cpa cDNA ORF clone, Drosophila melanogaster(fruit fly)

Gene
Clones
gRNAs

Summary

Gene Symbol	cpa
Entrez Gene ID	37387
Full Name	capping protein alpha
Synonyms	CG10540,Cap1,CapZalpha,Cpa,Dmel\CG10540,cpalpha,miro,scrd
General protein information	Preferred Names capping protein alpha Names CG10540 gene product from transcript CG10540-RA CG10540-PA capping alpha capping protein capping protein A capping proteinalpha cpa-PA
Gene Type	protein-coding
Organism	Drosophila melanogaster(fruit fly)
Genome	Chromosome: 2R Map Location: 57B16-57B16

mRNA and Protein(s)

mRNA	Protein	Name
NM_137695.4	NP_611539.1	capping protein alpha

Pathways from BioSystems

Homologies

Homo sapiens (human)	CAPZA1	NP_006126.1
	CAPZA1	XP_001107677.1
Mus musculus (house mouse)	Capza1	NP_033927.2
Rattus norvegicus (Norway rat)	Capza1	NP_001103095.2
Gallus gallus (chicken)	CAPZA1	NP_990846.1
Danio rerio (zebrafish)	capza1b	NP_001006664.1
Drosophila melanogaster (fruit fly)	cpa	NP_611539.1
Oryza sativa (rice)	Os07g0414800	NP_001059458.1
Canis lupus familiaris (dog)	CAPZA1	XP_533066.2
Caenorhabditis elegans (roundworm)	cap-1	NP_501145.1
Danio rerio (zebrafish)	capza1a	NP_997862.1
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP006141	XP_316203.2
Arabidopsis thaliana (thale cress)	AT3G05520	NP_001154593.1
Pan troglodytes (chimpanzee)	CAPZA1	XP_513632.2
Bos taurus (cattle)	CAPZA1	NP_001076949.1
Xenopus tropicalis (tropical clawed frog)	capza1	NP_001017324.1

Gene Ontology
Bibliography

Related articles in PubMed

Gene Model Annotations for Drosophila melanogaster: Impact of High-Throughput Data.
Matthews BB, Dos Santos G, Crosby MA, Emmert DB, St Pierre SE, Gramates LS, Zhou P, Schroeder AJ, Falls K, Strelets V, Russo SM, Gelbart WM,
G3 (Bethesda, Md.)5(8)1721-36(2015 Jun)

Gene Model Annotations for Drosophila melanogaster: The Rule-Benders.
Crosby MA, Gramates LS, Dos Santos G, Matthews BB, St Pierre SE, Zhou P, Schroeder AJ, Falls K, Emmert DB, Russo SM, Gelbart WM,
G3 (Bethesda, Md.)5(8)1737-49(2015 Jun)

Sequence finishing and mapping of Drosophila melanogaster heterochromatin.
Hoskins RA, Carlson JW, Kennedy C, Acevedo D, Evans-Holm M, Frise E, Wan KH, Park S, Mendez-Lago M, Rossi F, Villasante A, Dimitri P, Karpen GH, Celniker SE
Science (New York, N.Y.)316(5831)1625-8(2007 Jun)

The Release 5.1 annotation of Drosophila melanogaster heterochromatin.
Smith CD, Shu S, Mungall CJ, Karpen GH
Science (New York, N.Y.)316(5831)1586-91(2007 Jun)

Combined evidence annotation of transposable elements in genome sequences.
Quesneville H, Bergman CM, Andrieu O, Autard D, Nouaud D, Ashburner M, Anxolabehere D
PLoS computational biology1(2)166-75(2005 Jul)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Data show that the actin-Capping Protein (CP) alphabeta heterodimer, which regulates actin filament (F-actin) polymerization, limits Src-induced apoptosis or tissue overgrowth by restricting JNK activation.
Title: Drosophila actin-Capping Protein limits JNK activation by the Src proto-oncogene.

Data show that actin-capping protein subunits Cpa and Cpb stabilize each other's protein levels and can stimulate the production of each other's mRNA when the level of one of the subunit is reduced.
Title: Subunits of the Drosophila actin-capping protein heterodimer regulate each other at multiple levels.

findings show an interdependency between Hpo signaling activity and F-actin dynamics in which CP and Hpo pathway activities inhibit F-actin accumulation, and the reduction in F-actin in turn sustains Hpo pathway activity
Title: Actin-Capping Protein and the Hippo pathway regulate F-actin and tissue growth in Drosophila.

