAAG GGCGTCCTGA AGATCGCCGA CTTCGGTTGG 
TCCGTGCACG AGCCGAACTC CATGCGCATG ACACTGTGCG GCACTGTCGA CTACTTGCCA 
CCCGAAATGG TTCAGGGCAA GCCGCACACG AAAAACGTGG ATCTATGGAG CCTGGGTGTG 
CTCTGCTTTG AGCTGCTAGT GGGCCACGCT CCCTTCTACT CGAAGAACTA TGACGAGACC 
TACAAGAAGA TTCTCAAGGT GGACTACAAA CTGCCGGAGC ACATTTCCAA GGCAGCATCC 
CATCTCATTT CCAAGCTGCT GGTCCTTAAT CCGCAGCACC GCCTACCGCT GGATCAGGTG 
ATGGTGCATC CTTGGATCCT GGCGCACACG CAGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Gene Model Annotations for Drosophila melanogaster: Impact of High-Throughput Data.
G3 (Bethesda, Md.)5(8)1721-36(2015 Jun)
Matthews BB,Dos Santos G,Crosby MA,Emmert DB,St Pierre SE,Gramates LS,Zhou P,Schroeder AJ,Falls K,Strelets V,Russo SM,Gelbart WM,

Gene Model Annotations for Drosophila melanogaster: The Rule-Benders.
G3 (Bethesda, Md.)5(8)1737-49(2015 Jun)
Crosby MA,Gramates LS,Dos Santos G,Matthews BB,St Pierre SE,Zhou P,Schroeder AJ,Falls K,Emmert DB,Russo SM,Gelbart WM,

Sequence finishing and mapping of Drosophila melanogaster heterochromatin.
Science (New York, N.Y.)316(5831)1625-8(2007 Jun)
Hoskins RA,Carlson JW,Kennedy C,Acevedo D,Evans-Holm M,Frise E,Wan KH,Park S,Mendez-Lago M,Rossi F,Villasante A,Dimitri P,Karpen GH,Celniker SE

The Release 5.1 annotation of Drosophila melanogaster heterochromatin.
Science (New York, N.Y.)316(5831)1586-91(2007 Jun)
Smith CD,Shu S,Mungall CJ,Karpen GH

Combined evidence annotation of transposable elements in genome sequences.
PLoS computational biology1(2)166-75(2005 Jul)
Quesneville H,Bergman CM,Andrieu O,Autard D,Nouaud D,Ashburner M,Anxolabehere D

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aurA cDNA ORF clone, Drosophila melanogaster(fruit fly)

Gene

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Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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