Sec6 cDNA ORF clone, Drosophila melanogaster(fruit fly)

Gene
Clones
gRNAs

Summary

Gene Symbol	Sec6
Entrez Gene ID	37142
Full Name	Secretory 6
Synonyms	CG5341,Dmel\CG5341,Dsec6,Sec6p,dsec6,sec 6,sec6
General protein information	Preferred Names Secretory 6 Names CG5341 gene product from transcript CG5341-RA CG5341-PA Sec6 ortholog Sec6-PA sec6 secretory 6
Gene Type	protein-coding
Organism	Drosophila melanogaster(fruit fly)
Genome	Chromosome: 2R Map Location: 55E2-55E2

mRNA and Protein(s)

mRNA	Protein	Name
NM_137507.5	NP_611351.1	secretory 6

Pathways from BioSystems

Homologies

Pan troglodytes (chimpanzee)	EXOC3	XP_517603.2
Gallus gallus (chicken)	EXOC3	NP_001006384.1
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP009058	XP_319809.2
Caenorhabditis elegans (roundworm)	sec-6	NP_495006.2
Bos taurus (cattle)	EXOC3	NP_001069068.1
Homo sapiens (human)	EXOC3	NP_009208.2
Canis lupus familiaris (dog)	EXOC3	XP_848639.1
	EXOC3	XP_001094786.1
Mus musculus (house mouse)	Exoc3	NP_796307.2
Rattus norvegicus (Norway rat)	Exoc3	NP_001020135.1
Drosophila melanogaster (fruit fly)	sec6	NP_611351.1
Danio rerio (zebrafish)	exoc3	NP_997880.1
Xenopus tropicalis (tropical clawed frog)	exoc3	NP_001005685.1

Gene Ontology
Bibliography

Related articles in PubMed

Gene Model Annotations for Drosophila melanogaster: Impact of High-Throughput Data.
Matthews BB, Dos Santos G, Crosby MA, Emmert DB, St Pierre SE, Gramates LS, Zhou P, Schroeder AJ, Falls K, Strelets V, Russo SM, Gelbart WM,
G3 (Bethesda, Md.)5(8)1721-36(2015 Jun)

Gene Model Annotations for Drosophila melanogaster: The Rule-Benders.
Crosby MA, Gramates LS, Dos Santos G, Matthews BB, St Pierre SE, Zhou P, Schroeder AJ, Falls K, Emmert DB, Russo SM, Gelbart WM,
G3 (Bethesda, Md.)5(8)1737-49(2015 Jun)

Sequence finishing and mapping of Drosophila melanogaster heterochromatin.
Hoskins RA, Carlson JW, Kennedy C, Acevedo D, Evans-Holm M, Frise E, Wan KH, Park S, Mendez-Lago M, Rossi F, Villasante A, Dimitri P, Karpen GH, Celniker SE
Science (New York, N.Y.)316(5831)1625-8(2007 Jun)

The Release 5.1 annotation of Drosophila melanogaster heterochromatin.
Smith CD, Shu S, Mungall CJ, Karpen GH
Science (New York, N.Y.)316(5831)1586-91(2007 Jun)

Combined evidence annotation of transposable elements in genome sequences.
Quesneville H, Bergman CM, Andrieu O, Autard D, Nouaud D, Ashburner M, Anxolabehere D
PLoS computational biology1(2)166-75(2005 Jul)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The Drosophila exocyst component sec6 in epithelial cells results in DE-Cad accumulation in an enlarged Rab11 recycling endosomal compartment and inhibits DE-Cad delivery to the membrane.
Title: Drosophila exocyst components Sec5, Sec6, and Sec15 regulate DE-Cadherin trafficking from recycling endosomes to the plasma membrane.

Sec6 is an exocyst complex component believed to bind secretory vesicles to plasma membrane sites. Sec6 mutations cause cell death and disrupt plasma membrane growth. In developing photoreceptor cells (PRCs) Sec6 shows accumulation at adherens junctions
Title: Essential function of Drosophila Sec6 in apical exocytosis of epithelial photoreceptor cells.

