mof cDNA ORF clone, Drosophila melanogaster(fruit fly)

Gene
Clones
gRNAs

Summary

Gene Symbol	mof
Entrez Gene ID	31518
Full Name	males absent on the first
Synonyms	CG3025,Dmel\CG3025,MOF,Mof,dMOF,dmMOF,max
General protein information	Preferred Names males absent on the first Names CG3025 gene product from transcript CG3025-RA CG3025-PA MOF histone acetylase males absent on first males-absent on the X males-absent-on-the-first mof-PA
Gene Type	protein-coding
Organism	Drosophila melanogaster(fruit fly)
Genome	Chromosome: X Map Location: 5C5-5C5

mRNA and Protein(s)

mRNA	Protein	Name
NM_078496.3	NP_511051.1	males absent on the first

Pathways from BioSystems

Homologies

Homo sapiens (human)	KAT8	NP_115564.2
Bos taurus (cattle)	KAT8	NP_001098953.1
Mus musculus (house mouse)	Kat8	NP_080646.1
Xenopus tropicalis (tropical clawed frog)	kat8	NP_001016234.2
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP012229	XP_320309.4
Caenorhabditis elegans (roundworm)	mys-2	NP_493467.1
Arabidopsis thaliana (thale cress)	HAM2	NP_196536.1
Canis lupus familiaris (dog)	KAT8	XP_536904.2
Danio rerio (zebrafish)	kat8	NP_997907.1
Arabidopsis thaliana (thale cress)	HAM1	NP_201266.1
Pan troglodytes (chimpanzee)	KAT8	XP_523493.4
Rattus norvegicus (Norway rat)	Kat8	NP_001017378.1
Drosophila melanogaster (fruit fly)	mof	NP_511051.1
Oryza sativa (rice)	Os07g0626600	NP_001060338.1

Gene Ontology
Bibliography

Related articles in PubMed

Gene Model Annotations for Drosophila melanogaster: Impact of High-Throughput Data.
Matthews BB, Dos Santos G, Crosby MA, Emmert DB, St Pierre SE, Gramates LS, Zhou P, Schroeder AJ, Falls K, Strelets V, Russo SM, Gelbart WM,
G3 (Bethesda, Md.)5(8)1721-36(2015 Jun)

Gene Model Annotations for Drosophila melanogaster: The Rule-Benders.
Crosby MA, Gramates LS, Dos Santos G, Matthews BB, St Pierre SE, Zhou P, Schroeder AJ, Falls K, Emmert DB, Russo SM, Gelbart WM,
G3 (Bethesda, Md.)5(8)1737-49(2015 Jun)

Sequence finishing and mapping of Drosophila melanogaster heterochromatin.
Hoskins RA, Carlson JW, Kennedy C, Acevedo D, Evans-Holm M, Frise E, Wan KH, Park S, Mendez-Lago M, Rossi F, Villasante A, Dimitri P, Karpen GH, Celniker SE
Science (New York, N.Y.)316(5831)1625-8(2007 Jun)

The Release 5.1 annotation of Drosophila melanogaster heterochromatin.
Smith CD, Shu S, Mungall CJ, Karpen GH
Science (New York, N.Y.)316(5831)1586-91(2007 Jun)

Combined evidence annotation of transposable elements in genome sequences.
Quesneville H, Bergman CM, Andrieu O, Autard D, Nouaud D, Ashburner M, Anxolabehere D
PLoS computational biology1(2)166-75(2005 Jul)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Accumulation of Mof at the Diap1 promoter 800 bp upstream of the transcription start site in wild type larvae is significantly higher (up to two folds) compared to mof1 mutants.
Title: Drosophila MOF regulates DIAP1 and induces apoptosis in a JNK dependent pathway.

MOF controls Checkpoint protein2 and regulates genomic stability during early embryogenesis.
Title: Drosophila MOF controls Checkpoint protein2 and regulates genomic stability during early embryogenesis.

It was shown that the MOF chromobarrel domain is essential for H4K16 acetylation throughout the Drosophila genome and is required for spreading of the male-specific lethal complex on the X chromosome.
Title: The MOF chromobarrel domain controls genome-wide H4K16 acetylation and spreading of the MSL complex.

The role of MOF in the response to ionizing radiation is conserved between Drosophila and mammals.
Title: The role of MOF in the ionizing radiation response is conserved in Drosophila melanogaster.

