adrbk2 cDNA ORF clone, Danio rerio(zebrafish)

Gene
Clones
gRNAs

Summary

Gene Symbol	adrbk2
Entrez Gene ID	569403
Full Name	G protein-coupled receptor kinase 3
Synonyms	adrbk2,si:dz221d18.1
General protein information	Preferred Names G protein-coupled receptor kinase 3 Names beta-adrenergic receptor kinase 2 G-protein coupled receptor kinase 2/3 GRK2/3 adrenergic, beta, receptor kinase 2
Gene Type	protein-coding
Organism	Danio rerio(zebrafish)

mRNA and Protein(s)

mRNA	Protein	Name
XM_009305689.2	XP_009303964.1	beta-adrenergic receptor kinase 2 isoform X1
NM_001134725.1	NP_001128197.1	beta-adrenergic receptor kinase 2
XM_009305689.3	XP_009303964.1	beta-adrenergic receptor kinase 2 isoform X1

Pathways from BioSystems

Homologies

Homo sapiens (human)	ADRBK2	NP_005151.2
Caenorhabditis elegans (roundworm)	grk-2	NP_497235.2
Pan troglodytes (chimpanzee)	ADRBK2	XP_003317197.1
Mus musculus (house mouse)	Adrbk2	NP_796052.2
Canis lupus familiaris (dog)	ADRBK2	XP_543453.3
Drosophila melanogaster (fruit fly)	Gprk1	NP_001163051.1
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP012026	XP_320502.4
Xenopus tropicalis (tropical clawed frog)	adrbk2	XP_002932117.2
	ADRBK2	XP_001104308.1
Bos taurus (cattle)	ADRBK2	NP_776925.1
Rattus norvegicus (Norway rat)	Adrbk2	NP_037029.1
Gallus gallus (chicken)	ADRBK2	XP_415195.4
Danio rerio (zebrafish)	adrbk2	NP_001128197.1

Gene Ontology
Bibliography

Related articles in PubMed

Induction of cardiac dysfunction in developing and adult zebrafish by chronic isoproterenol stimulation.
Kossack M, Hein S, Juergensen L, Siragusa M, Benz A, Katus HA, Most P, Hassel D
Journal of molecular and cellular cardiology10895-105(2017 Jul)

Evolution of complexity in the zebrafish synapse proteome.
Bay?s ?, Collins MO, Reig-Viader R, Gou G, Goulding D, Izquierdo A, Choudhary JS, Emes RD, Grant SG
Nature communications814613(2017 Mar)

A Zebrafish Model for a Human Myopathy Associated with Mutation of the Unconventional Myosin MYO18B.
Gurung R, Ono Y, Baxendale S, Lee SL, Moore S, Calvert M, Ingham PW
Genetics205(2)725-735(2017 02)

An essential role for Grk2 in Hedgehog signalling downstream of Smoothened.
Zhao Z, Lee RT, Pusapati GV, Iyu A, Rohatgi R, Ingham PW
EMBO reports17(5)739-52(2016 05)

Gene evolution and gene expression after whole genome duplication in fish: the PhyloFish database.
Pasquier J, Cabau C, Nguyen T, Jouanno E, Severac D, Braasch I, Journot L, Pontarotti P, Klopp C, Postlethwait JH, Guiguen Y, Bobe J
BMC genomics17368(2016 05)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

beta-arrestin 2 and GRK2 colocalize with S1p2 in developing zebrafish embryos and depletion of GRK2 in the S1p2 R150H miles apart zebrafish partially rescued cardia bifida.
Title: Phenotypic regulation of the sphingosine 1-phosphate receptor miles apart by G protein-coupled receptor kinase 2.

GRK2 and GRK5 control cardiac function as well as morphogenesis during development although with different morphological outcomes.
Title: Overlapping and opposing functions of G protein-coupled receptor kinase 2 (GRK2) and GRK5 during heart development.

These data thus reveal a novel kinase activity-independent function for GRK and establish a role for GRK2 as a cell-cycle regulator during early embryonic development.
Title: Kinase activity-independent regulation of cyclin pathway by GRK2 is essential for zebrafish early development.

Data suggest that a G protein-coupled receptor kinase, perhaps GRK2 or 3, functions as a vertebrate kinase for Smoothened, promoting Hedgehog signal transduction during early development.
Title: Smoothened signaling in vertebrates is facilitated by a G protein-coupled receptor kinase.

The following adrbk2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the adrbk2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
ODa30897	NM_001134725.1 Latest version!	Danio rerio G protein-coupled receptor kinase 3 (grk3), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	12-14	$426.30 $609.00
ODa45736	XM_009305689.3 Latest version!	Danio rerio adrenergic, beta, receptor kinase 2 (adrbk2), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	12-14	$426.30 $609.00
View Old Accession Versions >>
ODa45736	XM_009305689.2	Danio rerio adrenergic, beta, receptor kinase 2 (adrbk2), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	12-14	$426.30 $609.00
Hide Old Accession Versions >>

ORF Online Only Promotion

Next-day Shipping ORF Clones ( in default vector with tag)
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5 or more Clone	50% OFF
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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

adrbk2 ( NM_001134725.1 ) cDNA ORF clone, Danio rerio(zebrafish) -> NP_001128197.1 Danio rerio G protein-coupled receptor kinase 3 (grk3), mRNA.

