exosc3 cDNA ORF clone, Danio rerio(zebrafish)

Gene
Clones
gRNAs

Summary

Gene Symbol	exosc3
Entrez Gene ID	565000
Full Name	exosome component 3
Synonyms	im:7140537,zgc:112345
General protein information	Preferred Names exosome component 3 Names exosome complex exonuclease RRP40
Gene Type	protein-coding
Organism	Danio rerio(zebrafish)

mRNA and Protein(s)

mRNA	Protein	Name
NM_001029961.1	NP_001025132.1	exosome complex exonuclease RRP40

Pathways from BioSystems

Homologies

Caenorhabditis elegans (roundworm)	exos-3	NP_492751.1
Eremothecium gossypii	AGOS_ADL196W	NP_983900.2
Schizosaccharomyces pombe (fission yeast)	SPAC22A12.12c	NP_593242.1
Bos taurus (cattle)	EXOSC3	NP_001030474.1
Rattus norvegicus (Norway rat)	Exosc3	NP_001101406.1
Saccharomyces cerevisiae (baker's yeast)	RRP40	NP_014499.2
Neurospora crassa	NCU00693	XP_965833.1
Canis lupus familiaris (dog)	EXOSC3	XP_538738.1
Mus musculus (house mouse)	Exosc3	NP_079789.1
Gallus gallus (chicken)	EXOSC3	NP_001186445.1
Danio rerio (zebrafish)	exosc3	NP_001025132.1
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP010247	XP_319438.3
Kluyveromyces lactis	KLLA0E02091g	XP_454042.1
	EXOSC3	XP_001114719.1
Arabidopsis thaliana (thale cress)	AT4G32175	NP_680755.2
Arabidopsis thaliana (thale cress)	AT2G25355	NP_565592.1
Oryza sativa (rice)	Os01g0661400	NP_001043778.1
Homo sapiens (human)	EXOSC3	NP_057126.2
Pan troglodytes (chimpanzee)	EXOSC3	XP_520587.2
Drosophila melanogaster (fruit fly)	Rrp40	NP_722725.1
Magnaporthe oryzae (rice blast fungus)	MGG_02843	XP_003720894.1
Xenopus tropicalis (tropical clawed frog)	LOC100491278	XP_002936379.2

Gene Ontology
Bibliography

Related articles in PubMed

The circadian clock regulates autophagy directly through the nuclear hormone receptor Nr1d1/Rev-erb? and indirectly via Cebpb/(C/ebp?) in zebrafish.
Huang G, Zhang F, Ye Q, Wang H
Autophagy12(8)1292-309(2016 Aug)

Altered RNA metabolism due to a homozygous RBM7 mutation in a patient with spinal motor neuropathy.
Giunta M, Edvardson S, Xu Y, Schuelke M, Gomez-Duran A, Boczonadi V, Elpeleg O, M?ller JS, Horvath R
Human molecular genetics25(14)2985-2996(2016 07)

Mutagenesis Screen Identifies agtpbp1 and eps15L1 as Essential for T lymphocyte Development in Zebrafish.
Seiler C, Gebhart N, Zhang Y, Shinton SA, Li YS, Ross NL, Liu X, Li Q, Bilbee AN, Varshney GK, LaFave MC, Burgess SM, Balciuniene J, Balciunas D, Hardy RR, Kappes DJ, Wiest DL, Rhodes J
PloS one10(7)e0131908(2015)

Mutations in the RNA exosome component gene EXOSC3 cause pontocerebellar hypoplasia and spinal motor neuron degeneration.
Wan J, Yourshaw M, Mamsa H, Rudnik-Sch?neborn S, Menezes MP, Hong JE, Leong DW, Senderek J, Salman MS, Chitayat D, Seeman P, von Moers A, Graul-Neumann L, Kornberg AJ, Castro-Gago M, Sobrido MJ, Sanefuji M, Shieh PB, Salamon N, Kim RC, Vinters HV, Chen Z, Zerres K, Ryan MM, Nelson SF, Jen JC
Nature genetics44(6)704-8(2012 Apr)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Knock-down of rbm7, exosc8 and exosc3 in zebrafish showed a common pattern of defects in motor neurons and cerebellum. Our data indicate that impaired RNA metabolism may underlie the clinical phenotype by fine tuning gene expression which is essential for correct neuronal differentiation
Title: Altered RNA metabolism due to a homozygous RBM7 mutation in a patient with spinal motor neuropathy.