Enabled and Capping actin regulator proteins shape oogenesis.
Title: Enabled and Capping protein play important roles in shaping cell behavior during Drosophila oogenesis.

Actin capping protein alpha maintains vestigial-expressing cells within the Drosophila wing disc epithelium
Title: Actin capping protein alpha maintains vestigial-expressing cells within the Drosophila wing disc epithelium.

The following cpa gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the cpa cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OFa10740	NM_137695.4 Latest version!	Drosophila melanogaster capping protein alpha (cpa), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$174.30 $249.00

ORF Online Only Promotion

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

cpa ( NM_137695.4 ) cDNA ORF clone, Drosophila melanogaster(fruit fly) -> NP_611539.1 Drosophila melanogaster capping protein alpha (cpa), mRNA.

Price & Availability↑

CloneID	OFa10740
Clone ID Related Accession (Same CDS sequence)	NM_137695.4
Accession Version	NM_137695.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 861bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-04-24
Organism	Drosophila melanogaster(fruit fly)
Product	capping protein alpha
Comment	Comment: REVIEWED REFSEQ: This record has been curated by FlyBase. This record is derived from an annotated genomic sequence (NT_033778). On Jul 15, 2014 this sequence version replaced NM_137695.3. ##Genome-Annotation-Data-START## Annotation Provider :: FlyBase Annotation Status :: Full annotation Annotation Version :: Release 6.26 URL :: http://flybase.org ##Genome-Annotation-Data-END##

ATGGAGCAGA CACCGATCAC CGATGCGGAG AAGGTGCGCA TCGTATCGGA CTTCATCCTA 
CATGCGCCGC CCGGCGAGTT CAACGAAGTG TTCAACGATG TGCGGGAGCT CCTCAAGAAT 
GACACTCTGC TAAAGGATGG GGCTAGCCAC GCCTTCGCCC AATACAACAA GGACCAGCTG 
ACTCCGGTTC GCATCGAGGG CACCGATCAT AACGCCATCA TATCGGAACA CAACGATCTG 
GGAAACGGTC GCTTCTACGA CCCGCGCACA AAGCAAGCCT TCAAATACGA CCACCTCCGA 
AAAGAGGCTT CCGACTACCA GGACGTAGAG GCAGATGCCA CTGCGGAGCC CTGGAGGGCG 
GCCCTCGACC TGGAGACGCT CGCCTACACT GCCAGTCATT ATAGACACGG GGTCAGCTCT 
GTTTTTGGAA AGGCGCAGGG CAACCAGATC ACCCTGACCA TTTGCATCGA AGACCACCAG 
TTCCAGCCGA AGAACTATTG GAATGGCCGA TGGCGCTCCC AGTGGCATGT GACCTTCCAG 
GCGGGCAGCG GAACCGCCGA ACTGAAGGGT GTGCTCAAGG TGCAGGTGCA TTACTACGAG 
GACGGCAACG TCCAGCTGGT GTCCTCAAAG GAGTGCCGCG AAAGCGTGGT GGTCAGCAAC 
GAGCAGCAGG TGGCCAAGGA GGTGATCCGT CTGATCGAGG ACGCCGAGAA TGAGTACCAG 
CTGGCCATTT CGGAGAACTA TCAGACGATG TCGGACACGA CATTCAAGGC AATGCGTCGC 
CAGTTGCCCA TCACCAGGAC CAAGATCGAC TGGAGCAAAA TCGTCTCGTA CAGCATTGGC 
AAGGAACTGA AGACGCAATA A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_611539.1
CDS	236..1096
Translation	MEQTPITDAEKVRIVSDFILHAPPGEFNEVFNDVRELLKNDTLLKDGASHAFAQYNKDQLTPVRIEGTDHNAIISEHNDLGNGRFYDPRTKQAFKYDHLRKEASDYQDVEADATAEPWRAALDLETLAYTASHYRHGVSSVFGKAQGNQITLTICIEDHQFQPKNYWNGRWRSQWHVTFQAGSGTAELKGVLKVQVHYYEDGNVQLVSSKECRESVVVSNEQQVAKEVIRLIEDAENEYQLAISENYQTMSDTTFKAMRRQLPITRTKIDWSKIVSYSIGKELKTQ