Price & Availability↑

CloneID	ODa30897
Clone ID Related Accession (Same CDS sequence)	NM_001134725.1
Accession Version	NM_001134725.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2067bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-01-26
Organism	Danio rerio(zebrafish)
Product	beta-adrenergic receptor kinase 2
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from EU924796.1. On Sep 5, 2008 this sequence version replaced XM_001920711.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: EU924796.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2168446, SAMEA2168447 [ECO:0000348] ##Evidence-Data-END##

ATGGCGGACC TCGAAGCAGT TCTCGCCGAC GTCAGTTACC TGATGGCGAT GGAGAAGAGC 
AAATCGACTC CAGCGGCCCG CGCGAGCAAG AAAATCATCC TCCCCGAACC CAGTATTCGA 
AGTGTCATGC AGAAGTATCT GGAGGAAAGG GATGAACTGG CGTTTGACAA AATCTTCAAC 
CAGAAGATCG GTTTCCTCCT CTTCAAGGAT TTCTGCATGA ACGAGATCGA CGAGGCCGTT 
CCGCAGCTCA AGTTTTACGA GGAGATTAAA GAGTACGAGA AGTTGGACTC AGAAGAGGAG 
AGGCTAACTC GCAGTCGACA GATTTATGAC GTCTACATAA TGAAGGAGCT GCTTTCATGT 
TCACATCCCT TCTCCAAGAA AGCCGTCGAC CATGTCCAGA CTCACCTAGC AAAGAAACAA 
GTTCCTCCAA ATCTCTTTCA GCCATATATT GTTGAAATCT GTGACAGTCT TCGAGGGAAT 
ATCTTTCAGA AGTTCATTGA AAGTGACAAG TTTACACGTT TCTGCCAGTG GAAGAATGTA 
GAGCTCAACA TCCATTTGAC AATGAATGAC TTCAGCGTGC ACCGCATCAT CGGCAGAGGA 
GGCTTTGGAG AGGTTTATGG ATGCAGAAAG GCAGACACGG GGAAGATGTA TGCTATGAAG 
TGTCTGGATA AAAAGCGTAT CAAAATGAAG CAGGGAGAAA CTCTGGCGCT TAATGAGAGA 
ATCATGCTGT CGCTGGTCAG CACCGGGGAC TGCCCGTTCA TAGTGTGTAT GACATATGCC 
TTCCACACCC CTGATAAACT GTGCTTCATC CTGGACCTGA TGAACGGTGG AGACCTCCAC 
TATCACCTGT CTCAGCACGG CGTCTTCAGC GAGAAGGACA TGCGCTTTTA TGCAGCGGAG 
ATCATTCTGG GCCTCGAACA CATGCACAAC CGCTTCGTCG TCTACAGAGA CCTCAAGCCT 
GCGAATATCC TCTTAGATGA GCACGGACAC GTCCGCATCT CTGACCTGGG TCTGGCCTGT 
GATTTCTCCA AGAAGAAGCC TCACGCCAGC GTAGGGACTC ATGGCTACAT GGCACCTGAG 
GTTCTGCAGA AGGGAACGGC GTACGACAGC AGCGCCGACT GGTTCTCTCT GGGCTGCATG 
CTGTTCAAAC TCCTGCGAGG GCACAGTCCA TTCAGGCAGC ACAAGACCAA AGACAAACAC 
GAGATCGACC GCATGACGCT TACCATGAAT GTGGAGTTGC CTGATTCCTT CACTCCCGAG 
CTCAAGTCTC TCCTGGAAGG ACTCCTACAG CGAGATGTGG CCAAACGATT GGGCTGCCTG 
GGACGAGGGG CGTCAGAGGT GAAGGAGCAC GTGTTCTTCA AGGGAATCGA TTGGCAGCAG 
GTTTATCTCC AGAAGTATCC TCCACCACTC ATCCCCCCCA GAGGAGAGGT CAACGCTGCG 
GACGCCTTCG ACATCGGCTC CTTCGACGAA GAGGACACCA AGGGAATCAA GCTTCTGGAC 
AGCGATCAGG AGCTGTATAA GAACTTTCCG CTGGTGATCT CCGAGCGCTG GCAGCAGGAG 
GTGGCCGAGA CCGTGTATGA AGCTGTGAAC AGCGACACGG ATAAAAACGA GGCTCGCAAG 
AGGGCCAAAA ACAAGCAGCA AGGCCACGAA GAAGATTACG CGCTGGGGAA GGACTGCATC 
ATGCACGGCT ACATGCTAAA GCTAGGAAAC CCCTTCCTGA CGCAGTGGCA GCGGCGCTAT 
TTCTATCTGT TCCCCAACCG TGTGGAGTGG AGAGGTGAAG GAGAGTCTCG GCAAAACCTG 
CTGACCATGG AGCATATCGT GACGGTGGAG GAGACGCAGA TCAAGGACAA GAAGTGCATC 
CTGCTGAGGG TTAAAGGAGG GAAGCAGTTC GTCCTGCAGT GTGAGAGCGA CCCAGAGTTC 
GTCCAGTGGA AGAAGGAGCT GACCGAAGCG TTCACCGAGG CCCAGAAGCT GCTGCGTCGA 
GCTCCTAAAG TCATCGGCAA GGGCAGAACT AACGTGGTGG AGCTCTCCAA ACCTCCGCTC 
ACACACCGCA ACAGCAACGG CCTGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001128197.1
CDS	1..2067
Translation	MADLEAVLADVSYLMAMEKSKSTPAARASKKIILPEPSIRSVMQKYLEERDELAFDKIFNQKIGFLLFKDFCMNEIDEAVPQLKFYEEIKEYEKLDSEEERLTRSRQIYDVYIMKELLSCSHPFSKKAVDHVQTHLAKKQVPPNLFQPYIVEICDSLRGNIFQKFIESDKFTRFCQWKNVELNIHLTMNDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSLVSTGDCPFIVCMTYAFHTPDKLCFILDLMNGGDLHYHLSQHGVFSEKDMRFYAAEIILGLEHMHNRFVVYRDLKPANILLDEHGHVRISDLGLACDFSKKKPHASVGTHGYMAPEVLQKGTAYDSSADWFSLGCMLFKLLRGHSPFRQHKTKDKHEIDRMTLTMNVELPDSFTPELKSLLEGLLQRDVAKRLGCLGRGASEVKEHVFFKGIDWQQVYLQKYPPPLIPPRGEVNAADAFDIGSFDEEDTKGIKLLDSDQELYKNFPLVISERWQQEVAETVYEAVNSDTDKNEARKRAKNKQQGHEEDYALGKDCIMHGYMLKLGNPFLTQWQRRYFYLFPNRVEWRGEGESRQNLLTMEHIVTVEETQIKDKKCILLRVKGGKQFVLQCESDPEFVQWKKELTEAFTEAQKLLRRAPKVIGKGRTNVVELSKPPLTHRNSNGL

