ildr1b cDNA ORF clone, Danio rerio(zebrafish)

Gene
Clones
gRNAs

Summary

Gene Symbol	ildr1b
Entrez Gene ID	447904
Full Name	immunoglobulin-like domain containing receptor 1b
Synonyms	ildr1,wu:fc95b03,zgc:101133
General protein information	Preferred Names immunoglobulin-like domain containing receptor 1b Names immunoglobulin-like domain containing receptor 1b fc95b03 immunoglobulin-like domain containing receptor 1
Gene Type	protein-coding
Organism	Danio rerio(zebrafish)

mRNA and Protein(s)

mRNA	Protein	Name
NM_001004642.2	NP_001004642.2	immunoglobulin-like domain containing receptor 1b precursor

Pathways from BioSystems

Homologies

Mus musculus (house mouse)	Ildr1	NP_001272717.1
Rattus norvegicus (Norway rat)	Ildr1	NP_001121008.2
Canis lupus familiaris (dog)	ILDR1	XP_005639611.1
Homo sapiens (human)	ILDR1	NP_001186728.1
Pan troglodytes (chimpanzee)	ILDR1	XP_526282.3
	ILDR1	XP_001111791.1
Danio rerio (zebrafish)	ildr1b	NP_001004642.1
Danio rerio (zebrafish)	ildr1a	NP_956687.1
Xenopus tropicalis (tropical clawed frog)	LOC100486057	XP_002940967.1
Bos taurus (cattle)	ILDR1	NP_001095684.1
Gallus gallus (chicken)	ILDR1	XP_004938277.1

Gene Ontology
Bibliography

Related articles in PubMed

RFX transcription factors are essential for hearing in mice.
Elkon R, Milon B, Morrison L, Shah M, Vijayakumar S, Racherla M, Leitch CC, Silipino L, Hadi S, Weiss-Gayet M, Barras E, Schmid CD, Ait-Lounis A, Barnes A, Song Y, Eisenman DJ, Eliyahu E, Frolenkov GI, Strome SE, Durand B, Zaghloul NA, Jones SM, Reith W, Hertzano R
Nature communications68549(2015 Oct)

High-throughput gene targeting and phenotyping in zebrafish using CRISPR/Cas9.
Varshney GK, Pei W, LaFave MC, Idol J, Xu L, Gallardo V, Carrington B, Bishop K, Jones M, Li M, Harper U, Huang SC, Prakash A, Chen W, Sood R, Ledin J, Burgess SM
Genome research25(7)1030-42(2015 Jul)

Ildr1b is essential for semicircular canal development, migration of the posterior lateral line primordium and hearing ability in zebrafish: implications for a role in the recessive hearing impairment DFNB42.
Sang Q, Zhang J, Feng R, Wang X, Li Q, Zhao X, Xing Q, Chen W, Du J, Sun S, Chai R, Liu D, Jin L, He L, Li H, Wang L
Human molecular genetics23(23)6201-11(2014 Dec)

Loss-of-function mutations of ILDR1 cause autosomal-recessive hearing impairment DFNB42.
Borck G, Ur Rehman A, Lee K, Pogoda HM, Kakar N, von Ameln S, Grillet N, Hildebrand MS, Ahmed ZM, N?rnberg G, Ansar M, Basit S, Javed Q, Morell RJ, Nasreen N, Shearer AE, Ahmad A, Kahrizi K, Shaikh RS, Ali RA, Khan SN, Goebel I, Meyer NC, Kimberling WJ, Webster JA, Stephan DA, Schiller MR, Bahlo M, Najmabadi H, Gillespie PG, N?rnberg P, Wollnik B, Riazuddin S, Smith RJ, Ahmad W, M?ller U, Hammerschmidt M, Friedman TB, Riazuddin S, Leal SM, Ahmad J, Kubisch C
American journal of human genetics88(2)127-37(2011 Feb)

The zebrafish gene map defines ancestral vertebrate chromosomes.
Woods IG, Wilson C, Friedlander B, Chang P, Reyes DK, Nix R, Kelly PD, Chu F, Postlethwait JH, Talbot WS
Genome research15(9)1307-14(2005 Sep)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

First evidence for the mechanism of Ildr1b on hearing in vivo and sheds light on the pathology of DFNB42.
Title: Ildr1b is essential for semicircular canal development, migration of the posterior lateral line primordium and hearing ability in zebrafish: implications for a role in the recessive hearing impairment DFNB42.