Target ORF information:

RefSeq Version	NM_137695.4
Organism	Drosophila melanogaster(fruit fly)
Definition	Drosophila melanogaster capping protein alpha (cpa), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_137695.4

ORF Insert Sequence:

ATGGAGCAGA CACCGATCAC CGATGCGGAG AAGGTGCGCA TCGTATCGGA CTTCATCCTA 
CATGCGCCGC CCGGCGAGTT CAACGAAGTG TTCAACGATG TGCGGGAGCT CCTCAAGAAT 
GACACTCTGC TAAAGGATGG GGCTAGCCAC GCCTTCGCCC AATACAACAA GGACCAGCTG 
ACTCCGGTTC GCATCGAGGG CACCGATCAT AACGCCATCA TATCGGAACA CAACGATCTG 
GGAAACGGTC GCTTCTACGA CCCGCGCACA AAGCAAGCCT TCAAATACGA CCACCTCCGA 
AAAGAGGCTT CCGACTACCA GGACGTAGAG GCAGATGCCA CTGCGGAGCC CTGGAGGGCG 
GCCCTCGACC TGGAGACGCT CGCCTACACT GCCAGTCATT ATAGACACGG GGTCAGCTCT 
GTTTTTGGAA AGGCGCAGGG CAACCAGATC ACCCTGACCA TTTGCATCGA AGACCACCAG 
TTCCAGCCGA AGAACTATTG GAATGGCCGA TGGCGCTCCC AGTGGCATGT GACCTTCCAG 
GCGGGCAGCG GAACCGCCGA ACTGAAGGGT GTGCTCAAGG TGCAGGTGCA TTACTACGAG 
GACGGCAACG TCCAGCTGGT GTCCTCAAAG GAGTGCCGCG AAAGCGTGGT GGTCAGCAAC 
GAGCAGCAGG TGGCCAAGGA GGTGATCCGT CTGATCGAGG ACGCCGAGAA TGAGTACCAG 
CTGGCCATTT CGGAGAACTA TCAGACGATG TCGGACACGA CATTCAAGGC AATGCGTCGC 
CAGTTGCCCA TCACCAGGAC CAAGATCGAC TGGAGCAAAA TCGTCTCGTA CAGCATTGGC 
AAGGAACTGA AGACGCAATA A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Gene Model Annotations for Drosophila melanogaster: Impact of High-Throughput Data.
G3 (Bethesda, Md.)5(8)1721-36(2015 Jun)
Matthews BB,Dos Santos G,Crosby MA,Emmert DB,St Pierre SE,Gramates LS,Zhou P,Schroeder AJ,Falls K,Strelets V,Russo SM,Gelbart WM,

Gene Model Annotations for Drosophila melanogaster: The Rule-Benders.
G3 (Bethesda, Md.)5(8)1737-49(2015 Jun)
Crosby MA,Gramates LS,Dos Santos G,Matthews BB,St Pierre SE,Zhou P,Schroeder AJ,Falls K,Emmert DB,Russo SM,Gelbart WM,

Sequence finishing and mapping of Drosophila melanogaster heterochromatin.
Science (New York, N.Y.)316(5831)1625-8(2007 Jun)
Hoskins RA,Carlson JW,Kennedy C,Acevedo D,Evans-Holm M,Frise E,Wan KH,Park S,Mendez-Lago M,Rossi F,Villasante A,Dimitri P,Karpen GH,Celniker SE

The Release 5.1 annotation of Drosophila melanogaster heterochromatin.
Science (New York, N.Y.)316(5831)1586-91(2007 Jun)
Smith CD,Shu S,Mungall CJ,Karpen GH

Combined evidence annotation of transposable elements in genome sequences.
PLoS computational biology1(2)166-75(2005 Jul)
Quesneville H,Bergman CM,Andrieu O,Autard D,Nouaud D,Ashburner M,Anxolabehere D

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cpa cDNA ORF clone, Drosophila melanogaster(fruit fly)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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見積依頼

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