sox4b cDNA ORF clone, Danio rerio(zebrafish)

Gene
Clones
gRNAs

Summary

Gene Symbol	sox4b
Entrez Gene ID	393875
Full Name	SRY (sex determining region Y)-box 4b
Synonyms	zgc:63851
General protein information	Preferred Names SRY (sex determining region Y)-box 4b Names SRY (sex determining region Y)-box 4b SRY-box containing gene 4b
Gene Type	protein-coding
Organism	Danio rerio(zebrafish)

mRNA and Protein(s)

mRNA	Protein	Name
NM_200901.1	NP_957195.1	SRY-box transcription factor 4b

Pathways from BioSystems

Homologies

	SOX4	XP_001098923.1
Pan troglodytes (chimpanzee)	SOX4	XP_527244.1
Danio rerio (zebrafish)	sox4b	NP_957195.1
Canis lupus familiaris (dog)	SOX4	XP_005640218.1
Mus musculus (house mouse)	Sox4	NP_033264.2
Bos taurus (cattle)	SOX4	NP_001071596.1
Rattus norvegicus (Norway rat)	Sox4	NP_001258134.1
Danio rerio (zebrafish)	sox4a	NP_998287.1
Homo sapiens (human)	SOX4	NP_003098.1
Xenopus tropicalis (tropical clawed frog)	sox4	NP_001039084.1

Gene Ontology
Bibliography

Related articles in PubMed

Overexpression of SOX4 correlates with poor prognosis of acute myeloid leukemia and is leukemogenic in zebrafish.
Lu JW, Hsieh MS, Hou HA, Chen CY, Tien HF, Lin LI
Blood cancer journal7(8)e593(2017 Aug)

Temporal effects of Notch signaling and potential cooperation with multiple downstream effectors on adenohypophysis cell specification in zebrafish.
Nakahara Y, Muto A, Hirabayashi R, Sakuma T, Yamamoto T, Kume S, Kikuchi Y
Genes to cells : devoted to molecular & cellular mechanisms21(5)492-504(2016 May)

Gene evolution and gene expression after whole genome duplication in fish: the PhyloFish database.
Pasquier J, Cabau C, Nguyen T, Jouanno E, Severac D, Braasch I, Journot L, Pontarotti P, Klopp C, Postlethwait JH, Guiguen Y, Bobe J
BMC genomics17368(2016 05)

The draft genome of the grass carp (Ctenopharyngodon idellus) provides insights into its evolution and vegetarian adaptation.
Wang Y, Lu Y, Zhang Y, Ning Z, Li Y, Zhao Q, Lu H, Huang R, Xia X, Feng Q, Liang X, Liu K, Zhang L, Lu T, Huang T, Fan D, Weng Q, Zhu C, Lu Y, Li W, Wen Z, Zhou C, Tian Q, Kang X, Shi M, Zhang W, Jang S, Du F, He S, Liao L, Li Y, Gui B, He H, Ning Z, Yang C, He L, Luo L, Yang R, Luo Q, Liu X, Li S, Huang W, Xiao L, Lin H, Han B, Zhu Z
Nature genetics47(6)625-31(2015 Jun)

Sox4 regulates choroid fissure closure by limiting Hedgehog signaling during ocular morphogenesis.
Wen W, Pillai-Kastoori L, Wilson SG, Morris AC
Developmental biology399(1)139-53(2015 Mar)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Sox4b is expressed in zebrafish during pituitary development and plays a crucial role in the differentiation of thyrotrope and gonadotrope cells through induction of gata2a expression
Title: The HMG-box transcription factor Sox4b is required for pituitary expression of gata2a and specification of thyrotrope and gonadotrope cells in zebrafish.

sox4b is expressed transiently during endocrine cell differentiation and plays a crucial role in the generation of alpha endocrine cells.
Title: sox4b is a key player of pancreatic alpha cell differentiation in zebrafish.

The following sox4b gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the sox4b cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ODa03314	NM_200901.1 Latest version!	Danio rerio SRY-box transcription factor 4b (sox4b), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$258.30 $369.00

ORF Online Only Promotion

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

sox4b ( NM_200901.1 ) cDNA ORF clone, Danio rerio(zebrafish) -> NP_957195.1 Danio rerio SRY-box transcription factor 4b (sox4b), mRNA.

