braf cDNA ORF clone, Danio rerio(zebrafish)

Gene
Clones
gRNAs

Summary

Gene Symbol	braf
Entrez Gene ID	403065
Full Name	B-Raf proto-oncogene, serine/threonine kinase
Synonyms	sierrabraf
General protein information	Preferred Names B-Raf proto-oncogene, serine/threonine kinase Names serine/threonine-protein kinase B-raf serine/threonine protein kinase BRAF v-raf murine sarcoma viral oncogene homolog B1
Gene Type	protein-coding
Organism	Danio rerio(zebrafish)

mRNA and Protein(s)

mRNA	Protein	Name
XM_021474974.1	XP_021330649.1	serine/threonine-protein kinase B-raf isoform X1
NM_205744.4	NP_991307.3	serine/threonine-protein kinase B-raf isoform 2
NM_001324516.1	NP_001311445.1	serine/threonine-protein kinase B-raf isoform 1

Pathways from BioSystems

Homologies

Mus musculus (house mouse)	Braf	NP_647455.3
Rattus norvegicus (Norway rat)	Braf	XP_006236418.1
Gallus gallus (chicken)	BRAF	NP_990633.1
Caenorhabditis elegans (roundworm)	lin-45	NP_741430.3
Pan troglodytes (chimpanzee)	BRAF	XP_003951208.1
	LOC693554	XP_002803541.1
Bos taurus (cattle)	BRAF	XP_005205968.1
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP004699	XP_318144.4
Canis lupus familiaris (dog)	BRAF	XP_005629607.1
Drosophila melanogaster (fruit fly)	phl	NP_525047.1
Xenopus tropicalis (tropical clawed frog)	braf	XP_004912520.1
Danio rerio (zebrafish)	braf	NP_991307.2
Homo sapiens (human)	BRAF	NP_004324.2

Gene Ontology
Bibliography

Related articles in PubMed

Evolution of complexity in the zebrafish synapse proteome.
Bay?s ?, Collins MO, Reig-Viader R, Gou G, Goulding D, Izquierdo A, Choudhary JS, Emes RD, Grant SG
Nature communications814613(2017 Mar)

Oncogenic BRAF disrupts thyroid morphogenesis and function via twist expression.
Anelli V, Villefranc JA, Chhangawala S, Martinez-McFaline R, Riva E, Nguyen A, Verma A, Bareja R, Chen Z, Scognamiglio T, Elemento O, Houvras Y
eLife6(2017 03)

RFX transcription factors are essential for hearing in mice.
Elkon R, Milon B, Morrison L, Shah M, Vijayakumar S, Racherla M, Leitch CC, Silipino L, Hadi S, Weiss-Gayet M, Barras E, Schmid CD, Ait-Lounis A, Barnes A, Song Y, Eisenman DJ, Eliyahu E, Frolenkov GI, Strome SE, Durand B, Zaghloul NA, Jones SM, Reith W, Hertzano R
Nature communications68549(2015 Oct)

RAP1-mediated MEK/ERK pathway defects in Kabuki syndrome.
B?gershausen N, Tsai IC, Pohl E, Kiper P?, Beleggia F, Percin EF, Keupp K, Matchan A, Milz E, Alanay Y, Kayserili H, Liu Y, Banka S, Kranz A, Zenker M, Wieczorek D, Elcioglu N, Prontera P, Lyonnet S, Meitinger T, Stewart AF, Donnai D, Strom TM, Boduroglu K, Yigit G, Li Y, Katsanis N, Wollnik B
The Journal of clinical investigation125(9)3585-99(2015 Sep)

Araf kinase antagonizes Nodal-Smad2 activity in mesendoderm development by directly phosphorylating the Smad2 linker region.
Liu X, Xiong C, Jia S, Zhang Y, Chen YG, Wang Q, Meng A
Nature communications41728(2013)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Gene expression studies nominated TWIST2 as a key effector downstream of BRAF.
Title: Oncogenic BRAF disrupts thyroid morphogenesis and function via twist expression.

BRAF alternative splicing is differentially regulated in vertebrates. Exon 9b is present in all vertebrates, including Danio rerio, but exon 8b is present only in eutherians.
Title: B-raf alternative splicing is dispensable for development but required for learning and memory associated with the hippocampus in the adult mouse.

BRAF activation is sufficient for f-nevus formation, and is among the primary events in melanoma development.
Title: BRAF mutations are sufficient to promote nevi formation and cooperate with p53 in the genesis of melanoma.

The following braf gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the braf cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
ODa09236	NM_001324516.1 Latest version!	Danio rerio B-Raf proto-oncogene, serine/threonine kinase (braf), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	12-14	$426.30 $609.00
ODa98535	NM_205744.4 Latest version!	Danio rerio B-Raf proto-oncogene, serine/threonine kinase (braf), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	14-16	$426.30 $609.00
ODa141968	XM_021474974.1 Latest version!	Danio rerio B-Raf proto-oncogene, serine/threonine kinase (braf), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	14-16	$342.30 $489.00

ORF Online Only Promotion

Next-day Shipping ORF Clones ( in default vector with tag)
1 Clone	30% OFF
2-4 Clone	40% OFF
5 or more Clone	50% OFF
All Other ORF Clones
30% OFF

*Business Day

** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

braf ( NM_001324516.1 ) cDNA ORF clone, Danio rerio(zebrafish) -> NP_001311445.1 Danio rerio B-Raf proto-oncogene, serine/threonine kinase (braf), transcript variant 1, mRNA.

