hic1 cDNA ORF clone, Danio rerio(zebrafish)

Gene
Clones
gRNAs

Summary

Gene Symbol	hic1
Entrez Gene ID	436585
Full Name	hypermethylated in cancer 1
Synonyms	zfHIC1
General protein information	Preferred Names hypermethylated in cancer 1 Names hypermethylated in cancer 1 protein etID142640.25
Gene Type	protein-coding
Organism	Danio rerio(zebrafish)

mRNA and Protein(s)

mRNA	Protein	Name
NM_001002314.1	NP_001002314.1	hypermethylated in cancer 1 protein

Pathways from BioSystems

Homologies

	LOC721284	XP_001117386.2
Mus musculus (house mouse)	Hic1	NP_034560.2
Gallus gallus (chicken)	HIC1	NP_990567.1
Xenopus tropicalis (tropical clawed frog)	hic1	XP_004911694.1
Canis lupus familiaris (dog)	HIC1	XP_548318.2
Danio rerio (zebrafish)	hic1	NP_001002314.1
Rattus norvegicus (Norway rat)	LOC100912068	XP_003750910.1
Homo sapiens (human)	HIC1	NP_001091672.1
Bos taurus (cattle)	HIC1	XP_003587448.2

Gene Ontology
Bibliography

Related articles in PubMed

Transcriptome comparison reveals a genetic network regulating the lower temperature limit in fish.
Hu P, Liu M, Liu Y, Wang J, Zhang D, Niu H, Jiang S, Wang J, Zhang D, Han B, Xu Q, Chen L
Scientific reports628952(2016 Jun)

Phenotypic chemical screening using a zebrafish neural crest EMT reporter identifies retinoic acid as an inhibitor of epithelial morphogenesis.
Jimenez L, Wang J, Morrison MA, Whatcott C, Soh KK, Warner S, Bearss D, Jette CA, Stewart RA
Disease models & mechanisms9(4)389-400(2016 Apr)

RFX transcription factors are essential for hearing in mice.
Elkon R, Milon B, Morrison L, Shah M, Vijayakumar S, Racherla M, Leitch CC, Silipino L, Hadi S, Weiss-Gayet M, Barras E, Schmid CD, Ait-Lounis A, Barnes A, Song Y, Eisenman DJ, Eliyahu E, Frolenkov GI, Strome SE, Durand B, Zaghloul NA, Jones SM, Reith W, Hertzano R
Nature communications68549(2015 Oct)

Retinoic acid receptor subtype-specific transcriptotypes in the early zebrafish embryo.
Samarut E, Gaudin C, Hughes S, Gillet B, de Bernard S, Jouve PE, Buffat L, Allot A, Lecompte O, Berekelya L, Rochette-Egly C, Laudet V
Molecular endocrinology (Baltimore, Md.)28(2)260-72(2014 Feb)

Identification and developmental expression of the zebrafish orthologue of the tumor suppressor gene HIC1.
Bertrand S, Pinte S, Stankovic-Valentin N, Deltour-Balerdi S, Gu?rardel C, B?gue A, Laudet V, Leprince D
Biochimica et biophysica acta1678(1)57-66(2004 Apr)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

These results suggest that up-regulation of MVP in multi-drug resistance (MDR) may involve chromatin remodeling.
Title: Identification and developmental expression of the zebrafish orthologue of the tumor suppressor gene HIC1.

The following hic1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the hic1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ODa01540	NM_001002314.1 Latest version!	Danio rerio hypermethylated in cancer 1 (hic1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	12-14	$426.30 $609.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

hic1 ( NM_001002314.1 ) cDNA ORF clone, Danio rerio(zebrafish) -> NP_001002314.1 Danio rerio hypermethylated in cancer 1 (hic1), mRNA.

Price & Availability↑

CloneID	ODa01540
Clone ID Related Accession (Same CDS sequence)	NM_001002314.1
Accession Version	NM_001002314.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2214bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2018-11-23
Organism	Danio rerio(zebrafish)
Product	hypermethylated in cancer 1 protein
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AJ429491.1. ##Evidence-Data-START## Transcript exon combination :: AJ429491.1, BC162587.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2168446, SAMEA2168447 [ECO:0000348] ##Evidence-Data-END##

