Arr2 cDNA ORF clone, Drosophila melanogaster(fruit fly)

Gene
Clones
gRNAs

Summary

Gene Symbol	Arr2
Entrez Gene ID	38993
Full Name	Arrestin 2
Synonyms	49,AH,ARR2,Arr,Arr-2,ArrB,ArrB-ml,CG5962,DAII,Dmel\CG5962,Dro.-Arr.II,PRI,arr,arr2
General protein information	Preferred Names Arrestin 2 Names CG5962 gene product from transcript CG5962-RA 49kD arrestin homolog Arr2-PA Arrestin-2 Beta-Arrestin CG5962-PA arrestin arrestin 2 arrestin B arrestin-like protein arrestin2 phosrestin I phosrestin-1
Gene Type	protein-coding
Organism	Drosophila melanogaster(fruit fly)
Genome	Chromosome: 3L Map Location: 66D9-66D9

mRNA and Protein(s)

mRNA	Protein	Name
NM_079252.3	NP_523976.1	arrestin 2

Pathways from BioSystems

Homologies

Drosophila melanogaster (fruit fly)	Arr2	NP_523976.1
Anopheles gambiae (African malaria mosquito)	ARR2	XP_316327.2

Gene Ontology
Bibliography

Related articles in PubMed

Gene Model Annotations for Drosophila melanogaster: Impact of High-Throughput Data.
Matthews BB, Dos Santos G, Crosby MA, Emmert DB, St Pierre SE, Gramates LS, Zhou P, Schroeder AJ, Falls K, Strelets V, Russo SM, Gelbart WM,
G3 (Bethesda, Md.)5(8)1721-36(2015 Jun)

Gene Model Annotations for Drosophila melanogaster: The Rule-Benders.
Crosby MA, Gramates LS, Dos Santos G, Matthews BB, St Pierre SE, Zhou P, Schroeder AJ, Falls K, Emmert DB, Russo SM, Gelbart WM,
G3 (Bethesda, Md.)5(8)1737-49(2015 Jun)

Sequence finishing and mapping of Drosophila melanogaster heterochromatin.
Hoskins RA, Carlson JW, Kennedy C, Acevedo D, Evans-Holm M, Frise E, Wan KH, Park S, Mendez-Lago M, Rossi F, Villasante A, Dimitri P, Karpen GH, Celniker SE
Science (New York, N.Y.)316(5831)1625-8(2007 Jun)

The Release 5.1 annotation of Drosophila melanogaster heterochromatin.
Smith CD, Shu S, Mungall CJ, Karpen GH
Science (New York, N.Y.)316(5831)1586-91(2007 Jun)

Combined evidence annotation of transposable elements in genome sequences.
Quesneville H, Bergman CM, Andrieu O, Autard D, Nouaud D, Ashburner M, Anxolabehere D
PLoS computational biology1(2)166-75(2005 Jul)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

identify a previously uncharacterized enzyme of ecdysone biosynthesis, GstE14, and find that ecdysone triggers pri expression to define the onset of epidermal trichome development
Title: Pri peptides are mediators of ecdysone for the temporal control of development.

Rapid calcium/calmodulin-dependent release of arrestin (Arr)2 from NINAC upon Ca2+ influx accounts for the acceleration of translocation by phototransduction.
Title: Regulation of arrestin translocation by Ca2+ and myosin III in Drosophila photoreceptors.

This study indicated that Arr2 translocation in Drosophila photoreceptors is driven by diffusion, but profoundly accelerated by phototransduction and Ca2+ influx.
Title: Arrestin translocation is stoichiometric to rhodopsin isomerization and accelerated by phototransduction in Drosophila photoreceptors.

Findings demonstrate that light-induced translocation of Arr2 occurs through a noncanonical rhodopsin/Rac2 pathway, which is distinct from the classical phototransduction cascade.
Title: Light-induced translocation of Drosophila visual Arrestin2 depends on Rac2.

We developed a steady-state stochastic model to interpret the dependence of the PDA on effective light intensity and arrestin content and to help deduce the arrestin to rhodopsin ratio from the sensitivity and PDA data.
Title: Photoreceptor responses of fruitflies with normal and reduced arrestin content studied by simultaneous measurements of visual pigment fluorescence and ERG.

The following Arr2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Arr2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OFa17927	NM_079252.3 Latest version!	Drosophila melanogaster arrestin 2 (Arr2), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$258.30 $369.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Arr2 ( NM_079252.3 ) cDNA ORF clone, Drosophila melanogaster(fruit fly) -> NP_523976.1 Drosophila melanogaster arrestin 2 (Arr2), mRNA.

