Xpd cDNA ORF clone, Drosophila melanogaster(fruit fly)

Gene
Clones
gRNAs

Summary

Gene Symbol	Xpd
Entrez Gene ID	37414
Full Name	Xeroderma pigmentosum D
Synonyms	CG9433,DhR3,DhXPD,DmXPD,Dmel\CG9433,ERCC2,XPD,XPD/ERCC2,l(2)SH2 2137,l(2)SH2137,xpd
General protein information	Preferred Names Xeroderma pigmentosum D Names CG9433 gene product from transcript CG9433-RA CG9433-PA Xpd-PA lethal (2) SH2137 xeroderma pigmentosum D xeroderma pigmentosum D ortholog
Gene Type	protein-coding
Organism	Drosophila melanogaster(fruit fly)
Genome	Chromosome: 2R Map Location: 57C7-57C7

mRNA and Protein(s)

mRNA	Protein	Name
NM_166429.3	NP_726036.2	xeroderma pigmentosum D

Pathways from BioSystems

Homologies

Mus musculus (house mouse)	Ercc2	NP_031975.2
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP002988	XP_311900.4
Bos taurus (cattle)	ERCC2	NP_001096787.1
Magnaporthe oryzae (rice blast fungus)	MGG_03132	XP_003716866.1
Pan troglodytes (chimpanzee)	ERCC2	NP_001233519.1
Danio rerio (zebrafish)	ercc2	NP_957220.1
Drosophila melanogaster (fruit fly)	Xpd	NP_726036.2
Schizosaccharomyces pombe (fission yeast)	rad15	NP_593025.1
Oryza sativa (rice)	Os05g0144800	NP_001054627.1
Xenopus tropicalis (tropical clawed frog)	ercc2	NP_001008131.1
Homo sapiens (human)	ERCC2	NP_000391.1
Canis lupus familiaris (dog)	ERCC2	XP_541562.3
Kluyveromyces lactis	KLLA0C17776g	XP_452994.1
Neurospora crassa	NCU01625	XP_956536.2
Arabidopsis thaliana (thale cress)	UVH6	NP_171818.1
	LOC715485	XP_002808245.1
Rattus norvegicus (Norway rat)	Ercc2	NP_001166280.1
Caenorhabditis elegans (roundworm)	Y50D7A.2	NP_497182.2
Saccharomyces cerevisiae (baker's yeast)	RAD3	NP_011098.3
Eremothecium gossypii	AGOS_AGR114C	NP_986780.1

Gene Ontology
Bibliography

Related articles in PubMed

Gene Model Annotations for Drosophila melanogaster: Impact of High-Throughput Data.
Matthews BB, Dos Santos G, Crosby MA, Emmert DB, St Pierre SE, Gramates LS, Zhou P, Schroeder AJ, Falls K, Strelets V, Russo SM, Gelbart WM,
G3 (Bethesda, Md.)5(8)1721-36(2015 Jun)

Gene Model Annotations for Drosophila melanogaster: The Rule-Benders.
Crosby MA, Gramates LS, Dos Santos G, Matthews BB, St Pierre SE, Zhou P, Schroeder AJ, Falls K, Emmert DB, Russo SM, Gelbart WM,
G3 (Bethesda, Md.)5(8)1737-49(2015 Jun)

Sequence finishing and mapping of Drosophila melanogaster heterochromatin.
Hoskins RA, Carlson JW, Kennedy C, Acevedo D, Evans-Holm M, Frise E, Wan KH, Park S, Mendez-Lago M, Rossi F, Villasante A, Dimitri P, Karpen GH, Celniker SE
Science (New York, N.Y.)316(5831)1625-8(2007 Jun)

The Release 5.1 annotation of Drosophila melanogaster heterochromatin.
Smith CD, Shu S, Mungall CJ, Karpen GH
Science (New York, N.Y.)316(5831)1586-91(2007 Jun)

Combined evidence annotation of transposable elements in genome sequences.
Quesneville H, Bergman CM, Andrieu O, Autard D, Nouaud D, Ashburner M, Anxolabehere D
PLoS computational biology1(2)166-75(2005 Jul)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

XPD expression significantly inhibited HepG2 cell proliferation, promoted HepG2 cell apoptosis, inhibited HepG2 colony formation, decreased HepG2 cells' migratory ability, and significantly lowered HepG2 cells' invasive capacity.
Title: XPD Functions as a Tumor Suppressor and Dysregulates Autophagy in Cultured HepG2 Cells.

