GluRIIA cDNA ORF clone, Drosophila melanogaster(fruit fly)

Gene
Clones
gRNAs

Summary

Gene Symbol	GluRIIA
Entrez Gene ID	33788
Full Name	Glutamate receptor IIA
Synonyms	CG6992,D-GluRIIA,DGluR-II,DGluR-IIA,DGluR2a,DGluRIIA,DGluRIIa,DgluRII,DmelGluRIIA,Dmel\CG6992,Glu-RII,Glu-RIIA,GluR,GluR-IIA,GluR2,GluR2a,GluRII,GluRII-A,GluRIIa,GluR[[IIa]],GlurIIA,dGluRII,dGluRIIA,dglur-IIA,dglurIIA,gluIIA,gluRIIA,glurIIA,gluriia
General protein information	Preferred Names Glutamate receptor IIA Names CG6992 gene product from transcript CG6992-RI CG6992-PI GluRIIA-PI glutamate IIA receptor glutamate receptor glutamate receptor IIA glutamate receptor subunit IIA
Gene Type	protein-coding
Organism	Drosophila melanogaster(fruit fly)
Genome	Chromosome: 2L Map Location: 25E6-25E6

mRNA and Protein(s)

mRNA	Protein	Name
NM_078760.3	NP_523484.2	glutamate receptor IIA

Pathways from BioSystems

Homologies

Drosophila melanogaster (fruit fly)	GluRIIC	NP_608557.4
Drosophila melanogaster (fruit fly)	GluRIIA	NP_523484.2
Drosophila melanogaster (fruit fly)	GluRIIB	NP_523485.3

Gene Ontology
Bibliography

Related articles in PubMed

Gene Model Annotations for Drosophila melanogaster: Impact of High-Throughput Data.
Matthews BB, Dos Santos G, Crosby MA, Emmert DB, St Pierre SE, Gramates LS, Zhou P, Schroeder AJ, Falls K, Strelets V, Russo SM, Gelbart WM,
G3 (Bethesda, Md.)5(8)1721-36(2015 Jun)

Gene Model Annotations for Drosophila melanogaster: The Rule-Benders.
Crosby MA, Gramates LS, Dos Santos G, Matthews BB, St Pierre SE, Zhou P, Schroeder AJ, Falls K, Emmert DB, Russo SM, Gelbart WM,
G3 (Bethesda, Md.)5(8)1737-49(2015 Jun)

Sequence finishing and mapping of Drosophila melanogaster heterochromatin.
Hoskins RA, Carlson JW, Kennedy C, Acevedo D, Evans-Holm M, Frise E, Wan KH, Park S, Mendez-Lago M, Rossi F, Villasante A, Dimitri P, Karpen GH, Celniker SE
Science (New York, N.Y.)316(5831)1625-8(2007 Jun)

The Release 5.1 annotation of Drosophila melanogaster heterochromatin.
Smith CD, Shu S, Mungall CJ, Karpen GH
Science (New York, N.Y.)316(5831)1586-91(2007 Jun)

Combined evidence annotation of transposable elements in genome sequences.
Quesneville H, Bergman CM, Andrieu O, Autard D, Nouaud D, Ashburner M, Anxolabehere D
PLoS computational biology1(2)166-75(2005 Jul)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

dPAK associated with Henji through the Kelch repeats which is the domain essential for Henji localization and function at postsynapses. We propose that Henji acts at postsynapses to restrict both presynaptic bouton growth and postsynaptic GluRIIA abundance by modulating dPAK.
Title: Dbo/Henji Modulates Synaptic dPAK to Gate Glutamate Receptor Abundance and Postsynaptic Response.

We propose that DMon1 is part of a presynaptically regulated transsynaptic mechanism that regulates GluRIIA levels at the larval neuromuscular junction.
Title: A Presynaptic Regulatory System Acts Transsynaptically via Mon1 to Regulate Glutamate Receptor Levels in Drosophila.

only Neto-beta restored PAK synaptic accumulation at neto null NMJs. Thus, Neto engages in intracellular interactions that regulate the iGluR subtype composition by preferentially recruiting and/or stabilizing selective receptor subtypes.
Title: Neto-mediated intracellular interactions shape postsynaptic composition at the Drosophila neuromuscular junction.

Activin signaling regulates postsynaptic membrane potential and GluRIIA/B abundance at the Drosophila neuromuscular junction
Title: Anterograde Activin signaling regulates postsynaptic membrane potential and GluRIIA/B abundance at the Drosophila neuromuscular junction.

