rb1 cDNA ORF clone, Danio rerio(zebrafish)

Gene
Clones
gRNAs

Summary

Gene Symbol	rb1
Entrez Gene ID	777733
Full Name	retinoblastoma 1
Synonyms	zgc:154147
General protein information	Preferred Names retinoblastoma 1 Names retinoblastoma-associated protein spc
Gene Type	protein-coding
Organism	Danio rerio(zebrafish)

mRNA and Protein(s)

mRNA	Protein	Name
NM_001077780.1	NP_001071248.1	retinoblastoma-associated protein

Pathways from BioSystems

Homologies

Bos taurus (cattle)	RB1	NP_001070375.1
Homo sapiens (human)	RB1	NP_000312.2
Mus musculus (house mouse)	Rb1	NP_033055.2
Gallus gallus (chicken)	RB1	NP_989750.1
Pan troglodytes (chimpanzee)	RB1	XP_509777.3
Rattus norvegicus (Norway rat)	Rb1	NP_058741.1
Danio rerio (zebrafish)	rb1	NP_001071248.1
Xenopus tropicalis (tropical clawed frog)	rb1	XP_002935161.2
Canis lupus familiaris (dog)	RB1	XP_534118.4

Gene Ontology
Bibliography

Related articles in PubMed

Retinoblastoma 1 protects T cell maturation from premature apoptosis by inhibiting E2F1.
Zhang Z, Liu W, Zhao L, Huang Z, Chen X, Ma N, Xu J, Zhang W, Zhang Y
Development (Cambridge, England)145(1)(2018 Jan)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Our results indicate that Rb-Raf-1 interaction plays an important role in spontaneous hair cell regeneration in zebrafish
Title: Disrupting Rb-Raf-1 interaction inhibits hair cell regeneration in zebrafish lateral line neuromasts.

our analysis of zebrafish rb1 mutants reveals a previously unknown yet critical role for rb1 during retinotectal tract development and visual function.
Title: The tumor suppressor gene retinoblastoma-1 is required for retinotectal development and visual function in zebrafish.

Zebrafish usp39 regulates embryonic pituitary homeostasis by targeting rb1 and e2f4 expression, respectively, contributing to increased adenohypophyseal sensitivity to these altered cell cycle regulators
Title: Zebrafish usp39 mutation leads to rb1 mRNA splicing defect and pituitary lineage expansion.

The following rb1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the rb1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ODa35057	NM_001077780.1 Latest version!	Danio rerio retinoblastoma 1 (rb1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	12-14	$510.30 $729.00

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

rb1 ( NM_001077780.1 ) cDNA ORF clone, Danio rerio(zebrafish) -> NP_001071248.1 Danio rerio retinoblastoma 1 (rb1), mRNA.

Price & Availability↑

CloneID	ODa35057
Clone ID Related Accession (Same CDS sequence)	NM_001077780.1
Accession Version	NM_001077780.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2712bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-06-22
Organism	Danio rerio(zebrafish)
Product	retinoblastoma-associated protein
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC125966.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC125966.1, BC154730.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA2168446, SAMEA2168447 [ECO:0000350] ##Evidence-Data-END##

