ptenb cDNA ORF clone, Danio rerio(zebrafish)

Gene
Clones
gRNAs

Summary

Gene Symbol	ptenb
Entrez Gene ID	368415
Full Name	phosphatase and tensin homolog B
Synonyms	fa11a08,fb73f10,fc83f12,fd16b10,fk90e11,pten,si:bz1g13.4,wu:fa11a08,wu:fb73f10,wu:fc83f12,wu:fd16b10,wu:fk90e11
General protein information	Preferred Names phosphatase and tensin homolog B Names phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN phosphatase and tensin homolog (mutated in multiple advanced cancers 1) phosphatase and tensin homolog B (mutated in multiple advanced cancers 1)
Gene Type	protein-coding
Organism	Danio rerio(zebrafish)

mRNA and Protein(s)

mRNA	Protein	Name
NM_001001822.2	NP_001001822.1	phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN

Pathways from BioSystems

Homologies

Mus musculus (house mouse)	Pten	NP_032986.1
Gallus gallus (chicken)	PTEN	XP_421555.2
Drosophila melanogaster (fruit fly)	Pten	NP_001162933.1
	PTEN	XP_001102542.1
Bos taurus (cattle)	PTEN	XP_002698416.1
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP009628	XP_553421.2
Pan troglodytes (chimpanzee)	PTEN	XP_521544.3
Danio rerio (zebrafish)	ptenb	NP_001001822.1
Homo sapiens (human)	PTEN	NP_000305.3
Rattus norvegicus (Norway rat)	Pten	NP_113794.1
Canis lupus familiaris (dog)	PTEN	NP_001003192.1
Xenopus tropicalis (tropical clawed frog)	pten	NP_001116943.1

Gene Ontology
Bibliography

Related articles in PubMed

Irf8 regulates the progression of myeloproliferative neoplasm-like syndrome via Mertk signaling in zebrafish.
Zhao F, Shi Y, Huang Y, Zhan Y, Zhou L, Li Y, Wan Y, Li H, Huang H, Ruan H, Luo L, Li L
Leukemia32(1)149-158(2018 Jan)

Oncogenic Role of THOR, a Conserved Cancer/Testis Long Non-coding RNA.
Hosono Y, Niknafs YS, Prensner JR, Iyer MK, Dhanasekaran SM, Mehra R, Pitchiaya S, Tien J, Escara-Wilke J, Poliakov A, Chu SC, Saleh S, Sankar K, Su F, Guo S, Qiao Y, Freier SM, Bui HH, Cao X, Malik R, Johnson TM, Beer DG, Feng FY, Zhou W, Chinnaiyan AM
Cell171(7)1559-1572.e20(2017 Dec)

Impaired caudal fin-fold regeneration in zebrafish deficient for the tumor suppressor Pten.
Hale AJ, Kiai A, Sikkens J, den Hertog J
Regeneration (Oxford, England)4(4)217-226(2017 Aug)

Ndrg1b and fam49ab modulate the PTEN pathway to control T-cell lymphopoiesis in the zebrafish.
Li RA, Traver D, Matthes T, Bertrand JY
Blood128(26)3052-3060(2016 12)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

ndrg1b and fam49ab are 2 new modulators of PTEN signaling that control lymphoid differentiation in the zebrafish thymus.
Title: Ndrg1b and fam49ab modulate the PTEN pathway to control T-cell lymphopoiesis in the zebrafish.

We further showed that PTEN knockdown in MCF-7 cells could increase cell migration in the xenograft zebrafish model. Our findings reveal new therapeutic targets for breast cancer patients with PTEN insufficiency.
Title: PTEN Insufficiency Increases Breast Cancer Cell Metastasis In Vitro and In Vivo in a Xenograft Zebrafish Model.

the role of Pten during zebrafish embryonic development
Title: Differential Requirement for Pten Lipid and Protein Phosphatase Activity during Zebrafish Embryonic Development.

Pten has an essential role in the balance between proliferation and differentiation of blood cells.
Title: Pivotal role of Pten in the balance between proliferation and differentiation of hematopoietic stem cells in zebrafish.

Vegfaa has a crucial role in angiogenesis and vegfaa expression was upregulated in embryos lacking functional Pten.
Title: Loss of Pten promotes angiogenesis and enhanced vegfaa expression in zebrafish.

