irf6 cDNA ORF clone, Danio rerio(zebrafish)

Bone morphogenetic protein signaling governs biliary-driven liver regeneration in zebrafish through tbx2b and id2a.
Choi TY, Khaliq M, Tsurusaki S, Ninov N, Stainier DYR, Tanaka M, Shin D
Hepatology (Baltimore, Md.)66(5)1616-1630(2017 11)

Rapid functional analysis of computationally complex rare human IRF6 gene variants using a novel zebrafish model.
Li EB, Truong D, Hallett SA, Mukherjee K, Schutte BC, Liao EC
PLoS genetics13(9)e1007009(2017 Sep)

Distinct Molecular Signature of Murine Fetal Liver and Adult Hematopoietic Stem Cells Identify Novel Regulators of Hematopoietic Stem Cell Function.
Manesia JK, Franch M, Tabas-Madrid D, Nogales-Cadenas R, Vanwelden T, Van Den Bosch E, Xu Z, Pascual-Montano A, Khurana S, Verfaillie CM
Stem cells and development26(8)573-584(2017 Apr)

Fish IRF6 is a positive regulator of IFN expression and involved in both of the MyD88 and TBK1 pathways.
Li S, Lu LF, Wang ZX, Chen DD, Zhang YA
Fish & shellfish immunology57262-268(2016 Oct)

Gene evolution and gene expression after whole genome duplication in fish: the PhyloFish database.
Pasquier J, Cabau C, Nguyen T, Jouanno E, Severac D, Braasch I, Journot L, Pontarotti P, Klopp C, Postlethwait JH, Guiguen Y, Bobe J
BMC genomics17368(2016 05)

Here, we demonstrate the protein functions of human IRF6 missense gene variants could be rapidly assessed in detail by their abilities to rescue the irf6 -/- phenotype in zebrafish through variant mRNA microinjections at the one-cell stage.
Title: Rapid functional analysis of computationally complex rare human IRF6 gene variants using a novel zebrafish model.

Fish IRF6 is distinguished from the homolog of mammals by being a positive regulator of IFN transcription and phosphorylated by MyD88 and TBK1, suggesting that differences in the IRF6 regulation pattern exist between lower and higher vertebrates.
Title: Fish IRF6 is a positive regulator of IFN expression and involved in both of the MyD88 and TBK1 pathways.

Authors report that Kruppel-like factor 17 (Klf17), like Grhl3, acts downstream of Irf6 in this network in zebrafish periderm.
Title: Irf6 directly regulates Klf17 in zebrafish periderm and Klf4 in murine oral epithelium, and dominant-negative KLF4 variants are present in patients with cleft lip and palate.

In zebrafish periderm, grainyhead-like 3 (grhl3) (an ancient regulator of the epidermal permeability barrier), was identified as acting downstream of Irf6. Simultaneous inhibition of grhl1 and grhl3 disrupted periderm differentiation in zebrafish.
Title: Interferon regulatory factor 6 promotes differentiation of the periderm by activating expression of Grainyhead-like 3.

These experiments reveal a conserved role for maternally-encoded Irf6 in differentiation of a simple epithelium in X. laevis and D. rerio.
Title: Maternal Interferon Regulatory Factor 6 is required for the differentiation of primary superficial epithelia in Danio and Xenopus embryos.