ATGCTGGATG CCATGGAAGT TCCAAGTCAT GCTAGGCACC TCCTCTTGCA ATTGAACACA 
CAACGAACCA AAGGTTTCTT GTGTGATGTT ATTATCGTGG TGCAGAATGC ACTGTTCCGT 
GCTCACAAGA ACATCCTGGC AGCCAGTAGC CTCTACCTTA AGTCTCTTGT TGTTCATGAC 
AACCTTATCA ATCTGGACCA TGAGATGGTC AGTCCAGGTG TGTTTCGAGT CATTCTTGAC 
TATATCTACA CAGGACGTTT AAGTGAATGT GACCCCACCT CTCCAAATGA GCCAAATATA 
GGGGCAGTGT TGGCAGCTGC AAGTTACCTG CAACTTCTGG ATCTGGTCAC CCTATGCAAA 
AAGAAGCTGA AAAAGAATAG GAAGTACCAT TTAAGTCATA ACCCTACATT TTTATCGTAC 
AAATTAAGCC TCAGTGGTGT GGGGGGAGGA CCGTTTCCAA TATCTACCCC TGTCATCCAC 
CCTTGCCACA CTGTAGTGAC CACCCCACGA CCTACAACAT TAGAGGACCT GCCCTCCATC 
CCACTGCCCC CCCATGCGGG AGAAATTTAT GCACCAGCTC CCATCAAGGG TCCACCACCT 
TACCCCCCAA CAAAGGCATC CCTGTCACCA CAGTCCAGTC TTTGCTTGCC TCCCAATGAA 
AGGAATTGTT CATCGGTTTA TGGCCTTGAC CTGTCTAAGA AAAGCCCAAA TTCCCAGTCT 
CAGCTTTCTT CTGGCAATCC CCACTTGATC TCTTCACTCC ACCCAGATGA GGAGCCTGAA 
GGCGAGCTTG ACCAAAGTAC CAGTCCCATG CTCAGTCCCA ACGATGGTTC TAGAAAAATG 
GACACAGGCC ATCATATGGG GTCTCTCACC CCACACCCCT TCCCACTACC CAACCATCCA 
CTTGCACCCA ATCTTCCCCA TCTGCATCGT TCTCAGGGAC AGGAACAGTA CCCCTGCCCT 
CCAAGCCCAG AACCCATAGA GGACACCAGA GATCAGCGGC GCGATGCTTC CAACATCTAT 
CGGTGGGTGA AGAATGAGCC TTCCAACCCA GAGGATGAAG ATGAGGACGA TGAAGAGGAT 
GACAGTGGGG GAATGGGTGA GCAGGATAAA GAGAGACATC ACCAGCACAT GAACCACCAT 
AAAAGCAATG AGGAAAAACT GAACACAAAT GAGCGGGGCT ATGACAGAGG GACCTGCGAT 
GATGGCGAGG ATGAGAATGG AACTGGCAGC GAGGAAACCG GAAGCAGTGA GGGTCGTCCA 
TCTCCTCCTG TACCAGGTGG AAGGTATCAC ATGCCATATG AGCCAGAGAG TTTCGGAGAT 
AACTTGTATG TGTGCATCCC CTGTGACAAA GGCTTTCCCA GCTCAGAGCA ACTCAATGCA 
CATGTAGAAA CCCATACAGA GGAAGAGTTA AACAATGGAA GTGAGATGGA CAGCAGCAAT 
AACAGCAACA GTAAACCTAC TACTGTCCGT GCACCTACAA GCTTGAACAG CTCTAGTGGC 
CTCCACAGCC CTTACCACGA TGGCAAGTTG GCACAAAACC TCCATTCCAT TGGTCTCGGG 
GAGATCATTC GACCATATCG ATGTTCTTCC TGCGACAAGT CTTATAAAGA TCCTGCCACC 
CTGCGGCAAC ATGAGAAAAC CCACTGGCTG ACACGTCCAT ACCCCTGTAG CATCTGTGGG 
AAGAAGTTCA CCCAACGTGG TACCATGACA CGTCACATGC GCAGTCACTT GGGCCTTAAA 
CCCTTCGCCT GTGATGCCTG TGGCATGCGC TTTACTCGGC AGTATCGTCT GACGGAACAT 
ATGCGCATCC ACTCCGGAGA GAAGCCCTAT GAGTGCCAGG TGTGTGGAGG CAAGTTTGCT 
CAGCAGCGCA ACCTCATCAG TCACATGAAG ATGCACAGCA GTGGAGCTGC TGGCGGAGGA 
CTAACTCCTG ACGGGAAGCT GAAGATAGAC TTCTCTGAGG GGATTTATCC TCTGAGCAAG 
TACACAGCTG AGCATCTGGG TCTGAAGCAG GAGAAAACCT CAGACCTTCT TGCAGCTTCT 
CAACACCTCC TTGCTGATGC CAAGGCCATG GAGAGCCTCT ACCCGCTGTC AAAACTGGCT 
GTAGATCAAC TCGGCCTTGC CCACAAAATG GACATCCTGA ACTCGTCACT TCCACCCACT 
TCCCAGCAGC TCTCAGCAGA GTCCCGCACC ATTGATCGCT ACTCTCCCAG CTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001002314.1
CDS	217..2430
Translation	MLDAMEVPSHARHLLLQLNTQRTKGFLCDVIIVVQNALFRAHKNILAASSLYLKSLVVHDNLINLDHEMVSPGVFRVILDYIYTGRLSECDPTSPNEPNIGAVLAAASYLQLLDLVTLCKKKLKKNRKYHLSHNPTFLSYKLSLSGVGGGPFPISTPVIHPCHTVVTTPRPTTLEDLPSIPLPPHAGEIYAPAPIKGPPPYPPTKASLSPQSSLCLPPNERNCSSVYGLDLSKKSPNSQSQLSSGNPHLISSLHPDEEPEGELDQSTSPMLSPNDGSRKMDTGHHMGSLTPHPFPLPNHPLAPNLPHLHRSQGQEQYPCPPSPEPIEDTRDQRRDASNIYRWVKNEPSNPEDEDEDDEEDDSGGMGEQDKERHHQHMNHHKSNEEKLNTNERGYDRGTCDDGEDENGTGSEETGSSEGRPSPPVPGGRYHMPYEPESFGDNLYVCIPCDKGFPSSEQLNAHVETHTEEELNNGSEMDSSNNSNSKPTTVRAPTSLNSSSGLHSPYHDGKLAQNLHSIGLGEIIRPYRCSSCDKSYKDPATLRQHEKTHWLTRPYPCSICGKKFTQRGTMTRHMRSHLGLKPFACDACGMRFTRQYRLTEHMRIHSGEKPYECQVCGGKFAQQRNLISHMKMHSSGAAGGGLTPDGKLKIDFSEGIYPLSKYTAEHLGLKQEKTSDLLAASQHLLADAKAMESLYPLSKLAVDQLGLAHKMDILNSSLPPTSQQLSAESRTIDRYSPS