GluR-IIA was rapidly removed from synapses whose activity failed to evoke substantial postsynaptic depolarization.
Title: Hebbian plasticity guides maturation of glutamate receptor fields in?vivo.

The following GluRIIA gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the GluRIIA cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OFa16289	NM_078760.3 Latest version!	Drosophila melanogaster glutamate receptor IIA (GluRIIA), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	12-14	$510.30 $729.00

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

GluRIIA ( NM_078760.3 ) cDNA ORF clone, Drosophila melanogaster(fruit fly) -> NP_523484.2 Drosophila melanogaster glutamate receptor IIA (GluRIIA), mRNA.

Price & Availability↑

CloneID	OFa16289
Clone ID Related Accession (Same CDS sequence)	NM_078760.3
Accession Version	NM_078760.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2724bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-04-24
Organism	Drosophila melanogaster(fruit fly)
Product	glutamate receptor IIA
Comment	Comment: REVIEWED REFSEQ: This record has been curated by FlyBase. This record is derived from an annotated genomic sequence (NT_033779). On Jul 15, 2014 this sequence version replaced NM_078760.2. ##Genome-Annotation-Data-START## Annotation Provider :: FlyBase Annotation Status :: Full annotation Annotation Version :: Release 6.26 URL :: http://flybase.org ##Genome-Annotation-Data-END##

