PGRP-SA cDNA ORF clone, Drosophila melanogaster(fruit fly)

Gene
Clones
gRNAs

Summary

Gene Symbol	PGRP-SA
Entrez Gene ID	32099
Full Name	Peptidoglycan recognition protein SA
Synonyms	BcDNA:AT30827,CG11709,Dm PGRP-SA,Dmel\CG11709,SA,SEMMELWEIS,pgrp-sa,seml
General protein information	Preferred Names Peptidoglycan recognition protein SA Names CG11709 gene product from transcript CG11709-RA CG11709-PA CG11709-PB PG recognition Protein-SA PGRP-SA-PA PGRP-SA-PB Peptidoglycan-recognition protein-SA precursor peptidoglycan recognition protein SA peptidoglycan recognition protein-SA protein semmelweis semmelweis semmelweiss
Gene Type	protein-coding
Organism	Drosophila melanogaster(fruit fly)
Genome	Chromosome: X Map Location: 10C6-10C6

mRNA and Protein(s)

mRNA	Protein	Name
NM_132499.3	NP_572727.1	peptidoglycan recognition protein SA, isoform A
NM_001298199.1	NP_001285128.1	peptidoglycan recognition protein SA, isoform B

Pathways from BioSystems

Homologies

Drosophila melanogaster (fruit fly)	PGRP-SA	NP_572727.1
Anopheles gambiae (African malaria mosquito)	PGRPS1	XP_310547.4

Gene Ontology
Bibliography

Related articles in PubMed

Gene Model Annotations for Drosophila melanogaster: Impact of High-Throughput Data.
Matthews BB, Dos Santos G, Crosby MA, Emmert DB, St Pierre SE, Gramates LS, Zhou P, Schroeder AJ, Falls K, Strelets V, Russo SM, Gelbart WM,
G3 (Bethesda, Md.)5(8)1721-36(2015 Jun)

Gene Model Annotations for Drosophila melanogaster: The Rule-Benders.
Crosby MA, Gramates LS, Dos Santos G, Matthews BB, St Pierre SE, Zhou P, Schroeder AJ, Falls K, Emmert DB, Russo SM, Gelbart WM,
G3 (Bethesda, Md.)5(8)1737-49(2015 Jun)

Sequence finishing and mapping of Drosophila melanogaster heterochromatin.
Hoskins RA, Carlson JW, Kennedy C, Acevedo D, Evans-Holm M, Frise E, Wan KH, Park S, Mendez-Lago M, Rossi F, Villasante A, Dimitri P, Karpen GH, Celniker SE
Science (New York, N.Y.)316(5831)1625-8(2007 Jun)

The Release 5.1 annotation of Drosophila melanogaster heterochromatin.
Smith CD, Shu S, Mungall CJ, Karpen GH
Science (New York, N.Y.)316(5831)1586-91(2007 Jun)

Combined evidence annotation of transposable elements in genome sequences.
Quesneville H, Bergman CM, Andrieu O, Autard D, Nouaud D, Ashburner M, Anxolabehere D
PLoS computational biology1(2)166-75(2005 Jul)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Wall teichoic acids of Staphylococcus aureus limit recognition by the drosophila peptidoglycan recognition protein-SA to promote pathogenicity.
Title: Wall teichoic acids of Staphylococcus aureus limit recognition by the drosophila peptidoglycan recognition protein-SA to promote pathogenicity.

GNBP1 presents a processed form of peptidoglycan for sensing by PGRP-SA and that a tripartite interaction between these proteins and peptidoglycan is essential for downstream signaling.
Title: Sensing of Gram-positive bacteria in Drosophila: GNBP1 is needed to process and present peptidoglycan to PGRP-SA.

PGRP-SA contains a peptidoglycan docking groove and unusual L,D-carboxypeptidase activity
Title: A Drosophila pattern recognition receptor contains a peptidoglycan docking groove and unusual L,D-carboxypeptidase activity.

results demonstrate that GNBP1 and PGRP-SA can jointly activate the Toll pathway
Title: Dual activation of the Drosophila toll pathway by two pattern recognition receptors.

