Sod1 cDNA ORF clone, Drosophila melanogaster(fruit fly)

Gene
Clones
gRNAs

Summary

Gene Symbol	Sod1
Entrez Gene ID	39251
Full Name	Superoxide dismutase 1
Synonyms	CG11793,Cu,Cu-Zn SOD,Cu/Zn SOD,Cu/Zn sod,Cu/Zn superoxide dismutase,Cu/ZnSOD,CuSOD,CuZn SOD,CuZn-SOD,CuZn-SOD1,CuZnSOD,Cu[2+]/Zn[2+]SOD,Dmel\CG11793,G,Mn SOD,SOD,SOD-1,SOD1,SODC_DROME,Sod,Sod-1,To,To-1,Zn SOD,Zn Sod,Zn-SOD,ZnSod,cSOD,cSod,dSOD1,l(3)108,l(3)68Af',l(3)G,sod,sod1
General protein information	Preferred Names Superoxide dismutase 1 Names CG11793 gene product from transcript CG11793-RA CG11793-PA CG11793-PD Cu, Zn superoxide dismutase Cu-Zn superoxide dismutase Cu/Zn superoxide dismutase Cu/Zn-Superoxide dismutase CuZn superoxide dismutase CuZn-superoxide dismutase CuZn-superoxide dismutase (SOD)1 CuZnSOD Cu[2+] Zn[2+] superoxide dismutase Cu[2+]Zn[2+] superoxide dismutase Mn superoxide dismutase Sod1-PA Sod1-PD complementation group G copper and zinc SOD copper-zinc superoxide copper-zinc superoxide dismutase cytoplasmic Cu/ZnSOD dismutase heart morphogenesis; GO:0003007 IMP paracrine signaling; GO:0038001 IMP reactive oxygen species metabolic process; GO:0072593 IMP super oxide dismutase superoxidase dismutase superoxide dismutase superoxide dismutase 1 superoxide dismutatase superoxide-dismutase superoxido dismutase tetrazolium oxidase tetrazolium oxidase-1
Gene Type	protein-coding
Organism	Drosophila melanogaster(fruit fly)
Genome	Chromosome: 3L Map Location: 68A7-68A7

mRNA and Protein(s)

mRNA	Protein	Name
NM_057387.5	NP_476735.1	superoxide dismutase 1, isoform A
NM_001274771.1	NP_001261700.1	superoxide dismutase 1, isoform D

Pathways from BioSystems

Homologies

Canis lupus familiaris (dog)	SOD1	NP_001003035.1
Gallus gallus (chicken)	SOD1	NP_990395.1
Anopheles gambiae (African malaria mosquito)	CUSOD3	XP_311594.2
Mus musculus (house mouse)	Sod1	NP_035564.1
Caenorhabditis elegans (roundworm)	sod-5	NP_494779.1
Schizosaccharomyces pombe (fission yeast)	sod1	NP_593163.1
Homo sapiens (human)	SOD1	NP_000445.1
Pan troglodytes (chimpanzee)	SOD1	NP_001009025.1
	SOD1	NP_001027976.1
Rattus norvegicus (Norway rat)	Sod1	NP_058746.1
Caenorhabditis elegans (roundworm)	sod-1	NP_001021956.1
Xenopus tropicalis (tropical clawed frog)	sod1	NP_001016252.1
Bos taurus (cattle)	SOD1	NP_777040.1
Saccharomyces cerevisiae (baker's yeast)	SOD1	NP_012638.1
Kluyveromyces lactis	KLLA0E05567g	XP_454197.1
Magnaporthe oryzae (rice blast fungus)	MGG_02625	XP_003721165.1
Arabidopsis thaliana (thale cress)	CSD1	NP_001077494.1
Danio rerio (zebrafish)	sod1	NP_571369.1
Drosophila melanogaster (fruit fly)	Sod	NP_001261700.1
Eremothecium gossypii	AGOS_AGL321W	NP_986346.2
Neurospora crassa	NCU02133	XP_964291.2
Oryza sativa (rice)	Os03g0351500	NP_001050118.1
Oryza sativa (rice)	Os07g0665200	NP_001060564.1