Target ORF information:

RefSeq Version	NM_001134725.1
Organism	Danio rerio(zebrafish)
Definition	Danio rerio G protein-coupled receptor kinase 3 (grk3), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001134725.1

ORF Insert Sequence:

ATGGCGGACC TCGAAGCAGT TCTCGCCGAC GTCAGTTACC TGATGGCGAT GGAGAAGAGC 
AAATCGACTC CAGCGGCCCG CGCGAGCAAG AAAATCATCC TCCCCGAACC CAGTATTCGA 
AGTGTCATGC AGAAGTATCT GGAGGAAAGG GATGAACTGG CGTTTGACAA AATCTTCAAC 
CAGAAGATCG GTTTCCTCCT CTTCAAGGAT TTCTGCATGA ACGAGATCGA CGAGGCCGTT 
CCGCAGCTCA AGTTTTACGA GGAGATTAAA GAGTACGAGA AGTTGGACTC AGAAGAGGAG 
AGGCTAACTC GCAGTCGACA GATTTATGAC GTCTACATAA TGAAGGAGCT GCTTTCATGT 
TCACATCCCT TCTCCAAGAA AGCCGTCGAC CATGTCCAGA CTCACCTAGC AAAGAAACAA 
GTTCCTCCAA ATCTCTTTCA GCCATATATT GTTGAAATCT GTGACAGTCT TCGAGGGAAT 
ATCTTTCAGA AGTTCATTGA AAGTGACAAG TTTACACGTT TCTGCCAGTG GAAGAATGTA 
GAGCTCAACA TCCATTTGAC AATGAATGAC TTCAGCGTGC ACCGCATCAT CGGCAGAGGA 
GGCTTTGGAG AGGTTTATGG ATGCAGAAAG GCAGACACGG GGAAGATGTA TGCTATGAAG 
TGTCTGGATA AAAAGCGTAT CAAAATGAAG CAGGGAGAAA CTCTGGCGCT TAATGAGAGA 
ATCATGCTGT CGCTGGTCAG CACCGGGGAC TGCCCGTTCA TAGTGTGTAT GACATATGCC 
TTCCACACCC CTGATAAACT GTGCTTCATC CTGGACCTGA TGAACGGTGG AGACCTCCAC 
TATCACCTGT CTCAGCACGG CGTCTTCAGC GAGAAGGACA TGCGCTTTTA TGCAGCGGAG 
ATCATTCTGG GCCTCGAACA CATGCACAAC CGCTTCGTCG TCTACAGAGA CCTCAAGCCT 
GCGAATATCC TCTTAGATGA GCACGGACAC GTCCGCATCT CTGACCTGGG TCTGGCCTGT 
GATTTCTCCA AGAAGAAGCC TCACGCCAGC GTAGGGACTC ATGGCTACAT GGCACCTGAG 
GTTCTGCAGA AGGGAACGGC GTACGACAGC AGCGCCGACT GGTTCTCTCT GGGCTGCATG 
CTGTTCAAAC TCCTGCGAGG GCACAGTCCA TTCAGGCAGC ACAAGACCAA AGACAAACAC 
GAGATCGACC GCATGACGCT TACCATGAAT GTGGAGTTGC CTGATTCCTT CACTCCCGAG 
CTCAAGTCTC TCCTGGAAGG ACTCCTACAG CGAGATGTGG CCAAACGATT GGGCTGCCTG 
GGACGAGGGG CGTCAGAGGT GAAGGAGCAC GTGTTCTTCA AGGGAATCGA TTGGCAGCAG 
GTTTATCTCC AGAAGTATCC TCCACCACTC ATCCCCCCCA GAGGAGAGGT CAACGCTGCG 
GACGCCTTCG ACATCGGCTC CTTCGACGAA GAGGACACCA AGGGAATCAA GCTTCTGGAC 
AGCGATCAGG AGCTGTATAA GAACTTTCCG CTGGTGATCT CCGAGCGCTG GCAGCAGGAG 
GTGGCCGAGA CCGTGTATGA AGCTGTGAAC AGCGACACGG ATAAAAACGA GGCTCGCAAG 
AGGGCCAAAA ACAAGCAGCA AGGCCACGAA GAAGATTACG CGCTGGGGAA GGACTGCATC 
ATGCACGGCT ACATGCTAAA GCTAGGAAAC CCCTTCCTGA CGCAGTGGCA GCGGCGCTAT 
TTCTATCTGT TCCCCAACCG TGTGGAGTGG AGAGGTGAAG GAGAGTCTCG GCAAAACCTG 
CTGACCATGG AGCATATCGT GACGGTGGAG GAGACGCAGA TCAAGGACAA GAAGTGCATC 
CTGCTGAGGG TTAAAGGAGG GAAGCAGTTC GTCCTGCAGT GTGAGAGCGA CCCAGAGTTC 
GTCCAGTGGA AGAAGGAGCT GACCGAAGCG TTCACCGAGG CCCAGAAGCT GCTGCGTCGA 
GCTCCTAAAG TCATCGGCAA GGGCAGAACT AACGTGGTGG AGCTCTCCAA ACCTCCGCTC 
ACACACCGCA ACAGCAACGG CCTGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

