Thor cDNA ORF clone, Drosophila melanogaster(fruit fly)

Gene
Clones
gRNAs

Summary

Gene Symbol	Thor
Entrez Gene ID	33569
Full Name	CG8846 gene product from transcript CG8846-RA
Synonyms	153432_at,43-BP,4E-BP,4E-BP1,4EBP,4e-BP,4e-bp,4eBP,4ebp,BcDNA.HL08053,BcDNA:HL08053,CG8846,CT8705,Dm 4E-BP,Dmel\CG8846,Phas1,Thor/EIF4EBP,anon-WO0172774.158,d4E-BP,d4E-BP1,d4EBP,d4e-bp,d4eBP,dthor,eIF4E-BP,l(2)06270,l(2)k07736,l(2)k13517,pp20,thor
Gene Type	protein-coding
Organism	Drosophila melanogaster(fruit fly)
Genome	Chromosome: 2L Map Location: 23F3-23F6

mRNA and Protein(s)

mRNA	Protein	Name
NM_057947.4	NP_477295.1	thor, isoform A
NM_001298659.1	NP_001285588.1	thor, isoform B

Pathways from BioSystems

Homologies

Drosophila melanogaster (fruit fly)	Thor	NP_477295.1
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP007781	XP_317732.2

Gene Ontology
Bibliography

Related articles in PubMed

Gene Model Annotations for Drosophila melanogaster: Impact of High-Throughput Data.
Matthews BB, Dos Santos G, Crosby MA, Emmert DB, St Pierre SE, Gramates LS, Zhou P, Schroeder AJ, Falls K, Strelets V, Russo SM, Gelbart WM,
G3 (Bethesda, Md.)5(8)1721-36(2015 Jun)

Gene Model Annotations for Drosophila melanogaster: The Rule-Benders.
Crosby MA, Gramates LS, Dos Santos G, Matthews BB, St Pierre SE, Zhou P, Schroeder AJ, Falls K, Emmert DB, Russo SM, Gelbart WM,
G3 (Bethesda, Md.)5(8)1737-49(2015 Jun)

Sequence finishing and mapping of Drosophila melanogaster heterochromatin.
Hoskins RA, Carlson JW, Kennedy C, Acevedo D, Evans-Holm M, Frise E, Wan KH, Park S, Mendez-Lago M, Rossi F, Villasante A, Dimitri P, Karpen GH, Celniker SE
Science (New York, N.Y.)316(5831)1625-8(2007 Jun)

The Release 5.1 annotation of Drosophila melanogaster heterochromatin.
Smith CD, Shu S, Mungall CJ, Karpen GH
Science (New York, N.Y.)316(5831)1586-91(2007 Jun)

Combined evidence annotation of transposable elements in genome sequences.
Quesneville H, Bergman CM, Andrieu O, Autard D, Nouaud D, Ashburner M, Anxolabehere D
PLoS computational biology1(2)166-75(2005 Jul)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

GCN2 and ATF4 are important regulators of 4E-BP transcription during normal drosophila development and aging.
Title: 4E-BP is a target of the GCN2-ATF4 pathway during Drosophila development and aging.

Here, the authors show that cell autonomous insulin signaling within the Drosophila CM9 motor neuron regulates the release of neurotransmitter via alteration of the synaptic vesicle fusion machinery. This effect of insulin utilizes the FOXO-dependent regulation of the thor gene, which encodes the Drosophila homologue of the eif-4e binding protein (4eBP).
Title: Insulin signaling controls neurotransmission via the 4eBP-dependent modification of the exocytotic machinery.

longevity assurance mutants of chico, the Drosophila insulin receptor substrate homolog, require Drosophila d4eBP to slow aging.
Title: Drosophila Longevity Assurance Conferred by Reduced Insulin Receptor Substrate Chico Partially Requires d4eBP.

These results indicate that the Ccr4-Not complex controls expression of 4E-BP at multiple levels and adjusts the magnitude of the total effect.
Title: Multi-functional regulation of 4E-BP gene expression by the Ccr4-Not complex.

eIF4E-binding protein requires non-canonical 4E-binding motifs and a lateral surface of eIF4E to repress translation.
Title: 4E-BPs require non-canonical 4E-binding motifs and a lateral surface of eIF4E to repress translation.