Sec5, Sec6 and Sec8 act as a complex, each member dependent on the others for proper localization and function
Title: Sec6 mutations and the Drosophila exocyst complex.

The following Sec6 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Sec6 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OFa10512	NM_137507.5 Latest version!	Drosophila melanogaster secretory 6 (Sec6), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	12-14	$426.30 $609.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Sec6 ( NM_137507.5 ) cDNA ORF clone, Drosophila melanogaster(fruit fly) -> NP_611351.1 Drosophila melanogaster secretory 6 (Sec6), mRNA.

Price & Availability↑

CloneID	OFa10512
Clone ID Related Accession (Same CDS sequence)	NM_137507.5
Accession Version	NM_137507.5 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2217bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-04-24
Organism	Drosophila melanogaster(fruit fly)
Product	secretory 6
Comment	Comment: REVIEWED REFSEQ: This record has been curated by FlyBase. This record is derived from an annotated genomic sequence (NT_033778). On Jul 15, 2014 this sequence version replaced NM_137507.4. ##Genome-Annotation-Data-START## Annotation Provider :: FlyBase Annotation Status :: Full annotation Annotation Version :: Release 6.26 URL :: http://flybase.org ##Genome-Annotation-Data-END##

ATGGATTTAC AGCAGCTGGA GGAGCAGGCT CGCCAGGCAG CGCTCAAGGA CATACAGAAC 
ATGTTGCAGC GACCAGGTCA ACTGGAGAAG GTGGAACAAT ATCGCCACCG AATCGCCCGG 
AAGAAGGCAT CCGTTGAGGC GCTCCTTAAG ACCGGAATGC AAGGACAGCT GGACGGGGTC 
AGGGTGGGAC TTAAGCAGTT GGAGACCTGC ATGCAGGACG TGCGCGAGGT AAGGCGTCGA 
ATGGACGAGG TGGAGCGCCT GCTGAGGGGC GTTCCCGAAG TCTACGACGC TTTGGAAGTT 
GTGCGGGAGG AAAACACAAA GCACTCCCAG TACGCCACCG CCATGGAGAA TCTGAAGCAC 
ATCTTCAACG TAGATGCCAG CGTACAAAAG ACGATGGCGC TGATCGAGGA TGATAAGCTG 
CTTAATGCCC ATCAGTGCCT GGCGGATCTG GAGAATTCGC GGGATGATCT TCTCTACGAA 
CTGCACAAGC AGCCCAAGCA GCATGCGTCC GACAAGATCA CCCTAAAGCG TCACTTCGAG 
AAGGTTGACA CGGTATCCCA AGAGCTGGAG AAAAAGCTGC GACTCATTCT TAGCCGCACG 
CTGAACACTC TGCGCAAGAA GCCCACCATC ATCGTTACCG CCCTACGCAT CATAGAGCGG 
GAAGAGAAAA ACGACCAGTT CGCGTTGCAG CAGCAAAAGG TCACAGGATT CCTGCCGCCT 
GGAAGACCAA AGGCTTGGCG CCGCATGATC ATGGACGTGC TACAACAGTC GGTGATAACG 
CGCATAGAGG GATCCAAGCT AGAGGAGCGG GCCGATAACA AGATGTGGTT AGTACGAGAC 
CTGGAGATAT TGCGTCAAAT CATTCTCGAG GATCTGCGCG TTGTGAAGTC CCTTTGTGTG 