adrbk2 ( XM_009305689.2 ) cDNA ORF clone, Danio rerio(zebrafish) -> XP_009303964.1 Danio rerio adrenergic, beta, receptor kinase 2 (adrbk2), transcript variant X1, mRNA.

Price & Availability↑

CloneID	ODa45736
Clone ID Related Accession (Same CDS sequence)	XM_009305689.2 , XM_009305689.3
Accession Version	XM_009305689.2	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2106bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-06-23
Organism	Danio rerio(Zebrafish)
Product	beta-adrenergic receptor kinase 2 isoform X1
Comment	MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_007121.6) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Jun 24, 2016 this sequence version replaced XM_009305689.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Danio rerio Annotation Release 105 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGGCGGACC TCGAAGCAGT TCTCGCCGAC GTCAGTTACC TGATGGCGAT GGAGAAGAGC 
AAATCGACTC CAGCGGCCCG CGCGAGCAAG AAAATCATCC TCCCCGAACC CAGTATTCGA 
AGTGTCATGC AGAAGTATCT GGAGGAAAGG GATGAACTGG CGTTTGACAA AATCTTCAAC 
CAGAAGATCG GTTTCCTCCT CTTCAAGGAT TTCTGCATGA ACGAGATCGA CGAGGCCGTT 
CCGCAGCTCA AGTTTTACGA GGAGATTAAA GAGTACGAGA AGTTGGACTC AGAAGAGGAG 
AGGCTAACTC GCAGTCGACA GATTTATGAC GTCTACATAA TGAAGGAGCT GCTTTCATGT 
TCACATCCCT TCTCCAAGAA AGCCGTCGAC CATGTCCAGA CTCACCTAGC AAAGAAACAA 
GTTCCTCCAA ATCTCTTTCA GCCATATATT GTTGAAATCT GTGACAGTCT TCGAGGGAAT 
ATCTTTCAGA AGTTCATTGA AAGTGACAAG TTTACACGTT TCTGCCAGTG GAAGAATGTA 
GAGCTCAACA TCCATTTGAC AATGAATGAC TTCAGCGTGC ACCGCATCAT CGGCAGAGGA 
GGCTTTGGAG AGGTTTATGG ATGCAGAAAG GCAGACACGG GGAAGATGTA TGCTATGAAG 
TGTCTGGATA AAAAGCGTAT CAAAATGAAG CAGGGAGAAA CTCTGGCGCT TAATGAGAGA 
ATCATGCTGT CGCTGGTCAG CACCGGGGAC TGCCCGTTCA TAGTGTGTAT GACATATGCC 
TTCCACACCC CTGATAAACT GTGCTTCATC CTGGACCTGA TGAACGGTGG AGACCTCCAC 
TATCACCTGT CTCAGCACGG CGTCTTCAGC GAGAAGGACA TGCGCTTTTA TGCAGCGGAG 
ATCATTCTGG GCCTCGAACA CATGCACAAC CGCTTCGTCG TCTACAGAGA CCTCAAGCCT 
GCGAATATCC TCTTAGATGA GCACGGACAC GTCCGCATCT CTGACCTGGG TCTGGCCTGT 