The activation potential of MOF is constrained in male cells in the context of the DCC to arrive at the 2-fold activation of transcription characteristic of dosage compensation.
Title: The activation potential of MOF is constrained for dosage compensation.

The following mof gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the mof cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OFa00905	NM_078496.3 Latest version!	Drosophila melanogaster males absent on the first (mof), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	12-14	$426.30 $609.00

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

mof ( NM_078496.3 ) cDNA ORF clone, Drosophila melanogaster(fruit fly) -> NP_511051.1 Drosophila melanogaster males absent on the first (mof), mRNA.

Price & Availability↑

CloneID	OFa00905
Clone ID Related Accession (Same CDS sequence)	NM_078496.3
Accession Version	NM_078496.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2484bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-04-24
Organism	Drosophila melanogaster(fruit fly)
Product	males absent on the first
Comment	Comment: REVIEWED REFSEQ: This record has been curated by FlyBase. This record is derived from an annotated genomic sequence (NC_004354). On Jul 15, 2014 this sequence version replaced NM_078496.2. ##Genome-Annotation-Data-START## Annotation Provider :: FlyBase Annotation Status :: Full annotation Annotation Version :: Release 6.26 URL :: http://flybase.org ##Genome-Annotation-Data-END##

ATGTCTGAAG CGGAGCTGGA ACAGACACCC AGCGCGGGCC ACGTGCAGGA GCAGCCGATT 
GAGGAGGAGC ATGAGCCGGA ACAGGAGCCA ACCGATGCGT ACACAATTGG CGGTCCGCCG 
AGGACGCCGG TTGAAGATGC GGCGGCCGAA TTGAGCGCCA GTCTAGACGT CAGCGGCTCG 
GATCAGTCGG CGGAGCAGTC GCTCGACCTC AGCGGTGTCC AAGCGGAGGC CGCGGCGGAG 
TCAGAGCCAC CGGCGAAGCG CCAGCATCGC GACATCAGTC CCATTTCGGA GGACAGCACG 
CCGGCGAGCA GCACATCGAC TAGTTCCACC AGGTCGTCCA GCTCCTCCCG CTACGACGAT 
GTTAGCGAGG CGGAGGAGGC ACCACCGGAG CCCGAGCCGG AGCAACCACA GCAGCAGCAG 
CAGGAGGAAA AGAAGGAGGA CGGTCAGGAT CAGGTGAAGT CACCAGGTCC AGTTGAATTG 
GAGGCACAGG AGCCCGCGCA GCCGCAGAAG CAGAAAGAGG TGGTGGACCA GGAAATTGAA 
ACCGAGGATG AGCCCTCCTC CGATACGGTA ATCTGCGTGG CCGACATCAA CCCCTACGGC 
AGTGGTTCCA ACATTGACGA CTTCGTTATG GATCCCGATG CTCCTCCCAA TGCAATAATC 
ACCGAGGTGG TTACCATTCC AGCTCCTCTT CATCTCAAAG GGACACAACA ACTGGGGCTG 
CCATTGGCTG CCCCACCGCC ACCACCACCT CCTCCAGCAG CGGAACAAGT CCCCGAGACT 
CCCGCCTCGC CCACAGATGA CGGCGAGGAA CCACCAGCAG TATATTTATC CCCCTACATA 
CGCTCTCGCT ACATGCAGGA ATCGACACCT GGCCTGCCCA CCCGCCTGGC GCCGCGTGAT 
CCTCGCCAGC GCAACATGCC GCCGCCAGCC GTAGTTCTGC CCATTCAAAC CGTACTTAGC 
