Pen cDNA ORF clone, Drosophila melanogaster(fruit fly)

Gene
Clones
gRNAs

Summary

Gene Symbol	Pen
Entrez Gene ID	34338
Full Name	Pendulin
Synonyms	2.1,CG4799,DPend,Dalpha2,Dimp-alpha2,Dmel\CG4799,IMPalpha2,Imp-alpha2,Kap alpha2,Kap-alpha2,Kpna2,OHO31,Oho31,Rch1,alpha2,alpha2A-Kap,alphaKap2,anon-WO0140519.258,bs29g06.y1,imp alpha2,imp-alpha2,impalpha2,importin alpha2/pendulin,l(2)144/1,l(2)k06324,l(2)k14401,oho-31,oho31,pen,pen-2
General protein information	Preferred Names Pendulin Names CG4799 gene product from transcript CG4799-RA CG4799-PA Importin-a2 Importin-alpha Importin-alpha2 Pen-PA alpha-importin i importin alpha importin alpha2 lethal (2) k06324 pendulin
Gene Type	protein-coding
Organism	Drosophila melanogaster(fruit fly)
Genome	Chromosome: 2L Map Location: 31A1-31A2

mRNA and Protein(s)

mRNA	Protein	Name
NM_057693.5	NP_477041.1	pendulin

Pathways from BioSystems

Homologies

	KPNA2	XP_002800621.1
Canis lupus familiaris (dog)	KPNA2	XP_861990.1
Mus musculus (house mouse)	Kpna2	NP_034785.1
Rattus norvegicus (Norway rat)	Kpna2	NP_001257731.1
Drosophila melanogaster (fruit fly)	Pen	NP_477041.1
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP009792	XP_318886.3
Xenopus tropicalis (tropical clawed frog)	kpna2	NP_001008155.1
Pan troglodytes (chimpanzee)	KPNA2	XP_003315744.1
Rattus norvegicus (Norway rat)	LOC100359600	XP_002729642.1
Gallus gallus (chicken)	KPNA2	NP_001006209.1
Bos taurus (cattle)	KPNA2	NP_001029621.1
Danio rerio (zebrafish)	kpna2	NP_001002335.1
Homo sapiens (human)	KPNA2	NP_002257.1

Gene Ontology
Bibliography

Related articles in PubMed

Gene Model Annotations for Drosophila melanogaster: Impact of High-Throughput Data.
Matthews BB, Dos Santos G, Crosby MA, Emmert DB, St Pierre SE, Gramates LS, Zhou P, Schroeder AJ, Falls K, Strelets V, Russo SM, Gelbart WM,
G3 (Bethesda, Md.)5(8)1721-36(2015 Jun)

Gene Model Annotations for Drosophila melanogaster: The Rule-Benders.
Crosby MA, Gramates LS, Dos Santos G, Matthews BB, St Pierre SE, Zhou P, Schroeder AJ, Falls K, Emmert DB, Russo SM, Gelbart WM,
G3 (Bethesda, Md.)5(8)1737-49(2015 Jun)

Sequence finishing and mapping of Drosophila melanogaster heterochromatin.
Hoskins RA, Carlson JW, Kennedy C, Acevedo D, Evans-Holm M, Frise E, Wan KH, Park S, Mendez-Lago M, Rossi F, Villasante A, Dimitri P, Karpen GH, Celniker SE
Science (New York, N.Y.)316(5831)1625-8(2007 Jun)

The Release 5.1 annotation of Drosophila melanogaster heterochromatin.
Smith CD, Shu S, Mungall CJ, Karpen GH
Science (New York, N.Y.)316(5831)1586-91(2007 Jun)

Combined evidence annotation of transposable elements in genome sequences.
Quesneville H, Bergman CM, Andrieu O, Autard D, Nouaud D, Ashburner M, Anxolabehere D
PLoS computational biology1(2)166-75(2005 Jul)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Importin-alpha2 is needed for some processes in the development of both the nervous system and the larval musculature
Title: Drosophila Importin-?2 is involved in synapse, axon and muscle development.