GATTTCTCCA AGAAGAAGCC TCACGCCAGC GTAGGGACTC ATGGCTACAT GGCACCTGAG 
GTTCTGCAGA AGGGAACGGC GTACGACAGC AGCGCCGACT GGTTCTCTCT GGGCTGCATG 
CTGTTCAAAC TCCTGCGAGG GCACAGTCCA TTCAGGCAGC ACAAGACCAA AGACAAACAC 
GAGATCGACC GCATGACGCT TACCATGAAT GTGGAGTTGC CTGATTCCTT CACTCCCGAG 
CTCAAGTCTC TCCTGGAAGG ACTCCTACAG CGAGATGTGG CCAAACGATT GGGCTGCCTG 
GGACGAGGGG CGTCAGAGGT GAAGGAGCAC GTGTTCTTCA AGGGAATCGA TTGGCAGCAG 
GTTTATCTCC AGAAGTATCC TCCACCACTC ATCCCCCCCA GAGGAGAGGT CAACGCTGCG 
GACGCCTTCG ACATCGGCTC CTTCGACGAA GAGGACACCA AGGGAATCAA GCTTCTGGAC 
AGCGATCAGG AGCTGTATAA GAACTTTCCG CTGGTGATCT CCGAGCGCTG GCAGCAGGAG 
GTGGCCGAGA CCGTGTATGA AGCTGTGAAC AGCGACACGG ATAAAAACGA GGCTCGCAAG 
AGGGCCAAAA ACAAGCAGCA AGGCCACGAA GAAGATTACG CGCTGGGGAA GGACTGCATC 
ATGCACGGCT ACATGCTAAA GCTAGGAAAC CCCTTCCTGA CGCAGTGGCA GCGGCGCTAT 
TTCTATCTGT TCCCCAACCG TGTGGAGTGG AGAGGTGAAG GAGAGTCTCG GGAATGTTGG 
ACTAAAACGT TAAAAAAACA TAAATTCAAG CAAAACCTGC TGACCATGGA GCATATCGTG 
ACGGTGGAGG AGACGCAGAT CAAGGACAAG AAGTGCATCC TGCTGAGGGT TAAAGGAGGG 
AAGCAGTTCG TCCTGCAGTG TGAGAGCGAC CCAGAGTTCG TCCAGTGGAA GAAGGAGCTG 
ACCGAAGCGT TCACCGAGGC CCAGAAGCTG CTGCGTCGAG CTCCTAAAGT CATCGGCAAG 
GGCAGAACTA ACGTGGTGGA GCTCTCCAAA CCTCCGCTCA CACACCGCAA CAGCAACGGC 
CTGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_009303964.1
CDS	1875..3980
Translation	MADLEAVLADVSYLMAMEKSKSTPAARASKKIILPEPSIRSVMQKYLEERDELAFDKIFNQKIGFLLFKDFCMNEIDEAVPQLKFYEEIKEYEKLDSEEERLTRSRQIYDVYIMKELLSCSHPFSKKAVDHVQTHLAKKQVPPNLFQPYIVEICDSLRGNIFQKFIESDKFTRFCQWKNVELNIHLTMNDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSLVSTGDCPFIVCMTYAFHTPDKLCFILDLMNGGDLHYHLSQHGVFSEKDMRFYAAEIILGLEHMHNRFVVYRDLKPANILLDEHGHVRISDLGLACDFSKKKPHASVGTHGYMAPEVLQKGTAYDSSADWFSLGCMLFKLLRGHSPFRQHKTKDKHEIDRMTLTMNVELPDSFTPELKSLLEGLLQRDVAKRLGCLGRGASEVKEHVFFKGIDWQQVYLQKYPPPLIPPRGEVNAADAFDIGSFDEEDTKGIKLLDSDQELYKNFPLVISERWQQEVAETVYEAVNSDTDKNEARKRAKNKQQGHEEDYALGKDCIMHGYMLKLGNPFLTQWQRRYFYLFPNRVEWRGEGESRECWTKTLKKHKFKQNLLTMEHIVTVEETQIKDKKCILLRVKGGKQFVLQCESDPEFVQWKKELTEAFTEAQKLLRRAPKVIGKGRTNVVELSKPPLTHRNSNGL

