fus cDNA ORF clone, Danio rerio(zebrafish)

Gene
Clones
gRNAs

Summary

Gene Symbol	fus
Entrez Gene ID	394058
Full Name	FUS RNA binding protein
Synonyms	zgc:56390
General protein information	Preferred Names FUS RNA binding protein Names RNA-binding protein FUS fusion (involved in t(12;16) in malignant liposarcoma)
Gene Type	protein-coding
Organism	Danio rerio(zebrafish)

mRNA and Protein(s)

mRNA	Protein	Name
NM_201083.2	NP_957377.2	RNA-binding protein FUS

Pathways from BioSystems
Gene Ontology
Bibliography

Related articles in PubMed

Integrated in silico and in vivo approaches to investigate effects of BDE-99 mediated by the nuclear receptors on developing zebrafish.
Zhang L, Jin Y, Han Z, Liu H, Shi L, Hua X, Doering JA, Tang S, Giesy JP, Yu H
Environmental toxicology and chemistry(2017 Oct)

The combination of in silico and in?vivo approaches for the investigation of disrupting effects of tris (2-chloroethyl) phosphate (TCEP) toward core receptors of zebrafish.
Wu Y, Su G, Tang S, Liu W, Ma Z, Zheng X, Liu H, Yu H
Chemosphere168122-130(2017 Feb)

Characterization of genetic loss-of-function of Fus in zebrafish.
Lebedeva S, de Jesus Domingues AM, Butter F, Ketting RF
RNA biology14(1)29-35(2017 01)

Neurotrophic effects of progranulin in vivo in reversing motor neuron defects caused by over or under expression of TDP-43 or FUS.
Chitramuthu BP, Kay DG, Bateman A, Bennett HP
PloS one12(3)e0174784(2017)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Data indicate a method for site-directed single nucleotide editing in two disease-related genes, DNA binding protein tardbp and RNA binding protein fus.
Title: Homology Directed Knockin of Point Mutations in the Zebrafish tardbp and fus Genes in ALS Using the CRISPR/Cas9 System.

TARDBP and FUS act in a pathogenic pathway that is independent of SOD1.
Title: FUS and TARDBP but not SOD1 interact in genetic models of amyotrophic lateral sclerosis.

The following fus gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the fus cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ODa02157	NM_201083.2 Latest version!	Danio rerio FUS RNA binding protein (fus), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$342.30 $489.00

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

fus ( NM_201083.2 ) cDNA ORF clone, Danio rerio(zebrafish) -> NP_957377.2 Danio rerio FUS RNA binding protein (fus), mRNA.

Price & Availability↑

CloneID	ODa02157
Clone ID Related Accession (Same CDS sequence)	NM_201083.2
Accession Version	NM_201083.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1626bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-04-12
Organism	Danio rerio(zebrafish)
Product	RNA-binding protein FUS
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BX571714.7. On Jul 22, 2009 this sequence version replaced NM_201083.1. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## RNAseq introns :: single sample supports all introns SAMEA2168446, SAMEA2168447 [ECO:0000348] ##Evidence-Data-END##