Price & Availability↑

CloneID	ODa09236
Clone ID Related Accession (Same CDS sequence)	NM_001324516.1
Accession Version	NM_001324516.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2454bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-01-26
Organism	Danio rerio(zebrafish)
Product	serine/threonine-protein kinase B-raf isoform 1
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from BX005210.10. On May 12, 2016 this sequence version replaced XM_005164617.2. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AB125105.2, GFIL01002496.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA2168446, SAMEA2168447 [ECO:0000350] ##Evidence-Data-END##

ATGGCGGCGT TGAGCAGCGC CGAGTCCCCA CCGCCCGTCT TCAACGGAGA CACCATGAAC 
CGCGATCCGG AGCGGGACCC GGGACTGGAC GAGCTGGGCG CGGGGCTCGA ACCCGCCTGT 
CCCGGAGAAG CGGCGATCCC CGAATGTCAA CAGGGCATTC CCGAGGAGAT ATGGAATATT 
AAACAGATGA TTAAGTTAAC TCAAGAGCAC CTAGAAGCCC TTTTAGATAA GTTTGGAGGA 
GAACACAATC CACCGTCTAT ATATCTAGAG GCCTATGAGG AGTACACTAG TAAGCTGGAT 
GCATTACAGC AGCGGGAGCA GCAGCTTTTG GAAGCTATTG GGAATGGGAC CGAGTTCTGC 
TCCTCGCCGA CACCCACCCT GCTGGACGTG AAGGGACAGG GCATTCAGAG TGCCCCCACT 
GCCCCAAACA CCCTAGCTGT CCTGCAGACG CCCACTGACG CAACACGAGG CAATCCCCGC 
TCGCCCCAGA AACCCATCGT CAGGGTCTTC CTGCCCAACA AACAGAGGAC TGTGGTTCCA 
GCTCGTTGTG GGATGACGGT CAGAGACTCC TTAAAGAAGG CTCTGATGAT GCGAGGCTTG 
ATCCCAGAAT GCTGTGCAGT CTATAGAGTT CAGGATGGGG AGAAGAAGCC CATTGGCTGG 
GACACAGACA TTTCCTGGTT GACGGGGGAG GAGCTTCACG TTGAAGTTTT AGAAAATGTG 
CCACTGACGA CCCATAATTT TGTGCGAAAG ACCTTCTTCA CGCTGGCCTT CTGTGATTTT 
TGCCGGAAGC TGTTGTTTCA AGGCTTCCGC TGTCAGACGT GTGGCTATAA GTTTCACCAG 
CGCTGCAGCA CGGAGGTCCC ACTCATGTGT GTCAACTACG ATCAGCTGGA TTTATTGCTG 
GCATCAAAAT TTCTGGTGCA CCACCCCATC ACCCAGGAGG AGGTGTCATC AGAGGGCACG 
ACACCCATTT CAGAGATGTG CCCCTCGCTA CCACCATCCG AATCTACTGG CTCTCTGTGC 
CATCCTACTG TGTCCCCGTC CAAATCCATC CCTATCCCGC AATCTTTTAG ACCTGGAGAA 
GAGGACCACC GTAACCAGTT TGGTCAGAGG GATCGCTCCT CATCAGCCCC TAACGTCCAT 
ATCAACACCA TTGAGCCGGT CAACATTGAT GATTTGATTC GTGATCAAGG CTTACCGAGG 
TCAGATGGAG CCCCCTCGCA ACACCCAGCC CGCTGCTTGA GGAAGAACCG AACACGGACC 
TCAAGCCCCC TTCTGTCCTC CCACCCCAAT GACATTGTCT TTGATTTTGA GCCTGAGCCA 
GTGTTCAGAG GCTCAACAAC AGGCCTGTCC GCCACTCCCC CTGCCTCCCT GCCAGGTTCC 
CTGCCCAATG TGAAGGTGTC CAAATCTCCG TGCCAACCGA GGGAGAGGAA GCCATCGTCT 
TCATCTGAGG ACCGCAATAA AATGAAAACT CTGGGTCGAC GGGACTCGAG CGATGATTGG 
GAGATTCCAG AAGGGCAGAT TACTCTGGGC CAGCGGATAG GATCTGGTTC TTTTGGGACA 
GTTTACAAGG GGAAATGGCA CGGTGACGTG GCGGTAAAGA TGTTGAATGT TACAGCTCCC 
ACTCCACAGC AGCTACAAGC CTTTAAGAAT GAAGTGGGTG TCCTCAGGAA AACCCGTCAT 
GTGAATATCC TGCTGTTCAT GGGCTACACC ACCAAACCCC AGCTGGCTAT TGTTACTCAG 
TGGTGCGAAG GCTCGAGTCT CTACCACCAC CTGCACATCA TCGAGACCAA GTTCGAGATG 
ATCAAGCTGA TCGACATTGC CCGACAGACA GCTCAGGGCA TGGACTATCT GCACGCAAAG 
TCCATCATCC ATAGAGATCT GAAGAGTAAC AACATCTTTT TGCACGAGGA TTTAACGGTA 
AAGATTGGAG ATTTCGGTCT GGCTACAGTG AAGTCCCGCT GGAGCGGATC ACACCAGTTT 
GAGCAACTTT CAGGCTCTAT CTTGTGGATG GCTCCAGAAG TGATCAGACT GCAGGATAAA 
AACCCATATA GTTTCCAGTC GGACGTCTAC GCATTCGGCA TAGTGCTTTA TGAGCTTATG 
TCAGGGGCTT TGCCTTATTC AAACATCAAC AACAGAGACC AGATTATCTT CATGGTTGGC 
CGGGGTTACT TGTCTCCTGA CTTGAGCAAG GTGCGCAGCA ATTGTCCTAA GGCCATGAAG 
AGACTTATGG CAGATTGTCT AAAGAAAAAG CGAGAAGAAA GACCTCTTTT CCCTCAGATC 
TTGGCCTCCA TCGAGTTATT GGCACGCTCT CTGCCCAAAA TCCACCGCAG CGCCTCTGAA 
CCGTCTCTGA ACCGCGCTGG CTTCCAGACG GAGGACTTCA GCCTATACAC CTGCGCTTCC 
CCCAAAACAC CCATTCAGGC CGGTGGCTAT GGTGAATTCA CAGCGTTTAA ATAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001311445.1
CDS	29..2482
Translation	MAALSSAESPPPVFNGDTMNRDPERDPGLDELGAGLEPACPGEAAIPECQQGIPEEIWNIKQMIKLTQEHLEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLEAIGNGTEFCSSPTPTLLDVKGQGIQSAPTAPNTLAVLQTPTDATRGNPRSPQKPIVRVFLPNKQRTVVPARCGMTVRDSLKKALMMRGLIPECCAVYRVQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLLASKFLVHHPITQEEVSSEGTTPISEMCPSLPPSESTGSLCHPTVSPSKSIPIPQSFRPGEEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGLPRSDGAPSQHPARCLRKNRTRTSSPLLSSHPNDIVFDFEPEPVFRGSTTGLSATPPASLPGSLPNVKVSKSPCQPRERKPSSSSEDRNKMKTLGRRDSSDDWEIPEGQITLGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYTTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRLQDKNPYSFQSDVYAFGIVLYELMSGALPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMADCLKKKREERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYTCASPKTPIQAGGYGEFTAFK