Gene Ontology
Bibliography

Related articles in PubMed

Gene Model Annotations for Drosophila melanogaster: Impact of High-Throughput Data.
Matthews BB, Dos Santos G, Crosby MA, Emmert DB, St Pierre SE, Gramates LS, Zhou P, Schroeder AJ, Falls K, Strelets V, Russo SM, Gelbart WM,
G3 (Bethesda, Md.)5(8)1721-36(2015 Jun)

Gene Model Annotations for Drosophila melanogaster: The Rule-Benders.
Crosby MA, Gramates LS, Dos Santos G, Matthews BB, St Pierre SE, Zhou P, Schroeder AJ, Falls K, Emmert DB, Russo SM, Gelbart WM,
G3 (Bethesda, Md.)5(8)1737-49(2015 Jun)

Sequence finishing and mapping of Drosophila melanogaster heterochromatin.
Hoskins RA, Carlson JW, Kennedy C, Acevedo D, Evans-Holm M, Frise E, Wan KH, Park S, Mendez-Lago M, Rossi F, Villasante A, Dimitri P, Karpen GH, Celniker SE
Science (New York, N.Y.)316(5831)1625-8(2007 Jun)

The Release 5.1 annotation of Drosophila melanogaster heterochromatin.
Smith CD, Shu S, Mungall CJ, Karpen GH
Science (New York, N.Y.)316(5831)1586-91(2007 Jun)

Combined evidence annotation of transposable elements in genome sequences.
Quesneville H, Bergman CM, Andrieu O, Autard D, Nouaud D, Ashburner M, Anxolabehere D
PLoS computational biology1(2)166-75(2005 Jul)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The functional SOD1 and SOD2 genes knockout and their overexpression in neurons and glial tissue increase the sensitivity of Drosophila melanogaster to oxidative stress conditions.
Title: [Influence of tissue-specific superoxide dismutase genes expression in brain cells on Drosophila melanogaster sensitivity to oxidative stress and viability].

Expression of zinc-deficient human superoxide dismutase in Drosophila neurons produces a locomotor defect linked to mitochondrial dysfunction.
Title: Expression of zinc-deficient human superoxide dismutase in Drosophila neurons produces a locomotor defect linked to mitochondrial dysfunction.

curcumin increases mean lifespan of Drosophila via regulating gene expression of the key enzyme SOD and reducing accumulation of MDA and lipid peroxidation.
Title: Curcumin-supplemented diets increase superoxide dismutase activity and mean lifespan in Drosophila.

The activity of carbohydrate metabolizing enzymes, lipid and triglyceride concentration, and steady state NADPH:NADP(+) in SOD1-null and control transgenic rescue flies, was analysed.
Title: A model of oxidative stress management: moderation of carbohydrate metabolizing enzymes in SOD1-null Drosophila melanogaster.

switching SOD1-deficient flies from normoxia into hypoxia fails to alter their mortality
Title: Hypoxia rescues early mortality conferred by superoxide dismutase deficiency.

The following Sod1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Sod1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OFa18212	NM_057387.5 Latest version!	Drosophila melanogaster superoxide dismutase 1, transcript variant A (Sod1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$104.30 $149.00
OFa19901	NM_001274771.1 Latest version!	Drosophila melanogaster superoxide dismutase 1, transcript variant D (Sod1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$104.30 $149.00

ORF Online Only Promotion

Next-day Shipping ORF Clones ( in default vector with tag)
1 Clone	30% OFF
2-4 Clone	40% OFF
5 or more Clone	50% OFF
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*Business Day

** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Sod1 ( NM_057387.5 ) cDNA ORF clone, Drosophila melanogaster(fruit fly) -> NP_476735.1 Drosophila melanogaster superoxide dismutase 1, transcript variant A (Sod1), mRNA.

Price & Availability↑

CloneID	OFa18212
Clone ID Related Accession (Same CDS sequence)	NM_057387.5
Accession Version	NM_057387.5 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 462bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-04-24
Organism	Drosophila melanogaster(fruit fly)
Product	superoxide dismutase 1, isoform A
Comment	Comment: REVIEWED REFSEQ: This record has been curated by FlyBase. This record is derived from an annotated genomic sequence (NT_037436). On Jan 16, 2013 this sequence version replaced NM_057387.4. ##Genome-Annotation-Data-START## Annotation Provider :: FlyBase Annotation Status :: Full annotation Annotation Version :: Release 6.26 URL :: http://flybase.org ##Genome-Annotation-Data-END##