Target ORF information:

RefSeq Version	XM_009305689.2
Organism	Danio rerio(Zebrafish)
Definition	Danio rerio adrenergic, beta, receptor kinase 2 (adrbk2), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_009305689.2

ORF Insert Sequence:

ATGGCGGACC TCGAAGCAGT TCTCGCCGAC GTCAGTTACC TGATGGCGAT GGAGAAGAGC 
AAATCGACTC CAGCGGCCCG CGCGAGCAAG AAAATCATCC TCCCCGAACC CAGTATTCGA 
AGTGTCATGC AGAAGTATCT GGAGGAAAGG GATGAACTGG CGTTTGACAA AATCTTCAAC 
CAGAAGATCG GTTTCCTCCT CTTCAAGGAT TTCTGCATGA ACGAGATCGA CGAGGCCGTT 
CCGCAGCTCA AGTTTTACGA GGAGATTAAA GAGTACGAGA AGTTGGACTC AGAAGAGGAG 
AGGCTAACTC GCAGTCGACA GATTTATGAC GTCTACATAA TGAAGGAGCT GCTTTCATGT 
TCACATCCCT TCTCCAAGAA AGCCGTCGAC CATGTCCAGA CTCACCTAGC AAAGAAACAA 
GTTCCTCCAA ATCTCTTTCA GCCATATATT GTTGAAATCT GTGACAGTCT TCGAGGGAAT 
ATCTTTCAGA AGTTCATTGA AAGTGACAAG TTTACACGTT TCTGCCAGTG GAAGAATGTA 
GAGCTCAACA TCCATTTGAC AATGAATGAC TTCAGCGTGC ACCGCATCAT CGGCAGAGGA 
GGCTTTGGAG AGGTTTATGG ATGCAGAAAG GCAGACACGG GGAAGATGTA TGCTATGAAG 
TGTCTGGATA AAAAGCGTAT CAAAATGAAG CAGGGAGAAA CTCTGGCGCT TAATGAGAGA 
ATCATGCTGT CGCTGGTCAG CACCGGGGAC TGCCCGTTCA TAGTGTGTAT GACATATGCC 
TTCCACACCC CTGATAAACT GTGCTTCATC CTGGACCTGA TGAACGGTGG AGACCTCCAC 
TATCACCTGT CTCAGCACGG CGTCTTCAGC GAGAAGGACA TGCGCTTTTA TGCAGCGGAG 
ATCATTCTGG GCCTCGAACA CATGCACAAC CGCTTCGTCG TCTACAGAGA CCTCAAGCCT 
GCGAATATCC TCTTAGATGA GCACGGACAC GTCCGCATCT CTGACCTGGG TCTGGCCTGT 
GATTTCTCCA AGAAGAAGCC TCACGCCAGC GTAGGGACTC ATGGCTACAT GGCACCTGAG 
GTTCTGCAGA AGGGAACGGC GTACGACAGC AGCGCCGACT GGTTCTCTCT GGGCTGCATG 
CTGTTCAAAC TCCTGCGAGG GCACAGTCCA TTCAGGCAGC ACAAGACCAA AGACAAACAC 
GAGATCGACC GCATGACGCT TACCATGAAT GTGGAGTTGC CTGATTCCTT CACTCCCGAG 
CTCAAGTCTC TCCTGGAAGG ACTCCTACAG CGAGATGTGG CCAAACGATT GGGCTGCCTG 
GGACGAGGGG CGTCAGAGGT GAAGGAGCAC GTGTTCTTCA AGGGAATCGA TTGGCAGCAG 
GTTTATCTCC AGAAGTATCC TCCACCACTC ATCCCCCCCA GAGGAGAGGT CAACGCTGCG 
GACGCCTTCG ACATCGGCTC CTTCGACGAA GAGGACACCA AGGGAATCAA GCTTCTGGAC 
AGCGATCAGG AGCTGTATAA GAACTTTCCG CTGGTGATCT CCGAGCGCTG GCAGCAGGAG 
GTGGCCGAGA CCGTGTATGA AGCTGTGAAC AGCGACACGG ATAAAAACGA GGCTCGCAAG 
AGGGCCAAAA ACAAGCAGCA AGGCCACGAA GAAGATTACG CGCTGGGGAA GGACTGCATC 
ATGCACGGCT ACATGCTAAA GCTAGGAAAC CCCTTCCTGA CGCAGTGGCA GCGGCGCTAT 
TTCTATCTGT TCCCCAACCG TGTGGAGTGG AGAGGTGAAG GAGAGTCTCG GGAATGTTGG 
ACTAAAACGT TAAAAAAACA TAAATTCAAG CAAAACCTGC TGACCATGGA GCATATCGTG 
ACGGTGGAGG AGACGCAGAT CAAGGACAAG AAGTGCATCC TGCTGAGGGT TAAAGGAGGG 
AAGCAGTTCG TCCTGCAGTG TGAGAGCGAC CCAGAGTTCG TCCAGTGGAA GAAGGAGCTG 
ACCGAAGCGT TCACCGAGGC CCAGAAGCTG CTGCGTCGAG CTCCTAAAGT CATCGGCAAG 
GGCAGAACTA ACGTGGTGGA GCTCTCCAAA CCTCCGCTCA CACACCGCAA CAGCAACGGC 
CTGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

adrbk2 ( XM_009305689.3 ) cDNA ORF clone, Danio rerio(zebrafish) -> XP_009303964.1 Danio rerio adrenergic, beta, receptor kinase 2 (adrbk2), transcript variant X1, mRNA.