The following ptenb gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the ptenb cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ODa01351	NM_001001822.2 Latest version!	Danio rerio phosphatase and tensin homolog B (ptenb), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$258.30 $369.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

ptenb ( NM_001001822.2 ) cDNA ORF clone, Danio rerio(zebrafish) -> NP_001001822.1 Danio rerio phosphatase and tensin homolog B (ptenb), mRNA.

Price & Availability↑

CloneID	ODa01351
Clone ID Related Accession (Same CDS sequence)	NM_001001822.2
Accession Version	NM_001001822.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1200bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-04-22
Organism	Danio rerio(zebrafish)
Product	phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC107962.1. On Jun 3, 2007 this sequence version replaced NM_001001822.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC107962.1, AY398671.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA2168446, SAMEA2168447 [ECO:0000350] ##Evidence-Data-END##

ATGGCTGCGA TCATAAAGGA ATTTGTCAGT AGAAATAAAA GGAGATACCA AGAAGACGGG 
TTCGACTTGG ACTTGACATA CATTTATCCT AACATAATAG CTATGGGTTT CCCTGCTGAA 
AGACTGGAGG GTGTATATAG AAACAACATA GATGATGTAG TGAGGTTTCT TGATTCAAAG 
CATAAAGATC ATTACAAGAT ATATAACCTA TGTGCAGAAA GACATTACGA TACTGCCAAA 
TTTAACTGCA GAGTTGCACA GTATCCATTT GAGGATCACA ATCCTCCTCA GCTAGAGCTC 
ATTAAACCTT TCTGTGAAGA TTTGGATAAA TGGCTCAGTG AAAATGACAA TCATGTGGCT 
GCCATTCACT GCAAAGCTGG AAAGGGAAGA ACGGGTGTCA TGATTTGTGC GTACTTGTTA 
CACCGAGGCA AATTCAAAAA AGCACAAGAG GCTCTGGACT TCTACGATGA AGTTAGGACC 
AGAGACAAGA AGGGAGTGAC TATTCCCAGT CAGAGGCGAT ATGTGTACTA CTATAGCTAC 
CTTCTGAGGA ATAAGCTGGA GTACAAACCT GTGGCCTTGC TCTTTCACAA GATGGTGTTT 
GAGACTGTGC CTATGTTCAG TGGAGGGACC TGCAATCCTC AGTTTGTGGT GTACCAGCTG 
AAGGTGAAAA TTCACACCTC AAACCCAGCG CACACAAGAA GAGAGGAGAA GTACATGTTC 
TTCGAATTTC CTCAACCACT GCCTGTGTGT GGGGACATCA AGGTGGAGTT CTTCCACAAA 
CAAAACAAGA TGATGAAGAA GGAGAAAATG TTCCACTTCT GGGTGAACAC CTTTTTCATC 
CCTGGGTCAG AGGAGAGCAC AGAGAAAGTG GAAAATGGAG GTTTAGTGAA GGACCTGGAT 
GGAATACAAA CAGCAGAGAG AGGAGAGAAT GACAAAGACT ATTTAATTCT TACTTTAAGT 
AAGACGGATT TGGATAAAGC GAACAAGGAT AAAGCCAACA GATACTTCTC TCCCAATTTT 
AAAGTGAAAA TGTTTTTCAC AAAAACAGTG GAGGAACCAT CCAACTCAGA GGCCAGCACT 
TCTACTTCTG TAACCCCGGA TGTTAGCGAT AATGAACCGG ACCATTATCG TTATTCGGAC 
ACAACAGACT CAGACCCTGA AAATGAACAG TACGATGAAG AACAGATTAC TAAAGTTTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001001822.1
CDS	607..1806
Translation	MAAIIKEFVSRNKRRYQEDGFDLDLTYIYPNIIAMGFPAERLEGVYRNNIDDVVRFLDSKHKDHYKIYNLCAERHYDTAKFNCRVAQYPFEDHNPPQLELIKPFCEDLDKWLSENDNHVAAIHCKAGKGRTGVMICAYLLHRGKFKKAQEALDFYDEVRTRDKKGVTIPSQRRYVYYYSYLLRNKLEYKPVALLFHKMVFETVPMFSGGTCNPQFVVYQLKVKIHTSNPAHTRREEKYMFFEFPQPLPVCGDIKVEFFHKQNKMMKKEKMFHFWVNTFFIPGSEESTEKVENGGLVKDLDGIQTAERGENDKDYLILTLSKTDLDKANKDKANRYFSPNFKVKMFFTKTVEEPSNSEASTSTSVTPDVSDNEPDHYRYSDTTDSDPENEQYDEEQITKV