ATGCGCCTTT GTCCAGTTGT CATCTATGCA TTTATAATCA TCATCGGGTT TCTGGAGGGG 
ATTATAGCCC TTGGTGGCGA CGATCGCAAT GAAATCACAG TGGGTGCCAT TTTCTACGAG 
AACGAGAAGG AGATCGAGCT CAGCTTCGAT CAGGCCTTTC GCGAGGTCAA CAATATGAAG 
TTCTCGGAGC TGCGATTCGT GACCATCAAA CGCTATATGC CCACCAACGA CAGTTTCCTT 
TTGCAGCAGA TTACATGTGA ACTGATTTCC AATGGCGTTG CGGCTATTTT CGGACCAAGT 
TCAAAGGCAG CCAGTGATAT TGTTGCGCAA ATCGCGAACG CGACCGGCAT TCCACACATT 
GAGTACGATT TGAAGCTGGA GGCCACGCGT CAGGAGCAGC TCAACCACCA GATGTCCATC 
AATGTGGCAC CCTCCTTGTC AGTACTCTCG CGTGCCTACT TCGAGATCAT CAAATCCAAC 
TATGAGTGGC GCACCTTCAC TCTGATCTAT GAGACTCCGG AGGGCCTGGC GCGCCTGCAG 
GATCTGATGA ACATCCAAGC GCTGAACAGT GACTATGTCA AGCTGCGAAA TTTGGCAGAC 
TATGCGGATG ACTATCGGAT ATTGTGGAAG GAGACAGACG AGACTTTCCA CGAGCAGCGC 
ATCATTTTGG ACTGTGAGCC GAAGACCCTT AAGGAGCTGC TTAAAGTATC CATAGACTTT 
AAGTTGCAGG GCCCGTTTAG GAACTGGTTT CTCACCCATC TGGATACGCA TAACTCGGGT 
CTGAGGGATA TTTATAATGA GGACTTCAAG GCCAACATTA CGTCGGTGCG ATTGAAAGTG 
GTCGACGCGA ATCCATTCGA GAGAAAGAAG ACCCGGCTCA CCAAAGTGGA TCAAATATTG 
GGGAACCAAA CCATGTTGCC CATTCTCATC TACGACGCTG TCGTCCTGTT TGCCAGTTCT 
GCCCGAAATG TTATTGCTGC CATGCAGCCC TTTCATCCAC CCAATCGCCA TTGCGGCAGT 
TCGTCTCCTT GGATGCTGGG AGCATTTATA GTCAACGAGA TGAAGACCAT TTCCGAGGAT 
GATGTGGAAC CGCACTTTAA GACCGAAAAT ATGAAGCTTG ACGAGTATGG GCAGCGCATC 
CACTTCAACC TGGAGATCTA CAAGCCAACG GTGAACGAAC CAATGATGGT CTGGACACCA 
GACAATGGGA TAAAGAAGCG TCTCCTCAAC TTGGAACTGG AAAGTGCCGG CACCACCCAG 
GATTTCTCGG AGCAGCGTAA AGTGTATACA GTGGTTACCC ACTACGAGGA GCCCTACTTC 
ATGATGAAGG AGGATCACGA GAACTTCAGA GGCAGGGAAA AGTACGAGGG CTATGCCGTG 
GATCTCATTA GCAAGCTTTC CGAGCTCATG GAGTTCGATT ACGAGTTCAT GATCGTTAAT 
GGCAATGGCA AATACAATCC GGAGACGAAG CAATGGGATG GCATTATACG GAAACTGATA 
GACCACCATG CCCAAATCGG CGTCTGCGAT CTGACCATCA CCCAAATGCG ACGTTCTGTG 
GTGGACTTCA CGGTGCCCTT CATGCAGTTG GGCATTAGCA TTCTGCACTA CAAGAGTCCT 
CCGGAGCCGA AGAATCAGTT TGCCTTCTTG GAACCGTTTG CCGTCGAAGT CTGGATCTAT 
ATGATCTTTG CCCAGTTGAT AATGACTTTG GCTTTTGTTT TCATAGCCAG ACTTTCGTAT 
CGCGAATGGT TGCCACCTAA TCCCGCCATT CAGGATCCAG ATGAGCTGGA AAATATCTGG 
AATGTGAACA ACTCGACTTG GCTGATGGTG GGCTCCATCA TGCAACAGGG CTGCGACATT 
CTGCCTAGAG GTCCACACAT GCGCATACTC ACTGGCATGT GGTGGTTCTT CGCCCTGATG 
ATGCTCAGTA CCTACACGGC CAACTTGGCC GCCTTCCTGA CCAGCAACAA GTGGCAGAGC 
AGCATAAAGA GCCTCCAGGA CCTCATCGAA CAGGATAAGG TGCACTTCGG CAGCATGCGC 
GGTGGCAGCA CCTCGTTGTT CTTTTCGGAG TCGAATGACA CGGATTACCA GCGTGCGTGG 
AACCAGATGA AGGACTTCAA TCCCTCGGCC TTCACCAGCA CCAACAAAGA GGGAGTGGCA 
CGTGTGCGCA AGGAGAAGGG CGGCTATGCC TTTCTGATGG AGACCACCAG TTTGACCTAC 
AATATCGAAC GGAACTGCGA TCTCACCCAG ATTGGCGAGC AGATCGGGGA GAAGCACTAC 
GGCCTGGCCG TGCCACTGGG CTCTGATTAC CGGACCAACC TCAGCGTGTC CATTCTCCAG 
CTGAGCGAAA GGGGCGAGCT GCAGAAGATG AAGAACAAGT GGTGGAAGAA CCACAATGTC 
ACCTGTGACT CCTACCACGA GGTGGATGGT GACGAGCTGT CCATTATTGA GCTGGGCGGC 
GTGTTTCTTG TTCTGGCCGG TGGCGTTCTC ATCGGCGTTA TCCTGGGCAT CTTTGAGTTC 
CTGTGGAACG TGCAGAACGT GGCGGTGGAG GAGCGAGTGA CTCCGTGGCA GGCTTTCAAG 
GCGGAGCTCA TCTTTGCCCT GAAGTTTTGG GTGCGCAAAA AGCCGATGCG CATCTCCAGC 
AGCAGCGACA AGTCGTCGTC CAGGCGATCA TCCGGTTCCA GACGCAGCTC CAAGGAAAAG 
TCCCGCAGCA AGACGGTTAG CTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_523484.2
CDS	233..2956
Translation	MRLCPVVIYAFIIIIGFLEGIIALGGDDRNEITVGAIFYENEKEIELSFDQAFREVNNMKFSELRFVTIKRYMPTNDSFLLQQITCELISNGVAAIFGPSSKAASDIVAQIANATGIPHIEYDLKLEATRQEQLNHQMSINVAPSLSVLSRAYFEIIKSNYEWRTFTLIYETPEGLARLQDLMNIQALNSDYVKLRNLADYADDYRILWKETDETFHEQRIILDCEPKTLKELLKVSIDFKLQGPFRNWFLTHLDTHNSGLRDIYNEDFKANITSVRLKVVDANPFERKKTRLTKVDQILGNQTMLPILIYDAVVLFASSARNVIAAMQPFHPPNRHCGSSSPWMLGAFIVNEMKTISEDDVEPHFKTENMKLDEYGQRIHFNLEIYKPTVNEPMMVWTPDNGIKKRLLNLELESAGTTQDFSEQRKVYTVVTHYEEPYFMMKEDHENFRGREKYEGYAVDLISKLSELMEFDYEFMIVNGNGKYNPETKQWDGIIRKLIDHHAQIGVCDLTITQMRRSVVDFTVPFMQLGISILHYKSPPEPKNQFAFLEPFAVEVWIYMIFAQLIMTLAFVFIARLSYREWLPPNPAIQDPDELENIWNVNNSTWLMVGSIMQQGCDILPRGPHMRILTGMWWFFALMMLSTYTANLAAFLTSNKWQSSIKSLQDLIEQDKVHFGSMRGGSTSLFFSESNDTDYQRAWNQMKDFNPSAFTSTNKEGVARVRKEKGGYAFLMETTSLTYNIERNCDLTQIGEQIGEKHYGLAVPLGSDYRTNLSVSILQLSERGELQKMKNKWWKNHNVTCDSYHEVDGDELSIIELGGVFLVLAGGVLIGVILGIFEFLWNVQNVAVEERVTPWQAFKAELIFALKFWVRKKPMRISSSSDKSSSRRSSGSRRSSKEKSRSKTVS