Target ORF information:

RefSeq Version	NM_001002314.1
Organism	Danio rerio(zebrafish)
Definition	Danio rerio hypermethylated in cancer 1 (hic1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001002314.1

ORF Insert Sequence:

ATGCTGGATG CCATGGAAGT TCCAAGTCAT GCTAGGCACC TCCTCTTGCA ATTGAACACA 
CAACGAACCA AAGGTTTCTT GTGTGATGTT ATTATCGTGG TGCAGAATGC ACTGTTCCGT 
GCTCACAAGA ACATCCTGGC AGCCAGTAGC CTCTACCTTA AGTCTCTTGT TGTTCATGAC 
AACCTTATCA ATCTGGACCA TGAGATGGTC AGTCCAGGTG TGTTTCGAGT CATTCTTGAC 
TATATCTACA CAGGACGTTT AAGTGAATGT GACCCCACCT CTCCAAATGA GCCAAATATA 
GGGGCAGTGT TGGCAGCTGC AAGTTACCTG CAACTTCTGG ATCTGGTCAC CCTATGCAAA 
AAGAAGCTGA AAAAGAATAG GAAGTACCAT TTAAGTCATA ACCCTACATT TTTATCGTAC 
AAATTAAGCC TCAGTGGTGT GGGGGGAGGA CCGTTTCCAA TATCTACCCC TGTCATCCAC 
CCTTGCCACA CTGTAGTGAC CACCCCACGA CCTACAACAT TAGAGGACCT GCCCTCCATC 
CCACTGCCCC CCCATGCGGG AGAAATTTAT GCACCAGCTC CCATCAAGGG TCCACCACCT 
TACCCCCCAA CAAAGGCATC CCTGTCACCA CAGTCCAGTC TTTGCTTGCC TCCCAATGAA 
AGGAATTGTT CATCGGTTTA TGGCCTTGAC CTGTCTAAGA AAAGCCCAAA TTCCCAGTCT 
CAGCTTTCTT CTGGCAATCC CCACTTGATC TCTTCACTCC ACCCAGATGA GGAGCCTGAA 
GGCGAGCTTG ACCAAAGTAC CAGTCCCATG CTCAGTCCCA ACGATGGTTC TAGAAAAATG 
GACACAGGCC ATCATATGGG GTCTCTCACC CCACACCCCT TCCCACTACC CAACCATCCA 
CTTGCACCCA ATCTTCCCCA TCTGCATCGT TCTCAGGGAC AGGAACAGTA CCCCTGCCCT 
CCAAGCCCAG AACCCATAGA GGACACCAGA GATCAGCGGC GCGATGCTTC CAACATCTAT 
CGGTGGGTGA AGAATGAGCC TTCCAACCCA GAGGATGAAG ATGAGGACGA TGAAGAGGAT 
GACAGTGGGG GAATGGGTGA GCAGGATAAA GAGAGACATC ACCAGCACAT GAACCACCAT 
AAAAGCAATG AGGAAAAACT GAACACAAAT GAGCGGGGCT ATGACAGAGG GACCTGCGAT 
GATGGCGAGG ATGAGAATGG AACTGGCAGC GAGGAAACCG GAAGCAGTGA GGGTCGTCCA 
TCTCCTCCTG TACCAGGTGG AAGGTATCAC ATGCCATATG AGCCAGAGAG TTTCGGAGAT 
AACTTGTATG TGTGCATCCC CTGTGACAAA GGCTTTCCCA GCTCAGAGCA ACTCAATGCA 
CATGTAGAAA CCCATACAGA GGAAGAGTTA AACAATGGAA GTGAGATGGA CAGCAGCAAT 
AACAGCAACA GTAAACCTAC TACTGTCCGT GCACCTACAA GCTTGAACAG CTCTAGTGGC 
CTCCACAGCC CTTACCACGA TGGCAAGTTG GCACAAAACC TCCATTCCAT TGGTCTCGGG 
GAGATCATTC GACCATATCG ATGTTCTTCC TGCGACAAGT CTTATAAAGA TCCTGCCACC 
CTGCGGCAAC ATGAGAAAAC CCACTGGCTG ACACGTCCAT ACCCCTGTAG CATCTGTGGG 
AAGAAGTTCA CCCAACGTGG TACCATGACA CGTCACATGC GCAGTCACTT GGGCCTTAAA 