Target ORF information:

RefSeq Version	NM_001001822.2
Organism	Danio rerio(zebrafish)
Definition	Danio rerio phosphatase and tensin homolog B (ptenb), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001001822.2

ORF Insert Sequence:

ATGGCTGCGA TCATAAAGGA ATTTGTCAGT AGAAATAAAA GGAGATACCA AGAAGACGGG 
TTCGACTTGG ACTTGACATA CATTTATCCT AACATAATAG CTATGGGTTT CCCTGCTGAA 
AGACTGGAGG GTGTATATAG AAACAACATA GATGATGTAG TGAGGTTTCT TGATTCAAAG 
CATAAAGATC ATTACAAGAT ATATAACCTA TGTGCAGAAA GACATTACGA TACTGCCAAA 
TTTAACTGCA GAGTTGCACA GTATCCATTT GAGGATCACA ATCCTCCTCA GCTAGAGCTC 
ATTAAACCTT TCTGTGAAGA TTTGGATAAA TGGCTCAGTG AAAATGACAA TCATGTGGCT 
GCCATTCACT GCAAAGCTGG AAAGGGAAGA ACGGGTGTCA TGATTTGTGC GTACTTGTTA 
CACCGAGGCA AATTCAAAAA AGCACAAGAG GCTCTGGACT TCTACGATGA AGTTAGGACC 
AGAGACAAGA AGGGAGTGAC TATTCCCAGT CAGAGGCGAT ATGTGTACTA CTATAGCTAC 
CTTCTGAGGA ATAAGCTGGA GTACAAACCT GTGGCCTTGC TCTTTCACAA GATGGTGTTT 
GAGACTGTGC CTATGTTCAG TGGAGGGACC TGCAATCCTC AGTTTGTGGT GTACCAGCTG 
AAGGTGAAAA TTCACACCTC AAACCCAGCG CACACAAGAA GAGAGGAGAA GTACATGTTC 
TTCGAATTTC CTCAACCACT GCCTGTGTGT GGGGACATCA AGGTGGAGTT CTTCCACAAA 
CAAAACAAGA TGATGAAGAA GGAGAAAATG TTCCACTTCT GGGTGAACAC CTTTTTCATC 
CCTGGGTCAG AGGAGAGCAC AGAGAAAGTG GAAAATGGAG GTTTAGTGAA GGACCTGGAT 
GGAATACAAA CAGCAGAGAG AGGAGAGAAT GACAAAGACT ATTTAATTCT TACTTTAAGT 
AAGACGGATT TGGATAAAGC GAACAAGGAT AAAGCCAACA GATACTTCTC TCCCAATTTT 
AAAGTGAAAA TGTTTTTCAC AAAAACAGTG GAGGAACCAT CCAACTCAGA GGCCAGCACT 
TCTACTTCTG TAACCCCGGA TGTTAGCGAT AATGAACCGG ACCATTATCG TTATTCGGAC 
ACAACAGACT CAGACCCTGA AAATGAACAG TACGATGAAG AACAGATTAC TAAAGTTTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Irf8 regulates the progression of myeloproliferative neoplasm-like syndrome via Mertk signaling in zebrafish.
Leukemia32(1)149-158(2018 Jan)
Zhao F,Shi Y,Huang Y,Zhan Y,Zhou L,Li Y,Wan Y,Li H,Huang H,Ruan H,Luo L,Li L

Oncogenic Role of THOR, a Conserved Cancer/Testis Long Non-coding RNA.
Cell171(7)1559-1572.e20(2017 Dec)
Hosono Y,Niknafs YS,Prensner JR,Iyer MK,Dhanasekaran SM,Mehra R,Pitchiaya S,Tien J,Escara-Wilke J,Poliakov A,Chu SC,Saleh S,Sankar K,Su F,Guo S,Qiao Y,Freier SM,Bui HH,Cao X,Malik R,Johnson TM,Beer DG,Feng FY,Zhou W,Chinnaiyan AM

Impaired caudal fin-fold regeneration in zebrafish deficient for the tumor suppressor Pten.
Regeneration (Oxford, England)4(4)217-226(2017 Aug)
Hale AJ,Kiai A,Sikkens J,den Hertog J

Ndrg1b and fam49ab modulate the PTEN pathway to control T-cell lymphopoiesis in the zebrafish.
Blood128(26)3052-3060(2016 12)
Li RA,Traver D,Matthes T,Bertrand JY

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ptenb cDNA ORF clone, Danio rerio(zebrafish)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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