Target ORF information:

RefSeq Version	NM_001324516.1
Organism	Danio rerio(zebrafish)
Definition	Danio rerio B-Raf proto-oncogene, serine/threonine kinase (braf), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001324516.1

ORF Insert Sequence:

ATGGCGGCGT TGAGCAGCGC CGAGTCCCCA CCGCCCGTCT TCAACGGAGA CACCATGAAC 
CGCGATCCGG AGCGGGACCC GGGACTGGAC GAGCTGGGCG CGGGGCTCGA ACCCGCCTGT 
CCCGGAGAAG CGGCGATCCC CGAATGTCAA CAGGGCATTC CCGAGGAGAT ATGGAATATT 
AAACAGATGA TTAAGTTAAC TCAAGAGCAC CTAGAAGCCC TTTTAGATAA GTTTGGAGGA 
GAACACAATC CACCGTCTAT ATATCTAGAG GCCTATGAGG AGTACACTAG TAAGCTGGAT 
GCATTACAGC AGCGGGAGCA GCAGCTTTTG GAAGCTATTG GGAATGGGAC CGAGTTCTGC 
TCCTCGCCGA CACCCACCCT GCTGGACGTG AAGGGACAGG GCATTCAGAG TGCCCCCACT 
GCCCCAAACA CCCTAGCTGT CCTGCAGACG CCCACTGACG CAACACGAGG CAATCCCCGC 
TCGCCCCAGA AACCCATCGT CAGGGTCTTC CTGCCCAACA AACAGAGGAC TGTGGTTCCA 
GCTCGTTGTG GGATGACGGT CAGAGACTCC TTAAAGAAGG CTCTGATGAT GCGAGGCTTG 
ATCCCAGAAT GCTGTGCAGT CTATAGAGTT CAGGATGGGG AGAAGAAGCC CATTGGCTGG 
GACACAGACA TTTCCTGGTT GACGGGGGAG GAGCTTCACG TTGAAGTTTT AGAAAATGTG 
CCACTGACGA CCCATAATTT TGTGCGAAAG ACCTTCTTCA CGCTGGCCTT CTGTGATTTT 
TGCCGGAAGC TGTTGTTTCA AGGCTTCCGC TGTCAGACGT GTGGCTATAA GTTTCACCAG 
CGCTGCAGCA CGGAGGTCCC ACTCATGTGT GTCAACTACG ATCAGCTGGA TTTATTGCTG 
GCATCAAAAT TTCTGGTGCA CCACCCCATC ACCCAGGAGG AGGTGTCATC AGAGGGCACG 
ACACCCATTT CAGAGATGTG CCCCTCGCTA CCACCATCCG AATCTACTGG CTCTCTGTGC 
CATCCTACTG TGTCCCCGTC CAAATCCATC CCTATCCCGC AATCTTTTAG ACCTGGAGAA 
GAGGACCACC GTAACCAGTT TGGTCAGAGG GATCGCTCCT CATCAGCCCC TAACGTCCAT 
ATCAACACCA TTGAGCCGGT CAACATTGAT GATTTGATTC GTGATCAAGG CTTACCGAGG 
TCAGATGGAG CCCCCTCGCA ACACCCAGCC CGCTGCTTGA GGAAGAACCG AACACGGACC 
TCAAGCCCCC TTCTGTCCTC CCACCCCAAT GACATTGTCT TTGATTTTGA GCCTGAGCCA 
GTGTTCAGAG GCTCAACAAC AGGCCTGTCC GCCACTCCCC CTGCCTCCCT GCCAGGTTCC 
CTGCCCAATG TGAAGGTGTC CAAATCTCCG TGCCAACCGA GGGAGAGGAA GCCATCGTCT 
TCATCTGAGG ACCGCAATAA AATGAAAACT CTGGGTCGAC GGGACTCGAG CGATGATTGG 
GAGATTCCAG AAGGGCAGAT TACTCTGGGC CAGCGGATAG GATCTGGTTC TTTTGGGACA 
GTTTACAAGG GGAAATGGCA CGGTGACGTG GCGGTAAAGA TGTTGAATGT TACAGCTCCC 
ACTCCACAGC AGCTACAAGC CTTTAAGAAT GAAGTGGGTG TCCTCAGGAA AACCCGTCAT 
GTGAATATCC TGCTGTTCAT GGGCTACACC ACCAAACCCC AGCTGGCTAT TGTTACTCAG 
TGGTGCGAAG GCTCGAGTCT CTACCACCAC CTGCACATCA TCGAGACCAA GTTCGAGATG 
ATCAAGCTGA TCGACATTGC CCGACAGACA GCTCAGGGCA TGGACTATCT GCACGCAAAG 
TCCATCATCC ATAGAGATCT GAAGAGTAAC AACATCTTTT TGCACGAGGA TTTAACGGTA 
AAGATTGGAG ATTTCGGTCT GGCTACAGTG AAGTCCCGCT GGAGCGGATC ACACCAGTTT 
GAGCAACTTT CAGGCTCTAT CTTGTGGATG GCTCCAGAAG TGATCAGACT GCAGGATAAA 
AACCCATATA GTTTCCAGTC GGACGTCTAC GCATTCGGCA TAGTGCTTTA TGAGCTTATG 
TCAGGGGCTT TGCCTTATTC AAACATCAAC AACAGAGACC AGATTATCTT CATGGTTGGC 
CGGGGTTACT TGTCTCCTGA CTTGAGCAAG GTGCGCAGCA ATTGTCCTAA GGCCATGAAG 
AGACTTATGG CAGATTGTCT AAAGAAAAAG CGAGAAGAAA GACCTCTTTT CCCTCAGATC 
TTGGCCTCCA TCGAGTTATT GGCACGCTCT CTGCCCAAAA TCCACCGCAG CGCCTCTGAA 
CCGTCTCTGA ACCGCGCTGG CTTCCAGACG GAGGACTTCA GCCTATACAC CTGCGCTTCC 
CCCAAAACAC CCATTCAGGC CGGTGGCTAT GGTGAATTCA CAGCGTTTAA ATAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