Price & Availability↑

CloneID	OFa17927
Clone ID Related Accession (Same CDS sequence)	NM_079252.3
Accession Version	NM_079252.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1206bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-04-24
Organism	Drosophila melanogaster(fruit fly)
Product	arrestin 2
Comment	Comment: REVIEWED REFSEQ: This record has been curated by FlyBase. This record is derived from an annotated genomic sequence (NT_037436). On Jan 16, 2013 this sequence version replaced NM_079252.2. ##Genome-Annotation-Data-START## Annotation Provider :: FlyBase Annotation Status :: Full annotation Annotation Version :: Release 6.26 URL :: http://flybase.org ##Genome-Annotation-Data-END##

ATGGTTGTAT CCGTGAAGGT CTTTAAGAAG GCCACGCCCA ACGGCAAGGT CACCTTTTAT 
CTGGGACGCC GCGACTTCAT CGACCACATC GACTACTGTG ATCCCGTCGA TGGAGTGATT 
GTGGTGGAAC CGGACTATCT AAAGAACAGG AAAGTCTTTG GCCAACTGGC CACCACCTAT 
CGCTATGGTC GCGAGGAGGA CGAGGTCATG GGAGTGAAGT TCTCCAAGGA GCTTATCCTG 
TGCCGGGAGC AAATTGTGCC CATGACCAAT CCCAACATGG AGATGACACC GATGCAGGAG 
AAGCTGGTCC GCAAACTGGG CAGCAACGCC TATCCGTTCA CCTTCCACTT CCCGCCCAAT 
TCGCCCAGCT CCGTTACTCT GCAGCAGGAG GGCGACGACA ATGGCAAGCC CCTGGGCGTC 
GAGTACACCA TCCGGGCATT TGTGGGCGAC TCCGAGGACG ATCGCCAGCA CAAGCGGAGC 
ATGGTCAGTC TGGTGATCAA GAAGCTGCAG TACGCTCCCC TCAATCGTGG CCAGCGTCTG 
CCCAGCTCGC TGGTCAGCAA GGGATTCACC TTCTCGAATG GCAAGATCAG TCTGGAGGTT 
ACGCTGGACA GGGAGATCTA CTATCATGGC GAGAAGACGG CTGCCACCGT CCAGGTGTCG 
AACAACTCCA AGAAGTCCGT GAAGAGCATC AAGTGCTTCA TTGTGCAGCA CACTGAGATC 
ACCATGGTGA ACGCCCAGTT CAGCAAGCAT GTGGCCCAGC TGGAGACCAA GGAGGGCTGC 
CCCATCACTC CGGGCGCCAA TCTCACCAAG ACCTTCTACT TGATTCCGCT GGCGGCTAAC 
AACAAGGATC GCCATGGTAT CGCCCTGGAT GGTCACTTGA AGGACGAGGA TGTCAACCTG 
GCTTCATCCA CCATGGTGCA GGAGGGCAAG TCCACGGGAG ATGCCTGTGG TATTGTCATC 
TCGTACTCGG TGCGCATTAA GCTCAACTGC GGCACTCTGG GAGGTGAAAT GCAGACGGAT 
GTGCCCTTCA AGCTACTCCA ACCGGCACCT GGAACCATTG AGAAGAAGCG CTCGAATGCC 
ATGAAGAAAA TGAAGTCCAT CGAGCAGCAC CGCAATGTGA AGGGCTATTA CCAGGATGAT 
GACGATAATA TTGTATTCGA GGACTTCGCC AAGATGCGCA TGAACAATGT GAACATGGCG 
GACTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_523976.1
CDS	112..1317
Translation	MVVSVKVFKKATPNGKVTFYLGRRDFIDHIDYCDPVDGVIVVEPDYLKNRKVFGQLATTYRYGREEDEVMGVKFSKELILCREQIVPMTNPNMEMTPMQEKLVRKLGSNAYPFTFHFPPNSPSSVTLQQEGDDNGKPLGVEYTIRAFVGDSEDDRQHKRSMVSLVIKKLQYAPLNRGQRLPSSLVSKGFTFSNGKISLEVTLDREIYYHGEKTAATVQVSNNSKKSVKSIKCFIVQHTEITMVNAQFSKHVAQLETKEGCPITPGANLTKTFYLIPLAANNKDRHGIALDGHLKDEDVNLASSTMVQEGKSTGDACGIVISYSVRIKLNCGTLGGEMQTDVPFKLLQPAPGTIEKKRSNAMKKMKSIEQHRNVKGYYQDDDDNIVFEDFAKMRMNNVNMAD

Target ORF information:

RefSeq Version	NM_079252.3
Organism	Drosophila melanogaster(fruit fly)
Definition	Drosophila melanogaster arrestin 2 (Arr2), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_079252.3