A novel Crb-Galla-Xpd complex and its function for proper chromosome segregation.
Title: Crumbs interacts with Xpd for nuclear division control in Drosophila.

The multitask protein Xpd also plays an essential role in cell cycle regulation that appears to be independent of transcription or nucleotide excision repair.
Title: Drosophila Xpd regulates Cdk7 localization, mitotic kinase activity, spindle dynamics, and chromosome segregation.

The variant genotypes of XPD Lys751Gln polymorphism are associated with a higher risk of esophageal adenocarcinoma.
Title: XRCC1 and XPD polymorphisms and esophageal adenocarcinoma risk.

The following Xpd gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Xpd cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OFa10764	NM_166429.3 Latest version!	Drosophila melanogaster xeroderma pigmentosum D (Xpd), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	12-14	$426.30 $609.00

ORF Online Only Promotion

Next-day Shipping ORF Clones ( in default vector with tag)
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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Xpd ( NM_166429.3 ) cDNA ORF clone, Drosophila melanogaster(fruit fly) -> NP_726036.2 Drosophila melanogaster xeroderma pigmentosum D (Xpd), mRNA.

Price & Availability↑

CloneID	OFa10764
Clone ID Related Accession (Same CDS sequence)	NM_166429.3
Accession Version	NM_166429.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2310bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-04-24
Organism	Drosophila melanogaster(fruit fly)
Product	xeroderma pigmentosum D
Comment	Comment: REVIEWED REFSEQ: This record has been curated by FlyBase. This record is derived from an annotated genomic sequence (NT_033778). On Jul 15, 2014 this sequence version replaced NM_166429.2. ##Genome-Annotation-Data-START## Annotation Provider :: FlyBase Annotation Status :: Full annotation Annotation Version :: Release 6.26 URL :: http://flybase.org ##Genome-Annotation-Data-END##