The following ildr1b gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the ildr1b cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ODa53174	NM_001004642.2 Latest version!	Danio rerio immunoglobulin-like domain containing receptor 1b (ildr1b), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	14-16	$342.30 $489.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

ildr1b ( NM_001004642.2 ) cDNA ORF clone, Danio rerio(zebrafish) -> NP_001004642.2 Danio rerio immunoglobulin-like domain containing receptor 1b (ildr1b), mRNA.

Price & Availability↑

CloneID	ODa53174
Clone ID Related Accession (Same CDS sequence)	NM_001004642.2
Accession Version	NM_001004642.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1656bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2018-11-23
Organism	Danio rerio(zebrafish)
Product	immunoglobulin-like domain containing receptor 1b precursor
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from BX294189.11, EH440533.1, EH568753.1 and EH530787.1. On Sep 1, 2015 this sequence version replaced NM_001004642.1. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. ##Evidence-Data-START## Transcript exon combination :: GDQQ01000627.1, CU638769.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA2168446, SAMEA2168447 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGAAACAAA AACTGCGGCT CAAGGTGCTT GTGCTTCTAC TCTGCGTATT TCCAGAAGAG 
ATTTTCTCTA TCCAGGTTAC TGTTCCTGAG ACAGAGAGAC ACACAATGCT GTTTGGTTCT 
GTCACTCTGC GCTGCGATTA TTCCACCTCT GCAAGCCAAC AGGATGTTTT GGTCACATGG 
CGGTACAAGT CCTTCTGTCT GGATCCAGTG CTGGAGTACT ACTCCGCTGC TTATCAGGCA 
GCTCTGAACA TGAAGCAGGA TCCAGCCAAT GACTGTCCAG ACAGCAAGCG CACAGTTCGC 
ATAGTGATTC AGAAAAGAGG CATCAATGAA CCTGTTCTGG GAACGGAGTA CCGACAGCGC 
AAAATCTCCA TTAAAAACAA TGCTGATCTG TCCATGAATG AGATCATGTG GTGGGACAAT 
GGCATGTATT TTTGTTCCAT TGATGCGCCT GGTGATGTTG TGGGAGACTC CGACAAGGAA 
ATCAGACTCA TTGTTTATAA CTGGCTAACT GTGCTGCTCA TCATCCTCGG GGCTCTACTG 
TTGATCATCC TGTTCGGGGT CTGCTGCTGT CAGTGCTGTC CTCAGAACTG CTGCTGTTAC 
GTCCGCTGTC CCTGCTGTCC TCGCACCTGC TGCTGCCCTG AAAAAGCGGT CATGCGACAC 
AAGATGATGC GTGAAGCTCA AAAGGCAATG GTACCATGGT TTCACGGCCA GCCCATCTAT 
GCCCCCATTG CCTCAAATGC ATCTTCTCAA GCAAATCCTT TACTTTATTC AGGCTCTTTT 
TCTGAACATT CATCCAAACA CAATCTTCCC ATGGCCCCTA TGGCTATCCC TCCACCTCAA 
CCGGTCCCAC AATTCGTACC TTCTCACGGA TACCATGCCA ATGGCAGCAT GAATGGAAAT 
GTACGTGCCA ATAATCAGAT GTTAGATTTT CTGGAGAACC AAGTACAAGG GATGGATATG 
GCCGTCCCAA TGCTCCAACC TCAACATCAC TACACAGGAG TCCCATTCCA AAACCATCAG 
CCTCAATACG CAGCCCAGCA ACCCCATTAC GCGTCACCAC CACCTCAATC CATTCCCCAG 
GCGGTGACTT TTCCAGCTAG GCCGCCCAGC ATGCTCTCTG CCCTGGATGA GATGGGGGTC 
CAAGGTGTGG AACGCAGGGT CATCCAGCTG CCTCCAATTT TAGGCCGACC GAAACAGAGC 
TCCCGGCGGA CCAATGATCA GAGGCCCAGG CAGTCAAGTC AGTCCAGCGG AAGCTCAAAC 
CGCAATGGTG TTCATCGTGA TCCTGCATCT TCACGGAGAG GAAACCAGCG CAGCTACAGC 
GACGAGTCAG ACTGGGATGA CCGACGGGGA GGTCGAAGTT CATCAGGACG CAGAGGAGAA 
TCAAACAGGT CTCGTCCACG AGTTCGCAGT AAAGCAGAGC TGCTAGAGGA GTTGGAGCAT 
GCAACTAACA ATGGAAACAG GAGCTATTCA TCTCCTCACA GAGGATCCTG GAGTTCAGAC 
GAAGAGGACA GTTACAGAAA GGGAAGGCGA TCTCAAGGGA AACTGTCTGA AAATCCTCCA 
GCTTACTCTT CCATTGACAT TTTGCCTGGC CACAGCAGGA GGGGTGAACA GCTCTCGGAC 
AAGAGCTCTC GCAGTGGCAC AAGCGTTGTG ATCTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001004642.2
CDS	228..1883
Translation	MKQKLRLKVLVLLLCVFPEEIFSIQVTVPETERHTMLFGSVTLRCDYSTSASQQDVLVTWRYKSFCLDPVLEYYSAAYQAALNMKQDPANDCPDSKRTVRIVIQKRGINEPVLGTEYRQRKISIKNNADLSMNEIMWWDNGMYFCSIDAPGDVVGDSDKEIRLIVYNWLTVLLIILGALLLIILFGVCCCQCCPQNCCCYVRCPCCPRTCCCPEKAVMRHKMMREAQKAMVPWFHGQPIYAPIASNASSQANPLLYSGSFSEHSSKHNLPMAPMAIPPPQPVPQFVPSHGYHANGSMNGNVRANNQMLDFLENQVQGMDMAVPMLQPQHHYTGVPFQNHQPQYAAQQPHYASPPPQSIPQAVTFPARPPSMLSALDEMGVQGVERRVIQLPPILGRPKQSSRRTNDQRPRQSSQSSGSSNRNGVHRDPASSRRGNQRSYSDESDWDDRRGGRSSSGRRGESNRSRPRVRSKAELLEELEHATNNGNRSYSSPHRGSWSSDEEDSYRKGRRSQGKLSENPPAYSSIDILPGHSRRGEQLSDKSSRSGTSVVI