ATGGCGTCAA ATGATTATGG CCAAACCTCA AGCCATGGCT ATGGGGGTTA TGGAGGACAG 
TCCGGTCAAA GCTACAGCCA ACCTTCTGCC CAGAACTACA GTCAGCAGAG CTATGGAGGA 
TACAACCAAA GCTCAGAGAG CAGCTCCGCT CCTTATAATC AGGGAGGATA CAGCTCCAAC 
TATGGACAGT CCCAGTCAGG AGGATATGGA TCTCAAGCCC CTTCTCAAGG CTACAGTCAG 
TCCAGTCAGT CGTATAGCTC TGGTGGCTAC AGTAACACCA GCCAGCCTCC ACCAGCTCAA 
AGCGGAGGCT ACAGCCAGCA GTCCTCTTAT TCTGGCTATA ACCAGTCTTC TCCTGCATCT 
GCCCCTGGTG GCTATAGCAG CAGCTCTCAG TCGTCTGGCT ACGGTCAGCA GCAGCAGCAG 
AGTGGAGGTG GGTATGGAGG CAGTGGTGGT CAGTCTGGAG GATATGGGAG CAGTGGAGGC 
CAGAGCAGTG GATTTGGGGG TAGCGGAGGC CAACACCAGT CCTCTCAGTC TGGAGGAGGG 
TCTTACAGCC CATCTCCTAA CTACAGCTCC CCTCCACCAC AAAGCTATGG GCAACAAAGT 
CAGTACGGAC AGGGAGGTTA CAACCAAGAT AGCCCACCAA TGAGTGGTGG GGGAGGTGGT 
GGGGGCTATG GTGGTCAGGA TGGCGGATAC AGCCAGGATG GTAGAGGTGG ACGTGGCCGT 
GGAGGTGGCT TTGGAGGTCG AGGAGCGGGT GGGTTTGACA GGGGTGGTCG TGGAGGACCC 
CGTGGCAGAG GAGGAATGGG AATGGGCGAT CGTGGAGGAT TCAATAAGTT TGGTGGGCCC 
AGGGATCATG GAGCTGGTGG GCCCAATATG CAGGAGCAGG ATAACTCTGA CAACAACACC 
ATCTTTGTAC AAGGTCTTGG AGACGACTAT ACTGTGGACT CTGTTGCAGA CTACTTTAAA 
CAGATCGGCA TCATCAAGGT GAATAAGAAG ACAGGATTGC CCATGATTAA TCTGTATACA 
GACAGAGAGA CGGGGAAGCT TAAAGGGGAG GCTACTGTTT CCTTTGATGA CCCTCCTTCA 
GCAAAAGCAG CCATTGATTG GTTTGATGGT AAAGATTTTA ATGGAAATCC AATCAAGGTG 
TCCTTCGCCA CCCGCAGAGC TGAGTTTGGT CGTGGTGGCA GCAGCGGTGG CATGAGAGGT 
GGCCGTGGTC GAGGAGGGCC AATGGGGCGT GGGGGATTTG GGGGTGGCAG AGGTGGTGGT 
GGTGGTGGTG GTGGTTTCCA AGGCAACAAT GGTGGTGGTA GTGGCAACGG CGGCGGTCAG 
CAAAGAGCAG GAGACTGGAA GTGTTCAAAC CCTTCATGTG GAAATTTGAA CTTCTCATGG 
CGAAACGAGT GCAATCAGTG CAAAGAACCC AAACCGGAAG GAAGTGGAGG AGGAATGTCC 
CCGATGGGAG GTGGTTTTGG TGGAGAGCGG GGCAGAAGTG GCTTCGATCG AGGTGGTTTC 
CGTGGTCGTG GTGGTGATCG AGGAGGTTTC AGAGGAGGAA GAGGAGGAGA TCGTGGAGGA 
TTTGGACCTG GAAAGATGGA CTCGAGGGGT GACCACAGAC ATGACCGCAG AGACCGCCCT 
TACTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_957377.2
CDS	82..1707
Translation	MASNDYGQTSSHGYGGYGGQSGQSYSQPSAQNYSQQSYGGYNQSSESSSAPYNQGGYSSNYGQSQSGGYGSQAPSQGYSQSSQSYSSGGYSNTSQPPPAQSGGYSQQSSYSGYNQSSPASAPGGYSSSSQSSGYGQQQQQSGGGYGGSGGQSGGYGSSGGQSSGFGGSGGQHQSSQSGGGSYSPSPNYSSPPPQSYGQQSQYGQGGYNQDSPPMSGGGGGGGYGGQDGGYSQDGRGGRGRGGGFGGRGAGGFDRGGRGGPRGRGGMGMGDRGGFNKFGGPRDHGAGGPNMQEQDNSDNNTIFVQGLGDDYTVDSVADYFKQIGIIKVNKKTGLPMINLYTDRETGKLKGEATVSFDDPPSAKAAIDWFDGKDFNGNPIKVSFATRRAEFGRGGSSGGMRGGRGRGGPMGRGGFGGGRGGGGGGGGFQGNNGGGSGNGGGQQRAGDWKCSNPSCGNLNFSWRNECNQCKEPKPEGSGGGMSPMGGGFGGERGRSGFDRGGFRGRGGDRGGFRGGRGGDRGGFGPGKMDSRGDHRHDRRDRPY

Target ORF information:

RefSeq Version	NM_201083.2
Organism	Danio rerio(zebrafish)
Definition	Danio rerio FUS RNA binding protein (fus), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_201083.2

ORF Insert Sequence:

ATGGCGTCAA ATGATTATGG CCAAACCTCA AGCCATGGCT ATGGGGGTTA TGGAGGACAG 
TCCGGTCAAA GCTACAGCCA ACCTTCTGCC CAGAACTACA GTCAGCAGAG CTATGGAGGA 
TACAACCAAA GCTCAGAGAG CAGCTCCGCT CCTTATAATC AGGGAGGATA CAGCTCCAAC 
TATGGACAGT CCCAGTCAGG AGGATATGGA TCTCAAGCCC CTTCTCAAGG CTACAGTCAG 
TCCAGTCAGT CGTATAGCTC TGGTGGCTAC AGTAACACCA GCCAGCCTCC ACCAGCTCAA 
AGCGGAGGCT ACAGCCAGCA GTCCTCTTAT TCTGGCTATA ACCAGTCTTC TCCTGCATCT 
GCCCCTGGTG GCTATAGCAG CAGCTCTCAG TCGTCTGGCT ACGGTCAGCA GCAGCAGCAG 
AGTGGAGGTG GGTATGGAGG CAGTGGTGGT CAGTCTGGAG GATATGGGAG CAGTGGAGGC 
CAGAGCAGTG GATTTGGGGG TAGCGGAGGC CAACACCAGT CCTCTCAGTC TGGAGGAGGG 
TCTTACAGCC CATCTCCTAA CTACAGCTCC CCTCCACCAC AAAGCTATGG GCAACAAAGT 
CAGTACGGAC AGGGAGGTTA CAACCAAGAT AGCCCACCAA TGAGTGGTGG GGGAGGTGGT 
GGGGGCTATG GTGGTCAGGA TGGCGGATAC AGCCAGGATG GTAGAGGTGG ACGTGGCCGT 
GGAGGTGGCT TTGGAGGTCG AGGAGCGGGT GGGTTTGACA GGGGTGGTCG TGGAGGACCC 
CGTGGCAGAG GAGGAATGGG AATGGGCGAT CGTGGAGGAT TCAATAAGTT TGGTGGGCCC 
AGGGATCATG GAGCTGGTGG GCCCAATATG CAGGAGCAGG ATAACTCTGA CAACAACACC 
ATCTTTGTAC AAGGTCTTGG AGACGACTAT ACTGTGGACT CTGTTGCAGA CTACTTTAAA 
CAGATCGGCA TCATCAAGGT GAATAAGAAG ACAGGATTGC CCATGATTAA TCTGTATACA 
GACAGAGAGA CGGGGAAGCT TAAAGGGGAG GCTACTGTTT CCTTTGATGA CCCTCCTTCA 
GCAAAAGCAG CCATTGATTG GTTTGATGGT AAAGATTTTA ATGGAAATCC AATCAAGGTG 
TCCTTCGCCA CCCGCAGAGC TGAGTTTGGT CGTGGTGGCA GCAGCGGTGG CATGAGAGGT 
GGCCGTGGTC GAGGAGGGCC AATGGGGCGT GGGGGATTTG GGGGTGGCAG AGGTGGTGGT 
GGTGGTGGTG GTGGTTTCCA AGGCAACAAT GGTGGTGGTA GTGGCAACGG CGGCGGTCAG 
CAAAGAGCAG GAGACTGGAA GTGTTCAAAC CCTTCATGTG GAAATTTGAA CTTCTCATGG 
CGAAACGAGT GCAATCAGTG CAAAGAACCC AAACCGGAAG GAAGTGGAGG AGGAATGTCC 
CCGATGGGAG GTGGTTTTGG TGGAGAGCGG GGCAGAAGTG GCTTCGATCG AGGTGGTTTC 
CGTGGTCGTG GTGGTGATCG AGGAGGTTTC AGAGGAGGAA GAGGAGGAGA TCGTGGAGGA 
TTTGGACCTG GAAAGATGGA CTCGAGGGGT GACCACAGAC ATGACCGCAG AGACCGCCCT 
TACTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Integrated in silico and in vivo approaches to investigate effects of BDE-99 mediated by the nuclear receptors on developing zebrafish.
Environmental toxicology and chemistry(2017 Oct)
Zhang L,Jin Y,Han Z,Liu H,Shi L,Hua X,Doering JA,Tang S,Giesy JP,Yu H

The combination of in silico and in?vivo approaches for the investigation of disrupting effects of tris (2-chloroethyl) phosphate (TCEP) toward core receptors of zebrafish.
Chemosphere168122-130(2017 Feb)
Wu Y,Su G,Tang S,Liu W,Ma Z,Zheng X,Liu H,Yu H

Characterization of genetic loss-of-function of Fus in zebrafish.
RNA biology14(1)29-35(2017 01)
Lebedeva S,de Jesus Domingues AM,Butter F,Ketting RF

Neurotrophic effects of progranulin in vivo in reversing motor neuron defects caused by over or under expression of TDP-43 or FUS.
PloS one12(3)e0174784(2017)
Chitramuthu BP,Kay DG,Bateman A,Bennett HP

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fus cDNA ORF clone, Danio rerio(zebrafish)

Gene

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gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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