ATGGTGGTTA AAGCTGTCTG CGTAATTAAC GGCGATGCCA AGGGCACGGT TTTCTTCGAA 
CAGGAGAGCA GCGGTACGCC CGTGAAGGTC TCCGGTGAGG TGTGCGGCCT GGCCAAGGGT 
CTGCACGGAT TCCACGTGCA CGAGTTCGGT GACAACACCA ATGGCTGCAT GTCGTCCGGA 
CCGCACTTCA ATCCGTATGG CAAGGAGCAT GGCGCTCCCG TCGACGAGAA TCGTCACCTG 
GGCGATCTGG GCAACATTGA GGCCACCGGC GACTGCCCCA CCAAGGTCAA CATCACCGAC 
TCCAAGATTA CGCTCTTCGG CGCCGACAGC ATCATCGGAC GCACCGTTGT CGTGCACGCC 
GATGCCGATG ATCTTGGCCA GGGTGGACAC GAGCTGAGCA AGTCAACGGG CAACGCTGGT 
GCCCGCATCG GGTGCGGCGT TATTGGCATT GCCAAGGTCT AA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_476735.1
CDS	102..563
Translation	MVVKAVCVINGDAKGTVFFEQESSGTPVKVSGEVCGLAKGLHGFHVHEFGDNTNGCMSSGPHFNPYGKEHGAPVDENRHLGDLGNIEATGDCPTKVNITDSKITLFGADSIIGRTVVVHADADDLGQGGHELSKSTGNAGARIGCGVIGIAKV

Target ORF information:

RefSeq Version	NM_057387.5
Organism	Drosophila melanogaster(fruit fly)
Definition	Drosophila melanogaster superoxide dismutase 1, transcript variant A (Sod1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_057387.5

ORF Insert Sequence:

ATGGTGGTTA AAGCTGTCTG CGTAATTAAC GGCGATGCCA AGGGCACGGT TTTCTTCGAA 
CAGGAGAGCA GCGGTACGCC CGTGAAGGTC TCCGGTGAGG TGTGCGGCCT GGCCAAGGGT 
CTGCACGGAT TCCACGTGCA CGAGTTCGGT GACAACACCA ATGGCTGCAT GTCGTCCGGA 
CCGCACTTCA ATCCGTATGG CAAGGAGCAT GGCGCTCCCG TCGACGAGAA TCGTCACCTG 
GGCGATCTGG GCAACATTGA GGCCACCGGC GACTGCCCCA CCAAGGTCAA CATCACCGAC 
TCCAAGATTA CGCTCTTCGG CGCCGACAGC ATCATCGGAC GCACCGTTGT CGTGCACGCC 
GATGCCGATG ATCTTGGCCA GGGTGGACAC GAGCTGAGCA AGTCAACGGG CAACGCTGGT 
GCCCGCATCG GGTGCGGCGT TATTGGCATT GCCAAGGTCT AA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Sod1 ( NM_001274771.1 ) cDNA ORF clone, Drosophila melanogaster(fruit fly) -> NP_001261700.1 Drosophila melanogaster superoxide dismutase 1, transcript variant D (Sod1), mRNA.

Price & Availability↑

CloneID	OFa19901
Clone ID Related Accession (Same CDS sequence)	NM_001274771.1
Accession Version	NM_001274771.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 504bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-04-24
Organism	Drosophila melanogaster(fruit fly)
Product	superoxide dismutase 1, isoform D
Comment	Comment: REVIEWED REFSEQ: This record has been curated by FlyBase. This record is derived from an annotated genomic sequence (NT_037436). ##Genome-Annotation-Data-START## Annotation Provider :: FlyBase Annotation Status :: Full annotation Annotation Version :: Release 6.26 URL :: http://flybase.org ##Genome-Annotation-Data-END##