ATGCCGCCGA AGAAGCGCAG CAGCGGGACC CCACAGAAGA AAGAGCTGAA GGGGAGCCTG 
AAGAGCCGAT CTCCGGACAG CGGCGACAAC GCAGTGCTCA GTCCGGAACG ACACAAGGAC 
AAGGATCCTG AGTTTGTGTT TCTCAGCGAG GAGCTCCAGT CCACTAACTC CATCTGTGAT 
CATGCATGGA GAATATGGGA GAGGGAGATC AGATCGATGG ACAAGACAAA TATGCCGTAT 
TCGAACAGAC AGCAGTGGGG AGCTTGTCTT TTTATTGCTG GCATGGAGCT TGAAGGCATC 
AACCTCACTT TTACGCAGTT CCTGAAAGCA GTTGGTCTGA GTGTGAAGCA GTTCATCAGT 
CTTGTGAGGA AGATGGATGT AAATGTAGAC ACAATAAGTC CTAAAGTGAA CTCTGCTGTG 
ACCCGCCTAG AGAACAAATA CGATGTGACT TTGGCCCTCT ACCAAAGATT TGTAAAGACT 
TGTGAGAAAA TCTTTGCAGA GCCTGACAAT GCAAAGAGAA AAGAGCTGTG GGAAAGCAGC 
TGGACCATGT TCCTCCTGGC CAAGGGAACA TTTCTGCAGA TGGAAGATGA CCTTGTGATC 
TCCTTCCAGT TGCTGCTGTG CGTTCTGGAG TTTTTCGCCA AGCGTTTGAG TCCGTCTCTC 
CTTCAGTCGC CCTACAATTC GGTGGTTAGT TCCTCTACCC TGAGTCCTCC GACCAGGACA 
TCACGCCGTA ATCAGGGCAA AAGCAAACCC CGTCCTGCAG AGATGGACAT GCAGCTGCTG 
GAGACGCTGT GCAAGGAGGG AGACTGCAGT GTTGATGAGG TGAAAAACGT GTACCAGAGC 
ACTTTCTGTG CCTTCCTGGA CTCTGTGGGT CTTTTAGGTC TCCAAGGGCT TCCTCCAATG 
GAAGCGCTTT CCAAGCAATA TGAAGAGTTG TATCACAAAA GCAAGGACTT TGATGCTAGG 
CTTTTCTTGT CTGACGATGA GACTCTTTCT CCCAATAAAA TCGAAGTGTC AAAGGTAGAA 
GTTACTCCAA GAAAGAATCT GTTTGCAGAG GACATTGCAA TTCCAGTTCC TCAAACTCCA 
ATCAGGGCTG CGATGACCTC CATACAGCAG CTCAGGGGTG ACCTCACCTC AGGGAGTGAC 
CAGCCTTCTA GCAATCTGCT GGTCTATTAC AAGAACTGCA CTGTTGACCC ATCTGGGGAG 
ATCAAAAAGA GGGTTGAGGA GCTTGGTGAG GTCTTCATCC AGAGGTTTGC TCAGGCTGTT 
GGTCAGCACT GTGAGGGGCT CGGCAGAAAG CGTTTTTATC TTGGTGCTCA GCTCTACTAC 
AAAGTAATGG AGTCCATGCT TAAATCGGAG GAGAAGAGGT TATCAGTGCA GAACTTTAGT 
AAACTTCTCA ACAATGCAGC GTTTCATACA TCATTGCTTG CATGCGCTCT GGAGGTTGTT 
ATAGCAACCT ATGTTGGGAG CTCCTTAAAG AATGGAGGTT TTGGCCGTAG TTCAGGGGCC 
AGCGACTCCG TTGAAAGCGA TCTGTGCTTC CCTTGGATTT TGAGTGTCTT CCAGCTGCCT 
GCTTTCGACT TTTACAAGGT GATCGAGAGC TTCATTAAAG CCGAGCCCAC CCTGAAACAT 
GACATGGTGA AGCACCTGGA GCAGTGCGAA CATGTGATCA TGGAGAGTCT TGCATGGAGA 
ACGGACTCTC CACTGTTTGA CCTGCTCAAA CAGTCTCGCG AGGAAGGACC CGGTGAACAA 
GCAGAGCCCC CTGCAACACT CAACCAGCCC CTCCATCACA ACCACACGGC TGCTGATCTG 
