aurB cDNA ORF clone, Drosophila melanogaster(fruit fly)

Gene
Clones
gRNAs

Summary

Gene Symbol	aurB
Entrez Gene ID	34504
Full Name	aurora B
Synonyms	ABK,Aur B,AurB,Aurora B,Aurora-B,CG6620,DmAIRK2,DmAurB,DmAuroraB,Dmel\CG6620,IAL,IAL1,Ial,ial,ial/AurB
General protein information	Preferred Names aurora B Names CG6620 gene product from transcript CG6620-RA AURORA-like CG6620-PA DmAuroraB IplI-aurora-like kinase aurB-PA aurora aurora B kinase aurora-B auroraB dAurora B
Gene Type	protein-coding
Organism	Drosophila melanogaster(fruit fly)
Genome	Chromosome: 2L Map Location: 32B2-32B2

mRNA and Protein(s)

mRNA	Protein	Name
NM_057988.4	NP_477336.1	aurora B

Pathways from BioSystems

Homologies

Mus musculus (house mouse)	Aurkc	NP_001074434.1
Arabidopsis thaliana (thale cress)	AUR3	NP_182073.1
Homo sapiens (human)	AURKC	NP_001015878.1
Drosophila melanogaster (fruit fly)	ial	NP_477336.1
Canis lupus familiaris (dog)	AURKC	XP_005616134.1
Pan troglodytes (chimpanzee)	AURKC	XP_001142357.1
	AURKC	XP_001098364.2
Bos taurus (cattle)	LOC618599	NP_001180124.1
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP007855	XP_317640.3
Oryza sativa (rice)	Os03g0765000	NP_001051373.1

Gene Ontology
Bibliography

Related articles in PubMed

Gene Model Annotations for Drosophila melanogaster: Impact of High-Throughput Data.
Matthews BB, Dos Santos G, Crosby MA, Emmert DB, St Pierre SE, Gramates LS, Zhou P, Schroeder AJ, Falls K, Strelets V, Russo SM, Gelbart WM,
G3 (Bethesda, Md.)5(8)1721-36(2015 Jun)

Gene Model Annotations for Drosophila melanogaster: The Rule-Benders.
Crosby MA, Gramates LS, Dos Santos G, Matthews BB, St Pierre SE, Zhou P, Schroeder AJ, Falls K, Emmert DB, Russo SM, Gelbart WM,
G3 (Bethesda, Md.)5(8)1737-49(2015 Jun)

Sequence finishing and mapping of Drosophila melanogaster heterochromatin.
Hoskins RA, Carlson JW, Kennedy C, Acevedo D, Evans-Holm M, Frise E, Wan KH, Park S, Mendez-Lago M, Rossi F, Villasante A, Dimitri P, Karpen GH, Celniker SE
Science (New York, N.Y.)316(5831)1625-8(2007 Jun)

The Release 5.1 annotation of Drosophila melanogaster heterochromatin.
Smith CD, Shu S, Mungall CJ, Karpen GH
Science (New York, N.Y.)316(5831)1586-91(2007 Jun)

Combined evidence annotation of transposable elements in genome sequences.
Quesneville H, Bergman CM, Andrieu O, Autard D, Nouaud D, Ashburner M, Anxolabehere D
PLoS computational biology1(2)166-75(2005 Jul)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Aurora A and B kinases directly phosphorylate Lgl to promote its mitotic relocalization.
Title: Aurora kinases phosphorylate Lgl to induce mitotic spindle orientation in Drosophila epithelia.

Regulation of Polo by Aurora B and Map205 is required for cytokinesis.
Title: Interdomain allosteric regulation of Polo kinase by Aurora B and Map205 is required for cytokinesis.

We propose that mutual inhibitions between Aurora B and Cyclin B regulate the duration of abscission and thereby the number of sister cells in each cyst.
Title: Aurora B and cyclin B have opposite effects on the timing of cytokinesis abscission in Drosophila germ cells and in vertebrate somatic cells.

Aurora B kinase activity is not required during contractile ring ingression, providing insight into the mechanism of cytokinesis.
Title: Binucleine 2, an isoform-specific inhibitor of Drosophila Aurora B kinase, provides insights into the mechanism of cytokinesis.