ATGAAGCTCA GCGTGGACGG CCTGTTGGTG TACTTTCCGT ACGAGTACAT CTACCCGGAA 
CAATATGCCT ACATGCTGGA ACTTAAGCGT AGCCTGGACG CCAAGGGCCA CTGCCTGTTG 
GAGATGCCCT CGGGAACGGG CAAGACGGCC ACGCTGCTCT CCCTGATCGT TGCCTACATG 
GTGGAGCATC CGGAAACGGT GCGCAAGCTC ATCTACTGCT CGCGTACTGT TCCGGAGATC 
GAGAAAGTGA TCGCCGAGCT GCAGAACCTG ATGGTTTACT ACGAGCGCCA CTGCCCCAAT 
CCACCACCCT TCACCGGTCT GGTGCTCAGC TCTAGGAAGA ACATGTGCAT CCATCCGGAG 
GTCAGTAAGG AGCGCGAGGG CAAGGCCGTG GACGGTAAAT GTTACGGACT CACTGCCAGC 
TACATTCGCG AACGGCACGA GATGGACACC GAGACGCCCA TTTGCCAGTA CTTTGAGGGA 
TTTAGCCTGG AAGGCAAGGA GTCCACATTG CCGGTCGGCG TCTACAGCAT CGATGATCTT 
AAGGAATACG GTCGGTCGCG CAACTGGTGT CCCTACTTTT TGGCTCGCTA TGCTATTGCC 
CATGCTCACA TTGTGGTATA CAGTTACCAC TATCTATTAG ATCCGAAAAT TGCCCAGGTG 
GTATCTAAGG AAATGAGCCG CGAGTCCTGT GTGGTCTTTG ATGAGGCGCA CAACATCGAC 
AACGTTTGCA TCGATTCGAT GAGTGTGAAG ATCAACAGAC GCACCGTGGA GCGAAGCACG 
AATGCTTTGA ACCATCTAAC TAAACTGGTT CAGGACATTC GCGAAGAGGA CACAAATCGT 
CTGAACGAGG AGTATCAGCG CATGGTGCAG GGTCTGAAGG ATGCCAGTGT GCAGCGCGAC 
ACGGACATGA TCCTGGCCAA TCCGGTCCTG CCAAACGATG TCCTAACCGA GGTGGTGCCC 
GGAAATATTA GGAACGCCGA TCATTTCCTT AGCTTTCTGC GTCGATTCAT CGAGTATATA 
AAGACAAGAC TGCGCGTTCA TCATGTCGTT CAGGAGTCAC CTGCGGGCTT CCTTAAGGAT 
ATTTCCTCCA AGATTTGTAT AGAGAGAAAG CCTCTGCGTT TTTGTGCTGA GCGCCTGTCC 
AGTCTGCTGC GCACGCTTGA GATCAGTGAT TTGACGGAGT ATGGAGCCCT TACACTGATT 
ACACACTTTG CCACCCTGGT GTCCACCTAC ACAAAGGGCT TCACAATCAT TATAGAACCC 
TTCGACGATA AAACGCCGAC TGTTTCGAAT CCCATTTTGC ACTTTAGTTG CCTAGACTCT 
TCCATTGCCA TGGCTCCGGT ATTTTCGAGA TTTCAAACCG TGGTCATCAC TTCTGGCACA 
TTGTCACCCA TGGACATGTA CCCGAAGATA CTCGATTTCG ATCCAGTGGT GATGAGCAGC 
TTTACCATGA CACTAGCCCG TCCGTGTCTT CTTCCTATGA TTGTATCGAA GGGCAACGAC 
CAGGTGACCA TTTCGTCCAA GTTCGAGACG CGAGAAGACA CCGCCGTCAT TCGAAACTAT 
GGCCAGCTTT TGGTGGAGGT GGCAAAGACA GTGCCCGACG GTATTGTATG CTTCTTCACC 
TCCTATTTGT ACTTGGAGTC TGTGGTGGCC TCTTGGTATG ATCAGGGAAT CGTCGATACC 
CTGCTTCGCT ACAAGCTTCT ATTCATTGAG ACTCAGGACA ATGCCGAGAC CAGCTACGCC 
CTGATGAACT ATGTTAAGGC CTGCGATTGT GGTCGTGGAG CAGTGCTGTT GGCTGTGGCG 
CGTGGCAAGG TCTCCGAGGG TGTGGATTTC GACCATCATT ATGGTCGCGC GGTGCTCATG 
TTCGGCATCC CCTACGTGTA CACGCAGTCG CGTATTCTGA AGGCCCGGTT GGACTACCTG 
CGGGATCAGT TTCAGATACG TGAGAATGAC TTCCTGACCT TCGACGCCAT GCGTCATGCT 
GCCCAGTGCG TGGGTCGTGC ACTGCGCGGC AAGACGGACT ACGGCATCAT GATCTTCGCG 
GACAAGCGCT TTTCGCGCCA CGACAAGAGG TCGCGTTTGC CCAAGTGGAT CCAAGAGCAT 
CTGGTGGACA GCTTCTGCAA CCTGAGCACG GAGGAGGCCG TCCAGCTGGC CCGTCGTTGG 
CTGCGGCGCA TGGCGCAACC GTTCACACGT GAGGACCAGC TGGGCATCTC GCTGCTGACC 
CTCGCCCAGC TGGAGAACAT GGAGCAGGAG AAGCTGGAGC GGCAGGCTCA GGGCAAGCAG 
GGCGTTGGCG GCGAGGTGCA GGAGCTGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_726036.2
CDS	62..2371
Translation	MKLSVDGLLVYFPYEYIYPEQYAYMLELKRSLDAKGHCLLEMPSGTGKTATLLSLIVAYMVEHPETVRKLIYCSRTVPEIEKVIAELQNLMVYYERHCPNPPPFTGLVLSSRKNMCIHPEVSKEREGKAVDGKCYGLTASYIRERHEMDTETPICQYFEGFSLEGKESTLPVGVYSIDDLKEYGRSRNWCPYFLARYAIAHAHIVVYSYHYLLDPKIAQVVSKEMSRESCVVFDEAHNIDNVCIDSMSVKINRRTVERSTNALNHLTKLVQDIREEDTNRLNEEYQRMVQGLKDASVQRDTDMILANPVLPNDVLTEVVPGNIRNADHFLSFLRRFIEYIKTRLRVHHVVQESPAGFLKDISSKICIERKPLRFCAERLSSLLRTLEISDLTEYGALTLITHFATLVSTYTKGFTIIIEPFDDKTPTVSNPILHFSCLDSSIAMAPVFSRFQTVVITSGTLSPMDMYPKILDFDPVVMSSFTMTLARPCLLPMIVSKGNDQVTISSKFETREDTAVIRNYGQLLVEVAKTVPDGIVCFFTSYLYLESVVASWYDQGIVDTLLRYKLLFIETQDNAETSYALMNYVKACDCGRGAVLLAVARGKVSEGVDFDHHYGRAVLMFGIPYVYTQSRILKARLDYLRDQFQIRENDFLTFDAMRHAAQCVGRALRGKTDYGIMIFADKRFSRHDKRSRLPKWIQEHLVDSFCNLSTEEAVQLARRWLRRMAQPFTREDQLGISLLTLAQLENMEQEKLERQAQGKQGVGGEVQEL