Target ORF information:

RefSeq Version	NM_001004642.2
Organism	Danio rerio(zebrafish)
Definition	Danio rerio immunoglobulin-like domain containing receptor 1b (ildr1b), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001004642.2

ORF Insert Sequence:

ATGAAACAAA AACTGCGGCT CAAGGTGCTT GTGCTTCTAC TCTGCGTATT TCCAGAAGAG 
ATTTTCTCTA TCCAGGTTAC TGTTCCTGAG ACAGAGAGAC ACACAATGCT GTTTGGTTCT 
GTCACTCTGC GCTGCGATTA TTCCACCTCT GCAAGCCAAC AGGATGTTTT GGTCACATGG 
CGGTACAAGT CCTTCTGTCT GGATCCAGTG CTGGAGTACT ACTCCGCTGC TTATCAGGCA 
GCTCTGAACA TGAAGCAGGA TCCAGCCAAT GACTGTCCAG ACAGCAAGCG CACAGTTCGC 
ATAGTGATTC AGAAAAGAGG CATCAATGAA CCTGTTCTGG GAACGGAGTA CCGACAGCGC 
AAAATCTCCA TTAAAAACAA TGCTGATCTG TCCATGAATG AGATCATGTG GTGGGACAAT 
GGCATGTATT TTTGTTCCAT TGATGCGCCT GGTGATGTTG TGGGAGACTC CGACAAGGAA 
ATCAGACTCA TTGTTTATAA CTGGCTAACT GTGCTGCTCA TCATCCTCGG GGCTCTACTG 
TTGATCATCC TGTTCGGGGT CTGCTGCTGT CAGTGCTGTC CTCAGAACTG CTGCTGTTAC 
GTCCGCTGTC CCTGCTGTCC TCGCACCTGC TGCTGCCCTG AAAAAGCGGT CATGCGACAC 
AAGATGATGC GTGAAGCTCA AAAGGCAATG GTACCATGGT TTCACGGCCA GCCCATCTAT 
GCCCCCATTG CCTCAAATGC ATCTTCTCAA GCAAATCCTT TACTTTATTC AGGCTCTTTT 
TCTGAACATT CATCCAAACA CAATCTTCCC ATGGCCCCTA TGGCTATCCC TCCACCTCAA 
CCGGTCCCAC AATTCGTACC TTCTCACGGA TACCATGCCA ATGGCAGCAT GAATGGAAAT 
GTACGTGCCA ATAATCAGAT GTTAGATTTT CTGGAGAACC AAGTACAAGG GATGGATATG 
GCCGTCCCAA TGCTCCAACC TCAACATCAC TACACAGGAG TCCCATTCCA AAACCATCAG 
CCTCAATACG CAGCCCAGCA ACCCCATTAC GCGTCACCAC CACCTCAATC CATTCCCCAG 
GCGGTGACTT TTCCAGCTAG GCCGCCCAGC ATGCTCTCTG CCCTGGATGA GATGGGGGTC 
CAAGGTGTGG AACGCAGGGT CATCCAGCTG CCTCCAATTT TAGGCCGACC GAAACAGAGC 
TCCCGGCGGA CCAATGATCA GAGGCCCAGG CAGTCAAGTC AGTCCAGCGG AAGCTCAAAC 
CGCAATGGTG TTCATCGTGA TCCTGCATCT TCACGGAGAG GAAACCAGCG CAGCTACAGC 
GACGAGTCAG ACTGGGATGA CCGACGGGGA GGTCGAAGTT CATCAGGACG CAGAGGAGAA 
TCAAACAGGT CTCGTCCACG AGTTCGCAGT AAAGCAGAGC TGCTAGAGGA GTTGGAGCAT 
GCAACTAACA ATGGAAACAG GAGCTATTCA TCTCCTCACA GAGGATCCTG GAGTTCAGAC 
GAAGAGGACA GTTACAGAAA GGGAAGGCGA TCTCAAGGGA AACTGTCTGA AAATCCTCCA 
GCTTACTCTT CCATTGACAT TTTGCCTGGC CACAGCAGGA GGGGTGAACA GCTCTCGGAC 
AAGAGCTCTC GCAGTGGCAC AAGCGTTGTG ATCTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

