cpb cDNA ORF clone, Drosophila melanogaster(fruit fly)

Gene
Clones
gRNAs

Summary

Gene Symbol	cpb
Entrez Gene ID	33346
Full Name	capping protein beta
Synonyms	CAPB_DROME,CG17158,CP,CP-beta,CPB,Cap2,CapZ,CapZbeta,Cpb,Dmel\CG17158,J,bnd,cpbeta
General protein information	Preferred Names capping protein beta Names CG17158 gene product from transcript CG17158-RA CG17158-PA CG17158-PB CP beta subunit Capping-protein-beta F-actin capping protein actin capping protein beta ancpbeta burned capping protein capping proteinbeta capping proteins beta cpb-PA cpb-PB
Gene Type	protein-coding
Organism	Drosophila melanogaster(fruit fly)
Genome	Chromosome: 2L Map Location: 22B1-22B1

mRNA and Protein(s)

mRNA	Protein	Name
NM_001272948.1	NP_001259877.1	capping protein beta, isoform B
NM_057657.5	NP_477005.1	capping protein beta, isoform A

Pathways from BioSystems

Homologies

Canis lupus familiaris (dog)	CAPZB	XP_005617941.1
Schizosaccharomyces pombe (fission yeast)	acp2	NP_593619.3
Neurospora crassa	NCU07471	XP_963750.2
Homo sapiens (human)	CAPZB	NP_001269091.1
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP007864	XP_317628.1
Caenorhabditis elegans (roundworm)	cap-2	NP_496336.1
Oryza sativa (rice)	Os03g0381200	NP_001050240.1
Pan troglodytes (chimpanzee)	CAPZB	XP_003307887.1
Rattus norvegicus (Norway rat)	Capzb	NP_001005903.1
Gallus gallus (chicken)	CAPZB	NP_001167000.1
Danio rerio (zebrafish)	capzb	NP_956229.1
Saccharomyces cerevisiae (baker's yeast)	CAP2	NP_012230.3
Kluyveromyces lactis	KLLA0E04225g	XP_454134.1
Eremothecium gossypii	AGOS_ADL101C	NP_983995.1
Bos taurus (cattle)	CAPZB	NP_788821.1
Magnaporthe oryzae (rice blast fungus)	MGG_09902	XP_003709997.1
Mus musculus (house mouse)	Capzb	NP_001258334.1
Drosophila melanogaster (fruit fly)	cpb	NP_477005.1
Arabidopsis thaliana (thale cress)	AT1G71790	NP_177324.2

Gene Ontology
Bibliography

Related articles in PubMed

Gene Model Annotations for Drosophila melanogaster: Impact of High-Throughput Data.
Matthews BB, Dos Santos G, Crosby MA, Emmert DB, St Pierre SE, Gramates LS, Zhou P, Schroeder AJ, Falls K, Strelets V, Russo SM, Gelbart WM,
G3 (Bethesda, Md.)5(8)1721-36(2015 Jun)

Gene Model Annotations for Drosophila melanogaster: The Rule-Benders.
Crosby MA, Gramates LS, Dos Santos G, Matthews BB, St Pierre SE, Zhou P, Schroeder AJ, Falls K, Emmert DB, Russo SM, Gelbart WM,
G3 (Bethesda, Md.)5(8)1737-49(2015 Jun)

Sequence finishing and mapping of Drosophila melanogaster heterochromatin.
Hoskins RA, Carlson JW, Kennedy C, Acevedo D, Evans-Holm M, Frise E, Wan KH, Park S, Mendez-Lago M, Rossi F, Villasante A, Dimitri P, Karpen GH, Celniker SE
Science (New York, N.Y.)316(5831)1625-8(2007 Jun)

The Release 5.1 annotation of Drosophila melanogaster heterochromatin.
Smith CD, Shu S, Mungall CJ, Karpen GH
Science (New York, N.Y.)316(5831)1586-91(2007 Jun)

Combined evidence annotation of transposable elements in genome sequences.
Quesneville H, Bergman CM, Andrieu O, Autard D, Nouaud D, Ashburner M, Anxolabehere D
PLoS computational biology1(2)166-75(2005 Jul)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Data show that the actin-Capping Protein (CP) alphabeta heterodimer, which regulates actin filament (F-actin) polymerization, limits Src-induced apoptosis or tissue overgrowth by restricting JNK activation.
Title: Drosophila actin-Capping Protein limits JNK activation by the Src proto-oncogene.

Data show that actin-capping protein subunits Cpa and Cpb stabilize each other's protein levels and can stimulate the production of each other's mRNA when the level of one of the subunit is reduced.
Title: Subunits of the Drosophila actin-capping protein heterodimer regulate each other at multiple levels.