INCENP binds to the cohesion protector protein MEI-S332, which is also an excellent in vitro substrate for Aurora B kinase.
Title: INCENP and Aurora B promote meiotic sister chromatid cohesion through localization of the Shugoshin MEI-S332 in Drosophila.

The following aurB gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the aurB cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OFa14426	NM_057988.4 Latest version!	Drosophila melanogaster aurora B (aurB), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$174.30 $249.00

ORF Online Only Promotion

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

aurB ( NM_057988.4 ) cDNA ORF clone, Drosophila melanogaster(fruit fly) -> NP_477336.1 Drosophila melanogaster aurora B (aurB), mRNA.

Price & Availability↑

CloneID	OFa14426
Clone ID Related Accession (Same CDS sequence)	NM_057988.4
Accession Version	NM_057988.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 990bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-04-24
Organism	Drosophila melanogaster(fruit fly)
Product	aurora B
Comment	Comment: REVIEWED REFSEQ: This record has been curated by FlyBase. This record is derived from an annotated genomic sequence (NT_033779). On Jan 16, 2013 this sequence version replaced NM_057988.3. ##Genome-Annotation-Data-START## Annotation Provider :: FlyBase Annotation Status :: Full annotation Annotation Version :: Release 6.26 URL :: http://flybase.org ##Genome-Annotation-Data-END##

ATGACGCTTT CCCGCGCGAA GCACGCCAAC CGCAACCACC TGCCGCACCT GCTGGCCAAG 
GTGCCCGAGG AGCACCAGGA GCCGATCAAG AATATGTGCC TCAAGATGAT GTCCCACGAC 
GCATACGGAC AGCCATACGA TTGGAGTCCC CGGGACTTTG AGATGGGCGC CCACTTGGGA 
CGCGGCAAAT TTGGACGTGT CTACTTGGCG CGGGAGCGCC ACTCGCACTA TCTGGTGGCC 
ATGAAGGTGA TGTTCAAAGA GGAGCTGCGC AAGGGCTGCG TGCAGCGTCA GGTTCTACGC 
GAGATCGAGA TCCAGTCGCG ACTGAAGCAC CCGCACATCC TGCGCCTGCT CACTTGGTTC 
CACGACGAGA GCCGCATCTA TCTGGCCCTG GAAATTGCGT CCGAGGGCGA GCTGTTCAAG 
CACCTGCGTG GCGCACCCAA TCATCGATTC GATGAACCGC GGTCTGCGAA GTACACCTAC 
CAAGTGGCGA ATGCCCTCAA CTACTGTCAC CTGAACAACG TGATCCATCG GGATCTGAAG 
CCGGAGAACA TTCTGCTAAC CAGCACGGAC GACCTTAAGC TGGCCGACTT TGGTTGGTCG 
GCGCACACGC CGAACAACAA GCGCAGGACT CTGTGCGGCA CCCTGGACTA TCTGCCGCCG 
GAGATGGTGG ATGGGAACTC CTACGACGAC TCGGTGGACC AGTGGTGCCT GGGCATTCTG 
TGCTACGAGT TCGTCGTCGG CTGTCCGCCC TTCGAGTCGA ACAGCACGGA GAGCACCTAC 
AGCAAGATCC GGCGCATGGA GATCTCCTAC CCATCGCATT TGTCCAAGGG CTGCAAGGAA 
TTGATTGGCG GGCTGCTTCG CAAGGAAAGC AAGGGCCGCA TCACCTTGGT GGATGTGATG 
ACCCATTATT GGGTGAAGGC GGGAATGGCC GAAAGGGAGC TGCAGCTGCA GAAACGGGAG 
CGCGGCAAGG AGAACACGGC CAGAAATTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_477336.1
CDS	118..1107
Translation	MTLSRAKHANRNHLPHLLAKVPEEHQEPIKNMCLKMMSHDAYGQPYDWSPRDFEMGAHLGRGKFGRVYLARERHSHYLVAMKVMFKEELRKGCVQRQVLREIEIQSRLKHPHILRLLTWFHDESRIYLALEIASEGELFKHLRGAPNHRFDEPRSAKYTYQVANALNYCHLNNVIHRDLKPENILLTSTDDLKLADFGWSAHTPNNKRRTLCGTLDYLPPEMVDGNSYDDSVDQWCLGILCYEFVVGCPPFESNSTESTYSKIRRMEISYPSHLSKGCKELIGGLLRKESKGRITLVDVMTHYWVKAGMAERELQLQKRERGKENTARN

