selenoh cDNA ORF clone, Danio rerio(zebrafish)

Gene
Clones
gRNAs

Summary

Gene Symbol	selenoh
Entrez Gene ID	347743
Full Name	selenoprotein H
Synonyms	cb697,selh,seph,wu:fa11g07,wu:fb23d03
General protein information	Preferred Names selenoprotein H Names selenoprotein H etID39515.8
Gene Type	protein-coding
Organism	Danio rerio(zebrafish)
Summary	This gene encodes a nucleolar protein, which belongs to the SelWTH family. It functions as an oxidoreductase; and in mammals, it has been shown to protect neurons against UVB-induced damage, promote mitochondrial biogenesis, and suppress cellular senescence. This protein is a selenoprotein, containing the rare amino acid selenocysteine (Sec) at its active site. Sec is encoded by the UGA codon, which normally signals translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, designated the Sec insertion sequence (SECIS) element, that is necessary for the recognition of UGA as a Sec codon, rather than as a stop signal. [provided by RefSeq, Aug 2017].

mRNA and Protein(s)

mRNA	Protein	Name
NM_178133.3	NP_835234.2	selenoprotein H

Pathways from BioSystems

Homologies

Pan troglodytes (chimpanzee)	C11H11orf31	NP_001140163.1
	C14H11orf31	NP_001152973.1
Bos taurus (cattle)	C15H11orf31	NP_001157564.1
Mus musculus (house mouse)	2700094K13Rik	NP_001028338.1
Gallus gallus (chicken)	LOC100858006	NP_001264794.1
Canis lupus familiaris (dog)	C18H11orf31	NP_001157978.1
Homo sapiens (human)	C11orf31	NP_734467.1
Rattus norvegicus (Norway rat)	RGD1563348	NP_001108411.1
Danio rerio (zebrafish)	seph	NP_835234.2

Gene Ontology
Bibliography

Related articles in PubMed

Selenoprotein H is an essential regulator of redox homeostasis that cooperates with p53 in development and tumorigenesis.
Cox AG, Tsomides A, Kim AJ, Saunders D, Hwang KL, Evason KJ, Heidel J, Brown KK, Yuan M, Lien EC, Lee BC, Nissim S, Dickinson B, Chhangawala S, Chang CJ, Asara JM, Houvras Y, Gladyshev VN, Goessling W
Proceedings of the National Academy of Sciences of the United States of America113(38)E5562-71(2016 09)

Selenium prevents downregulation of antioxidant selenoprotein genes by methylmercury.
Penglase S, Hamre K, Ellingsen S
Free radical biology & medicine7595-104(2014 Oct)

Composition and evolution of the vertebrate and mammalian selenoproteomes.
Mariotti M, Ridge PG, Zhang Y, Lobanov AV, Pringle TH, Guigo R, Hatfield DL, Gladyshev VN
PloS one7(3)e33066(2012)

Identification of 315 genes essential for early zebrafish development.
Amsterdam A, Nissen RM, Sun Z, Swindell EC, Farrington S, Hopkins N
Proceedings of the National Academy of Sciences of the United States of America101(35)12792-7(2004 Aug)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The following selenoh gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the selenoh cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ODa05299	NM_178133.3 Latest version!	Danio rerio selenoprotein H (selenoh), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$104.30 $149.00

ORF Online Only Promotion

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

selenoh ( NM_178133.3 ) cDNA ORF clone, Danio rerio(zebrafish) -> NP_835234.2 Danio rerio selenoprotein H (selenoh), mRNA.

Price & Availability↑

CloneID	ODa05299
Clone ID Related Accession (Same CDS sequence)	NM_178133.3
Accession Version	NM_178133.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 384bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-07-28
Organism	Danio rerio(zebrafish)
Product	selenoprotein H
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from EH510258.1 and CT670471.2. On Mar 1, 2008 this sequence version replaced NM_178133.2. ##RefSeq-Attributes-START## protein contains selenocysteine :: inferred from conservation ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGGCGACTC GAGGCAAGTC AGCTCGCAAG CGAAAGGCGG ATTCAGACGA AAAAGAAAAG 
CTTGACGATG CCAAGAAAGA AAAGCTTGAG GATAAGGATG AAGAAACAGG ACTGAGGGTG 
GTCATCGAGC ATTGTAAGAG CTGACGGGTT TACGGGCGCA ACGCGGTCGT CGTGCGGGAA 
GCTCTTGCAG ATTCGCACCC TGAACTCAAA GTGATGATAA ACCCGCACAA TCCCCGGAGA 
AACAGCTTTG AAATCACGCT GATGGACGGA GAAAGAGCGG ATGTTTTGTG GTCCGGCATT 
AAAAAGGGTC CTCCACGCAA ACTCAAGTTC CCTGAGCCTG CTGAAGTGGT GACCGCCCTG 
AAACAAGCGC TGGAGAAAGA GTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_835234.2
CDS	158..541
Translation	MATRGKSARKRKADSDEKEKLDDAKKEKLEDKDEETGLRVVIEHCKS*RVYGRNAVVVREALADSHPELKVMINPHNPRRNSFEITLMDGERADVLWSGIKKGPPRKLKFPEPAEVVTALKQALEKE

Target ORF information:

RefSeq Version	NM_178133.3
Organism	Danio rerio(zebrafish)
Definition	Danio rerio selenoprotein H (selenoh), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_178133.3

ORF Insert Sequence:

ATGGCGACTC GAGGCAAGTC AGCTCGCAAG CGAAAGGCGG ATTCAGACGA AAAAGAAAAG 
CTTGACGATG CCAAGAAAGA AAAGCTTGAG GATAAGGATG AAGAAACAGG ACTGAGGGTG 
GTCATCGAGC ATTGTAAGAG CTGACGGGTT TACGGGCGCA ACGCGGTCGT CGTGCGGGAA 
GCTCTTGCAG ATTCGCACCC TGAACTCAAA GTGATGATAA ACCCGCACAA TCCCCGGAGA 
AACAGCTTTG AAATCACGCT GATGGACGGA GAAAGAGCGG ATGTTTTGTG GTCCGGCATT 
AAAAAGGGTC CTCCACGCAA ACTCAAGTTC CCTGAGCCTG CTGAAGTGGT GACCGCCCTG 
AAACAAGCGC TGGAGAAAGA GTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Selenoprotein H is an essential regulator of redox homeostasis that cooperates with p53 in development and tumorigenesis.
Proceedings of the National Academy of Sciences of the United States of America113(38)E5562-71(2016 09)
Cox AG,Tsomides A,Kim AJ,Saunders D,Hwang KL,Evason KJ,Heidel J,Brown KK,Yuan M,Lien EC,Lee BC,Nissim S,Dickinson B,Chhangawala S,Chang CJ,Asara JM,Houvras Y,Gladyshev VN,Goessling W

Selenium prevents downregulation of antioxidant selenoprotein genes by methylmercury.
Free radical biology & medicine7595-104(2014 Oct)
Penglase S,Hamre K,Ellingsen S

Composition and evolution of the vertebrate and mammalian selenoproteomes.
PloS one7(3)e33066(2012)
Mariotti M,Ridge PG,Zhang Y,Lobanov AV,Pringle TH,Guigo R,Hatfield DL,Gladyshev VN

Identification of 315 genes essential for early zebrafish development.
Proceedings of the National Academy of Sciences of the United States of America101(35)12792-7(2004 Aug)
Amsterdam A,Nissen RM,Sun Z,Swindell EC,Farrington S,Hopkins N

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selenoh cDNA ORF clone, Danio rerio(zebrafish)

Gene

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Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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