The following PGRP-SA gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the PGRP-SA cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OFa01287	NM_132499.3 Latest version!	Drosophila melanogaster peptidoglycan recognition protein SA, transcript variant A (PGRP-SA), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$174.30 $249.00
OFa01287	NM_001298199.1 Latest version!	Drosophila melanogaster peptidoglycan recognition protein SA, transcript variant B (PGRP-SA), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$174.30 $249.00

ORF Online Only Promotion

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

PGRP-SA ( NM_132499.3 ) cDNA ORF clone, Drosophila melanogaster(fruit fly) -> NP_572727.1 Drosophila melanogaster peptidoglycan recognition protein SA, transcript variant A (PGRP-SA), mRNA.

Price & Availability↑

CloneID	OFa01287
Clone ID Related Accession (Same CDS sequence)	NM_132499.3 , NM_001298199.1
Accession Version	NM_132499.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 612bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-04-24
Organism	Drosophila melanogaster(fruit fly)
Product	peptidoglycan recognition protein SA, isoform A
Comment	Comment: REVIEWED REFSEQ: This record has been curated by FlyBase. This record is derived from an annotated genomic sequence (NC_004354). On Jul 15, 2014 this sequence version replaced NM_132499.2. ##Genome-Annotation-Data-START## Annotation Provider :: FlyBase Annotation Status :: Full annotation Annotation Version :: Release 6.26 URL :: http://flybase.org ##Genome-Annotation-Data-END##

ATGCAGCCGG TTCGATTCGG ATCTCCTTGG ATTATGGCCA TTGGGCTGGT GCTACTACTG 
CTGGCATTCG TCTCCGCCGG AAAGTCGCGT CAGCGTTCGC CAGCCAATTG CCCCACCATC 
AAGCTGAAGC GTCAGTGGGG CGGCAAGCCT TCGTTGGGAC TCCACTACCA AGTGCGTCCC 
ATCCGCTATG TGGTCATCCA TCACACGGTC ACCGGCGAGT GCAGCGGACT GCTCAAGTGC 
GCCGAGATTC TCCAGAACAT GCAGGCGTAT CATCAGAACG AGCTGGACTT CAACGATATT 
AGTTACAACT TCCTGATCGG CAACGATGGT ATCGTATACG AAGGCACTGG TTGGGGATTG 
CGCGGTGCCC ACACCTATGG ATACAATGCC ATTGGCACGG GCATAGCCTT TATCGGCAAC 
TTTGTGGATA AACTTCCATC GGATGCGGCT CTCCAGGCGG CCAAAGATCT GCTGGCCTGC 
GGAGTGCAGC AGGGTGAGCT GAGCGAGGAT TACGCCCTGA TCGCCGGCTC CCAGGTGATC 
AGCACCCAGA GTCCCGGACT GACTCTATAC AACGAGATCC AAGAGTGGCC GCACTGGCTC 
TCAAATCCCT AA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_572727.1
CDS	331..942
Translation	MQPVRFGSPWIMAIGLVLLLLAFVSAGKSRQRSPANCPTIKLKRQWGGKPSLGLHYQVRPIRYVVIHHTVTGECSGLLKCAEILQNMQAYHQNELDFNDISYNFLIGNDGIVYEGTGWGLRGAHTYGYNAIGTGIAFIGNFVDKLPSDAALQAAKDLLACGVQQGELSEDYALIAGSQVISTQSPGLTLYNEIQEWPHWLSNP

Target ORF information:

RefSeq Version	NM_132499.3
Organism	Drosophila melanogaster(fruit fly)
Definition	Drosophila melanogaster peptidoglycan recognition protein SA, transcript variant A (PGRP-SA), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_132499.3

ORF Insert Sequence:

ATGCAGCCGG TTCGATTCGG ATCTCCTTGG ATTATGGCCA TTGGGCTGGT GCTACTACTG 
CTGGCATTCG TCTCCGCCGG AAAGTCGCGT CAGCGTTCGC CAGCCAATTG CCCCACCATC 
AAGCTGAAGC GTCAGTGGGG CGGCAAGCCT TCGTTGGGAC TCCACTACCA AGTGCGTCCC 
ATCCGCTATG TGGTCATCCA TCACACGGTC ACCGGCGAGT GCAGCGGACT GCTCAAGTGC 
GCCGAGATTC TCCAGAACAT GCAGGCGTAT CATCAGAACG AGCTGGACTT CAACGATATT 
AGTTACAACT TCCTGATCGG CAACGATGGT ATCGTATACG AAGGCACTGG TTGGGGATTG 
CGCGGTGCCC ACACCTATGG ATACAATGCC ATTGGCACGG GCATAGCCTT TATCGGCAAC 
TTTGTGGATA AACTTCCATC GGATGCGGCT CTCCAGGCGG CCAAAGATCT GCTGGCCTGC 
GGAGTGCAGC AGGGTGAGCT GAGCGAGGAT TACGCCCTGA TCGCCGGCTC CCAGGTGATC 
AGCACCCAGA GTCCCGGACT GACTCTATAC AACGAGATCC AAGAGTGGCC GCACTGGCTC 
TCAAATCCCT AA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PGRP-SA ( NM_001298199.1 ) cDNA ORF clone, Drosophila melanogaster(fruit fly) -> NP_001285128.1 Drosophila melanogaster peptidoglycan recognition protein SA, transcript variant B (PGRP-SA), mRNA.

Price & Availability↑

CloneID	OFa01287
Clone ID Related Accession (Same CDS sequence)	NM_132499.3 , NM_001298199.1
Accession Version	NM_001298199.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 612bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-04-24
Organism	Drosophila melanogaster(fruit fly)
Product	peptidoglycan recognition protein SA, isoform B
Comment	Comment: REVIEWED REFSEQ: This record has been curated by FlyBase. This record is derived from an annotated genomic sequence (NC_004354). ##Genome-Annotation-Data-START## Annotation Provider :: FlyBase Annotation Status :: Full annotation Annotation Version :: Release 6.26 URL :: http://flybase.org ##Genome-Annotation-Data-END##

ATGCAGCCGG TTCGATTCGG ATCTCCTTGG ATTATGGCCA TTGGGCTGGT GCTACTACTG 
CTGGCATTCG TCTCCGCCGG AAAGTCGCGT CAGCGTTCGC CAGCCAATTG CCCCACCATC 
AAGCTGAAGC GTCAGTGGGG CGGCAAGCCT TCGTTGGGAC TCCACTACCA AGTGCGTCCC 
ATCCGCTATG TGGTCATCCA TCACACGGTC ACCGGCGAGT GCAGCGGACT GCTCAAGTGC 
GCCGAGATTC TCCAGAACAT GCAGGCGTAT CATCAGAACG AGCTGGACTT CAACGATATT 
AGTTACAACT TCCTGATCGG CAACGATGGT ATCGTATACG AAGGCACTGG TTGGGGATTG 
CGCGGTGCCC ACACCTATGG ATACAATGCC ATTGGCACGG GCATAGCCTT TATCGGCAAC 
TTTGTGGATA AACTTCCATC GGATGCGGCT CTCCAGGCGG CCAAAGATCT GCTGGCCTGC 
GGAGTGCAGC AGGGTGAGCT GAGCGAGGAT TACGCCCTGA TCGCCGGCTC CCAGGTGATC 
AGCACCCAGA GTCCCGGACT GACTCTATAC AACGAGATCC AAGAGTGGCC GCACTGGCTC 
TCAAATCCCT AA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001285128.1
CDS	39..650
Translation	MQPVRFGSPWIMAIGLVLLLLAFVSAGKSRQRSPANCPTIKLKRQWGGKPSLGLHYQVRPIRYVVIHHTVTGECSGLLKCAEILQNMQAYHQNELDFNDISYNFLIGNDGIVYEGTGWGLRGAHTYGYNAIGTGIAFIGNFVDKLPSDAALQAAKDLLACGVQQGELSEDYALIAGSQVISTQSPGLTLYNEIQEWPHWLSNP