RFX transcription factors are essential for hearing in mice.
Nature communications68549(2015 Oct)
Elkon R,Milon B,Morrison L,Shah M,Vijayakumar S,Racherla M,Leitch CC,Silipino L,Hadi S,Weiss-Gayet M,Barras E,Schmid CD,Ait-Lounis A,Barnes A,Song Y,Eisenman DJ,Eliyahu E,Frolenkov GI,Strome SE,Durand B,Zaghloul NA,Jones SM,Reith W,Hertzano R

High-throughput gene targeting and phenotyping in zebrafish using CRISPR/Cas9.
Genome research25(7)1030-42(2015 Jul)
Varshney GK,Pei W,LaFave MC,Idol J,Xu L,Gallardo V,Carrington B,Bishop K,Jones M,Li M,Harper U,Huang SC,Prakash A,Chen W,Sood R,Ledin J,Burgess SM

Ildr1b is essential for semicircular canal development, migration of the posterior lateral line primordium and hearing ability in zebrafish: implications for a role in the recessive hearing impairment DFNB42.
Human molecular genetics23(23)6201-11(2014 Dec)
Sang Q,Zhang J,Feng R,Wang X,Li Q,Zhao X,Xing Q,Chen W,Du J,Sun S,Chai R,Liu D,Jin L,He L,Li H,Wang L

Loss-of-function mutations of ILDR1 cause autosomal-recessive hearing impairment DFNB42.
American journal of human genetics88(2)127-37(2011 Feb)
Borck G,Ur Rehman A,Lee K,Pogoda HM,Kakar N,von Ameln S,Grillet N,Hildebrand MS,Ahmed ZM,N?rnberg G,Ansar M,Basit S,Javed Q,Morell RJ,Nasreen N,Shearer AE,Ahmad A,Kahrizi K,Shaikh RS,Ali RA,Khan SN,Goebel I,Meyer NC,Kimberling WJ,Webster JA,Stephan DA,Schiller MR,Bahlo M,Najmabadi H,Gillespie PG,N?rnberg P,Wollnik B,Riazuddin S,Smith RJ,Ahmad W,M?ller U,Hammerschmidt M,Friedman TB,Riazuddin S,Leal SM,Ahmad J,Kubisch C

The zebrafish gene map defines ancestral vertebrate chromosomes.
Genome research15(9)1307-14(2005 Sep)
Woods IG,Wilson C,Friedlander B,Chang P,Reyes DK,Nix R,Kelly PD,Chu F,Postlethwait JH,Talbot WS

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ildr1b cDNA ORF clone, Danio rerio(zebrafish)

Gene

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gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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