ORF Insert Sequence:

ATGGTTGTAT CCGTGAAGGT CTTTAAGAAG GCCACGCCCA ACGGCAAGGT CACCTTTTAT 
CTGGGACGCC GCGACTTCAT CGACCACATC GACTACTGTG ATCCCGTCGA TGGAGTGATT 
GTGGTGGAAC CGGACTATCT AAAGAACAGG AAAGTCTTTG GCCAACTGGC CACCACCTAT 
CGCTATGGTC GCGAGGAGGA CGAGGTCATG GGAGTGAAGT TCTCCAAGGA GCTTATCCTG 
TGCCGGGAGC AAATTGTGCC CATGACCAAT CCCAACATGG AGATGACACC GATGCAGGAG 
AAGCTGGTCC GCAAACTGGG CAGCAACGCC TATCCGTTCA CCTTCCACTT CCCGCCCAAT 
TCGCCCAGCT CCGTTACTCT GCAGCAGGAG GGCGACGACA ATGGCAAGCC CCTGGGCGTC 
GAGTACACCA TCCGGGCATT TGTGGGCGAC TCCGAGGACG ATCGCCAGCA CAAGCGGAGC 
ATGGTCAGTC TGGTGATCAA GAAGCTGCAG TACGCTCCCC TCAATCGTGG CCAGCGTCTG 
CCCAGCTCGC TGGTCAGCAA GGGATTCACC TTCTCGAATG GCAAGATCAG TCTGGAGGTT 
ACGCTGGACA GGGAGATCTA CTATCATGGC GAGAAGACGG CTGCCACCGT CCAGGTGTCG 
AACAACTCCA AGAAGTCCGT GAAGAGCATC AAGTGCTTCA TTGTGCAGCA CACTGAGATC 
ACCATGGTGA ACGCCCAGTT CAGCAAGCAT GTGGCCCAGC TGGAGACCAA GGAGGGCTGC 
CCCATCACTC CGGGCGCCAA TCTCACCAAG ACCTTCTACT TGATTCCGCT GGCGGCTAAC 
AACAAGGATC GCCATGGTAT CGCCCTGGAT GGTCACTTGA AGGACGAGGA TGTCAACCTG 
GCTTCATCCA CCATGGTGCA GGAGGGCAAG TCCACGGGAG ATGCCTGTGG TATTGTCATC 
TCGTACTCGG TGCGCATTAA GCTCAACTGC GGCACTCTGG GAGGTGAAAT GCAGACGGAT 
GTGCCCTTCA AGCTACTCCA ACCGGCACCT GGAACCATTG AGAAGAAGCG CTCGAATGCC 
ATGAAGAAAA TGAAGTCCAT CGAGCAGCAC CGCAATGTGA AGGGCTATTA CCAGGATGAT 
GACGATAATA TTGTATTCGA GGACTTCGCC AAGATGCGCA TGAACAATGT GAACATGGCG 
GACTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Gene Model Annotations for Drosophila melanogaster: Impact of High-Throughput Data.
G3 (Bethesda, Md.)5(8)1721-36(2015 Jun)
Matthews BB,Dos Santos G,Crosby MA,Emmert DB,St Pierre SE,Gramates LS,Zhou P,Schroeder AJ,Falls K,Strelets V,Russo SM,Gelbart WM,

Gene Model Annotations for Drosophila melanogaster: The Rule-Benders.
G3 (Bethesda, Md.)5(8)1737-49(2015 Jun)
Crosby MA,Gramates LS,Dos Santos G,Matthews BB,St Pierre SE,Zhou P,Schroeder AJ,Falls K,Emmert DB,Russo SM,Gelbart WM,

Sequence finishing and mapping of Drosophila melanogaster heterochromatin.
Science (New York, N.Y.)316(5831)1625-8(2007 Jun)
Hoskins RA,Carlson JW,Kennedy C,Acevedo D,Evans-Holm M,Frise E,Wan KH,Park S,Mendez-Lago M,Rossi F,Villasante A,Dimitri P,Karpen GH,Celniker SE

The Release 5.1 annotation of Drosophila melanogaster heterochromatin.
Science (New York, N.Y.)316(5831)1586-91(2007 Jun)
Smith CD,Shu S,Mungall CJ,Karpen GH

Combined evidence annotation of transposable elements in genome sequences.
PLoS computational biology1(2)166-75(2005 Jul)
Quesneville H,Bergman CM,Andrieu O,Autard D,Nouaud D,Ashburner M,Anxolabehere D

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Arr2 cDNA ORF clone, Drosophila melanogaster(fruit fly)

Gene

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Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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