braf ( NM_205744.4 ) cDNA ORF clone, Danio rerio(zebrafish) -> NP_991307.3 Danio rerio B-Raf proto-oncogene, serine/threonine kinase (braf), transcript variant 2, mRNA.

Price & Availability↑

CloneID	ODa98535
Clone ID Related Accession (Same CDS sequence)	NM_205744.4
Accession Version	NM_205744.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2334bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-01-26
Organism	Danio rerio(zebrafish)
Product	serine/threonine-protein kinase B-raf isoform 2
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from BX005210.10 and BC162198.1. On May 12, 2016 this sequence version replaced NM_205744.3. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AB113402.3, GFIL01002497.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA2168446, SAMEA2168447 [ECO:0000350] ##Evidence-Data-END##

ATGGCGGCGT TGAGCAGCGC CGAGTCCCCA CCGCCCGTCT TCAACGGAGA CACCATGAAC 
CGCGATCCGG AGCGGGACCC GGGACTGGAC GAGCTGGGCG CGGGGCTCGA ACCCGCCTGT 
CCCGGAGAAG CGGCGATCCC CGAATGTCAA CAGGGCATTC CCGAGGAGAT ATGGAATATT 
AAACAGATGA TTAAGTTAAC TCAAGAGCAC CTAGAAGCCC TTTTAGATAA GTTTGGAGGA 
GAACACAATC CACCGTCTAT ATATCTAGAG GCCTATGAGG AGTACACTAG TAAGCTGGAT 
GCATTACAGC AGCGGGAGCA GCAGCTTTTG GAAGCTATTG GGAATGGGAC CGAGTTCTGC 
TCCTCGCCGA CACCCACCCT GCTGGACGTG AAGGGACAGG GCATTCAGAG TGCCCCCACT 
GCCCCAAACA CCCTAGCTGT CCTGCAGACG CCCACTGACG CAACACGAGG CAATCCCCGC 
TCGCCCCAGA AACCCATCGT CAGGGTCTTC CTGCCCAACA AACAGAGGAC TGTGGTTCCA 
GCTCGTTGTG GGATGACGGT CAGAGACTCC TTAAAGAAGG CTCTGATGAT GCGAGGCTTG 
ATCCCAGAAT GCTGTGCAGT CTATAGAGTT CAGGATGGGG AGAAGAAGCC CATTGGCTGG 
GACACAGACA TTTCCTGGTT GACGGGGGAG GAGCTTCACG TTGAAGTTTT AGAAAATGTG 
CCACTGACGA CCCATAATTT TGTGCGAAAG ACCTTCTTCA CGCTGGCCTT CTGTGATTTT 
TGCCGGAAGC TGTTGTTTCA AGGCTTCCGC TGTCAGACGT GTGGCTATAA GTTTCACCAG 
CGCTGCAGCA CGGAGGTCCC ACTCATGTGT GTCAACTACG ATCAGCTGGA TTTATTGCTG 
GCATCAAAAT TTCTGGTGCA CCACCCCATC ACCCAGGAGG AGGTGTCATC AGAGGGCACG 
ACACCCATTT CAGAGATGTG CCCCTCGCTA CCACCATCCG AATCTACTGG CTCTCTGTGC 
CATCCTACTG TGTCCCCGTC CAAATCCATC CCTATCCCGC AATCTTTTAG ACCTGGAGAA 
GAGGACCACC GTAACCAGTT TGGTCAGAGG GATCGCTCCT CATCAGCCCC TAACGTCCAT 
ATCAACACCA TTGAGCCGGT CAACATTGAT GATTTGATTC GTGATCAAGG CTTACCGAGG 
TCAGATGGAG GCTCAACAAC AGGCCTGTCC GCCACTCCCC CTGCCTCCCT GCCAGGTTCC 