Target ORF information:

RefSeq Version	NM_078760.3
Organism	Drosophila melanogaster(fruit fly)
Definition	Drosophila melanogaster glutamate receptor IIA (GluRIIA), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_078760.3

ORF Insert Sequence:

ATGCGCCTTT GTCCAGTTGT CATCTATGCA TTTATAATCA TCATCGGGTT TCTGGAGGGG 
ATTATAGCCC TTGGTGGCGA CGATCGCAAT GAAATCACAG TGGGTGCCAT TTTCTACGAG 
AACGAGAAGG AGATCGAGCT CAGCTTCGAT CAGGCCTTTC GCGAGGTCAA CAATATGAAG 
TTCTCGGAGC TGCGATTCGT GACCATCAAA CGCTATATGC CCACCAACGA CAGTTTCCTT 
TTGCAGCAGA TTACATGTGA ACTGATTTCC AATGGCGTTG CGGCTATTTT CGGACCAAGT 
TCAAAGGCAG CCAGTGATAT TGTTGCGCAA ATCGCGAACG CGACCGGCAT TCCACACATT 
GAGTACGATT TGAAGCTGGA GGCCACGCGT CAGGAGCAGC TCAACCACCA GATGTCCATC 
AATGTGGCAC CCTCCTTGTC AGTACTCTCG CGTGCCTACT TCGAGATCAT CAAATCCAAC 
TATGAGTGGC GCACCTTCAC TCTGATCTAT GAGACTCCGG AGGGCCTGGC GCGCCTGCAG 
GATCTGATGA ACATCCAAGC GCTGAACAGT GACTATGTCA AGCTGCGAAA TTTGGCAGAC 
TATGCGGATG ACTATCGGAT ATTGTGGAAG GAGACAGACG AGACTTTCCA CGAGCAGCGC 
ATCATTTTGG ACTGTGAGCC GAAGACCCTT AAGGAGCTGC TTAAAGTATC CATAGACTTT 
AAGTTGCAGG GCCCGTTTAG GAACTGGTTT CTCACCCATC TGGATACGCA TAACTCGGGT 
CTGAGGGATA TTTATAATGA GGACTTCAAG GCCAACATTA CGTCGGTGCG ATTGAAAGTG 
GTCGACGCGA ATCCATTCGA GAGAAAGAAG ACCCGGCTCA CCAAAGTGGA TCAAATATTG 
GGGAACCAAA CCATGTTGCC CATTCTCATC TACGACGCTG TCGTCCTGTT TGCCAGTTCT 
GCCCGAAATG TTATTGCTGC CATGCAGCCC TTTCATCCAC CCAATCGCCA TTGCGGCAGT 
TCGTCTCCTT GGATGCTGGG AGCATTTATA GTCAACGAGA TGAAGACCAT TTCCGAGGAT 
GATGTGGAAC CGCACTTTAA GACCGAAAAT ATGAAGCTTG ACGAGTATGG GCAGCGCATC 
CACTTCAACC TGGAGATCTA CAAGCCAACG GTGAACGAAC CAATGATGGT CTGGACACCA 
GACAATGGGA TAAAGAAGCG TCTCCTCAAC TTGGAACTGG AAAGTGCCGG CACCACCCAG 
GATTTCTCGG AGCAGCGTAA AGTGTATACA GTGGTTACCC ACTACGAGGA GCCCTACTTC 
ATGATGAAGG AGGATCACGA GAACTTCAGA GGCAGGGAAA AGTACGAGGG CTATGCCGTG 
GATCTCATTA GCAAGCTTTC CGAGCTCATG GAGTTCGATT ACGAGTTCAT GATCGTTAAT 
GGCAATGGCA AATACAATCC GGAGACGAAG CAATGGGATG GCATTATACG GAAACTGATA 
GACCACCATG CCCAAATCGG CGTCTGCGAT CTGACCATCA CCCAAATGCG ACGTTCTGTG 
GTGGACTTCA CGGTGCCCTT CATGCAGTTG GGCATTAGCA TTCTGCACTA CAAGAGTCCT 
CCGGAGCCGA AGAATCAGTT TGCCTTCTTG GAACCGTTTG CCGTCGAAGT CTGGATCTAT 
ATGATCTTTG CCCAGTTGAT AATGACTTTG GCTTTTGTTT TCATAGCCAG ACTTTCGTAT 
CGCGAATGGT TGCCACCTAA TCCCGCCATT CAGGATCCAG ATGAGCTGGA AAATATCTGG 
AATGTGAACA ACTCGACTTG GCTGATGGTG GGCTCCATCA TGCAACAGGG CTGCGACATT 
CTGCCTAGAG GTCCACACAT GCGCATACTC ACTGGCATGT GGTGGTTCTT CGCCCTGATG 
ATGCTCAGTA CCTACACGGC CAACTTGGCC GCCTTCCTGA CCAGCAACAA GTGGCAGAGC 
AGCATAAAGA GCCTCCAGGA CCTCATCGAA CAGGATAAGG TGCACTTCGG CAGCATGCGC 
GGTGGCAGCA CCTCGTTGTT CTTTTCGGAG TCGAATGACA CGGATTACCA GCGTGCGTGG 
AACCAGATGA AGGACTTCAA TCCCTCGGCC TTCACCAGCA CCAACAAAGA GGGAGTGGCA 
CGTGTGCGCA AGGAGAAGGG CGGCTATGCC TTTCTGATGG AGACCACCAG TTTGACCTAC 
AATATCGAAC GGAACTGCGA TCTCACCCAG ATTGGCGAGC AGATCGGGGA GAAGCACTAC 
GGCCTGGCCG TGCCACTGGG CTCTGATTAC CGGACCAACC TCAGCGTGTC CATTCTCCAG 
CTGAGCGAAA GGGGCGAGCT GCAGAAGATG AAGAACAAGT GGTGGAAGAA CCACAATGTC 
ACCTGTGACT CCTACCACGA GGTGGATGGT GACGAGCTGT CCATTATTGA GCTGGGCGGC 
GTGTTTCTTG TTCTGGCCGG TGGCGTTCTC ATCGGCGTTA TCCTGGGCAT CTTTGAGTTC 
CTGTGGAACG TGCAGAACGT GGCGGTGGAG GAGCGAGTGA CTCCGTGGCA GGCTTTCAAG 
GCGGAGCTCA TCTTTGCCCT GAAGTTTTGG GTGCGCAAAA AGCCGATGCG CATCTCCAGC 
AGCAGCGACA AGTCGTCGTC CAGGCGATCA TCCGGTTCCA GACGCAGCTC CAAGGAAAAG 
TCCCGCAGCA AGACGGTTAG CTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Gene Model Annotations for Drosophila melanogaster: Impact of High-Throughput Data.
G3 (Bethesda, Md.)5(8)1721-36(2015 Jun)
Matthews BB,Dos Santos G,Crosby MA,Emmert DB,St Pierre SE,Gramates LS,Zhou P,Schroeder AJ,Falls K,Strelets V,Russo SM,Gelbart WM,