Target ORF information:

RefSeq Version	NM_057988.4
Organism	Drosophila melanogaster(fruit fly)
Definition	Drosophila melanogaster aurora B (aurB), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_057988.4

ORF Insert Sequence:

ATGACGCTTT CCCGCGCGAA GCACGCCAAC CGCAACCACC TGCCGCACCT GCTGGCCAAG 
GTGCCCGAGG AGCACCAGGA GCCGATCAAG AATATGTGCC TCAAGATGAT GTCCCACGAC 
GCATACGGAC AGCCATACGA TTGGAGTCCC CGGGACTTTG AGATGGGCGC CCACTTGGGA 
CGCGGCAAAT TTGGACGTGT CTACTTGGCG CGGGAGCGCC ACTCGCACTA TCTGGTGGCC 
ATGAAGGTGA TGTTCAAAGA GGAGCTGCGC AAGGGCTGCG TGCAGCGTCA GGTTCTACGC 
GAGATCGAGA TCCAGTCGCG ACTGAAGCAC CCGCACATCC TGCGCCTGCT CACTTGGTTC 
CACGACGAGA GCCGCATCTA TCTGGCCCTG GAAATTGCGT CCGAGGGCGA GCTGTTCAAG 
CACCTGCGTG GCGCACCCAA TCATCGATTC GATGAACCGC GGTCTGCGAA GTACACCTAC 
CAAGTGGCGA ATGCCCTCAA CTACTGTCAC CTGAACAACG TGATCCATCG GGATCTGAAG 
CCGGAGAACA TTCTGCTAAC CAGCACGGAC GACCTTAAGC TGGCCGACTT TGGTTGGTCG 
GCGCACACGC CGAACAACAA GCGCAGGACT CTGTGCGGCA CCCTGGACTA TCTGCCGCCG 
GAGATGGTGG ATGGGAACTC CTACGACGAC TCGGTGGACC AGTGGTGCCT GGGCATTCTG 
TGCTACGAGT TCGTCGTCGG CTGTCCGCCC TTCGAGTCGA ACAGCACGGA GAGCACCTAC 
AGCAAGATCC GGCGCATGGA GATCTCCTAC CCATCGCATT TGTCCAAGGG CTGCAAGGAA 
TTGATTGGCG GGCTGCTTCG CAAGGAAAGC AAGGGCCGCA TCACCTTGGT GGATGTGATG 
ACCCATTATT GGGTGAAGGC GGGAATGGCC GAAAGGGAGC TGCAGCTGCA GAAACGGGAG 
CGCGGCAAGG AGAACACGGC CAGAAATTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Gene Model Annotations for Drosophila melanogaster: Impact of High-Throughput Data.
G3 (Bethesda, Md.)5(8)1721-36(2015 Jun)
Matthews BB,Dos Santos G,Crosby MA,Emmert DB,St Pierre SE,Gramates LS,Zhou P,Schroeder AJ,Falls K,Strelets V,Russo SM,Gelbart WM,

Gene Model Annotations for Drosophila melanogaster: The Rule-Benders.
G3 (Bethesda, Md.)5(8)1737-49(2015 Jun)
Crosby MA,Gramates LS,Dos Santos G,Matthews BB,St Pierre SE,Zhou P,Schroeder AJ,Falls K,Emmert DB,Russo SM,Gelbart WM,

Sequence finishing and mapping of Drosophila melanogaster heterochromatin.
Science (New York, N.Y.)316(5831)1625-8(2007 Jun)
Hoskins RA,Carlson JW,Kennedy C,Acevedo D,Evans-Holm M,Frise E,Wan KH,Park S,Mendez-Lago M,Rossi F,Villasante A,Dimitri P,Karpen GH,Celniker SE

The Release 5.1 annotation of Drosophila melanogaster heterochromatin.
Science (New York, N.Y.)316(5831)1586-91(2007 Jun)
Smith CD,Shu S,Mungall CJ,Karpen GH

Combined evidence annotation of transposable elements in genome sequences.
PLoS computational biology1(2)166-75(2005 Jul)
Quesneville H,Bergman CM,Andrieu O,Autard D,Nouaud D,Ashburner M,Anxolabehere D

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aurB cDNA ORF clone, Drosophila melanogaster(fruit fly)

Gene

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gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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