CTGCCCAATG TGAAGGTGTC CAAATCTCCG TGCCAACCGA GGGAGAGGAA GCCATCGTCT 
TCATCTGAGG ACCGCAATAA AATGAAAACT CTGGGTCGAC GGGACTCGAG CGATGATTGG 
GAGATTCCAG AAGGGCAGAT TACTCTGGGC CAGCGGATAG GATCTGGTTC TTTTGGGACA 
GTTTACAAGG GGAAATGGCA CGGTGACGTG GCGGTAAAGA TGTTGAATGT TACAGCTCCC 
ACTCCACAGC AGCTACAAGC CTTTAAGAAT GAAGTGGGTG TCCTCAGGAA AACCCGTCAT 
GTGAATATCC TGCTGTTCAT GGGCTACACC ACCAAACCCC AGCTGGCTAT TGTTACTCAG 
TGGTGCGAAG GCTCGAGTCT CTACCACCAC CTGCACATCA TCGAGACCAA GTTCGAGATG 
ATCAAGCTGA TCGACATTGC CCGACAGACA GCTCAGGGCA TGGACTATCT GCACGCAAAG 
TCCATCATCC ATAGAGATCT GAAGAGTAAC AACATCTTTT TGCACGAGGA TTTAACGGTA 
AAGATTGGAG ATTTCGGTCT GGCTACAGTG AAGTCCCGCT GGAGCGGATC ACACCAGTTT 
GAGCAACTTT CAGGCTCTAT CTTGTGGATG GCTCCAGAAG TGATCAGACT GCAGGATAAA 
AACCCATATA GTTTCCAGTC GGACGTCTAC GCATTCGGCA TAGTGCTTTA TGAGCTTATG 
TCAGGGGCTT TGCCTTATTC AAACATCAAC AACAGAGACC AGATTATCTT CATGGTTGGC 
CGGGGTTACT TGTCTCCTGA CTTGAGCAAG GTGCGCAGCA ATTGTCCTAA GGCCATGAAG 
AGACTTATGG CAGATTGTCT AAAGAAAAAG CGAGAAGAAA GACCTCTTTT CCCTCAGATC 
TTGGCCTCCA TCGAGTTATT GGCACGCTCT CTGCCCAAAA TCCACCGCAG CGCCTCTGAA 
CCGTCTCTGA ACCGCGCTGG CTTCCAGACG GAGGACTTCA GCCTATACAC CTGCGCTTCC 
CCCAAAACAC CCATTCAGGC CGGTGGCTAT GGTGAATTCA CAGCGTTTAA ATAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_991307.3
CDS	29..2362
Translation	MAALSSAESPPPVFNGDTMNRDPERDPGLDELGAGLEPACPGEAAIPECQQGIPEEIWNIKQMIKLTQEHLEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLEAIGNGTEFCSSPTPTLLDVKGQGIQSAPTAPNTLAVLQTPTDATRGNPRSPQKPIVRVFLPNKQRTVVPARCGMTVRDSLKKALMMRGLIPECCAVYRVQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLLASKFLVHHPITQEEVSSEGTTPISEMCPSLPPSESTGSLCHPTVSPSKSIPIPQSFRPGEEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGLPRSDGGSTTGLSATPPASLPGSLPNVKVSKSPCQPRERKPSSSSEDRNKMKTLGRRDSSDDWEIPEGQITLGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYTTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRLQDKNPYSFQSDVYAFGIVLYELMSGALPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMADCLKKKREERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYTCASPKTPIQAGGYGEFTAFK

Target ORF information:

RefSeq Version	NM_205744.4
Organism	Danio rerio(zebrafish)
Definition	Danio rerio B-Raf proto-oncogene, serine/threonine kinase (braf), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_205744.4

ORF Insert Sequence:

ATGGCGGCGT TGAGCAGCGC CGAGTCCCCA CCGCCCGTCT TCAACGGAGA CACCATGAAC 
CGCGATCCGG AGCGGGACCC GGGACTGGAC GAGCTGGGCG CGGGGCTCGA ACCCGCCTGT 
CCCGGAGAAG CGGCGATCCC CGAATGTCAA CAGGGCATTC CCGAGGAGAT ATGGAATATT 
AAACAGATGA TTAAGTTAAC TCAAGAGCAC CTAGAAGCCC TTTTAGATAA GTTTGGAGGA 
GAACACAATC CACCGTCTAT ATATCTAGAG GCCTATGAGG AGTACACTAG TAAGCTGGAT 
GCATTACAGC AGCGGGAGCA GCAGCTTTTG GAAGCTATTG GGAATGGGAC CGAGTTCTGC 
TCCTCGCCGA CACCCACCCT GCTGGACGTG AAGGGACAGG GCATTCAGAG TGCCCCCACT 
GCCCCAAACA CCCTAGCTGT CCTGCAGACG CCCACTGACG CAACACGAGG CAATCCCCGC 
TCGCCCCAGA AACCCATCGT CAGGGTCTTC CTGCCCAACA AACAGAGGAC TGTGGTTCCA 
GCTCGTTGTG GGATGACGGT CAGAGACTCC TTAAAGAAGG CTCTGATGAT GCGAGGCTTG 
ATCCCAGAAT GCTGTGCAGT CTATAGAGTT CAGGATGGGG AGAAGAAGCC CATTGGCTGG 
GACACAGACA TTTCCTGGTT GACGGGGGAG GAGCTTCACG TTGAAGTTTT AGAAAATGTG 
CCACTGACGA CCCATAATTT TGTGCGAAAG ACCTTCTTCA CGCTGGCCTT CTGTGATTTT 
TGCCGGAAGC TGTTGTTTCA AGGCTTCCGC TGTCAGACGT GTGGCTATAA GTTTCACCAG 
CGCTGCAGCA CGGAGGTCCC ACTCATGTGT GTCAACTACG ATCAGCTGGA TTTATTGCTG 
GCATCAAAAT TTCTGGTGCA CCACCCCATC ACCCAGGAGG AGGTGTCATC AGAGGGCACG 
ACACCCATTT CAGAGATGTG CCCCTCGCTA CCACCATCCG AATCTACTGG CTCTCTGTGC 
CATCCTACTG TGTCCCCGTC CAAATCCATC CCTATCCCGC AATCTTTTAG ACCTGGAGAA 
GAGGACCACC GTAACCAGTT TGGTCAGAGG GATCGCTCCT CATCAGCCCC TAACGTCCAT 
ATCAACACCA TTGAGCCGGT CAACATTGAT GATTTGATTC GTGATCAAGG CTTACCGAGG 
TCAGATGGAG GCTCAACAAC AGGCCTGTCC GCCACTCCCC CTGCCTCCCT GCCAGGTTCC 
CTGCCCAATG TGAAGGTGTC CAAATCTCCG TGCCAACCGA GGGAGAGGAA GCCATCGTCT 
TCATCTGAGG ACCGCAATAA AATGAAAACT CTGGGTCGAC GGGACTCGAG CGATGATTGG 
GAGATTCCAG AAGGGCAGAT TACTCTGGGC CAGCGGATAG GATCTGGTTC TTTTGGGACA 
GTTTACAAGG GGAAATGGCA CGGTGACGTG GCGGTAAAGA TGTTGAATGT TACAGCTCCC 
ACTCCACAGC AGCTACAAGC CTTTAAGAAT GAAGTGGGTG TCCTCAGGAA AACCCGTCAT 
GTGAATATCC TGCTGTTCAT GGGCTACACC ACCAAACCCC AGCTGGCTAT TGTTACTCAG 
TGGTGCGAAG GCTCGAGTCT CTACCACCAC CTGCACATCA TCGAGACCAA GTTCGAGATG 
ATCAAGCTGA TCGACATTGC CCGACAGACA GCTCAGGGCA TGGACTATCT GCACGCAAAG 
TCCATCATCC ATAGAGATCT GAAGAGTAAC AACATCTTTT TGCACGAGGA TTTAACGGTA 
AAGATTGGAG ATTTCGGTCT GGCTACAGTG AAGTCCCGCT GGAGCGGATC ACACCAGTTT 
GAGCAACTTT CAGGCTCTAT CTTGTGGATG GCTCCAGAAG TGATCAGACT GCAGGATAAA 
AACCCATATA GTTTCCAGTC GGACGTCTAC GCATTCGGCA TAGTGCTTTA TGAGCTTATG 
TCAGGGGCTT TGCCTTATTC AAACATCAAC AACAGAGACC AGATTATCTT CATGGTTGGC 
CGGGGTTACT TGTCTCCTGA CTTGAGCAAG GTGCGCAGCA ATTGTCCTAA GGCCATGAAG 
AGACTTATGG CAGATTGTCT AAAGAAAAAG CGAGAAGAAA GACCTCTTTT CCCTCAGATC 
TTGGCCTCCA TCGAGTTATT GGCACGCTCT CTGCCCAAAA TCCACCGCAG CGCCTCTGAA 
CCGTCTCTGA ACCGCGCTGG CTTCCAGACG GAGGACTTCA GCCTATACAC CTGCGCTTCC 
CCCAAAACAC CCATTCAGGC CGGTGGCTAT GGTGAATTCA CAGCGTTTAA ATAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

braf ( XM_021474974.1 ) cDNA ORF clone, Danio rerio(zebrafish) -> XP_021330649.1 Danio rerio B-Raf proto-oncogene, serine/threonine kinase (braf), transcript variant X1, mRNA.