CCCTGCTTCC CGCCGCACTA CGACATTTTC GGCGAATATG TCAAGTTCTA TCACGAAGGA 
CTTTCTAGCT ATCTTGACAA CATTGTGCGC TCGGGCTTGG AGGGCAATGA ATATGTATCA 
ATGATGGCTT GGGTTACACA CACCTATCCT GGCGTCGAGC TGATGTCCCA TCCGGATCTT 
AATGTGGATG TACACCGACA GATAGGTACT CTGCTGCGTC CGGAACATCT CAAAGCGCTG 
GAAGATGAAT ATCTGCAAAA TATGCAGAGA AACTTCCAGG AATGGATGAC CAAGGCCGCA 
GAAACGGAGA AGCAGGAGTG GTTTACTGAG ACGGTGCCCG ATCAGGATGA GGAGTACTAC 
CACACTTCAG CGCCTGTCAT CATATTCCAG ATGATCGACC AGCATCTGCA GGTGACCAAC 
ACAATTCATC AGGAACTGAC GTTCAAGGCG TTGGTAATGA GCATTCAGCA GGTGGAGATC 
TTTGGCCAGA CATATCTTAA GAACGTAATC GAGCTGAAGG AACACCATTT TCGCAATCGG 
GACCAGATCA AATACTTCAC TCACTACATC ATCACCATCG TGAATAACAG TCAGCAAATG 
GTTGAACTGG CGCAGCAGAT GAAACAACTC TACTGGCCCA AGTCACGTAC TGAGCATTAT 
GAGGATTTCG AACGTTTGCT TGCCACATTC CAGCGGATCC GGGCTCATGC CGCAAGTTAC 
TTGCTGGAGG AAGCCTTCCT GGACATGGAG TGTCACTTTA ACGACCTATT CACTGCCAAG 
TGGCTGGCCA GTAACATTGC CGTGGACACC ATTTGTGTAA CGCTGGACGA TTACTTCCAG 
GACTATAATC ACCTGCGACC CAATAACTTC GAGATGGTCA TCAACGAGGC CCAGAAGCTG 
CTGGCCAAGC GCTACATTAG GGCACTGCTA TCCAAGCGAC TGTCTAAGCC ACGGGCCGAG 
TGCGATGCCA TTACGCGAAA AATCAAGACC GAAGCCAAGC GGTTTAAGCT CTTCTTTGAG 
AAAATCGCGC CGAAGATTTC CCTCAGCGAC TCTCCATTGG ATCTTATATC CACGCTATCG 
GCACTGCTTA GCTCGGATAT CGAACTGCTC GTCTTGGACC TGCACACCTT GCTGGGCAGC 
TATCCGTCTC TGAACGAGGA CCACCTGGTA CGGCTCTTTT ACATTCGCAA CGATGTGAAG 
GCGGCCGAGG TGCGCGAGAA GGTGCAGGAT GCCATGAAGT CGAAGAAGGC AATGGTCAGC 
ATCGCCAAGC AGGATTGCAT CTTCAAGGAG ATCGTGTTCA GCGACAAACT GTGGTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_611351.1
CDS	95..2311
Translation	MDLQQLEEQARQAALKDIQNMLQRPGQLEKVEQYRHRIARKKASVEALLKTGMQGQLDGVRVGLKQLETCMQDVREVRRRMDEVERLLRGVPEVYDALEVVREENTKHSQYATAMENLKHIFNVDASVQKTMALIEDDKLLNAHQCLADLENSRDDLLYELHKQPKQHASDKITLKRHFEKVDTVSQELEKKLRLILSRTLNTLRKKPTIIVTALRIIEREEKNDQFALQQQKVTGFLPPGRPKAWRRMIMDVLQQSVITRIEGSKLEERADNKMWLVRDLEILRQIILEDLRVVKSLCVPCFPPHYDIFGEYVKFYHEGLSSYLDNIVRSGLEGNEYVSMMAWVTHTYPGVELMSHPDLNVDVHRQIGTLLRPEHLKALEDEYLQNMQRNFQEWMTKAAETEKQEWFTETVPDQDEEYYHTSAPVIIFQMIDQHLQVTNTIHQELTFKALVMSIQQVEIFGQTYLKNVIELKEHHFRNRDQIKYFTHYIITIVNNSQQMVELAQQMKQLYWPKSRTEHYEDFERLLATFQRIRAHAASYLLEEAFLDMECHFNDLFTAKWLASNIAVDTICVTLDDYFQDYNHLRPNNFEMVINEAQKLLAKRYIRALLSKRLSKPRAECDAITRKIKTEAKRFKLFFEKIAPKISLSDSPLDLISTLSALLSSDIELLVLDLHTLLGSYPSLNEDHLVRLFYIRNDVKAAEVREKVQDAMKSKKAMVSIAKQDCIFKEIVFSDKLW