Target ORF information:

RefSeq Version	NM_166429.3
Organism	Drosophila melanogaster(fruit fly)
Definition	Drosophila melanogaster xeroderma pigmentosum D (Xpd), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_166429.3

ORF Insert Sequence:

ATGAAGCTCA GCGTGGACGG CCTGTTGGTG TACTTTCCGT ACGAGTACAT CTACCCGGAA 
CAATATGCCT ACATGCTGGA ACTTAAGCGT AGCCTGGACG CCAAGGGCCA CTGCCTGTTG 
GAGATGCCCT CGGGAACGGG CAAGACGGCC ACGCTGCTCT CCCTGATCGT TGCCTACATG 
GTGGAGCATC CGGAAACGGT GCGCAAGCTC ATCTACTGCT CGCGTACTGT TCCGGAGATC 
GAGAAAGTGA TCGCCGAGCT GCAGAACCTG ATGGTTTACT ACGAGCGCCA CTGCCCCAAT 
CCACCACCCT TCACCGGTCT GGTGCTCAGC TCTAGGAAGA ACATGTGCAT CCATCCGGAG 
GTCAGTAAGG AGCGCGAGGG CAAGGCCGTG GACGGTAAAT GTTACGGACT CACTGCCAGC 
TACATTCGCG AACGGCACGA GATGGACACC GAGACGCCCA TTTGCCAGTA CTTTGAGGGA 
TTTAGCCTGG AAGGCAAGGA GTCCACATTG CCGGTCGGCG TCTACAGCAT CGATGATCTT 
AAGGAATACG GTCGGTCGCG CAACTGGTGT CCCTACTTTT TGGCTCGCTA TGCTATTGCC 
CATGCTCACA TTGTGGTATA CAGTTACCAC TATCTATTAG ATCCGAAAAT TGCCCAGGTG 
GTATCTAAGG AAATGAGCCG CGAGTCCTGT GTGGTCTTTG ATGAGGCGCA CAACATCGAC 
AACGTTTGCA TCGATTCGAT GAGTGTGAAG ATCAACAGAC GCACCGTGGA GCGAAGCACG 
AATGCTTTGA ACCATCTAAC TAAACTGGTT CAGGACATTC GCGAAGAGGA CACAAATCGT 
CTGAACGAGG AGTATCAGCG CATGGTGCAG GGTCTGAAGG ATGCCAGTGT GCAGCGCGAC 
ACGGACATGA TCCTGGCCAA TCCGGTCCTG CCAAACGATG TCCTAACCGA GGTGGTGCCC 
GGAAATATTA GGAACGCCGA TCATTTCCTT AGCTTTCTGC GTCGATTCAT CGAGTATATA 
AAGACAAGAC TGCGCGTTCA TCATGTCGTT CAGGAGTCAC CTGCGGGCTT CCTTAAGGAT 
ATTTCCTCCA AGATTTGTAT AGAGAGAAAG CCTCTGCGTT TTTGTGCTGA GCGCCTGTCC 
AGTCTGCTGC GCACGCTTGA GATCAGTGAT TTGACGGAGT ATGGAGCCCT TACACTGATT 
ACACACTTTG CCACCCTGGT GTCCACCTAC ACAAAGGGCT TCACAATCAT TATAGAACCC 
TTCGACGATA AAACGCCGAC TGTTTCGAAT CCCATTTTGC ACTTTAGTTG CCTAGACTCT 
TCCATTGCCA TGGCTCCGGT ATTTTCGAGA TTTCAAACCG TGGTCATCAC TTCTGGCACA 
TTGTCACCCA TGGACATGTA CCCGAAGATA CTCGATTTCG ATCCAGTGGT GATGAGCAGC 
TTTACCATGA CACTAGCCCG TCCGTGTCTT CTTCCTATGA TTGTATCGAA GGGCAACGAC 
CAGGTGACCA TTTCGTCCAA GTTCGAGACG CGAGAAGACA CCGCCGTCAT TCGAAACTAT 
GGCCAGCTTT TGGTGGAGGT GGCAAAGACA GTGCCCGACG GTATTGTATG CTTCTTCACC 
TCCTATTTGT ACTTGGAGTC TGTGGTGGCC TCTTGGTATG ATCAGGGAAT CGTCGATACC 
CTGCTTCGCT ACAAGCTTCT ATTCATTGAG ACTCAGGACA ATGCCGAGAC CAGCTACGCC 
CTGATGAACT ATGTTAAGGC CTGCGATTGT GGTCGTGGAG CAGTGCTGTT GGCTGTGGCG 
CGTGGCAAGG TCTCCGAGGG TGTGGATTTC GACCATCATT ATGGTCGCGC GGTGCTCATG 
TTCGGCATCC CCTACGTGTA CACGCAGTCG CGTATTCTGA AGGCCCGGTT GGACTACCTG 
CGGGATCAGT TTCAGATACG TGAGAATGAC TTCCTGACCT TCGACGCCAT GCGTCATGCT 
GCCCAGTGCG TGGGTCGTGC ACTGCGCGGC AAGACGGACT ACGGCATCAT GATCTTCGCG 
GACAAGCGCT TTTCGCGCCA CGACAAGAGG TCGCGTTTGC CCAAGTGGAT CCAAGAGCAT 
CTGGTGGACA GCTTCTGCAA CCTGAGCACG GAGGAGGCCG TCCAGCTGGC CCGTCGTTGG 
CTGCGGCGCA TGGCGCAACC GTTCACACGT GAGGACCAGC TGGGCATCTC GCTGCTGACC 
CTCGCCCAGC TGGAGAACAT GGAGCAGGAG AAGCTGGAGC GGCAGGCTCA GGGCAAGCAG 
GGCGTTGGCG GCGAGGTGCA GGAGCTGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Gene Model Annotations for Drosophila melanogaster: Impact of High-Throughput Data.
G3 (Bethesda, Md.)5(8)1721-36(2015 Jun)
Matthews BB,Dos Santos G,Crosby MA,Emmert DB,St Pierre SE,Gramates LS,Zhou P,Schroeder AJ,Falls K,Strelets V,Russo SM,Gelbart WM,