GCCAACGTTG AGGCCATTTC TGACGACAGC AGCGAAACTA GCAGCAGCGA TGACGATGAA 
GAGGAAGAGG AGGACGAAGA TGATGCCTTG ACCATGGAGC ACGACAACAC TTCCAGGGAG 
ACGGTCATCA CAACAGGTGA CCCTCTGATG CAAAAGATCG ATATAAGCGA AAATCCCGAC 
AAGATCTATT TTATTCGGCG CGAGGATGGC ACCGTGCACC GTGGCCAGGT GCTTCAGTCT 
CGCACCACTG AGAATGCGGC CGCTCCCGAT GAGTACTACG TCCACTATGT TGGTCTCAAT 
CGCCGCCTGG ACGGATGGGT GGGCAGGCAT AGGATCTCGG ACAATGCGGA TGACTTGGGC 
GGTATTACCG TGCTGCCAGC GCCACCATTA GCCCCCGATC AGCCAAGTAC TAGCAGGGAA 
ATGCTCGCCC AACAGGCCGC CGCGGCGGCA GCTGCCTCAT CCGAACGGCA GAAGCGTGCG 
GCCAACAAGG ATTACTATCT GTCCTATTGC GAGAACAGTC GCTATGACTA CAGCGACCGC 
AAGATGACAC GCTACCAGAA GCGGCGCTAC GATGAGATCA ACCACGTGCA GAAGAGCCAC 
GCTGAGCTGA CCGCCACGCA GGCGGCGCTG GAGAAGGAGC ACGAGTCCAT TACGAAGATC 
AAGTACATTG ATAAGCTGCA GTTTGGCAAC TACGAGATCG ACACCTGGTA CTTTAGTCCC 
TTCCCCGAAG AATATGGCAA GGCACGTACG TTATATGTTT GCGAGTACTG CCTAAAGTAC 
ATGCGCTTCA GGTCGAGCTA TGCCTATCAT CTGCACGAAT GCGACCGCAG GCGTCCGCCC 
GGAAGAGAGA TCTACCGCAA GGGCAATATA TCCATTTACG AGGTGAACGG CAAGGAGGAG 
TCACTATACT GCCAACTTTT GTGTCTGATG GCCAAGCTCT TTTTGGACCA CAAGGTTCTA 
TACTTCGACA TGGACCCGTT TCTCTTTTAC ATCCTTTGCG AGACGGACAA GGAGGGCAGT 
CACATTGTGG GCTATTTCTC CAAGGAAAAG AAGTCGCTGG AAAACTACAA CGTGGCCTGC 
ATTCTGGTAT TGCCGCCGCA TCAGCGTAAG GGATTTGGAA AGCTACTAAT AGCCTTTAGC 
TATGAGCTGT CGCGCAAGGA GGGCGTAATC GGTAGTCCGG AGAAACCGCT CTCGGATCTG 
GGTAGGCTGA GCTATCGCAG CTATTGGGCA TACACGCTGC TGGAGCTGAT GAAAACCCGC 
TGCGCTCCAG AGCAGATCAC AATCAAGGAG CTGAGCGAAA TGAGTGGCAT CACCCACGAC 
GACATTATCT ACACGCTGCA GTCCATGAAG ATGATCAAGT ATTGGAAGGG CCAGAATGTC 
ATTTGCGTTA CGTCCAAGAC CATTCAAGAC CACCTCCAGC TGCCGCAGTT CAAGCAGCCC 
AAGCTGACCA TCGACACCGA TTACCTCGTC TGGAGTCCGC AAACTGCAGC GGCAGTGGTC 
AGAGCTCCGG GAAATTCCGG CTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_511051.1
CDS	102..2585
Translation	MSEAELEQTPSAGHVQEQPIEEEHEPEQEPTDAYTIGGPPRTPVEDAAAELSASLDVSGSDQSAEQSLDLSGVQAEAAAESEPPAKRQHRDISPISEDSTPASSTSTSSTRSSSSSRYDDVSEAEEAPPEPEPEQPQQQQQEEKKEDGQDQVKSPGPVELEAQEPAQPQKQKEVVDQEIETEDEPSSDTVICVADINPYGSGSNIDDFVMDPDAPPNAIITEVVTIPAPLHLKGTQQLGLPLAAPPPPPPPPAAEQVPETPASPTDDGEEPPAVYLSPYIRSRYMQESTPGLPTRLAPRDPRQRNMPPPAVVLPIQTVLSANVEAISDDSSETSSSDDDEEEEEDEDDALTMEHDNTSRETVITTGDPLMQKIDISENPDKIYFIRREDGTVHRGQVLQSRTTENAAAPDEYYVHYVGLNRRLDGWVGRHRISDNADDLGGITVLPAPPLAPDQPSTSREMLAQQAAAAAAASSERQKRAANKDYYLSYCENSRYDYSDRKMTRYQKRRYDEINHVQKSHAELTATQAALEKEHESITKIKYIDKLQFGNYEIDTWYFSPFPEEYGKARTLYVCEYCLKYMRFRSSYAYHLHECDRRRPPGREIYRKGNISIYEVNGKEESLYCQLLCLMAKLFLDHKVLYFDMDPFLFYILCETDKEGSHIVGYFSKEKKSLENYNVACILVLPPHQRKGFGKLLIAFSYELSRKEGVIGSPEKPLSDLGRLSYRSYWAYTLLELMKTRCAPEQITIKELSEMSGITHDDIIYTLQSMKMIKYWKGQNVICVTSKTIQDHLQLPQFKQPKLTIDTDYLVWSPQTAAAVVRAPGNSG