Target ORF information:

RefSeq Version	NM_137507.5
Organism	Drosophila melanogaster(fruit fly)
Definition	Drosophila melanogaster secretory 6 (Sec6), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_137507.5

ORF Insert Sequence:

ATGGATTTAC AGCAGCTGGA GGAGCAGGCT CGCCAGGCAG CGCTCAAGGA CATACAGAAC 
ATGTTGCAGC GACCAGGTCA ACTGGAGAAG GTGGAACAAT ATCGCCACCG AATCGCCCGG 
AAGAAGGCAT CCGTTGAGGC GCTCCTTAAG ACCGGAATGC AAGGACAGCT GGACGGGGTC 
AGGGTGGGAC TTAAGCAGTT GGAGACCTGC ATGCAGGACG TGCGCGAGGT AAGGCGTCGA 
ATGGACGAGG TGGAGCGCCT GCTGAGGGGC GTTCCCGAAG TCTACGACGC TTTGGAAGTT 
GTGCGGGAGG AAAACACAAA GCACTCCCAG TACGCCACCG CCATGGAGAA TCTGAAGCAC 
ATCTTCAACG TAGATGCCAG CGTACAAAAG ACGATGGCGC TGATCGAGGA TGATAAGCTG 
CTTAATGCCC ATCAGTGCCT GGCGGATCTG GAGAATTCGC GGGATGATCT TCTCTACGAA 
CTGCACAAGC AGCCCAAGCA GCATGCGTCC GACAAGATCA CCCTAAAGCG TCACTTCGAG 
AAGGTTGACA CGGTATCCCA AGAGCTGGAG AAAAAGCTGC GACTCATTCT TAGCCGCACG 
CTGAACACTC TGCGCAAGAA GCCCACCATC ATCGTTACCG CCCTACGCAT CATAGAGCGG 
GAAGAGAAAA ACGACCAGTT CGCGTTGCAG CAGCAAAAGG TCACAGGATT CCTGCCGCCT 
GGAAGACCAA AGGCTTGGCG CCGCATGATC ATGGACGTGC TACAACAGTC GGTGATAACG 
CGCATAGAGG GATCCAAGCT AGAGGAGCGG GCCGATAACA AGATGTGGTT AGTACGAGAC 
CTGGAGATAT TGCGTCAAAT CATTCTCGAG GATCTGCGCG TTGTGAAGTC CCTTTGTGTG 
CCCTGCTTCC CGCCGCACTA CGACATTTTC GGCGAATATG TCAAGTTCTA TCACGAAGGA 
CTTTCTAGCT ATCTTGACAA CATTGTGCGC TCGGGCTTGG AGGGCAATGA ATATGTATCA 
ATGATGGCTT GGGTTACACA CACCTATCCT GGCGTCGAGC TGATGTCCCA TCCGGATCTT 
AATGTGGATG TACACCGACA GATAGGTACT CTGCTGCGTC CGGAACATCT CAAAGCGCTG 
GAAGATGAAT ATCTGCAAAA TATGCAGAGA AACTTCCAGG AATGGATGAC CAAGGCCGCA 
GAAACGGAGA AGCAGGAGTG GTTTACTGAG ACGGTGCCCG ATCAGGATGA GGAGTACTAC 
CACACTTCAG CGCCTGTCAT CATATTCCAG ATGATCGACC AGCATCTGCA GGTGACCAAC 
ACAATTCATC AGGAACTGAC GTTCAAGGCG TTGGTAATGA GCATTCAGCA GGTGGAGATC 
TTTGGCCAGA CATATCTTAA GAACGTAATC GAGCTGAAGG AACACCATTT TCGCAATCGG 
GACCAGATCA AATACTTCAC TCACTACATC ATCACCATCG TGAATAACAG TCAGCAAATG 
GTTGAACTGG CGCAGCAGAT GAAACAACTC TACTGGCCCA AGTCACGTAC TGAGCATTAT 
GAGGATTTCG AACGTTTGCT TGCCACATTC CAGCGGATCC GGGCTCATGC CGCAAGTTAC 
TTGCTGGAGG AAGCCTTCCT GGACATGGAG TGTCACTTTA ACGACCTATT CACTGCCAAG 
TGGCTGGCCA GTAACATTGC CGTGGACACC ATTTGTGTAA CGCTGGACGA TTACTTCCAG 
GACTATAATC ACCTGCGACC CAATAACTTC GAGATGGTCA TCAACGAGGC CCAGAAGCTG 
CTGGCCAAGC GCTACATTAG GGCACTGCTA TCCAAGCGAC TGTCTAAGCC ACGGGCCGAG 
TGCGATGCCA TTACGCGAAA AATCAAGACC GAAGCCAAGC GGTTTAAGCT CTTCTTTGAG 
AAAATCGCGC CGAAGATTTC CCTCAGCGAC TCTCCATTGG ATCTTATATC CACGCTATCG 
GCACTGCTTA GCTCGGATAT CGAACTGCTC GTCTTGGACC TGCACACCTT GCTGGGCAGC 
TATCCGTCTC TGAACGAGGA CCACCTGGTA CGGCTCTTTT ACATTCGCAA CGATGTGAAG 
GCGGCCGAGG TGCGCGAGAA GGTGCAGGAT GCCATGAAGT CGAAGAAGGC AATGGTCAGC 
ATCGCCAAGC AGGATTGCAT CTTCAAGGAG ATCGTGTTCA GCGACAAACT GTGGTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Gene Model Annotations for Drosophila melanogaster: Impact of High-Throughput Data.
G3 (Bethesda, Md.)5(8)1721-36(2015 Jun)
Matthews BB,Dos Santos G,Crosby MA,Emmert DB,St Pierre SE,Gramates LS,Zhou P,Schroeder AJ,Falls K,Strelets V,Russo SM,Gelbart WM,

