MtnA cDNA ORF clone, Drosophila melanogaster(fruit fly)

Gene
Clones
gRNAs

Summary

Gene Symbol	MtnA
Entrez Gene ID	41202
Full Name	Metallothionein A
Synonyms	BcDNA:GH18460,CG9470,Dmel\CG9470,DrosMtn,MTN,Mtn,anon-WO0153538.42,anon-WO0153538.44,anon-WO0153538.49,mtnA
General protein information	Preferred Names Metallothionein A Names CG9470 gene product from transcript CG9470-RB CG9470-PA CG9470-PB MtnA-PA MtnA-PB metallothionein metallothionein A metallothionein N
Gene Type	protein-coding
Organism	Drosophila melanogaster(fruit fly)
Genome	Chromosome: 3R Map Location: 85E9-85E9

mRNA and Protein(s)

mRNA	Protein	Name
NM_079575.2	NP_524299.1	metallothionein A, isoform A
NM_001275509.1	NP_001262438.1	metallothionein A, isoform B

Pathways from BioSystems
Gene Ontology
Bibliography

Related articles in PubMed

Gene Model Annotations for Drosophila melanogaster: Impact of High-Throughput Data.
Matthews BB, Dos Santos G, Crosby MA, Emmert DB, St Pierre SE, Gramates LS, Zhou P, Schroeder AJ, Falls K, Strelets V, Russo SM, Gelbart WM,
G3 (Bethesda, Md.)5(8)1721-36(2015 Jun)

Gene Model Annotations for Drosophila melanogaster: The Rule-Benders.
Crosby MA, Gramates LS, Dos Santos G, Matthews BB, St Pierre SE, Zhou P, Schroeder AJ, Falls K, Emmert DB, Russo SM, Gelbart WM,
G3 (Bethesda, Md.)5(8)1737-49(2015 Jun)

Sequence finishing and mapping of Drosophila melanogaster heterochromatin.
Hoskins RA, Carlson JW, Kennedy C, Acevedo D, Evans-Holm M, Frise E, Wan KH, Park S, Mendez-Lago M, Rossi F, Villasante A, Dimitri P, Karpen GH, Celniker SE
Science (New York, N.Y.)316(5831)1625-8(2007 Jun)

The Release 5.1 annotation of Drosophila melanogaster heterochromatin.
Smith CD, Shu S, Mungall CJ, Karpen GH
Science (New York, N.Y.)316(5831)1586-91(2007 Jun)

Combined evidence annotation of transposable elements in genome sequences.
Quesneville H, Bergman CM, Andrieu O, Autard D, Nouaud D, Ashburner M, Anxolabehere D
PLoS computational biology1(2)166-75(2005 Jul)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

the 3' UTR deletion has been a target of selection for its ability to confer increased levels of MtnA expression in northern European populations, likely due to a local adaptive advantage of increased oxidative stress tolerance.
Title: An Indel Polymorphism in the MtnA 3' Untranslated Region Is Associated with Gene Expression Variation and Local Adaptation in Drosophila melanogaster.

Data suggest a gene other than metallothionein may be involved in cadmium resistance.
Title: Decreased accumulation of cadmium in Drosophila selected for resistance suggests a mechanism independent of metallothionein.

Data indicate that MTF-1 is capable of binding to different regions of MtnA and Ctr1b genes depending on different metal stimulation.
Title: Single nucleotide in the MTF-1 binding site can determine metal-specific transcription activation.

the preferential protection against copper and cadmium toxicity by MtnA and MtnB, respectively, are the result of a combination of promoter preference and metal binding
Title: The four members of the Drosophila metallothionein family exhibit distinct yet overlapping roles in heavy metal homeostasis and detoxification.

MTO metal binding features were analyzed for comparison with MTN, the paralogous Drosophila metallothionein, and to classify MTO as either zinc- or copper-thionein.
Title: MTO: the second member of a Drosophila dual copper-thionein system.

The following MtnA gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the MtnA cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OFa04398	NM_001275509.1 Latest version!	Drosophila melanogaster metallothionein A, transcript variant B (MtnA), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$104.30 $149.00
OFa04398	NM_079575.2 Latest version!	Drosophila melanogaster metallothionein A, transcript variant A (MtnA), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$104.30 $149.00

ORF Online Only Promotion

Next-day Shipping ORF Clones ( in default vector with tag)
1 Clone	30% OFF
2-4 Clone	40% OFF
5 or more Clone	50% OFF
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*Business Day

** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

MtnA ( NM_079575.2 ) cDNA ORF clone, Drosophila melanogaster(fruit fly) -> NP_524299.1 Drosophila melanogaster metallothionein A, transcript variant A (MtnA), mRNA.