Target ORF information:

RefSeq Version	NM_078496.3
Organism	Drosophila melanogaster(fruit fly)
Definition	Drosophila melanogaster males absent on the first (mof), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_078496.3

ORF Insert Sequence:

ATGTCTGAAG CGGAGCTGGA ACAGACACCC AGCGCGGGCC ACGTGCAGGA GCAGCCGATT 
GAGGAGGAGC ATGAGCCGGA ACAGGAGCCA ACCGATGCGT ACACAATTGG CGGTCCGCCG 
AGGACGCCGG TTGAAGATGC GGCGGCCGAA TTGAGCGCCA GTCTAGACGT CAGCGGCTCG 
GATCAGTCGG CGGAGCAGTC GCTCGACCTC AGCGGTGTCC AAGCGGAGGC CGCGGCGGAG 
TCAGAGCCAC CGGCGAAGCG CCAGCATCGC GACATCAGTC CCATTTCGGA GGACAGCACG 
CCGGCGAGCA GCACATCGAC TAGTTCCACC AGGTCGTCCA GCTCCTCCCG CTACGACGAT 
GTTAGCGAGG CGGAGGAGGC ACCACCGGAG CCCGAGCCGG AGCAACCACA GCAGCAGCAG 
CAGGAGGAAA AGAAGGAGGA CGGTCAGGAT CAGGTGAAGT CACCAGGTCC AGTTGAATTG 
GAGGCACAGG AGCCCGCGCA GCCGCAGAAG CAGAAAGAGG TGGTGGACCA GGAAATTGAA 
ACCGAGGATG AGCCCTCCTC CGATACGGTA ATCTGCGTGG CCGACATCAA CCCCTACGGC 
AGTGGTTCCA ACATTGACGA CTTCGTTATG GATCCCGATG CTCCTCCCAA TGCAATAATC 
ACCGAGGTGG TTACCATTCC AGCTCCTCTT CATCTCAAAG GGACACAACA ACTGGGGCTG 
CCATTGGCTG CCCCACCGCC ACCACCACCT CCTCCAGCAG CGGAACAAGT CCCCGAGACT 
CCCGCCTCGC CCACAGATGA CGGCGAGGAA CCACCAGCAG TATATTTATC CCCCTACATA 
CGCTCTCGCT ACATGCAGGA ATCGACACCT GGCCTGCCCA CCCGCCTGGC GCCGCGTGAT 
CCTCGCCAGC GCAACATGCC GCCGCCAGCC GTAGTTCTGC CCATTCAAAC CGTACTTAGC 
GCCAACGTTG AGGCCATTTC TGACGACAGC AGCGAAACTA GCAGCAGCGA TGACGATGAA 
GAGGAAGAGG AGGACGAAGA TGATGCCTTG ACCATGGAGC ACGACAACAC TTCCAGGGAG 
ACGGTCATCA CAACAGGTGA CCCTCTGATG CAAAAGATCG ATATAAGCGA AAATCCCGAC 
AAGATCTATT TTATTCGGCG CGAGGATGGC ACCGTGCACC GTGGCCAGGT GCTTCAGTCT 
CGCACCACTG AGAATGCGGC CGCTCCCGAT GAGTACTACG TCCACTATGT TGGTCTCAAT 
CGCCGCCTGG ACGGATGGGT GGGCAGGCAT AGGATCTCGG ACAATGCGGA TGACTTGGGC 
GGTATTACCG TGCTGCCAGC GCCACCATTA GCCCCCGATC AGCCAAGTAC TAGCAGGGAA 
ATGCTCGCCC AACAGGCCGC CGCGGCGGCA GCTGCCTCAT CCGAACGGCA GAAGCGTGCG 
GCCAACAAGG ATTACTATCT GTCCTATTGC GAGAACAGTC GCTATGACTA CAGCGACCGC 
AAGATGACAC GCTACCAGAA GCGGCGCTAC GATGAGATCA ACCACGTGCA GAAGAGCCAC 
GCTGAGCTGA CCGCCACGCA GGCGGCGCTG GAGAAGGAGC ACGAGTCCAT TACGAAGATC 
AAGTACATTG ATAAGCTGCA GTTTGGCAAC TACGAGATCG ACACCTGGTA CTTTAGTCCC 
TTCCCCGAAG AATATGGCAA GGCACGTACG TTATATGTTT GCGAGTACTG CCTAAAGTAC 
ATGCGCTTCA GGTCGAGCTA TGCCTATCAT CTGCACGAAT GCGACCGCAG GCGTCCGCCC 
GGAAGAGAGA TCTACCGCAA GGGCAATATA TCCATTTACG AGGTGAACGG CAAGGAGGAG 
TCACTATACT GCCAACTTTT GTGTCTGATG GCCAAGCTCT TTTTGGACCA CAAGGTTCTA 
TACTTCGACA TGGACCCGTT TCTCTTTTAC ATCCTTTGCG AGACGGACAA GGAGGGCAGT 
CACATTGTGG GCTATTTCTC CAAGGAAAAG AAGTCGCTGG AAAACTACAA CGTGGCCTGC 
ATTCTGGTAT TGCCGCCGCA TCAGCGTAAG GGATTTGGAA AGCTACTAAT AGCCTTTAGC 
TATGAGCTGT CGCGCAAGGA GGGCGTAATC GGTAGTCCGG AGAAACCGCT CTCGGATCTG 
GGTAGGCTGA GCTATCGCAG CTATTGGGCA TACACGCTGC TGGAGCTGAT GAAAACCCGC 
TGCGCTCCAG AGCAGATCAC AATCAAGGAG CTGAGCGAAA TGAGTGGCAT CACCCACGAC 
GACATTATCT ACACGCTGCA GTCCATGAAG ATGATCAAGT ATTGGAAGGG CCAGAATGTC 
ATTTGCGTTA CGTCCAAGAC CATTCAAGAC CACCTCCAGC TGCCGCAGTT CAAGCAGCCC 
AAGCTGACCA TCGACACCGA TTACCTCGTC TGGAGTCCGC AAACTGCAGC GGCAGTGGTC 
AGAGCTCCGG GAAATTCCGG CTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Gene Model Annotations for Drosophila melanogaster: Impact of High-Throughput Data.
G3 (Bethesda, Md.)5(8)1721-36(2015 Jun)
Matthews BB,Dos Santos G,Crosby MA,Emmert DB,St Pierre SE,Gramates LS,Zhou P,Schroeder AJ,Falls K,Strelets V,Russo SM,Gelbart WM,