TATCTCTCTC CTGTCCGGCC ATGTCGTCAA CCCCCTGTAA TGGAAGCCGA GCCCCCCACA 
CCAGGCACCA GAGCCCCCCG TTCAAACTCA CTGAGCCTTT TCTACAAGAA ATTGTACAGG 
ATGGCCTACC TGCGACTGAA GATGCTGTTC TCCAATCTGC TCACCTCACA TCCAGAAATG 
GAGCCAATAA TATGGACTCT GCTTCAGCAC ACCCTCCAGA ACGAGTATGA ATTAATGCGG 
GACAGACACT TAGATCAGTT GATCATGTCA GCCATGTATG CCATATGCAA GGTGAAAAAC 
GTGGATTTGC GCTTCAAAAC TATTGTGACT GCTTACAAAG AGCTGCCAAA TACTAATCAA 
GAGACATTCA AGCGTGTGCT GATCAGAGAG GGTCAATACG ACTCCATCAT CGTCTTCTAC 
AACCTGGTGT TCATGCAGAA GCTGAAGACT AACATTCTCC AGTATTCCTC TCCTCGGCCA 
CCGCCTCTGT CTCCCATTCC CCACATCCCC TGCAGCCCCT ATAAAAACTC TCCCCTTCGG 
GTTCCTGGCA GCAATAATGT TTACGTGTCT CCTCTGAAAA GCAGCCGTGT GTCTCCTCTG 
GTCATGACCC CGCGGAGCAG AATTCTTATA TCCATTGGCG AATCCTTTGG GTCGGCAGAC 
AAATTTCAGA AGATCAATCA GATGTTGAGC AGCTCTGACT GGTCACTCAA GAGGAGTCTG 
GATGGAGGCT CTGCCCCTAA ACCCCTGAAG AGGCTGCGCT TTGACATGGA CGGACAAGAT 
GAAGCAGACG GAAGCAAATC CAGTGGCGAG TCAGCACTGA TCCAGAAGCT GGCTGAGATG 
AGCTCGACAC GTTCTCGAAT GCAGGAACAG AAACTGAAAG AGGAGTCTGA TAAAGATCAT 
CCAGAGCCCT AA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001071248.1
CDS	140..2851
Translation	MPPKKRSSGTPQKKELKGSLKSRSPDSGDNAVLSPERHKDKDPEFVFLSEELQSTNSICDHAWRIWEREIRSMDKTNMPYSNRQQWGACLFIAGMELEGINLTFTQFLKAVGLSVKQFISLVRKMDVNVDTISPKVNSAVTRLENKYDVTLALYQRFVKTCEKIFAEPDNAKRKELWESSWTMFLLAKGTFLQMEDDLVISFQLLLCVLEFFAKRLSPSLLQSPYNSVVSSSTLSPPTRTSRRNQGKSKPRPAEMDMQLLETLCKEGDCSVDEVKNVYQSTFCAFLDSVGLLGLQGLPPMEALSKQYEELYHKSKDFDARLFLSDDETLSPNKIEVSKVEVTPRKNLFAEDIAIPVPQTPIRAAMTSIQQLRGDLTSGSDQPSSNLLVYYKNCTVDPSGEIKKRVEELGEVFIQRFAQAVGQHCEGLGRKRFYLGAQLYYKVMESMLKSEEKRLSVQNFSKLLNNAAFHTSLLACALEVVIATYVGSSLKNGGFGRSSGASDSVESDLCFPWILSVFQLPAFDFYKVIESFIKAEPTLKHDMVKHLEQCEHVIMESLAWRTDSPLFDLLKQSREEGPGEQAEPPATLNQPLHHNHTAADLYLSPVRPCRQPPVMEAEPPTPGTRAPRSNSLSLFYKKLYRMAYLRLKMLFSNLLTSHPEMEPIIWTLLQHTLQNEYELMRDRHLDQLIMSAMYAICKVKNVDLRFKTIVTAYKELPNTNQETFKRVLIREGQYDSIIVFYNLVFMQKLKTNILQYSSPRPPPLSPIPHIPCSPYKNSPLRVPGSNNVYVSPLKSSRVSPLVMTPRSRILISIGESFGSADKFQKINQMLSSSDWSLKRSLDGGSAPKPLKRLRFDMDGQDEADGSKSSGESALIQKLAEMSSTRSRMQEQKLKEESDKDHPEP