Capping protein beta is required for actin cytoskeleton organisation and cell migration during Drosophila oogenesis
Title: Capping protein beta is required for actin cytoskeleton organisation and cell migration during Drosophila oogenesis.

the actin-capping protein heterodimer, which regulates actin filament polymerization, has a dual function on DE-cadherin in restricted epithelia
Title: A dual function of Drosophila capping protein on DE-cadherin maintains epithelial integrity and prevents JNK-mediated apoptosis.

findings show an interdependency between Hpo signaling activity and F-actin dynamics in which CP and Hpo pathway activities inhibit F-actin accumulation, and the reduction in F-actin in turn sustains Hpo pathway activity
Title: Actin-Capping Protein and the Hippo pathway regulate F-actin and tissue growth in Drosophila.

The following cpb gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the cpb cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OFa13456	NM_001272948.1 Latest version!	Drosophila melanogaster capping protein beta (cpb), transcript variant B, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$174.30 $249.00
OFa13456	NM_057657.5 Latest version!	Drosophila melanogaster capping protein beta (cpb), transcript variant A, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$174.30 $249.00

ORF Online Only Promotion

Next-day Shipping ORF Clones ( in default vector with tag)
1 Clone	30% OFF
2-4 Clone	40% OFF
5 or more Clone	50% OFF
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*Business Day

** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

cpb ( NM_001272948.1 ) cDNA ORF clone, Drosophila melanogaster(fruit fly) -> NP_001259877.1 Drosophila melanogaster capping protein beta (cpb), transcript variant B, mRNA.

Price & Availability↑

CloneID	OFa13456
Clone ID Related Accession (Same CDS sequence)	NM_001272948.1 , NM_057657.5
Accession Version	NM_001272948.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 831bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-04-24
Organism	Drosophila melanogaster(fruit fly)
Product	capping protein beta, isoform B
Comment	Comment: REVIEWED REFSEQ: This record has been curated by FlyBase. This record is derived from an annotated genomic sequence (NT_033779). ##Genome-Annotation-Data-START## Annotation Provider :: FlyBase Annotation Status :: Full annotation Annotation Version :: Release 6.26 URL :: http://flybase.org ##Genome-Annotation-Data-END##

ATGTCGGAAA TGCAGATGGA CTGTGCTTTG GATCTGATGC GGAGGCTGCC GCCCCAGCAG 
ATCGAGAAGA ACCTTATTGA TCTGATAGAC TTGGCACCGG ATCTCTGCGA GGACTTGCTC 
TCCTCCGTGG ACCAGCCGCT GAAGATCGCC AAGGACAAGG AGCACGGCAA GGACTATCTG 
CTGTGCGACT ATAACCGGGA TGGGGACTCC TACAGATCGC CCTGGTCGAA CTCCTACTAT 
CCGCCGCTGG AGGATGGCCA AATGCCCTCG GAACGACTGC GCAAACTGGA AATCGAGGCG 
AACTATGCCT TCGATCAGTA CAGGGAGATG TACTACGAGG GAGGCGTCTC CTCCGTCTAC 
CTATGGGATC TGGATCACGG GTTTGCCGCC GTTATACTGA TCAAAAAGGC GGGAGATGGC 
AGCAAGATGA TCCGCGGCTG CTGGGACTCC ATCCATGTGG TCGAGGTACA GGAGAAGACC 
ACCGGCAGGA CGGCCCACTA CAAGCTCACC TCCACGGCAA TGCTCTGGCT GCAGACCAAC 
AAACAGGGTT CGGGAACCAT GAATCTGGGC GGATCCCTCA CCCGGCAGCA GGAGCAGGAC 
GCCAACGTCA GCGAGTCGTC GCCGCACATC GCCAACATTG GCAAGATGGT CGAGGAGATG 
GAGAACAAGA TCAGGAACAC CCTGAACGAG ATCTACTTTG GCAAGACCAA GGACATCGTG 
AACGGACTAA GGAGCACACA ATCACTGGCC GATCAGCGCC AGCAGGCGGC CATGAAGCAG 
GACCTCGCAG CGGCAATCCT GCGACGCAAT GTCAAGCCCG AATCGAACTG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001259877.1
CDS	148..978
Translation	MSEMQMDCALDLMRRLPPQQIEKNLIDLIDLAPDLCEDLLSSVDQPLKIAKDKEHGKDYLLCDYNRDGDSYRSPWSNSYYPPLEDGQMPSERLRKLEIEANYAFDQYREMYYEGGVSSVYLWDLDHGFAAVILIKKAGDGSKMIRGCWDSIHVVEVQEKTTGRTAHYKLTSTAMLWLQTNKQGSGTMNLGGSLTRQQEQDANVSESSPHIANIGKMVEEMENKIRNTLNEIYFGKTKDIVNGLRSTQSLADQRQQAAMKQDLAAAILRRNVKPESN

Target ORF information:

RefSeq Version	NM_001272948.1
Organism	Drosophila melanogaster(fruit fly)
Definition	Drosophila melanogaster capping protein beta (cpb), transcript variant B, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001272948.1

ORF Insert Sequence:

ATGTCGGAAA TGCAGATGGA CTGTGCTTTG GATCTGATGC GGAGGCTGCC GCCCCAGCAG 
ATCGAGAAGA ACCTTATTGA TCTGATAGAC TTGGCACCGG ATCTCTGCGA GGACTTGCTC 
TCCTCCGTGG ACCAGCCGCT GAAGATCGCC AAGGACAAGG AGCACGGCAA GGACTATCTG 
CTGTGCGACT ATAACCGGGA TGGGGACTCC TACAGATCGC CCTGGTCGAA CTCCTACTAT 
CCGCCGCTGG AGGATGGCCA AATGCCCTCG GAACGACTGC GCAAACTGGA AATCGAGGCG 
AACTATGCCT TCGATCAGTA CAGGGAGATG TACTACGAGG GAGGCGTCTC CTCCGTCTAC 
CTATGGGATC TGGATCACGG GTTTGCCGCC GTTATACTGA TCAAAAAGGC GGGAGATGGC 
AGCAAGATGA TCCGCGGCTG CTGGGACTCC ATCCATGTGG TCGAGGTACA GGAGAAGACC 
ACCGGCAGGA CGGCCCACTA CAAGCTCACC TCCACGGCAA TGCTCTGGCT GCAGACCAAC 
AAACAGGGTT CGGGAACCAT GAATCTGGGC GGATCCCTCA CCCGGCAGCA GGAGCAGGAC 
GCCAACGTCA GCGAGTCGTC GCCGCACATC GCCAACATTG GCAAGATGGT CGAGGAGATG 
GAGAACAAGA TCAGGAACAC CCTGAACGAG ATCTACTTTG GCAAGACCAA GGACATCGTG 
AACGGACTAA GGAGCACACA ATCACTGGCC GATCAGCGCC AGCAGGCGGC CATGAAGCAG 
GACCTCGCAG CGGCAATCCT GCGACGCAAT GTCAAGCCCG AATCGAACTG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

cpb ( NM_057657.5 ) cDNA ORF clone, Drosophila melanogaster(fruit fly) -> NP_477005.1 Drosophila melanogaster capping protein beta (cpb), transcript variant A, mRNA.

Price & Availability↑

CloneID	OFa13456
Clone ID Related Accession (Same CDS sequence)	NM_001272948.1 , NM_057657.5
Accession Version	NM_057657.5 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 831bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-04-24
Organism	Drosophila melanogaster(fruit fly)
Product	capping protein beta, isoform A
Comment	Comment: REVIEWED REFSEQ: This record has been curated by FlyBase. This record is derived from an annotated genomic sequence (NT_033779). On Jan 16, 2013 this sequence version replaced NM_057657.4. ##Genome-Annotation-Data-START## Annotation Provider :: FlyBase Annotation Status :: Full annotation Annotation Version :: Release 6.26 URL :: http://flybase.org ##Genome-Annotation-Data-END##

ATGTCGGAAA TGCAGATGGA CTGTGCTTTG GATCTGATGC GGAGGCTGCC GCCCCAGCAG 
ATCGAGAAGA ACCTTATTGA TCTGATAGAC TTGGCACCGG ATCTCTGCGA GGACTTGCTC 
TCCTCCGTGG ACCAGCCGCT GAAGATCGCC AAGGACAAGG AGCACGGCAA GGACTATCTG 
CTGTGCGACT ATAACCGGGA TGGGGACTCC TACAGATCGC CCTGGTCGAA CTCCTACTAT 
CCGCCGCTGG AGGATGGCCA AATGCCCTCG GAACGACTGC GCAAACTGGA AATCGAGGCG 
AACTATGCCT TCGATCAGTA CAGGGAGATG TACTACGAGG GAGGCGTCTC CTCCGTCTAC 
CTATGGGATC TGGATCACGG GTTTGCCGCC GTTATACTGA TCAAAAAGGC GGGAGATGGC 
AGCAAGATGA TCCGCGGCTG CTGGGACTCC ATCCATGTGG TCGAGGTACA GGAGAAGACC 
ACCGGCAGGA CGGCCCACTA CAAGCTCACC TCCACGGCAA TGCTCTGGCT GCAGACCAAC 
AAACAGGGTT CGGGAACCAT GAATCTGGGC GGATCCCTCA CCCGGCAGCA GGAGCAGGAC 
GCCAACGTCA GCGAGTCGTC GCCGCACATC GCCAACATTG GCAAGATGGT CGAGGAGATG 
GAGAACAAGA TCAGGAACAC CCTGAACGAG ATCTACTTTG GCAAGACCAA GGACATCGTG 
AACGGACTAA GGAGCACACA ATCACTGGCC GATCAGCGCC AGCAGGCGGC CATGAAGCAG 
GACCTCGCAG CGGCAATCCT GCGACGCAAT GTCAAGCCCG AATCGAACTG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_477005.1
CDS	211..1041
Translation	MSEMQMDCALDLMRRLPPQQIEKNLIDLIDLAPDLCEDLLSSVDQPLKIAKDKEHGKDYLLCDYNRDGDSYRSPWSNSYYPPLEDGQMPSERLRKLEIEANYAFDQYREMYYEGGVSSVYLWDLDHGFAAVILIKKAGDGSKMIRGCWDSIHVVEVQEKTTGRTAHYKLTSTAMLWLQTNKQGSGTMNLGGSLTRQQEQDANVSESSPHIANIGKMVEEMENKIRNTLNEIYFGKTKDIVNGLRSTQSLADQRQQAAMKQDLAAAILRRNVKPESN