Price & Availability↑

CloneID	OFa04398
Clone ID Related Accession (Same CDS sequence)	NM_079575.2 , NM_001275509.1
Accession Version	NM_079575.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 123bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-04-24
Organism	Drosophila melanogaster(fruit fly)
Product	metallothionein A, isoform A
Comment	Comment: REVIEWED REFSEQ: This record has been curated by FlyBase. This record is derived from an annotated genomic sequence (NT_033777). On Jan 16, 2013 this sequence version replaced NM_079575.1. ##Genome-Annotation-Data-START## Annotation Provider :: FlyBase Annotation Status :: Full annotation Annotation Version :: Release 6.26 URL :: http://flybase.org ##Genome-Annotation-Data-END##

1
61
121

ATGCCTTGCC CATGCGGAAG CGGATGCAAA TGCGCCAGCC AGGCCACCAA GGGATCCTGC 
AACTGCGGAT CTGACTGCAA GTGCGGCGGC GACAAGAAAT CCGCCTGCGG CTGCTCCGAG 
TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_524299.1
CDS	126..248
Translation	MPCPCGSGCKCASQATKGSCNCGSDCKCGGDKKSACGCSE

Target ORF information:

RefSeq Version	NM_079575.2
Organism	Drosophila melanogaster(fruit fly)
Definition	Drosophila melanogaster metallothionein A, transcript variant A (MtnA), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_079575.2

ORF Insert Sequence:

1
61
121

ATGCCTTGCC CATGCGGAAG CGGATGCAAA TGCGCCAGCC AGGCCACCAA GGGATCCTGC 
AACTGCGGAT CTGACTGCAA GTGCGGCGGC GACAAGAAAT CCGCCTGCGG CTGCTCCGAG 
TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

MtnA ( NM_001275509.1 ) cDNA ORF clone, Drosophila melanogaster(fruit fly) -> NP_001262438.1 Drosophila melanogaster metallothionein A, transcript variant B (MtnA), mRNA.

Price & Availability↑

CloneID	OFa04398
Clone ID Related Accession (Same CDS sequence)	NM_079575.2 , NM_001275509.1
Accession Version	NM_001275509.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 123bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-04-24
Organism	Drosophila melanogaster(fruit fly)
Product	metallothionein A, isoform B
Comment	Comment: REVIEWED REFSEQ: This record has been curated by FlyBase. This record is derived from an annotated genomic sequence (NT_033777). ##Genome-Annotation-Data-START## Annotation Provider :: FlyBase Annotation Status :: Full annotation Annotation Version :: Release 6.26 URL :: http://flybase.org ##Genome-Annotation-Data-END##

1
61
121

ATGCCTTGCC CATGCGGAAG CGGATGCAAA TGCGCCAGCC AGGCCACCAA GGGATCCTGC 
AACTGCGGAT CTGACTGCAA GTGCGGCGGC GACAAGAAAT CCGCCTGCGG CTGCTCCGAG 
TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001262438.1
CDS	126..248
Translation	MPCPCGSGCKCASQATKGSCNCGSDCKCGGDKKSACGCSE

Target ORF information:

RefSeq Version	NM_001275509.1
Organism	Drosophila melanogaster(fruit fly)
Definition	Drosophila melanogaster metallothionein A, transcript variant B (MtnA), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001275509.1

ORF Insert Sequence:

1
61
121

ATGCCTTGCC CATGCGGAAG CGGATGCAAA TGCGCCAGCC AGGCCACCAA GGGATCCTGC 
AACTGCGGAT CTGACTGCAA GTGCGGCGGC GACAAGAAAT CCGCCTGCGG CTGCTCCGAG 
TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Gene Model Annotations for Drosophila melanogaster: Impact of High-Throughput Data.
G3 (Bethesda, Md.)5(8)1721-36(2015 Jun)
Matthews BB,Dos Santos G,Crosby MA,Emmert DB,St Pierre SE,Gramates LS,Zhou P,Schroeder AJ,Falls K,Strelets V,Russo SM,Gelbart WM,

Gene Model Annotations for Drosophila melanogaster: The Rule-Benders.
G3 (Bethesda, Md.)5(8)1737-49(2015 Jun)
Crosby MA,Gramates LS,Dos Santos G,Matthews BB,St Pierre SE,Zhou P,Schroeder AJ,Falls K,Emmert DB,Russo SM,Gelbart WM,

Sequence finishing and mapping of Drosophila melanogaster heterochromatin.
Science (New York, N.Y.)316(5831)1625-8(2007 Jun)
Hoskins RA,Carlson JW,Kennedy C,Acevedo D,Evans-Holm M,Frise E,Wan KH,Park S,Mendez-Lago M,Rossi F,Villasante A,Dimitri P,Karpen GH,Celniker SE

The Release 5.1 annotation of Drosophila melanogaster heterochromatin.
Science (New York, N.Y.)316(5831)1586-91(2007 Jun)
Smith CD,Shu S,Mungall CJ,Karpen GH

Combined evidence annotation of transposable elements in genome sequences.
PLoS computational biology1(2)166-75(2005 Jul)
Quesneville H,Bergman CM,Andrieu O,Autard D,Nouaud D,Ashburner M,Anxolabehere D

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MtnA cDNA ORF clone, Drosophila melanogaster(fruit fly)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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