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CloneID	ODa141968
Clone ID Related Accession (Same CDS sequence)	XM_021474974.1
Accession Version	XM_021474974.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1728bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-06-14
Organism	Danio rerio(zebrafish)
Product	serine/threonine-protein kinase B-raf isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_007115.7) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Danio rerio Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.4 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGGCGGCGT TGAGCAGCGC CGAGTCCCCA CCGCCCGTCT TCAACGGAGA CACCATGAAC 
CGCGATCCGG AGCGGGACCC GGGACTGGAC GAGCTGGGCG CGGGGCTCGA ACCCGCCTGT 
CCCGGAGAAG CGGCGATCCC CGAATGTCAA CAGGGCATTC CCGAGGAGAT ATGGAATATT 
AAACAGATGA TTAAGTTAAC TCAAGAGCAC CTAGAAGCCC TTTTAGATAA GTTTGGAGGA 
GAACACAATC CACCGTCTAT ATATCTAGAG GCCTATGAGG AGTACACTAG TAAGCTGGAT 
GCATTACAGC AGCGGGAGCA GCAGCTTTTG GAAGCTATTG GGAATGGGAC CGAGTTCTGC 
TCCTCGCCGA CACCCACCCT GCTGGACGTG AAGGGACAGG GCATTCAGAG TGCCCCCACT 
GCCCCAAACA CCCTAGCTGT CCTGCAGACG CCCACTGACG CAACACGAGG CAATCCCCGC 
TCGCCCCAGA AACCCATCGT CAGGGTCTTC CTGCCCAACA AACAGAGGAC TGTGGTTCCA 
GCTCGTTGTG GGATGACGGT CAGAGACTCC TTAAAGAAGG CTCTGATGAT GCGAGGCTTG 
ATCCCAGAAT GCTGTGCAGT CTATAGAGTT CAGGATGGGG AGAAGAAGCC CATTGGCTGG 
GACACAGACA TTTCCTGGTT GACGGGGGAG GAGCTTCACG TTGAAGTTTT AGAAAATGTG 
CCACTGACGA CCCATAATTT TGTGCGAAAG ACCTTCTTCA CGCTGGCCTT CTGTGATTTT 
TGCCGGAAGC TGTTGTTTCA AGGCTTCCGC TGTCAGACGT GTGGCTATAA GTTTCACCAG 
CGCTGCAGCA CGGAGGTCCC ACTCATGTGT GTCAACTACG ATCAGCTGGA TTTATTGCTG 
GCATCAAAAT TTCTGGTGCA CCACCCCATC ACCCAGGAGG AGGTGTCATC AGAGGGCACG 
ACACCCATTT CAGAGATGTG CCCCTCGCTA CCACCATCCG AATCTACTGG CTCTCTGTGC 
CATCCTACTG TGTCCCCGTC CAAATCCATC CCTATCCCGC AATCTTTTAG ACCTGGAGAA 
GAGGACCACC GTAACCAGTT TGGTCAGAGG GATCGCTCCT CATCAGCCCC TAACGTCCAT 
ATCAACACCA TTGAGCCGGT CAACATTGAT GATTTGATTC GTGATCAAGG CTTACCGAGG 
TCAGATGGAG GCTCAACAAC AGGCCTGTCC GCCACTCCCC CTGCCTCCCT GCCAGGTTCC 
CTGCCCAATG TGAAGGTGTC CAAATCTCCG TGCCAACCGA GGGAGAGGAA GCCATCGTCT 
TCATCTGAGG ACCGCAATAA AATGAAAACT CTGGGTCGAC GGGACTCGAG CGATGATTGG 
GAGATTCCAG AAGGGCAGAT TACTCTGGGC CAGCGGATAG GATCTGGTTC TTTTGGGACA 
GTTTACAAGG GGAAATGGCA CGGTGACGTG GCGGTAAAGA TGTTGAATGT TACAGCTCCC 
ACTCCACAGC AGCTACAAGC CTTTAAGAAT GAAGTGGGTG TCCTCAGGAA AACCCGTCAT 
GTGAATATCC TGCTGTTCAT GGGCTACACC ACCAAACCCC AGCTGGCTAT TGTTACTCAG 
TGGTGCGAAG GCTCGAGTCT CTACCACCAC CTGCACATCA TCGAGACCAA GTTCGAGATG 
ATCAAGCTGA TCGACATTGC CCGACAGACA GCTCAGGGCA TGGAGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_021330649.1
CDS	116..1843
Translation	MAALSSAESPPPVFNGDTMNRDPERDPGLDELGAGLEPACPGEAAIPECQQGIPEEIWNIKQMIKLTQEHLEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLEAIGNGTEFCSSPTPTLLDVKGQGIQSAPTAPNTLAVLQTPTDATRGNPRSPQKPIVRVFLPNKQRTVVPARCGMTVRDSLKKALMMRGLIPECCAVYRVQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLLASKFLVHHPITQEEVSSEGTTPISEMCPSLPPSESTGSLCHPTVSPSKSIPIPQSFRPGEEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGLPRSDGGSTTGLSATPPASLPGSLPNVKVSKSPCQPRERKPSSSSEDRNKMKTLGRRDSSDDWEIPEGQITLGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYTTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGME

Target ORF information:

RefSeq Version	XM_021474974.1
Organism	Danio rerio(zebrafish)
Definition	Danio rerio B-Raf proto-oncogene, serine/threonine kinase (braf), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_021474974.1

ORF Insert Sequence:

ATGGCGGCGT TGAGCAGCGC CGAGTCCCCA CCGCCCGTCT TCAACGGAGA CACCATGAAC 
CGCGATCCGG AGCGGGACCC GGGACTGGAC GAGCTGGGCG CGGGGCTCGA ACCCGCCTGT 
CCCGGAGAAG CGGCGATCCC CGAATGTCAA CAGGGCATTC CCGAGGAGAT ATGGAATATT 
AAACAGATGA TTAAGTTAAC TCAAGAGCAC CTAGAAGCCC TTTTAGATAA GTTTGGAGGA 
GAACACAATC CACCGTCTAT ATATCTAGAG GCCTATGAGG AGTACACTAG TAAGCTGGAT 
GCATTACAGC AGCGGGAGCA GCAGCTTTTG GAAGCTATTG GGAATGGGAC CGAGTTCTGC 
TCCTCGCCGA CACCCACCCT GCTGGACGTG AAGGGACAGG GCATTCAGAG TGCCCCCACT 
GCCCCAAACA CCCTAGCTGT CCTGCAGACG CCCACTGACG CAACACGAGG CAATCCCCGC 
TCGCCCCAGA AACCCATCGT CAGGGTCTTC CTGCCCAACA AACAGAGGAC TGTGGTTCCA 
GCTCGTTGTG GGATGACGGT CAGAGACTCC TTAAAGAAGG CTCTGATGAT GCGAGGCTTG 
ATCCCAGAAT GCTGTGCAGT CTATAGAGTT CAGGATGGGG AGAAGAAGCC CATTGGCTGG 
GACACAGACA TTTCCTGGTT GACGGGGGAG GAGCTTCACG TTGAAGTTTT AGAAAATGTG 
CCACTGACGA CCCATAATTT TGTGCGAAAG ACCTTCTTCA CGCTGGCCTT CTGTGATTTT 
TGCCGGAAGC TGTTGTTTCA AGGCTTCCGC TGTCAGACGT GTGGCTATAA GTTTCACCAG 
CGCTGCAGCA CGGAGGTCCC ACTCATGTGT GTCAACTACG ATCAGCTGGA TTTATTGCTG 
GCATCAAAAT TTCTGGTGCA CCACCCCATC ACCCAGGAGG AGGTGTCATC AGAGGGCACG 
ACACCCATTT CAGAGATGTG CCCCTCGCTA CCACCATCCG AATCTACTGG CTCTCTGTGC 
CATCCTACTG TGTCCCCGTC CAAATCCATC CCTATCCCGC AATCTTTTAG ACCTGGAGAA 
GAGGACCACC GTAACCAGTT TGGTCAGAGG GATCGCTCCT CATCAGCCCC TAACGTCCAT 
ATCAACACCA TTGAGCCGGT CAACATTGAT GATTTGATTC GTGATCAAGG CTTACCGAGG 
TCAGATGGAG GCTCAACAAC AGGCCTGTCC GCCACTCCCC CTGCCTCCCT GCCAGGTTCC 
CTGCCCAATG TGAAGGTGTC CAAATCTCCG TGCCAACCGA GGGAGAGGAA GCCATCGTCT 
TCATCTGAGG ACCGCAATAA AATGAAAACT CTGGGTCGAC GGGACTCGAG CGATGATTGG 
GAGATTCCAG AAGGGCAGAT TACTCTGGGC CAGCGGATAG GATCTGGTTC TTTTGGGACA 
GTTTACAAGG GGAAATGGCA CGGTGACGTG GCGGTAAAGA TGTTGAATGT TACAGCTCCC 
ACTCCACAGC AGCTACAAGC CTTTAAGAAT GAAGTGGGTG TCCTCAGGAA AACCCGTCAT 
GTGAATATCC TGCTGTTCAT GGGCTACACC ACCAAACCCC AGCTGGCTAT TGTTACTCAG 
TGGTGCGAAG GCTCGAGTCT CTACCACCAC CTGCACATCA TCGAGACCAA GTTCGAGATG 
ATCAAGCTGA TCGACATTGC CCGACAGACA GCTCAGGGCA TGGAGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Evolution of complexity in the zebrafish synapse proteome.
Nature communications814613(2017 Mar)
Bay?s ?,Collins MO,Reig-Viader R,Gou G,Goulding D,Izquierdo A,Choudhary JS,Emes RD,Grant SG

Oncogenic BRAF disrupts thyroid morphogenesis and function via twist expression.
eLife6(2017 03)
Anelli V,Villefranc JA,Chhangawala S,Martinez-McFaline R,Riva E,Nguyen A,Verma A,Bareja R,Chen Z,Scognamiglio T,Elemento O,Houvras Y

RFX transcription factors are essential for hearing in mice.
Nature communications68549(2015 Oct)
Elkon R,Milon B,Morrison L,Shah M,Vijayakumar S,Racherla M,Leitch CC,Silipino L,Hadi S,Weiss-Gayet M,Barras E,Schmid CD,Ait-Lounis A,Barnes A,Song Y,Eisenman DJ,Eliyahu E,Frolenkov GI,Strome SE,Durand B,Zaghloul NA,Jones SM,Reith W,Hertzano R

RAP1-mediated MEK/ERK pathway defects in Kabuki syndrome.
The Journal of clinical investigation125(9)3585-99(2015 Sep)
B?gershausen N,Tsai IC,Pohl E,Kiper P?,Beleggia F,Percin EF,Keupp K,Matchan A,Milz E,Alanay Y,Kayserili H,Liu Y,Banka S,Kranz A,Zenker M,Wieczorek D,Elcioglu N,Prontera P,Lyonnet S,Meitinger T,Stewart AF,Donnai D,Strom TM,Boduroglu K,Yigit G,Li Y,Katsanis N,Wollnik B

Araf kinase antagonizes Nodal-Smad2 activity in mesendoderm development by directly phosphorylating the Smad2 linker region.
Nature communications41728(2013)
Liu X,Xiong C,Jia S,Zhang Y,Chen YG,Wang Q,Meng A

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braf cDNA ORF clone, Danio rerio(zebrafish)

Gene

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gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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