Syt4 cDNA ORF clone, Drosophila melanogaster(fruit fly)

Gene
Clones
gRNAs

Summary

Gene Symbol	Syt4
Entrez Gene ID	40876
Full Name	Synaptotagmin 4
Synonyms	CG10047,D.Syt IV,Dmel\CG10047,SYT4,Syt IV,SytIV,dsyt4,syt 4,syt4,sytIV
General protein information	Preferred Names Synaptotagmin 4 Names CG10047 gene product from transcript CG10047-RA CG10047-PA Syt4-PA synaptotagmin 4 synaptotagmin IV
Gene Type	protein-coding
Organism	Drosophila melanogaster(fruit fly)
Genome	Chromosome: 3R Map Location: 84D3-84D3

mRNA and Protein(s)

mRNA	Protein	Name
NM_058116.5	NP_477464.1	synaptotagmin 4

Pathways from BioSystems

Homologies

Drosophila melanogaster (fruit fly)	Syt4	NP_477464.1
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP001800	XP_003435948.1
Caenorhabditis elegans (roundworm)	snt-4	NP_491853.2

Gene Ontology
Bibliography

Related articles in PubMed

Gene Model Annotations for Drosophila melanogaster: Impact of High-Throughput Data.
Matthews BB, Dos Santos G, Crosby MA, Emmert DB, St Pierre SE, Gramates LS, Zhou P, Schroeder AJ, Falls K, Strelets V, Russo SM, Gelbart WM,
G3 (Bethesda, Md.)5(8)1721-36(2015 Jun)

Gene Model Annotations for Drosophila melanogaster: The Rule-Benders.
Crosby MA, Gramates LS, Dos Santos G, Matthews BB, St Pierre SE, Zhou P, Schroeder AJ, Falls K, Emmert DB, Russo SM, Gelbart WM,
G3 (Bethesda, Md.)5(8)1737-49(2015 Jun)

Sequence finishing and mapping of Drosophila melanogaster heterochromatin.
Hoskins RA, Carlson JW, Kennedy C, Acevedo D, Evans-Holm M, Frise E, Wan KH, Park S, Mendez-Lago M, Rossi F, Villasante A, Dimitri P, Karpen GH, Celniker SE
Science (New York, N.Y.)316(5831)1625-8(2007 Jun)

The Release 5.1 annotation of Drosophila melanogaster heterochromatin.
Smith CD, Shu S, Mungall CJ, Karpen GH
Science (New York, N.Y.)316(5831)1586-91(2007 Jun)

Combined evidence annotation of transposable elements in genome sequences.
Quesneville H, Bergman CM, Andrieu O, Autard D, Nouaud D, Ashburner M, Anxolabehere D
PLoS computational biology1(2)166-75(2005 Jul)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Genetic interaction experiments demonstrate Syx4, Syt4, and Nlg1 regulate synaptic growth and plasticity through both shared and parallel signaling pathways.
Title: The postsynaptic t-SNARE Syntaxin 4 controls traffic of Neuroligin 1 and Synaptotagmin 4 to regulate retrograde signaling.

A retrograde signal mediated by Synaptotagmin 4 is transmitted to the postsynaptic cell through anterograde delivery of Synaptotagmin 4 via exosomes.
Title: Regulation of postsynaptic retrograde signaling by presynaptic exosome release.

Rat and Drosophila synaptotagmin 4 have opposite effects during SNARE-catalyzed membrane fusion.
Title: Rat and Drosophila synaptotagmin 4 have opposite effects during SNARE-catalyzed membrane fusion.

Syt 4 regulates activity-dependent release of postsynaptic retrograde signals that promote synaptic plasticity, similar to the role of Syt 1 as a Ca(2+) sensor for presynaptic vesicle fusion.
Title: Postsynaptic regulation of synaptic plasticity by synaptotagmin 4 requires both C2 domains.

results demonstrate that acute plasticity and synapse-specific growth require Syt 4-dependent retrograde signaling at Drosophila neuromuscular junctions
Title: Retrograde signaling by Syt 4 induces presynaptic release and synapse-specific growth.

The following Syt4 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Syt4 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OFa04186	NM_058116.5 Latest version!	Drosophila melanogaster synaptotagmin 4 (Syt4), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$258.30 $369.00

ORF Online Only Promotion

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Syt4 ( NM_058116.5 ) cDNA ORF clone, Drosophila melanogaster(fruit fly) -> NP_477464.1 Drosophila melanogaster synaptotagmin 4 (Syt4), mRNA.