Gene Model Annotations for Drosophila melanogaster: The Rule-Benders.
G3 (Bethesda, Md.)5(8)1737-49(2015 Jun)
Crosby MA,Gramates LS,Dos Santos G,Matthews BB,St Pierre SE,Zhou P,Schroeder AJ,Falls K,Emmert DB,Russo SM,Gelbart WM,

Sequence finishing and mapping of Drosophila melanogaster heterochromatin.
Science (New York, N.Y.)316(5831)1625-8(2007 Jun)
Hoskins RA,Carlson JW,Kennedy C,Acevedo D,Evans-Holm M,Frise E,Wan KH,Park S,Mendez-Lago M,Rossi F,Villasante A,Dimitri P,Karpen GH,Celniker SE

The Release 5.1 annotation of Drosophila melanogaster heterochromatin.
Science (New York, N.Y.)316(5831)1586-91(2007 Jun)
Smith CD,Shu S,Mungall CJ,Karpen GH

Combined evidence annotation of transposable elements in genome sequences.
PLoS computational biology1(2)166-75(2005 Jul)
Quesneville H,Bergman CM,Andrieu O,Autard D,Nouaud D,Ashburner M,Anxolabehere D

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mof cDNA ORF clone, Drosophila melanogaster(fruit fly)

Gene

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gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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