Gene Model Annotations for Drosophila melanogaster: The Rule-Benders.
G3 (Bethesda, Md.)5(8)1737-49(2015 Jun)
Crosby MA,Gramates LS,Dos Santos G,Matthews BB,St Pierre SE,Zhou P,Schroeder AJ,Falls K,Emmert DB,Russo SM,Gelbart WM,

Sequence finishing and mapping of Drosophila melanogaster heterochromatin.
Science (New York, N.Y.)316(5831)1625-8(2007 Jun)
Hoskins RA,Carlson JW,Kennedy C,Acevedo D,Evans-Holm M,Frise E,Wan KH,Park S,Mendez-Lago M,Rossi F,Villasante A,Dimitri P,Karpen GH,Celniker SE

The Release 5.1 annotation of Drosophila melanogaster heterochromatin.
Science (New York, N.Y.)316(5831)1586-91(2007 Jun)
Smith CD,Shu S,Mungall CJ,Karpen GH

Combined evidence annotation of transposable elements in genome sequences.
PLoS computational biology1(2)166-75(2005 Jul)
Quesneville H,Bergman CM,Andrieu O,Autard D,Nouaud D,Ashburner M,Anxolabehere D

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Sec6 cDNA ORF clone, Drosophila melanogaster(fruit fly)

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Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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