Wnt-activated growth of the postsynaptic membrane is mediated by the synapse-to-nucleus translocation and active nuclear import of Fz2-C via a selective Importin-beta11/alpha2 pathway.
Title: The nuclear import of Frizzled2-C by Importins-beta11 and alpha2 promotes postsynaptic development.

Imp-alpha 2 protein plays a critical role in Kelch function by regulating its deposition on ring canals during their assembly.
Title: Importin-alpha 2 is critically required for the assembly of ring canals during Drosophila oogenesis.

each Imp-alpha protein carries during Drosophila spermatogenesis distinct, albeit overlapping, functions that may involve nuclear import of proteins, microtubule organisation, and other yet unknown processes
Title: Patterns of importin-alpha expression during Drosophila spermatogenesis.

The following Pen gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Pen cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OFa14269	NM_057693.5 Latest version!	Drosophila melanogaster pendulin (Pen), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$342.30 $489.00

ORF Online Only Promotion

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Pen ( NM_057693.5 ) cDNA ORF clone, Drosophila melanogaster(fruit fly) -> NP_477041.1 Drosophila melanogaster pendulin (Pen), mRNA.

Price & Availability↑

CloneID	OFa14269
Clone ID Related Accession (Same CDS sequence)	NM_057693.5
Accession Version	NM_057693.5 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1569bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-04-24
Organism	Drosophila melanogaster(fruit fly)
Product	pendulin
Comment	Comment: REVIEWED REFSEQ: This record has been curated by FlyBase. This record is derived from an annotated genomic sequence (NT_033779). On Jul 15, 2014 this sequence version replaced NM_057693.4. ##Genome-Annotation-Data-START## Annotation Provider :: FlyBase Annotation Status :: Full annotation Annotation Version :: Release 6.26 URL :: http://flybase.org ##Genome-Annotation-Data-END##