The following Thor gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Thor cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OFa13648	NM_057947.4 Latest version!	Drosophila melanogaster thor, transcript variant A (Thor), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$104.30 $149.00
OFa13648	NM_001298659.1 Latest version!	Drosophila melanogaster thor, transcript variant B (Thor), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$104.30 $149.00

ORF Online Only Promotion

Next-day Shipping ORF Clones ( in default vector with tag)
1 Clone	30% OFF
2-4 Clone	40% OFF
5 or more Clone	50% OFF
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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Thor ( NM_057947.4 ) cDNA ORF clone, Drosophila melanogaster(fruit fly) -> NP_477295.1 Drosophila melanogaster thor, transcript variant A (Thor), mRNA.

Price & Availability↑

CloneID	OFa13648
Clone ID Related Accession (Same CDS sequence)	NM_057947.4 , NM_001298659.1
Accession Version	NM_057947.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 354bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-04-24
Organism	Drosophila melanogaster(fruit fly)
Product	thor, isoform A
Comment	Comment: REVIEWED REFSEQ: This record has been curated by FlyBase. This record is derived from an annotated genomic sequence (NT_033779). On Dec 17, 2009 this sequence version replaced NM_057947.3. ##Genome-Annotation-Data-START## Annotation Provider :: FlyBase Annotation Status :: Full annotation Annotation Version :: Release 6.26 URL :: http://flybase.org ##Genome-Annotation-Data-END##

ATGTCCGCTT CACCCACCGC CCGTCAAGCC ATCACCCAGG CCCTGCCCAT GATCACCAGG 
AAGGTTGTCA TCTCGGATCC GATCCAGATG CCCGAGGTGT ACTCCTCGAC GCCCGGCGGA 
ACCCTCTACT CCACCACTCC TGGAGGCACC AAACTTATCT ACGAGCGGGC TTTCATGAAG 
AATCTCCGTG GCTCCCCATT GAGCCAAACT CCGCCGTCCA ACGTGCCCAG TTGCTTGCTG 
AGGGGAACTC CGCGTACTCC CTTCCGCAAG TGCGTGCCCG TCCCCACGGA ACTGATCAAG 
CAGACCAAGT CGCTGAAGAT TGAGGACCAG GAACAGTTCC AACTGGATCT GTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_477295.1
CDS	183..536
Translation	MSASPTARQAITQALPMITRKVVISDPIQMPEVYSSTPGGTLYSTTPGGTKLIYERAFMKNLRGSPLSQTPPSNVPSCLLRGTPRTPFRKCVPVPTELIKQTKSLKIEDQEQFQLDL

Target ORF information:

RefSeq Version	NM_057947.4
Organism	Drosophila melanogaster(fruit fly)
Definition	Drosophila melanogaster thor, transcript variant A (Thor), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_057947.4

ORF Insert Sequence:

ATGTCCGCTT CACCCACCGC CCGTCAAGCC ATCACCCAGG CCCTGCCCAT GATCACCAGG 
AAGGTTGTCA TCTCGGATCC GATCCAGATG CCCGAGGTGT ACTCCTCGAC GCCCGGCGGA 
ACCCTCTACT CCACCACTCC TGGAGGCACC AAACTTATCT ACGAGCGGGC TTTCATGAAG 
AATCTCCGTG GCTCCCCATT GAGCCAAACT CCGCCGTCCA ACGTGCCCAG TTGCTTGCTG 
AGGGGAACTC CGCGTACTCC CTTCCGCAAG TGCGTGCCCG TCCCCACGGA ACTGATCAAG 
CAGACCAAGT CGCTGAAGAT TGAGGACCAG GAACAGTTCC AACTGGATCT GTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Thor ( NM_001298659.1 ) cDNA ORF clone, Drosophila melanogaster(fruit fly) -> NP_001285588.1 Drosophila melanogaster thor, transcript variant B (Thor), mRNA.