Gene Model Annotations for Drosophila melanogaster: The Rule-Benders.
G3 (Bethesda, Md.)5(8)1737-49(2015 Jun)
Crosby MA,Gramates LS,Dos Santos G,Matthews BB,St Pierre SE,Zhou P,Schroeder AJ,Falls K,Emmert DB,Russo SM,Gelbart WM,

Sequence finishing and mapping of Drosophila melanogaster heterochromatin.
Science (New York, N.Y.)316(5831)1625-8(2007 Jun)
Hoskins RA,Carlson JW,Kennedy C,Acevedo D,Evans-Holm M,Frise E,Wan KH,Park S,Mendez-Lago M,Rossi F,Villasante A,Dimitri P,Karpen GH,Celniker SE

The Release 5.1 annotation of Drosophila melanogaster heterochromatin.
Science (New York, N.Y.)316(5831)1586-91(2007 Jun)
Smith CD,Shu S,Mungall CJ,Karpen GH

Combined evidence annotation of transposable elements in genome sequences.
PLoS computational biology1(2)166-75(2005 Jul)
Quesneville H,Bergman CM,Andrieu O,Autard D,Nouaud D,Ashburner M,Anxolabehere D

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Xpd cDNA ORF clone, Drosophila melanogaster(fruit fly)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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