The following exosc3 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the exosc3 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ODa30711	NM_001029961.1 Latest version!	Danio rerio exosome component 3 (exosc3), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$174.30 $249.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

exosc3 ( NM_001029961.1 ) cDNA ORF clone, Danio rerio(zebrafish) -> NP_001025132.1 Danio rerio exosome component 3 (exosc3), mRNA.

Price & Availability↑

CloneID	ODa30711
Clone ID Related Accession (Same CDS sequence)	NM_001029961.1
Accession Version	NM_001029961.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 744bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-02-16
Organism	Danio rerio(zebrafish)
Product	exosome complex exonuclease RRP40
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC098620.1. On Jul 30, 2005 this sequence version replaced XM_688310.1. ##Evidence-Data-START## Transcript exon combination :: BC098620.1, EH585205.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505371, SAMEA3505378 [ECO:0000348] ##Evidence-Data-END##

ATGGACTCCT CAGTGCACAC TAGTCTGCTG GAGAGGATAG GAGATGTGGT TCTTCCAGGC 
GACCTGCTGT TCTCCTTCAG TCCTCCTGAA GCCGGAGACG CGAACCCGAA AGCGGACAGG 
CTGATCTGCG GCCCGGGGCT GCGGCGGAGC GGAGCGGAGA TCCGTGTGTG TAGAGCGGGA 
GTCCTGAAAC ACAAACAACC CAACATGTAC TGGGTCAACT GTCAGCAGAG ACGGTATGTT 
CCAGCTAAGG GTGAGAGTGT GATCGGCATC GTGACCGCAA AGTCTGGAGA CGTCTTCAAA 
GTGGACGTTG GAGGAAGTGA GCAGGCGTCT CTGTCCTACC TGGCCTTTGA AGGAGCCACC 
AAGAGGAACA GACCCAACGT GCAGGTTGGA GATCTGGTGT TCGGGCAGTT CACCATCGCC 
AACAAGGACA TGGAGCCGGA GCTGGTGTGT ATCGACAGCT GCGGGAGAGC CAACGGGATG 
GGTGTGTTCG GAGGCGACGG GCTGCTCTTT AAAGTGTCGC TGGGACTCGT GCGCAGGCTG 
CTGGCTCCAC AAAGTGATCT GGTTTCGGAT CTGGAGAAGA TGTTCCCCTG TGAGATGGTG 
GTGGGCATGA ACGGCAGAGT GTGGGTGAAG GCCAGAACCG TCCAACACAC ACTGATCCTG 
AGCAACCTGC TGGAGGCCTG CGAGAACATG AGCACCGCGC AGAGACACAC ACTGTTCAGG 
AGAGTGGCGG ACGGAGGAAT ATAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001025132.1
CDS	21..764
Translation	MDSSVHTSLLERIGDVVLPGDLLFSFSPPEAGDANPKADRLICGPGLRRSGAEIRVCRAGVLKHKQPNMYWVNCQQRRYVPAKGESVIGIVTAKSGDVFKVDVGGSEQASLSYLAFEGATKRNRPNVQVGDLVFGQFTIANKDMEPELVCIDSCGRANGMGVFGGDGLLFKVSLGLVRRLLAPQSDLVSDLEKMFPCEMVVGMNGRVWVKARTVQHTLILSNLLEACENMSTAQRHTLFRRVADGGI