Price & Availability↑

CloneID	OFa13648
Clone ID Related Accession (Same CDS sequence)	NM_057947.4 , NM_001298659.1
Accession Version	NM_001298659.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 354bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-04-24
Organism	Drosophila melanogaster(fruit fly)
Product	thor, isoform B
Comment	Comment: REVIEWED REFSEQ: This record has been curated by FlyBase. This record is derived from an annotated genomic sequence (NT_033779). ##Genome-Annotation-Data-START## Annotation Provider :: FlyBase Annotation Status :: Full annotation Annotation Version :: Release 6.26 URL :: http://flybase.org ##Genome-Annotation-Data-END##

ATGTCCGCTT CACCCACCGC CCGTCAAGCC ATCACCCAGG CCCTGCCCAT GATCACCAGG 
AAGGTTGTCA TCTCGGATCC GATCCAGATG CCCGAGGTGT ACTCCTCGAC GCCCGGCGGA 
ACCCTCTACT CCACCACTCC TGGAGGCACC AAACTTATCT ACGAGCGGGC TTTCATGAAG 
AATCTCCGTG GCTCCCCATT GAGCCAAACT CCGCCGTCCA ACGTGCCCAG TTGCTTGCTG 
AGGGGAACTC CGCGTACTCC CTTCCGCAAG TGCGTGCCCG TCCCCACGGA ACTGATCAAG 
CAGACCAAGT CGCTGAAGAT TGAGGACCAG GAACAGTTCC AACTGGATCT GTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001285588.1
CDS	95..448
Translation	MSASPTARQAITQALPMITRKVVISDPIQMPEVYSSTPGGTLYSTTPGGTKLIYERAFMKNLRGSPLSQTPPSNVPSCLLRGTPRTPFRKCVPVPTELIKQTKSLKIEDQEQFQLDL

Target ORF information:

RefSeq Version	NM_001298659.1
Organism	Drosophila melanogaster(fruit fly)
Definition	Drosophila melanogaster thor, transcript variant B (Thor), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001298659.1

ORF Insert Sequence:

ATGTCCGCTT CACCCACCGC CCGTCAAGCC ATCACCCAGG CCCTGCCCAT GATCACCAGG 
AAGGTTGTCA TCTCGGATCC GATCCAGATG CCCGAGGTGT ACTCCTCGAC GCCCGGCGGA 
ACCCTCTACT CCACCACTCC TGGAGGCACC AAACTTATCT ACGAGCGGGC TTTCATGAAG 
AATCTCCGTG GCTCCCCATT GAGCCAAACT CCGCCGTCCA ACGTGCCCAG TTGCTTGCTG 
AGGGGAACTC CGCGTACTCC CTTCCGCAAG TGCGTGCCCG TCCCCACGGA ACTGATCAAG 
CAGACCAAGT CGCTGAAGAT TGAGGACCAG GAACAGTTCC AACTGGATCT GTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Gene Model Annotations for Drosophila melanogaster: Impact of High-Throughput Data.
G3 (Bethesda, Md.)5(8)1721-36(2015 Jun)
Matthews BB,Dos Santos G,Crosby MA,Emmert DB,St Pierre SE,Gramates LS,Zhou P,Schroeder AJ,Falls K,Strelets V,Russo SM,Gelbart WM,

Gene Model Annotations for Drosophila melanogaster: The Rule-Benders.
G3 (Bethesda, Md.)5(8)1737-49(2015 Jun)
Crosby MA,Gramates LS,Dos Santos G,Matthews BB,St Pierre SE,Zhou P,Schroeder AJ,Falls K,Emmert DB,Russo SM,Gelbart WM,

Sequence finishing and mapping of Drosophila melanogaster heterochromatin.
Science (New York, N.Y.)316(5831)1625-8(2007 Jun)
Hoskins RA,Carlson JW,Kennedy C,Acevedo D,Evans-Holm M,Frise E,Wan KH,Park S,Mendez-Lago M,Rossi F,Villasante A,Dimitri P,Karpen GH,Celniker SE

The Release 5.1 annotation of Drosophila melanogaster heterochromatin.
Science (New York, N.Y.)316(5831)1586-91(2007 Jun)
Smith CD,Shu S,Mungall CJ,Karpen GH

Combined evidence annotation of transposable elements in genome sequences.
PLoS computational biology1(2)166-75(2005 Jul)
Quesneville H,Bergman CM,Andrieu O,Autard D,Nouaud D,Ashburner M,Anxolabehere D

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Thor cDNA ORF clone, Drosophila melanogaster(fruit fly)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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