ATGGTGGTTA AAGCTGTCTG CGTAATTAAC GGCGATGCCA AGGGCACGGT TTTCTTCGAA 
CAGGAGGTGA GAATCCAAAA TCATTTGAAC TTCTCTGCTC GGCAAAATAG CAGCGGTACG 
CCCGTGAAGG TCTCCGGTGA GGTGTGCGGC CTGGCCAAGG GTCTGCACGG ATTCCACGTG 
CACGAGTTCG GTGACAACAC CAATGGCTGC ATGTCGTCCG GACCGCACTT CAATCCGTAT 
GGCAAGGAGC ATGGCGCTCC CGTCGACGAG AATCGTCACC TGGGCGATCT GGGCAACATT 
GAGGCCACCG GCGACTGCCC CACCAAGGTC AACATCACCG ACTCCAAGAT TACGCTCTTC 
GGCGCCGACA GCATCATCGG ACGCACCGTT GTCGTGCACG CCGATGCCGA TGATCTTGGC 
CAGGGTGGAC ACGAGCTGAG CAAGTCAACG GGCAACGCTG GTGCCCGCAT CGGGTGCGGC 
GTTATTGGCA TTGCCAAGGT CTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001261700.1
CDS	102..605
Translation	MVVKAVCVINGDAKGTVFFEQEVRIQNHLNFSARQNSSGTPVKVSGEVCGLAKGLHGFHVHEFGDNTNGCMSSGPHFNPYGKEHGAPVDENRHLGDLGNIEATGDCPTKVNITDSKITLFGADSIIGRTVVVHADADDLGQGGHELSKSTGNAGARIGCGVIGIAKV

Target ORF information:

RefSeq Version	NM_001274771.1
Organism	Drosophila melanogaster(fruit fly)
Definition	Drosophila melanogaster superoxide dismutase 1, transcript variant D (Sod1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001274771.1

ORF Insert Sequence:

ATGGTGGTTA AAGCTGTCTG CGTAATTAAC GGCGATGCCA AGGGCACGGT TTTCTTCGAA 
CAGGAGGTGA GAATCCAAAA TCATTTGAAC TTCTCTGCTC GGCAAAATAG CAGCGGTACG 
CCCGTGAAGG TCTCCGGTGA GGTGTGCGGC CTGGCCAAGG GTCTGCACGG ATTCCACGTG 
CACGAGTTCG GTGACAACAC CAATGGCTGC ATGTCGTCCG GACCGCACTT CAATCCGTAT 
GGCAAGGAGC ATGGCGCTCC CGTCGACGAG AATCGTCACC TGGGCGATCT GGGCAACATT 
GAGGCCACCG GCGACTGCCC CACCAAGGTC AACATCACCG ACTCCAAGAT TACGCTCTTC 
GGCGCCGACA GCATCATCGG ACGCACCGTT GTCGTGCACG CCGATGCCGA TGATCTTGGC 
CAGGGTGGAC ACGAGCTGAG CAAGTCAACG GGCAACGCTG GTGCCCGCAT CGGGTGCGGC 
GTTATTGGCA TTGCCAAGGT CTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Gene Model Annotations for Drosophila melanogaster: Impact of High-Throughput Data.
G3 (Bethesda, Md.)5(8)1721-36(2015 Jun)
Matthews BB,Dos Santos G,Crosby MA,Emmert DB,St Pierre SE,Gramates LS,Zhou P,Schroeder AJ,Falls K,Strelets V,Russo SM,Gelbart WM,

Gene Model Annotations for Drosophila melanogaster: The Rule-Benders.
G3 (Bethesda, Md.)5(8)1737-49(2015 Jun)
Crosby MA,Gramates LS,Dos Santos G,Matthews BB,St Pierre SE,Zhou P,Schroeder AJ,Falls K,Emmert DB,Russo SM,Gelbart WM,

Sequence finishing and mapping of Drosophila melanogaster heterochromatin.
Science (New York, N.Y.)316(5831)1625-8(2007 Jun)
Hoskins RA,Carlson JW,Kennedy C,Acevedo D,Evans-Holm M,Frise E,Wan KH,Park S,Mendez-Lago M,Rossi F,Villasante A,Dimitri P,Karpen GH,Celniker SE

The Release 5.1 annotation of Drosophila melanogaster heterochromatin.
Science (New York, N.Y.)316(5831)1586-91(2007 Jun)
Smith CD,Shu S,Mungall CJ,Karpen GH

Combined evidence annotation of transposable elements in genome sequences.
PLoS computational biology1(2)166-75(2005 Jul)
Quesneville H,Bergman CM,Andrieu O,Autard D,Nouaud D,Ashburner M,Anxolabehere D

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Sod1 cDNA ORF clone, Drosophila melanogaster(fruit fly)

Gene

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gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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