Target ORF information:

RefSeq Version	NM_001029961.1
Organism	Danio rerio(zebrafish)
Definition	Danio rerio exosome component 3 (exosc3), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001029961.1

ORF Insert Sequence:

ATGGACTCCT CAGTGCACAC TAGTCTGCTG GAGAGGATAG GAGATGTGGT TCTTCCAGGC 
GACCTGCTGT TCTCCTTCAG TCCTCCTGAA GCCGGAGACG CGAACCCGAA AGCGGACAGG 
CTGATCTGCG GCCCGGGGCT GCGGCGGAGC GGAGCGGAGA TCCGTGTGTG TAGAGCGGGA 
GTCCTGAAAC ACAAACAACC CAACATGTAC TGGGTCAACT GTCAGCAGAG ACGGTATGTT 
CCAGCTAAGG GTGAGAGTGT GATCGGCATC GTGACCGCAA AGTCTGGAGA CGTCTTCAAA 
GTGGACGTTG GAGGAAGTGA GCAGGCGTCT CTGTCCTACC TGGCCTTTGA AGGAGCCACC 
AAGAGGAACA GACCCAACGT GCAGGTTGGA GATCTGGTGT TCGGGCAGTT CACCATCGCC 
AACAAGGACA TGGAGCCGGA GCTGGTGTGT ATCGACAGCT GCGGGAGAGC CAACGGGATG 
GGTGTGTTCG GAGGCGACGG GCTGCTCTTT AAAGTGTCGC TGGGACTCGT GCGCAGGCTG 
CTGGCTCCAC AAAGTGATCT GGTTTCGGAT CTGGAGAAGA TGTTCCCCTG TGAGATGGTG 
GTGGGCATGA ACGGCAGAGT GTGGGTGAAG GCCAGAACCG TCCAACACAC ACTGATCCTG 
AGCAACCTGC TGGAGGCCTG CGAGAACATG AGCACCGCGC AGAGACACAC ACTGTTCAGG 
AGAGTGGCGG ACGGAGGAAT ATAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

The circadian clock regulates autophagy directly through the nuclear hormone receptor Nr1d1/Rev-erb? and indirectly via Cebpb/(C/ebp?) in zebrafish.
Autophagy12(8)1292-309(2016 Aug)
Huang G,Zhang F,Ye Q,Wang H

Altered RNA metabolism due to a homozygous RBM7 mutation in a patient with spinal motor neuropathy.
Human molecular genetics25(14)2985-2996(2016 07)
Giunta M,Edvardson S,Xu Y,Schuelke M,Gomez-Duran A,Boczonadi V,Elpeleg O,M?ller JS,Horvath R

Mutagenesis Screen Identifies agtpbp1 and eps15L1 as Essential for T lymphocyte Development in Zebrafish.
PloS one10(7)e0131908(2015)
Seiler C,Gebhart N,Zhang Y,Shinton SA,Li YS,Ross NL,Liu X,Li Q,Bilbee AN,Varshney GK,LaFave MC,Burgess SM,Balciuniene J,Balciunas D,Hardy RR,Kappes DJ,Wiest DL,Rhodes J

Mutations in the RNA exosome component gene EXOSC3 cause pontocerebellar hypoplasia and spinal motor neuron degeneration.
Nature genetics44(6)704-8(2012 Apr)
Wan J,Yourshaw M,Mamsa H,Rudnik-Sch?neborn S,Menezes MP,Hong JE,Leong DW,Senderek J,Salman MS,Chitayat D,Seeman P,von Moers A,Graul-Neumann L,Kornberg AJ,Castro-Gago M,Sobrido MJ,Sanefuji M,Shieh PB,Salamon N,Kim RC,Vinters HV,Chen Z,Zerres K,Ryan MM,Nelson SF,Jen JC

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exosc3 cDNA ORF clone, Danio rerio(zebrafish)

Gene

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gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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