Price & Availability↑

CloneID	OFa04186
Clone ID Related Accession (Same CDS sequence)	NM_058116.5
Accession Version	NM_058116.5 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1425bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-04-24
Organism	Drosophila melanogaster(fruit fly)
Product	synaptotagmin 4
Comment	Comment: REVIEWED REFSEQ: This record has been curated by FlyBase. This record is derived from an annotated genomic sequence (NT_033777). On Jul 15, 2014 this sequence version replaced NM_058116.4. ##Genome-Annotation-Data-START## Annotation Provider :: FlyBase Annotation Status :: Full annotation Annotation Version :: Release 6.26 URL :: http://flybase.org ##Genome-Annotation-Data-END##

ATGGCCGAAG AGTATATCCC AGATGCCAGC GTCATGGACA CGATTGTCCC CGCCATCCTG 
GGACTGACTG CGGCTGCTGT CCTCTCGTCA GTGGCCTGCA TCTGCGCCCG GCAGATGCGC 
CTCCGGAACA AGAAACAGAG CCAGCACGAC GCCTCGTTCC CCTTCCAGCC GACCCGGCGA 
CCGACCGCCG TTCGATCGCC CAGCGGCCAG CCGCCGCACT ACTTGAAGAA GTCGCCCTCG 
CCGACGGGAG GCAAGCAGAT GGGACTGCTG TCGCCGATGC AGGACCAGTC CACCTCCCCG 
ATTGCGCAAC CGAATGTCAA GTACAGCGAG GAGGGAGATG GACCCGCCCA GCATGCGGAG 
CAGCAGAATG GCAATCAACT GACCGTGGTG GATGGTAATG GGTTGAAGCA CTCGCTGCAC 
AACAGCCTTC ACCACTCGCC GGTAGAGACG ATCGCCAACG GAAGTGTGAC CATTACCCTG 
GACGACCATT CGCTGACCAA CGGGAAGGAG CTGACCGTGA CCGACCAGTA CGGCAAGCTG 
GGTACCATCT ATTTTAAGCT GCGCTACTTG GCCGAAAGGA ACGCCCTTAT GGTGTCCATC 
ATCCGTTGTC GCGGACTCCC CTGCAAGGGA GGATCGAGCG GAACCGGAGA TATTCCCACT 
GGCATGAATG GACGCACTCA GGCGGCAACG GATCCGTATG TCAAGCTGCA GCTGCTGCCG 
GACAAGCAGC ACAAGGTCAA GACCCGGGTG GTGCGAAATA CCCGGAACCC GGTTTACGAC 
GAGGACTTCA CCTTCTACGG CCTGAACATG AACGACCTGC AGAACATGTC GCTGCACTTT 
GTCATCCTCA GCTTCGATCG ATACTCACGT GACGACGTCA TTGGCGAAGT GGTGTGCCCA 
TTGACCTCCA TCGAGATCGG GGACATCTCC AAAGAGGCTT TGTCCATCAG CAAAGAGATC 
CAGCCACGGA GCTTGAAGAT TCGAGCCCAG GGTCGCGGGG AGCTGCTCAT CTCCCTCTGC 
TGGCAACCAG CTGCCGGTCG CCTCACCGTC GTCTTGCTGA AGGCCCGAAA CTTACCGCGC 
ATGGATGTCA CCGGACTGGC CGATCCGTAT GTTAAGATAT ATCTCCTCTA CAATGGCCAA 
CGCATCGCCA AGAAGAAGAC GCACGTGAAG AAACGAACTC TGAGCCCCGT TTTCAACGAG 
AGCTTCGCAT TCGATATTCC CGCCGCCGAA GGCGCTGGCG CCAGTCTTGA GGGTGTGTCT 
TTGGAACTGA TGCTGCTCGA CTGGGATCGC GTGACCAAGA ATGAGGTCAT CGGTCGGCTG 
GAGCTGGGCG GCCCGAACTC GAGCAGCACC GCCTTGAACC ACTGGAACGA GGTTTGCAAC 
TCGCCGCGCC GCCAGATCGC CGAGTGGCAC AAGCTGAACG AGTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_477464.1
CDS	182..1606
Translation	MAEEYIPDASVMDTIVPAILGLTAAAVLSSVACICARQMRLRNKKQSQHDASFPFQPTRRPTAVRSPSGQPPHYLKKSPSPTGGKQMGLLSPMQDQSTSPIAQPNVKYSEEGDGPAQHAEQQNGNQLTVVDGNGLKHSLHNSLHHSPVETIANGSVTITLDDHSLTNGKELTVTDQYGKLGTIYFKLRYLAERNALMVSIIRCRGLPCKGGSSGTGDIPTGMNGRTQAATDPYVKLQLLPDKQHKVKTRVVRNTRNPVYDEDFTFYGLNMNDLQNMSLHFVILSFDRYSRDDVIGEVVCPLTSIEIGDISKEALSISKEIQPRSLKIRAQGRGELLISLCWQPAAGRLTVVLLKARNLPRMDVTGLADPYVKIYLLYNGQRIAKKKTHVKKRTLSPVFNESFAFDIPAAEGAGASLEGVSLELMLLDWDRVTKNEVIGRLELGGPNSSSTALNHWNEVCNSPRRQIAEWHKLNE

Target ORF information:

RefSeq Version	NM_058116.5
Organism	Drosophila melanogaster(fruit fly)
Definition	Drosophila melanogaster synaptotagmin 4 (Syt4), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_058116.5

ORF Insert Sequence:

ATGGCCGAAG AGTATATCCC AGATGCCAGC GTCATGGACA CGATTGTCCC CGCCATCCTG 
GGACTGACTG CGGCTGCTGT CCTCTCGTCA GTGGCCTGCA TCTGCGCCCG GCAGATGCGC 
CTCCGGAACA AGAAACAGAG CCAGCACGAC GCCTCGTTCC CCTTCCAGCC GACCCGGCGA 
CCGACCGCCG TTCGATCGCC CAGCGGCCAG CCGCCGCACT ACTTGAAGAA GTCGCCCTCG 
CCGACGGGAG GCAAGCAGAT GGGACTGCTG TCGCCGATGC AGGACCAGTC CACCTCCCCG 
ATTGCGCAAC CGAATGTCAA GTACAGCGAG GAGGGAGATG GACCCGCCCA GCATGCGGAG 
CAGCAGAATG GCAATCAACT GACCGTGGTG GATGGTAATG GGTTGAAGCA CTCGCTGCAC 
AACAGCCTTC ACCACTCGCC GGTAGAGACG ATCGCCAACG GAAGTGTGAC CATTACCCTG 
GACGACCATT CGCTGACCAA CGGGAAGGAG CTGACCGTGA CCGACCAGTA CGGCAAGCTG 
GGTACCATCT ATTTTAAGCT GCGCTACTTG GCCGAAAGGA ACGCCCTTAT GGTGTCCATC 
ATCCGTTGTC GCGGACTCCC CTGCAAGGGA GGATCGAGCG GAACCGGAGA TATTCCCACT 
GGCATGAATG GACGCACTCA GGCGGCAACG GATCCGTATG TCAAGCTGCA GCTGCTGCCG 
GACAAGCAGC ACAAGGTCAA GACCCGGGTG GTGCGAAATA CCCGGAACCC GGTTTACGAC 
GAGGACTTCA CCTTCTACGG CCTGAACATG AACGACCTGC AGAACATGTC GCTGCACTTT 
GTCATCCTCA GCTTCGATCG ATACTCACGT GACGACGTCA TTGGCGAAGT GGTGTGCCCA 
TTGACCTCCA TCGAGATCGG GGACATCTCC AAAGAGGCTT TGTCCATCAG CAAAGAGATC 
CAGCCACGGA GCTTGAAGAT TCGAGCCCAG GGTCGCGGGG AGCTGCTCAT CTCCCTCTGC 
TGGCAACCAG CTGCCGGTCG CCTCACCGTC GTCTTGCTGA AGGCCCGAAA CTTACCGCGC 
ATGGATGTCA CCGGACTGGC CGATCCGTAT GTTAAGATAT ATCTCCTCTA CAATGGCCAA 
CGCATCGCCA AGAAGAAGAC GCACGTGAAG AAACGAACTC TGAGCCCCGT TTTCAACGAG 
AGCTTCGCAT TCGATATTCC CGCCGCCGAA GGCGCTGGCG CCAGTCTTGA GGGTGTGTCT 
TTGGAACTGA TGCTGCTCGA CTGGGATCGC GTGACCAAGA ATGAGGTCAT CGGTCGGCTG 
GAGCTGGGCG GCCCGAACTC GAGCAGCACC GCCTTGAACC ACTGGAACGA GGTTTGCAAC 
TCGCCGCGCC GCCAGATCGC CGAGTGGCAC AAGCTGAACG AGTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Gene Model Annotations for Drosophila melanogaster: Impact of High-Throughput Data.
G3 (Bethesda, Md.)5(8)1721-36(2015 Jun)
Matthews BB,Dos Santos G,Crosby MA,Emmert DB,St Pierre SE,Gramates LS,Zhou P,Schroeder AJ,Falls K,Strelets V,Russo SM,Gelbart WM,

Gene Model Annotations for Drosophila melanogaster: The Rule-Benders.
G3 (Bethesda, Md.)5(8)1737-49(2015 Jun)
Crosby MA,Gramates LS,Dos Santos G,Matthews BB,St Pierre SE,Zhou P,Schroeder AJ,Falls K,Emmert DB,Russo SM,Gelbart WM,

Sequence finishing and mapping of Drosophila melanogaster heterochromatin.
Science (New York, N.Y.)316(5831)1625-8(2007 Jun)
Hoskins RA,Carlson JW,Kennedy C,Acevedo D,Evans-Holm M,Frise E,Wan KH,Park S,Mendez-Lago M,Rossi F,Villasante A,Dimitri P,Karpen GH,Celniker SE

The Release 5.1 annotation of Drosophila melanogaster heterochromatin.
Science (New York, N.Y.)316(5831)1586-91(2007 Jun)
Smith CD,Shu S,Mungall CJ,Karpen GH

Combined evidence annotation of transposable elements in genome sequences.
PLoS computational biology1(2)166-75(2005 Jul)
Quesneville H,Bergman CM,Andrieu O,Autard D,Nouaud D,Ashburner M,Anxolabehere D

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Syt4 cDNA ORF clone, Drosophila melanogaster(fruit fly)

Gene

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gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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