Target ORF information:

RefSeq Version	NM_001298199.1
Organism	Drosophila melanogaster(fruit fly)
Definition	Drosophila melanogaster peptidoglycan recognition protein SA, transcript variant B (PGRP-SA), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001298199.1

ORF Insert Sequence:

ATGCAGCCGG TTCGATTCGG ATCTCCTTGG ATTATGGCCA TTGGGCTGGT GCTACTACTG 
CTGGCATTCG TCTCCGCCGG AAAGTCGCGT CAGCGTTCGC CAGCCAATTG CCCCACCATC 
AAGCTGAAGC GTCAGTGGGG CGGCAAGCCT TCGTTGGGAC TCCACTACCA AGTGCGTCCC 
ATCCGCTATG TGGTCATCCA TCACACGGTC ACCGGCGAGT GCAGCGGACT GCTCAAGTGC 
GCCGAGATTC TCCAGAACAT GCAGGCGTAT CATCAGAACG AGCTGGACTT CAACGATATT 
AGTTACAACT TCCTGATCGG CAACGATGGT ATCGTATACG AAGGCACTGG TTGGGGATTG 
CGCGGTGCCC ACACCTATGG ATACAATGCC ATTGGCACGG GCATAGCCTT TATCGGCAAC 
TTTGTGGATA AACTTCCATC GGATGCGGCT CTCCAGGCGG CCAAAGATCT GCTGGCCTGC 
GGAGTGCAGC AGGGTGAGCT GAGCGAGGAT TACGCCCTGA TCGCCGGCTC CCAGGTGATC 
AGCACCCAGA GTCCCGGACT GACTCTATAC AACGAGATCC AAGAGTGGCC GCACTGGCTC 
TCAAATCCCT AA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Gene Model Annotations for Drosophila melanogaster: Impact of High-Throughput Data.
G3 (Bethesda, Md.)5(8)1721-36(2015 Jun)
Matthews BB,Dos Santos G,Crosby MA,Emmert DB,St Pierre SE,Gramates LS,Zhou P,Schroeder AJ,Falls K,Strelets V,Russo SM,Gelbart WM,

Gene Model Annotations for Drosophila melanogaster: The Rule-Benders.
G3 (Bethesda, Md.)5(8)1737-49(2015 Jun)
Crosby MA,Gramates LS,Dos Santos G,Matthews BB,St Pierre SE,Zhou P,Schroeder AJ,Falls K,Emmert DB,Russo SM,Gelbart WM,

Sequence finishing and mapping of Drosophila melanogaster heterochromatin.
Science (New York, N.Y.)316(5831)1625-8(2007 Jun)
Hoskins RA,Carlson JW,Kennedy C,Acevedo D,Evans-Holm M,Frise E,Wan KH,Park S,Mendez-Lago M,Rossi F,Villasante A,Dimitri P,Karpen GH,Celniker SE

The Release 5.1 annotation of Drosophila melanogaster heterochromatin.
Science (New York, N.Y.)316(5831)1586-91(2007 Jun)
Smith CD,Shu S,Mungall CJ,Karpen GH

Combined evidence annotation of transposable elements in genome sequences.
PLoS computational biology1(2)166-75(2005 Jul)
Quesneville H,Bergman CM,Andrieu O,Autard D,Nouaud D,Ashburner M,Anxolabehere D

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PGRP-SA cDNA ORF clone, Drosophila melanogaster(fruit fly)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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