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CloneID	ODa45736
Clone ID Related Accession (Same CDS sequence)	XM_009305689.2 , XM_009305689.3
Accession Version	XM_009305689.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2106bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-06-14
Organism	Danio rerio(zebrafish)
Product	beta-adrenergic receptor kinase 2 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_007121.7) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Jun 15, 2017 this sequence version replaced XM_009305689.2. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Danio rerio Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.4 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGGCGGACC TCGAAGCAGT TCTCGCCGAC GTCAGTTACC TGATGGCGAT GGAGAAGAGC 
AAATCGACTC CAGCGGCCCG CGCGAGCAAG AAAATCATCC TCCCCGAACC CAGTATTCGA 
AGTGTCATGC AGAAGTATCT GGAGGAAAGG GATGAACTGG CGTTTGACAA AATCTTCAAC 
CAGAAGATCG GTTTCCTCCT CTTCAAGGAT TTCTGCATGA ACGAGATCGA CGAGGCCGTT 
CCGCAGCTCA AGTTTTACGA GGAGATTAAA GAGTACGAGA AGTTGGACTC AGAAGAGGAG 
AGGCTAACTC GCAGTCGACA GATTTATGAC GTCTACATAA TGAAGGAGCT GCTTTCATGT 
TCACATCCCT TCTCCAAGAA AGCCGTCGAC CATGTCCAGA CTCACCTAGC AAAGAAACAA 
GTTCCTCCAA ATCTCTTTCA GCCATATATT GTTGAAATCT GTGACAGTCT TCGAGGGAAT 
ATCTTTCAGA AGTTCATTGA AAGTGACAAG TTTACACGTT TCTGCCAGTG GAAGAATGTA 
GAGCTCAACA TCCATTTGAC AATGAATGAC TTCAGCGTGC ACCGCATCAT CGGCAGAGGA 
GGCTTTGGAG AGGTTTATGG ATGCAGAAAG GCAGACACGG GGAAGATGTA TGCTATGAAG 
TGTCTGGATA AAAAGCGTAT CAAAATGAAG CAGGGAGAAA CTCTGGCGCT TAATGAGAGA 
ATCATGCTGT CGCTGGTCAG CACCGGGGAC TGCCCGTTCA TAGTGTGTAT GACATATGCC 
TTCCACACCC CTGATAAACT GTGCTTCATC CTGGACCTGA TGAACGGTGG AGACCTCCAC 
TATCACCTGT CTCAGCACGG CGTCTTCAGC GAGAAGGACA TGCGCTTTTA TGCAGCGGAG 
ATCATTCTGG GCCTCGAACA CATGCACAAC CGCTTCGTCG TCTACAGAGA CCTCAAGCCT 
GCGAATATCC TCTTAGATGA GCACGGACAC GTCCGCATCT CTGACCTGGG TCTGGCCTGT 
GATTTCTCCA AGAAGAAGCC TCACGCCAGC GTAGGGACTC ATGGCTACAT GGCACCTGAG 
GTTCTGCAGA AGGGAACGGC GTACGACAGC AGCGCCGACT GGTTCTCTCT GGGCTGCATG 
CTGTTCAAAC TCCTGCGAGG GCACAGTCCA TTCAGGCAGC ACAAGACCAA AGACAAACAC 
GAGATCGACC GCATGACGCT TACCATGAAT GTGGAGTTGC CTGATTCCTT CACTCCCGAG 
CTCAAGTCTC TCCTGGAAGG ACTCCTACAG CGAGATGTGG CCAAACGATT GGGCTGCCTG 
GGACGAGGGG CGTCAGAGGT GAAGGAGCAC GTGTTCTTCA AGGGAATCGA TTGGCAGCAG 
GTTTATCTCC AGAAGTATCC TCCACCACTC ATCCCCCCCA GAGGAGAGGT CAACGCTGCG 
GACGCCTTCG ACATCGGCTC CTTCGACGAA GAGGACACCA AGGGAATCAA GCTTCTGGAC 
AGCGATCAGG AGCTGTATAA GAACTTTCCG CTGGTGATCT CCGAGCGCTG GCAGCAGGAG 
GTGGCCGAGA CCGTGTATGA AGCTGTGAAC AGCGACACGG ATAAAAACGA GGCTCGCAAG 
AGGGCCAAAA ACAAGCAGCA AGGCCACGAA GAAGATTACG CGCTGGGGAA GGACTGCATC 
ATGCACGGCT ACATGCTAAA GCTAGGAAAC CCCTTCCTGA CGCAGTGGCA GCGGCGCTAT 
TTCTATCTGT TCCCCAACCG TGTGGAGTGG AGAGGTGAAG GAGAGTCTCG GGAATGTTGG 
ACTAAAACGT TAAAAAAACA TAAATTCAAG CAAAACCTGC TGACCATGGA GCATATCGTG 
ACGGTGGAGG AGACGCAGAT CAAGGACAAG AAGTGCATCC TGCTGAGGGT TAAAGGAGGG 
AAGCAGTTCG TCCTGCAGTG TGAGAGCGAC CCAGAGTTCG TCCAGTGGAA GAAGGAGCTG 
ACCGAAGCGT TCACCGAGGC CCAGAAGCTG CTGCGTCGAG CTCCTAAAGT CATCGGCAAG 
GGCAGAACTA ACGTGGTGGA GCTCTCCAAA CCTCCGCTCA CACACCGCAA CAGCAACGGC 
CTGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_009303964.1
CDS	1847..3952
Translation	MADLEAVLADVSYLMAMEKSKSTPAARASKKIILPEPSIRSVMQKYLEERDELAFDKIFNQKIGFLLFKDFCMNEIDEAVPQLKFYEEIKEYEKLDSEEERLTRSRQIYDVYIMKELLSCSHPFSKKAVDHVQTHLAKKQVPPNLFQPYIVEICDSLRGNIFQKFIESDKFTRFCQWKNVELNIHLTMNDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSLVSTGDCPFIVCMTYAFHTPDKLCFILDLMNGGDLHYHLSQHGVFSEKDMRFYAAEIILGLEHMHNRFVVYRDLKPANILLDEHGHVRISDLGLACDFSKKKPHASVGTHGYMAPEVLQKGTAYDSSADWFSLGCMLFKLLRGHSPFRQHKTKDKHEIDRMTLTMNVELPDSFTPELKSLLEGLLQRDVAKRLGCLGRGASEVKEHVFFKGIDWQQVYLQKYPPPLIPPRGEVNAADAFDIGSFDEEDTKGIKLLDSDQELYKNFPLVISERWQQEVAETVYEAVNSDTDKNEARKRAKNKQQGHEEDYALGKDCIMHGYMLKLGNPFLTQWQRRYFYLFPNRVEWRGEGESRECWTKTLKKHKFKQNLLTMEHIVTVEETQIKDKKCILLRVKGGKQFVLQCESDPEFVQWKKELTEAFTEAQKLLRRAPKVIGKGRTNVVELSKPPLTHRNSNGL

Target ORF information:

RefSeq Version	XM_009305689.3
Organism	Danio rerio(zebrafish)
Definition	Danio rerio adrenergic, beta, receptor kinase 2 (adrbk2), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_009305689.3

ORF Insert Sequence:

ATGGCGGACC TCGAAGCAGT TCTCGCCGAC GTCAGTTACC TGATGGCGAT GGAGAAGAGC 
AAATCGACTC CAGCGGCCCG CGCGAGCAAG AAAATCATCC TCCCCGAACC CAGTATTCGA 
AGTGTCATGC AGAAGTATCT GGAGGAAAGG GATGAACTGG CGTTTGACAA AATCTTCAAC 
CAGAAGATCG GTTTCCTCCT CTTCAAGGAT TTCTGCATGA ACGAGATCGA CGAGGCCGTT 
CCGCAGCTCA AGTTTTACGA GGAGATTAAA GAGTACGAGA AGTTGGACTC AGAAGAGGAG 
AGGCTAACTC GCAGTCGACA GATTTATGAC GTCTACATAA TGAAGGAGCT GCTTTCATGT 
TCACATCCCT TCTCCAAGAA AGCCGTCGAC CATGTCCAGA CTCACCTAGC AAAGAAACAA 
GTTCCTCCAA ATCTCTTTCA GCCATATATT GTTGAAATCT GTGACAGTCT TCGAGGGAAT 
ATCTTTCAGA AGTTCATTGA AAGTGACAAG TTTACACGTT TCTGCCAGTG GAAGAATGTA 
GAGCTCAACA TCCATTTGAC AATGAATGAC TTCAGCGTGC ACCGCATCAT CGGCAGAGGA 
GGCTTTGGAG AGGTTTATGG ATGCAGAAAG GCAGACACGG GGAAGATGTA TGCTATGAAG 
TGTCTGGATA AAAAGCGTAT CAAAATGAAG CAGGGAGAAA CTCTGGCGCT TAATGAGAGA 
ATCATGCTGT CGCTGGTCAG CACCGGGGAC TGCCCGTTCA TAGTGTGTAT GACATATGCC 
TTCCACACCC CTGATAAACT GTGCTTCATC CTGGACCTGA TGAACGGTGG AGACCTCCAC 
TATCACCTGT CTCAGCACGG CGTCTTCAGC GAGAAGGACA TGCGCTTTTA TGCAGCGGAG 
ATCATTCTGG GCCTCGAACA CATGCACAAC CGCTTCGTCG TCTACAGAGA CCTCAAGCCT 
GCGAATATCC TCTTAGATGA GCACGGACAC GTCCGCATCT CTGACCTGGG TCTGGCCTGT 
GATTTCTCCA AGAAGAAGCC TCACGCCAGC GTAGGGACTC ATGGCTACAT GGCACCTGAG 
GTTCTGCAGA AGGGAACGGC GTACGACAGC AGCGCCGACT GGTTCTCTCT GGGCTGCATG 
CTGTTCAAAC TCCTGCGAGG GCACAGTCCA TTCAGGCAGC ACAAGACCAA AGACAAACAC 
GAGATCGACC GCATGACGCT TACCATGAAT GTGGAGTTGC CTGATTCCTT CACTCCCGAG 
CTCAAGTCTC TCCTGGAAGG ACTCCTACAG CGAGATGTGG CCAAACGATT GGGCTGCCTG 
GGACGAGGGG CGTCAGAGGT GAAGGAGCAC GTGTTCTTCA AGGGAATCGA TTGGCAGCAG 
GTTTATCTCC AGAAGTATCC TCCACCACTC ATCCCCCCCA GAGGAGAGGT CAACGCTGCG 
GACGCCTTCG ACATCGGCTC CTTCGACGAA GAGGACACCA AGGGAATCAA GCTTCTGGAC 
AGCGATCAGG AGCTGTATAA GAACTTTCCG CTGGTGATCT CCGAGCGCTG GCAGCAGGAG 
GTGGCCGAGA CCGTGTATGA AGCTGTGAAC AGCGACACGG ATAAAAACGA GGCTCGCAAG 
AGGGCCAAAA ACAAGCAGCA AGGCCACGAA GAAGATTACG CGCTGGGGAA GGACTGCATC 
ATGCACGGCT ACATGCTAAA GCTAGGAAAC CCCTTCCTGA CGCAGTGGCA GCGGCGCTAT 
TTCTATCTGT TCCCCAACCG TGTGGAGTGG AGAGGTGAAG GAGAGTCTCG GGAATGTTGG 
ACTAAAACGT TAAAAAAACA TAAATTCAAG CAAAACCTGC TGACCATGGA GCATATCGTG 
ACGGTGGAGG AGACGCAGAT CAAGGACAAG AAGTGCATCC TGCTGAGGGT TAAAGGAGGG 
AAGCAGTTCG TCCTGCAGTG TGAGAGCGAC CCAGAGTTCG TCCAGTGGAA GAAGGAGCTG 
ACCGAAGCGT TCACCGAGGC CCAGAAGCTG CTGCGTCGAG CTCCTAAAGT CATCGGCAAG 
GGCAGAACTA ACGTGGTGGA GCTCTCCAAA CCTCCGCTCA CACACCGCAA CAGCAACGGC 
CTGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Induction of cardiac dysfunction in developing and adult zebrafish by chronic isoproterenol stimulation.
Journal of molecular and cellular cardiology10895-105(2017 Jul)
Kossack M,Hein S,Juergensen L,Siragusa M,Benz A,Katus HA,Most P,Hassel D

Evolution of complexity in the zebrafish synapse proteome.
Nature communications814613(2017 Mar)
Bay?s ?,Collins MO,Reig-Viader R,Gou G,Goulding D,Izquierdo A,Choudhary JS,Emes RD,Grant SG

A Zebrafish Model for a Human Myopathy Associated with Mutation of the Unconventional Myosin MYO18B.
Genetics205(2)725-735(2017 02)
Gurung R,Ono Y,Baxendale S,Lee SL,Moore S,Calvert M,Ingham PW

An essential role for Grk2 in Hedgehog signalling downstream of Smoothened.
EMBO reports17(5)739-52(2016 05)
Zhao Z,Lee RT,Pusapati GV,Iyu A,Rohatgi R,Ingham PW

Gene evolution and gene expression after whole genome duplication in fish: the PhyloFish database.
BMC genomics17368(2016 05)
Pasquier J,Cabau C,Nguyen T,Jouanno E,Severac D,Braasch I,Journot L,Pontarotti P,Klopp C,Postlethwait JH,Guiguen Y,Bobe J

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adrbk2 cDNA ORF clone, Danio rerio(zebrafish)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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