ATGAGTAAGG CGGATTCTAA CTCACGACAG GGCTCCTACA AGGCCAACAG CATTAACACG 
CAGGACTCAC GCATGCGCCG CCATGAGGTG ACCATCGAGC TGCGCAAGTC CAAAAAGGAG 
GACCAGATGT TCAAGCGGCG CAACATCAAC GACGAGGATC TAACGTCGCC GCTCAAAGAG 
CTCAATGGCC AGTCGCCGGT GCAGCTGTCC GTGGACGAGA TAGTGGCGGC CATGAACAGC 
GAGGATCAGG AGCGCCAGTT TCTGGGCATG CAGTCTGCCC GCAAGATGCT CAGTCGGGAG 
CGCAATCCAC CCATCGACCT GATGATCGGC CATGGTATTG TGCCCATTTG CATACGCTTC 
CTGCAGAATA CCAACAACTC AATGCTGCAG TTCGAGGCCG CTTGGGCGCT TACCAACATC 
GCCTCTGGCA CATCCGACCA AACGCGCTGC GTTATCGAAC ACAATGCTGT GCCGCATTTC 
GTGGCTCTGC TCCAGTCCAA GTCCATGAAC CTGGCCGAGC AGGCAGTCTG GGCTCTGGGC 
AACATTGCCG GCGACGGAGC CGCCGCCCGC GACATTGTCA TCCACCACAA CGTAATTGAC 
GGAATCTTGC CACTGATCAA CAATGAGACA CCGCTCTCTT TTCTGCGCAA CATCGTCTGG 
CTGATGTCCA ACCTGTGCCG GAACAAGAAT CCATCGCCGC CATTCGATCA GGTGAAGCGG 
CTGTTGCCCG TCCTGTCGCA GCTTCTGCTT AGTCAGGACA TCCAAGTGCT GGCCGACGCC 
TGCTGGGCTT TGTCCTACGT CACGGACGAC GATAACACCA AGATCCAGGC TGTGGTCGAC 
TCGGACGCAG TGCCGCGCCT GGTCAAACTG CTGCAAATGG ACGAGCCGAG CATTATTGTG 
CCCGCCCTGC GCAGCGTTGG CAACATTGTG ACTGGCACAG ATCAACAGAC TGACGTTGTA 
ATTGCATCTG GAGGTTTACC AAGGCTGGGA CTCCTTCTAC AGCACAACAA AAGCAACATT 
GTGAAGGAGG CTGCCTGGAC GGTCAGCAAC ATCACAGCAG GTAACCAGAA GCAGATCCAG 
GCTGTGATTC AGGCCGGCAT CTTCCAGCAG CTGCGCACCG TGCTGGAGAA GGGTGATTTC 
AAGGCTCAAA AAGAGGCTGC CTGGGCGGTG ACAAACACCA CGACATCTGG CACTCCCGAA 
CAGATCGTCG ATCTAATTGA GAAGTACAAA ATATTGAAGC CTTTTATCGA TTTGCTGGAC 
ACAAAGGATC CGCGTACCAT CAAGGTGGTG CAGACGGGCC TATCCAATCT GTTTGCCCTG 
GCGGAGAAAC TTGGTGGCAC CGAGAACCTA TGCTTGATGG TCGAGGAGAT GGGCGGTCTA 
GACAAGCTGG AAACTCTGCA GCAGCACGAG AACGAGGAGG TCTACAAGAA GGCCTACGCC 
ATCATTGACA CATACTTCAG CAACGGCGAC GACGAGGCCG AGCAAGAGCT CGCACCTCAG 
GAGGTCAACG GAGCCCTCGA GTTCAATGCC ACCCAGCCCA AGGCTCCCGA AGGTGGCTAC 
ACGTTCTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_477041.1
CDS	381..1949
Translation	MSKADSNSRQGSYKANSINTQDSRMRRHEVTIELRKSKKEDQMFKRRNINDEDLTSPLKELNGQSPVQLSVDEIVAAMNSEDQERQFLGMQSARKMLSRERNPPIDLMIGHGIVPICIRFLQNTNNSMLQFEAAWALTNIASGTSDQTRCVIEHNAVPHFVALLQSKSMNLAEQAVWALGNIAGDGAAARDIVIHHNVIDGILPLINNETPLSFLRNIVWLMSNLCRNKNPSPPFDQVKRLLPVLSQLLLSQDIQVLADACWALSYVTDDDNTKIQAVVDSDAVPRLVKLLQMDEPSIIVPALRSVGNIVTGTDQQTDVVIASGGLPRLGLLLQHNKSNIVKEAAWTVSNITAGNQKQIQAVIQAGIFQQLRTVLEKGDFKAQKEAAWAVTNTTTSGTPEQIVDLIEKYKILKPFIDLLDTKDPRTIKVVQTGLSNLFALAEKLGGTENLCLMVEEMGGLDKLETLQQHENEEVYKKAYAIIDTYFSNGDDEAEQELAPQEVNGALEFNATQPKAPEGGYTF

Target ORF information:

RefSeq Version	NM_057693.5
Organism	Drosophila melanogaster(fruit fly)
Definition	Drosophila melanogaster pendulin (Pen), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_057693.5

ORF Insert Sequence:

ATGAGTAAGG CGGATTCTAA CTCACGACAG GGCTCCTACA AGGCCAACAG CATTAACACG 
CAGGACTCAC GCATGCGCCG CCATGAGGTG ACCATCGAGC TGCGCAAGTC CAAAAAGGAG 
GACCAGATGT TCAAGCGGCG CAACATCAAC GACGAGGATC TAACGTCGCC GCTCAAAGAG 
CTCAATGGCC AGTCGCCGGT GCAGCTGTCC GTGGACGAGA TAGTGGCGGC CATGAACAGC 
GAGGATCAGG AGCGCCAGTT TCTGGGCATG CAGTCTGCCC GCAAGATGCT CAGTCGGGAG 
CGCAATCCAC CCATCGACCT GATGATCGGC CATGGTATTG TGCCCATTTG CATACGCTTC 
CTGCAGAATA CCAACAACTC AATGCTGCAG TTCGAGGCCG CTTGGGCGCT TACCAACATC 
GCCTCTGGCA CATCCGACCA AACGCGCTGC GTTATCGAAC ACAATGCTGT GCCGCATTTC 
GTGGCTCTGC TCCAGTCCAA GTCCATGAAC CTGGCCGAGC AGGCAGTCTG GGCTCTGGGC 
AACATTGCCG GCGACGGAGC CGCCGCCCGC GACATTGTCA TCCACCACAA CGTAATTGAC 
GGAATCTTGC CACTGATCAA CAATGAGACA CCGCTCTCTT TTCTGCGCAA CATCGTCTGG 
CTGATGTCCA ACCTGTGCCG GAACAAGAAT CCATCGCCGC CATTCGATCA GGTGAAGCGG 
CTGTTGCCCG TCCTGTCGCA GCTTCTGCTT AGTCAGGACA TCCAAGTGCT GGCCGACGCC 
TGCTGGGCTT TGTCCTACGT CACGGACGAC GATAACACCA AGATCCAGGC TGTGGTCGAC 
TCGGACGCAG TGCCGCGCCT GGTCAAACTG CTGCAAATGG ACGAGCCGAG CATTATTGTG 
CCCGCCCTGC GCAGCGTTGG CAACATTGTG ACTGGCACAG ATCAACAGAC TGACGTTGTA 
ATTGCATCTG GAGGTTTACC AAGGCTGGGA CTCCTTCTAC AGCACAACAA AAGCAACATT 
GTGAAGGAGG CTGCCTGGAC GGTCAGCAAC ATCACAGCAG GTAACCAGAA GCAGATCCAG 
GCTGTGATTC AGGCCGGCAT CTTCCAGCAG CTGCGCACCG TGCTGGAGAA GGGTGATTTC 
AAGGCTCAAA AAGAGGCTGC CTGGGCGGTG ACAAACACCA CGACATCTGG CACTCCCGAA 
CAGATCGTCG ATCTAATTGA GAAGTACAAA ATATTGAAGC CTTTTATCGA TTTGCTGGAC 
ACAAAGGATC CGCGTACCAT CAAGGTGGTG CAGACGGGCC TATCCAATCT GTTTGCCCTG 
GCGGAGAAAC TTGGTGGCAC CGAGAACCTA TGCTTGATGG TCGAGGAGAT GGGCGGTCTA 
GACAAGCTGG AAACTCTGCA GCAGCACGAG AACGAGGAGG TCTACAAGAA GGCCTACGCC 
ATCATTGACA CATACTTCAG CAACGGCGAC GACGAGGCCG AGCAAGAGCT CGCACCTCAG 
GAGGTCAACG GAGCCCTCGA GTTCAATGCC ACCCAGCCCA AGGCTCCCGA AGGTGGCTAC 
ACGTTCTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Gene Model Annotations for Drosophila melanogaster: Impact of High-Throughput Data.
G3 (Bethesda, Md.)5(8)1721-36(2015 Jun)
Matthews BB,Dos Santos G,Crosby MA,Emmert DB,St Pierre SE,Gramates LS,Zhou P,Schroeder AJ,Falls K,Strelets V,Russo SM,Gelbart WM,

Gene Model Annotations for Drosophila melanogaster: The Rule-Benders.
G3 (Bethesda, Md.)5(8)1737-49(2015 Jun)
Crosby MA,Gramates LS,Dos Santos G,Matthews BB,St Pierre SE,Zhou P,Schroeder AJ,Falls K,Emmert DB,Russo SM,Gelbart WM,

Sequence finishing and mapping of Drosophila melanogaster heterochromatin.
Science (New York, N.Y.)316(5831)1625-8(2007 Jun)
Hoskins RA,Carlson JW,Kennedy C,Acevedo D,Evans-Holm M,Frise E,Wan KH,Park S,Mendez-Lago M,Rossi F,Villasante A,Dimitri P,Karpen GH,Celniker SE

The Release 5.1 annotation of Drosophila melanogaster heterochromatin.
Science (New York, N.Y.)316(5831)1586-91(2007 Jun)
Smith CD,Shu S,Mungall CJ,Karpen GH

Combined evidence annotation of transposable elements in genome sequences.
PLoS computational biology1(2)166-75(2005 Jul)
Quesneville H,Bergman CM,Andrieu O,Autard D,Nouaud D,Ashburner M,Anxolabehere D

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Pen cDNA ORF clone, Drosophila melanogaster(fruit fly)

Gene

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Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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