Target ORF information:

RefSeq Version	NM_057657.5
Organism	Drosophila melanogaster(fruit fly)
Definition	Drosophila melanogaster capping protein beta (cpb), transcript variant A, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_057657.5

ORF Insert Sequence:

ATGTCGGAAA TGCAGATGGA CTGTGCTTTG GATCTGATGC GGAGGCTGCC GCCCCAGCAG 
ATCGAGAAGA ACCTTATTGA TCTGATAGAC TTGGCACCGG ATCTCTGCGA GGACTTGCTC 
TCCTCCGTGG ACCAGCCGCT GAAGATCGCC AAGGACAAGG AGCACGGCAA GGACTATCTG 
CTGTGCGACT ATAACCGGGA TGGGGACTCC TACAGATCGC CCTGGTCGAA CTCCTACTAT 
CCGCCGCTGG AGGATGGCCA AATGCCCTCG GAACGACTGC GCAAACTGGA AATCGAGGCG 
AACTATGCCT TCGATCAGTA CAGGGAGATG TACTACGAGG GAGGCGTCTC CTCCGTCTAC 
CTATGGGATC TGGATCACGG GTTTGCCGCC GTTATACTGA TCAAAAAGGC GGGAGATGGC 
AGCAAGATGA TCCGCGGCTG CTGGGACTCC ATCCATGTGG TCGAGGTACA GGAGAAGACC 
ACCGGCAGGA CGGCCCACTA CAAGCTCACC TCCACGGCAA TGCTCTGGCT GCAGACCAAC 
AAACAGGGTT CGGGAACCAT GAATCTGGGC GGATCCCTCA CCCGGCAGCA GGAGCAGGAC 
GCCAACGTCA GCGAGTCGTC GCCGCACATC GCCAACATTG GCAAGATGGT CGAGGAGATG 
GAGAACAAGA TCAGGAACAC CCTGAACGAG ATCTACTTTG GCAAGACCAA GGACATCGTG 
AACGGACTAA GGAGCACACA ATCACTGGCC GATCAGCGCC AGCAGGCGGC CATGAAGCAG 
GACCTCGCAG CGGCAATCCT GCGACGCAAT GTCAAGCCCG AATCGAACTG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Gene Model Annotations for Drosophila melanogaster: Impact of High-Throughput Data.
G3 (Bethesda, Md.)5(8)1721-36(2015 Jun)
Matthews BB,Dos Santos G,Crosby MA,Emmert DB,St Pierre SE,Gramates LS,Zhou P,Schroeder AJ,Falls K,Strelets V,Russo SM,Gelbart WM,

Gene Model Annotations for Drosophila melanogaster: The Rule-Benders.
G3 (Bethesda, Md.)5(8)1737-49(2015 Jun)
Crosby MA,Gramates LS,Dos Santos G,Matthews BB,St Pierre SE,Zhou P,Schroeder AJ,Falls K,Emmert DB,Russo SM,Gelbart WM,

Sequence finishing and mapping of Drosophila melanogaster heterochromatin.
Science (New York, N.Y.)316(5831)1625-8(2007 Jun)
Hoskins RA,Carlson JW,Kennedy C,Acevedo D,Evans-Holm M,Frise E,Wan KH,Park S,Mendez-Lago M,Rossi F,Villasante A,Dimitri P,Karpen GH,Celniker SE

The Release 5.1 annotation of Drosophila melanogaster heterochromatin.
Science (New York, N.Y.)316(5831)1586-91(2007 Jun)
Smith CD,Shu S,Mungall CJ,Karpen GH

Combined evidence annotation of transposable elements in genome sequences.
PLoS computational biology1(2)166-75(2005 Jul)
Quesneville H,Bergman CM,Andrieu O,Autard D,Nouaud D,Ashburner M,Anxolabehere D

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cpb cDNA ORF clone, Drosophila melanogaster(fruit fly)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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