CCCTTCGCCT GTGATGCCTG TGGCATGCGC TTTACTCGGC AGTATCGTCT GACGGAACAT 
ATGCGCATCC ACTCCGGAGA GAAGCCCTAT GAGTGCCAGG TGTGTGGAGG CAAGTTTGCT 
CAGCAGCGCA ACCTCATCAG TCACATGAAG ATGCACAGCA GTGGAGCTGC TGGCGGAGGA 
CTAACTCCTG ACGGGAAGCT GAAGATAGAC TTCTCTGAGG GGATTTATCC TCTGAGCAAG 
TACACAGCTG AGCATCTGGG TCTGAAGCAG GAGAAAACCT CAGACCTTCT TGCAGCTTCT 
CAACACCTCC TTGCTGATGC CAAGGCCATG GAGAGCCTCT ACCCGCTGTC AAAACTGGCT 
GTAGATCAAC TCGGCCTTGC CCACAAAATG GACATCCTGA ACTCGTCACT TCCACCCACT 
TCCCAGCAGC TCTCAGCAGA GTCCCGCACC ATTGATCGCT ACTCTCCCAG CTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Transcriptome comparison reveals a genetic network regulating the lower temperature limit in fish.
Scientific reports628952(2016 Jun)
Hu P,Liu M,Liu Y,Wang J,Zhang D,Niu H,Jiang S,Wang J,Zhang D,Han B,Xu Q,Chen L

Phenotypic chemical screening using a zebrafish neural crest EMT reporter identifies retinoic acid as an inhibitor of epithelial morphogenesis.
Disease models & mechanisms9(4)389-400(2016 Apr)
Jimenez L,Wang J,Morrison MA,Whatcott C,Soh KK,Warner S,Bearss D,Jette CA,Stewart RA

RFX transcription factors are essential for hearing in mice.
Nature communications68549(2015 Oct)
Elkon R,Milon B,Morrison L,Shah M,Vijayakumar S,Racherla M,Leitch CC,Silipino L,Hadi S,Weiss-Gayet M,Barras E,Schmid CD,Ait-Lounis A,Barnes A,Song Y,Eisenman DJ,Eliyahu E,Frolenkov GI,Strome SE,Durand B,Zaghloul NA,Jones SM,Reith W,Hertzano R

Retinoic acid receptor subtype-specific transcriptotypes in the early zebrafish embryo.
Molecular endocrinology (Baltimore, Md.)28(2)260-72(2014 Feb)
Samarut E,Gaudin C,Hughes S,Gillet B,de Bernard S,Jouve PE,Buffat L,Allot A,Lecompte O,Berekelya L,Rochette-Egly C,Laudet V

Identification and developmental expression of the zebrafish orthologue of the tumor suppressor gene HIC1.
Biochimica et biophysica acta1678(1)57-66(2004 Apr)
Bertrand S,Pinte S,Stankovic-Valentin N,Deltour-Balerdi S,Gu?rardel C,B?gue A,Laudet V,Leprince D

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hic1 cDNA ORF clone, Danio rerio(zebrafish)

Gene

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gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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