Target ORF information:

RefSeq Version	NM_001077780.1
Organism	Danio rerio(zebrafish)
Definition	Danio rerio retinoblastoma 1 (rb1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001077780.1

ORF Insert Sequence:

ATGCCGCCGA AGAAGCGCAG CAGCGGGACC CCACAGAAGA AAGAGCTGAA GGGGAGCCTG 
AAGAGCCGAT CTCCGGACAG CGGCGACAAC GCAGTGCTCA GTCCGGAACG ACACAAGGAC 
AAGGATCCTG AGTTTGTGTT TCTCAGCGAG GAGCTCCAGT CCACTAACTC CATCTGTGAT 
CATGCATGGA GAATATGGGA GAGGGAGATC AGATCGATGG ACAAGACAAA TATGCCGTAT 
TCGAACAGAC AGCAGTGGGG AGCTTGTCTT TTTATTGCTG GCATGGAGCT TGAAGGCATC 
AACCTCACTT TTACGCAGTT CCTGAAAGCA GTTGGTCTGA GTGTGAAGCA GTTCATCAGT 
CTTGTGAGGA AGATGGATGT AAATGTAGAC ACAATAAGTC CTAAAGTGAA CTCTGCTGTG 
ACCCGCCTAG AGAACAAATA CGATGTGACT TTGGCCCTCT ACCAAAGATT TGTAAAGACT 
TGTGAGAAAA TCTTTGCAGA GCCTGACAAT GCAAAGAGAA AAGAGCTGTG GGAAAGCAGC 
TGGACCATGT TCCTCCTGGC CAAGGGAACA TTTCTGCAGA TGGAAGATGA CCTTGTGATC 
TCCTTCCAGT TGCTGCTGTG CGTTCTGGAG TTTTTCGCCA AGCGTTTGAG TCCGTCTCTC 
CTTCAGTCGC CCTACAATTC GGTGGTTAGT TCCTCTACCC TGAGTCCTCC GACCAGGACA 
TCACGCCGTA ATCAGGGCAA AAGCAAACCC CGTCCTGCAG AGATGGACAT GCAGCTGCTG 
GAGACGCTGT GCAAGGAGGG AGACTGCAGT GTTGATGAGG TGAAAAACGT GTACCAGAGC 
ACTTTCTGTG CCTTCCTGGA CTCTGTGGGT CTTTTAGGTC TCCAAGGGCT TCCTCCAATG 
GAAGCGCTTT CCAAGCAATA TGAAGAGTTG TATCACAAAA GCAAGGACTT TGATGCTAGG 
CTTTTCTTGT CTGACGATGA GACTCTTTCT CCCAATAAAA TCGAAGTGTC AAAGGTAGAA 
GTTACTCCAA GAAAGAATCT GTTTGCAGAG GACATTGCAA TTCCAGTTCC TCAAACTCCA 
ATCAGGGCTG CGATGACCTC CATACAGCAG CTCAGGGGTG ACCTCACCTC AGGGAGTGAC 
CAGCCTTCTA GCAATCTGCT GGTCTATTAC AAGAACTGCA CTGTTGACCC ATCTGGGGAG 
ATCAAAAAGA GGGTTGAGGA GCTTGGTGAG GTCTTCATCC AGAGGTTTGC TCAGGCTGTT 
GGTCAGCACT GTGAGGGGCT CGGCAGAAAG CGTTTTTATC TTGGTGCTCA GCTCTACTAC 
AAAGTAATGG AGTCCATGCT TAAATCGGAG GAGAAGAGGT TATCAGTGCA GAACTTTAGT 
AAACTTCTCA ACAATGCAGC GTTTCATACA TCATTGCTTG CATGCGCTCT GGAGGTTGTT 
ATAGCAACCT ATGTTGGGAG CTCCTTAAAG AATGGAGGTT TTGGCCGTAG TTCAGGGGCC 
AGCGACTCCG TTGAAAGCGA TCTGTGCTTC CCTTGGATTT TGAGTGTCTT CCAGCTGCCT 
GCTTTCGACT TTTACAAGGT GATCGAGAGC TTCATTAAAG CCGAGCCCAC CCTGAAACAT 
GACATGGTGA AGCACCTGGA GCAGTGCGAA CATGTGATCA TGGAGAGTCT TGCATGGAGA 
ACGGACTCTC CACTGTTTGA CCTGCTCAAA CAGTCTCGCG AGGAAGGACC CGGTGAACAA 
GCAGAGCCCC CTGCAACACT CAACCAGCCC CTCCATCACA ACCACACGGC TGCTGATCTG 
TATCTCTCTC CTGTCCGGCC ATGTCGTCAA CCCCCTGTAA TGGAAGCCGA GCCCCCCACA 
CCAGGCACCA GAGCCCCCCG TTCAAACTCA CTGAGCCTTT TCTACAAGAA ATTGTACAGG 
ATGGCCTACC TGCGACTGAA GATGCTGTTC TCCAATCTGC TCACCTCACA TCCAGAAATG 
GAGCCAATAA TATGGACTCT GCTTCAGCAC ACCCTCCAGA ACGAGTATGA ATTAATGCGG 
GACAGACACT TAGATCAGTT GATCATGTCA GCCATGTATG CCATATGCAA GGTGAAAAAC 
GTGGATTTGC GCTTCAAAAC TATTGTGACT GCTTACAAAG AGCTGCCAAA TACTAATCAA 
GAGACATTCA AGCGTGTGCT GATCAGAGAG GGTCAATACG ACTCCATCAT CGTCTTCTAC 
AACCTGGTGT TCATGCAGAA GCTGAAGACT AACATTCTCC AGTATTCCTC TCCTCGGCCA 
CCGCCTCTGT CTCCCATTCC CCACATCCCC TGCAGCCCCT ATAAAAACTC TCCCCTTCGG 
GTTCCTGGCA GCAATAATGT TTACGTGTCT CCTCTGAAAA GCAGCCGTGT GTCTCCTCTG 
GTCATGACCC CGCGGAGCAG AATTCTTATA TCCATTGGCG AATCCTTTGG GTCGGCAGAC 
AAATTTCAGA AGATCAATCA GATGTTGAGC AGCTCTGACT GGTCACTCAA GAGGAGTCTG 
GATGGAGGCT CTGCCCCTAA ACCCCTGAAG AGGCTGCGCT TTGACATGGA CGGACAAGAT 
GAAGCAGACG GAAGCAAATC CAGTGGCGAG TCAGCACTGA TCCAGAAGCT GGCTGAGATG 
AGCTCGACAC GTTCTCGAAT GCAGGAACAG AAACTGAAAG AGGAGTCTGA TAAAGATCAT 
CCAGAGCCCT AA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Retinoblastoma 1 protects T cell maturation from premature apoptosis by inhibiting E2F1.
Development (Cambridge, England)145(1)(2018 Jan)
Zhang Z,Liu W,Zhao L,Huang Z,Chen X,Ma N,Xu J,Zhang W,Zhang Y

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rb1 cDNA ORF clone, Danio rerio(zebrafish)

Gene

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gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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