Gene Model Annotations for Drosophila melanogaster: The Rule-Benders.
G3 (Bethesda, Md.)5(8)1737-49(2015 Jun)
Crosby MA,Gramates LS,Dos Santos G,Matthews BB,St Pierre SE,Zhou P,Schroeder AJ,Falls K,Emmert DB,Russo SM,Gelbart WM,

Sequence finishing and mapping of Drosophila melanogaster heterochromatin.
Science (New York, N.Y.)316(5831)1625-8(2007 Jun)
Hoskins RA,Carlson JW,Kennedy C,Acevedo D,Evans-Holm M,Frise E,Wan KH,Park S,Mendez-Lago M,Rossi F,Villasante A,Dimitri P,Karpen GH,Celniker SE

The Release 5.1 annotation of Drosophila melanogaster heterochromatin.
Science (New York, N.Y.)316(5831)1586-91(2007 Jun)
Smith CD,Shu S,Mungall CJ,Karpen GH

Combined evidence annotation of transposable elements in genome sequences.
PLoS computational biology1(2)166-75(2005 Jul)
Quesneville H,Bergman CM,Andrieu O,Autard D,Nouaud D,Ashburner M,Anxolabehere D

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GluRIIA cDNA ORF clone, Drosophila melanogaster(fruit fly)

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gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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