Price & Availability↑

CloneID	ODa03314
Clone ID Related Accession (Same CDS sequence)	NM_200901.1
Accession Version	NM_200901.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1029bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-06-30
Organism	Danio rerio(zebrafish)
Product	SRY-box transcription factor 4b
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC064664.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC064664.1 [ECO:0000332] ##Evidence-Data-END##

ATGCTCCAGA GATCCAGCAG CAGCAGCGCG CTGTTTGACG GGGACTCCTC CGACTCCGGC 
GCGCTGGATC TGGACGCACA TGCTGCCTCT CCGAGCCCCG GCTCCACGGC GTCCGGCGGG 
GAAAAGCTCA ACCCCGGCTG GTGCAAAACC GCCAGCGGCC ACATCAAGAG ACCGATGAAC 
GCCTTCATGG TGTGGTCGCA GATCGAGCGG CGCAAGATCA TGGAGCAGTC GCCGGACATG 
CACAACGCGG AGATCTCCAA GCGGCTGGGC AAACGTTGGA AGCTGCTGAA GGACGGAGAC 
AAGATCCCGT TCATCCGGGA GGCGGAGCGG CTCAGGCTCA AGCACATGGC GGATTACCCG 
GACTACAAGT ACCGGCCGAG GAAGAAGGTG AAGTCGAGCG GCTCCAAGCC GAGCGAGAAG 
CTGAGCATCT CCAAGCCGTC CTCCAAGAAG AGATCTGCGG GGAAACCGCA CAAGAAGGAG 
CCGGGACCCG CCGACCACCA CTCGTTGTAT AAAGCCAAAG CGGCGCCGGT GGTCAAGCAG 
AGCCCCGAGA AGAAGAAGCG GCTGTACATC TTCAGCAGCA GCAGCAGCCC GTCCCCCGCC 
GCGGTGCCCG CCAGCCCGAC GCTCAGCAGC TCCGCCGACA CCAGCGACCC GCTCAGCCTG 
TACGAGGACG CGTCGGGCAG CGGCAAGGAG GACGCGGATA CTCGGTACAC CGGCAGCAGC 
ATGCGCGCGC CATCCCCCAC CCCGTCCGCC GCGCACTCGT CCTCCTCATC GCAGTTCTCC 
TCTTCCTCAG ATGAGGAGCC GGACGACGAC GCGCTGGACG CGAACACGAG CCCGGGCTTC 
GACAGCATGT CCCTGGGCAG CATCGGCTCG TCGGTGCTCG ACCGAGACTT CGACATGCAC 
TTCGACTCCG GCGCTTCGCA CTTCGAGTTC CCCGATTACT GCACGCCCGA GGTGAGCCAG 
CTGATCTCCG GGGACTGGCT GGAGTCCACC ATCTCCAACC TGGTGTTCAC GGCGCACGTG 
TTGAACTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_957195.1
CDS	299..1327
Translation	MLQRSSSSSALFDGDSSDSGALDLDAHAASPSPGSTASGGEKLNPGWCKTASGHIKRPMNAFMVWSQIERRKIMEQSPDMHNAEISKRLGKRWKLLKDGDKIPFIREAERLRLKHMADYPDYKYRPRKKVKSSGSKPSEKLSISKPSSKKRSAGKPHKKEPGPADHHSLYKAKAAPVVKQSPEKKKRLYIFSSSSSPSPAAVPASPTLSSSADTSDPLSLYEDASGSGKEDADTRYTGSSMRAPSPTPSAAHSSSSSQFSSSSDEEPDDDALDANTSPGFDSMSLGSIGSSVLDRDFDMHFDSGASHFEFPDYCTPEVSQLISGDWLESTISNLVFTAHVLN

Target ORF information:

RefSeq Version	NM_200901.1
Organism	Danio rerio(zebrafish)
Definition	Danio rerio SRY-box transcription factor 4b (sox4b), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_200901.1

ORF Insert Sequence:

ATGCTCCAGA GATCCAGCAG CAGCAGCGCG CTGTTTGACG GGGACTCCTC CGACTCCGGC 
GCGCTGGATC TGGACGCACA TGCTGCCTCT CCGAGCCCCG GCTCCACGGC GTCCGGCGGG 
GAAAAGCTCA ACCCCGGCTG GTGCAAAACC GCCAGCGGCC ACATCAAGAG ACCGATGAAC 
GCCTTCATGG TGTGGTCGCA GATCGAGCGG CGCAAGATCA TGGAGCAGTC GCCGGACATG 
CACAACGCGG AGATCTCCAA GCGGCTGGGC AAACGTTGGA AGCTGCTGAA GGACGGAGAC 
AAGATCCCGT TCATCCGGGA GGCGGAGCGG CTCAGGCTCA AGCACATGGC GGATTACCCG 
GACTACAAGT ACCGGCCGAG GAAGAAGGTG AAGTCGAGCG GCTCCAAGCC GAGCGAGAAG 
CTGAGCATCT CCAAGCCGTC CTCCAAGAAG AGATCTGCGG GGAAACCGCA CAAGAAGGAG 
CCGGGACCCG CCGACCACCA CTCGTTGTAT AAAGCCAAAG CGGCGCCGGT GGTCAAGCAG 
AGCCCCGAGA AGAAGAAGCG GCTGTACATC TTCAGCAGCA GCAGCAGCCC GTCCCCCGCC 
GCGGTGCCCG CCAGCCCGAC GCTCAGCAGC TCCGCCGACA CCAGCGACCC GCTCAGCCTG 
TACGAGGACG CGTCGGGCAG CGGCAAGGAG GACGCGGATA CTCGGTACAC CGGCAGCAGC 
ATGCGCGCGC CATCCCCCAC CCCGTCCGCC GCGCACTCGT CCTCCTCATC GCAGTTCTCC 
TCTTCCTCAG ATGAGGAGCC GGACGACGAC GCGCTGGACG CGAACACGAG CCCGGGCTTC 
GACAGCATGT CCCTGGGCAG CATCGGCTCG TCGGTGCTCG ACCGAGACTT CGACATGCAC 
TTCGACTCCG GCGCTTCGCA CTTCGAGTTC CCCGATTACT GCACGCCCGA GGTGAGCCAG 
CTGATCTCCG GGGACTGGCT GGAGTCCACC ATCTCCAACC TGGTGTTCAC GGCGCACGTG 
TTGAACTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Overexpression of SOX4 correlates with poor prognosis of acute myeloid leukemia and is leukemogenic in zebrafish.
Blood cancer journal7(8)e593(2017 Aug)
Lu JW,Hsieh MS,Hou HA,Chen CY,Tien HF,Lin LI

Temporal effects of Notch signaling and potential cooperation with multiple downstream effectors on adenohypophysis cell specification in zebrafish.
Genes to cells : devoted to molecular & cellular mechanisms21(5)492-504(2016 May)
Nakahara Y,Muto A,Hirabayashi R,Sakuma T,Yamamoto T,Kume S,Kikuchi Y

Gene evolution and gene expression after whole genome duplication in fish: the PhyloFish database.
BMC genomics17368(2016 05)
Pasquier J,Cabau C,Nguyen T,Jouanno E,Severac D,Braasch I,Journot L,Pontarotti P,Klopp C,Postlethwait JH,Guiguen Y,Bobe J

The draft genome of the grass carp (Ctenopharyngodon idellus) provides insights into its evolution and vegetarian adaptation.
Nature genetics47(6)625-31(2015 Jun)
Wang Y,Lu Y,Zhang Y,Ning Z,Li Y,Zhao Q,Lu H,Huang R,Xia X,Feng Q,Liang X,Liu K,Zhang L,Lu T,Huang T,Fan D,Weng Q,Zhu C,Lu Y,Li W,Wen Z,Zhou C,Tian Q,Kang X,Shi M,Zhang W,Jang S,Du F,He S,Liao L,Li Y,Gui B,He H,Ning Z,Yang C,He L,Luo L,Yang R,Luo Q,Liu X,Li S,Huang W,Xiao L,Lin H,Han B,Zhu Z

Sox4 regulates choroid fissure closure by limiting Hedgehog signaling during ocular morphogenesis.
Developmental biology399(1)139-53(2015 Mar)
Wen W,Pillai-Kastoori L,Wilson SG,Morris AC

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sox4b cDNA ORF clone, Danio rerio(zebrafish)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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