CNBPB cDNA ORF clone, Danio rerio(Zebrafish)

Gene
Clones
gRNAs

Summary

Gene Symbol	CNBPB
Entrez Gene ID	335839
Full Name	CCHC-type zinc finger, nucleic acid binding protein b
Synonyms	cnbp,wu:fj34c03
General protein information	Preferred Names CCHC-type zinc finger, nucleic acid binding protein b Names zinc finger protein 9
Gene Type	protein-coding
Organism	Danio rerio(Zebrafish)

mRNA and Protein(s)

mRNA	Protein	Name
XM_001922848.6	XP_001922883.1	zinc finger protein 9 isoform X1
NM_001326405.1	NP_001313334.1	zinc finger protein 9
XM_001922848.5	XP_001922883.1	zinc finger protein 9 isoform X1

Pathways from BioSystems

Homologies

Homo sapiens (human)	CNBP	NP_003409.1
Mus musculus (house mouse)	Cnbp	NP_001103216.1
Kluyveromyces lactis	KLLA0C02805g	XP_452322.1
Pan troglodytes (chimpanzee)	CNBP	XP_003950234.1
Eremothecium gossypii	AGOS_AFR646W	NP_986194.1
Danio rerio (zebrafish)	cnbpa	NP_956043.2
Magnaporthe oryzae (rice blast fungus)	MGG_13778	XP_003710840.1
Neurospora crassa	NCU05800	XP_960060.1
	LOC705622	XP_001093980.2
Canis lupus familiaris (dog)	CNBP	NP_001239193.1
Rattus norvegicus (Norway rat)	Cnbp	NP_072120.1
Gallus gallus (chicken)	CNBP	NP_990238.1
Danio rerio (zebrafish)	cnbpb	XP_003199446.2
Saccharomyces cerevisiae (baker's yeast)	GIS2	NP_014144.1

Gene Ontology
Bibliography

Related articles in PubMed

CNBP acts as a key transcriptional regulator of sustained expression of interleukin-6.
Lee E, Lee TA, Kim JH, Park A, Ra EA, Kang S, Choi HJ, Choi JL, Huh HD, Lee JE, Lee S, Park B
Nucleic acids research45(6)3280-3296(2017 Apr)

Evolution of complexity in the zebrafish synapse proteome.
Bay?s ?, Collins MO, Reig-Viader R, Gou G, Goulding D, Izquierdo A, Choudhary JS, Emes RD, Grant SG
Nature communications814613(2017 Mar)

Cnbp ameliorates Treacher Collins Syndrome craniofacial anomalies through a pathway that involves redox-responsive genes.
de Peralta MS, Mouguelar VS, Sdrigotti MA, Ishiy FA, Fanganiello RD, Passos-Bueno MR, Coux G, Calcaterra NB
Cell death & disease7(10)e2397(2016 Oct)

Gene evolution and gene expression after whole genome duplication in fish: the PhyloFish database.
Pasquier J, Cabau C, Nguyen T, Jouanno E, Severac D, Braasch I, Journot L, Pontarotti P, Klopp C, Postlethwait JH, Guiguen Y, Bobe J
BMC genomics17368(2016 05)

RFX transcription factors are essential for hearing in mice.
Elkon R, Milon B, Morrison L, Shah M, Vijayakumar S, Racherla M, Leitch CC, Silipino L, Hadi S, Weiss-Gayet M, Barras E, Schmid CD, Ait-Lounis A, Barnes A, Song Y, Eisenman DJ, Eliyahu E, Frolenkov GI, Strome SE, Durand B, Zaghloul NA, Jones SM, Reith W, Hertzano R
Nature communications68549(2015 Oct)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The cnbp overexpression rescued the Treacher Collins Syndrome phenotype in a dose-dependent manner by a reactive oxygen species-cytoprotective action that prevented the redox-responsive genes' upregulation but did not normalize the synthesis of ribosomal RNAs.
Title: Cnbp ameliorates Treacher Collins Syndrome craniofacial anomalies through a pathway that involves redox-responsive genes.

Role for CNBP in transcriptional control of components of the Wnt signaling pathway, which might explain its requirement for proper craniofacial development.
Title: CNBP modulates the transcription of Wnt signaling pathway components.

CNBP up-regulates tbx2b and smarca5, and down-regulates wnt5b gene expression.
Title: Beyond the binding site: in vivo identification of tbx2, smarca5 and wnt5b as molecular targets of CNBP during embryonic development.

Cnbp loss-of-function adversely affects the formation and survival of craniofacial cartilaginous structures not only controlling the ratio of cell proliferation and apoptosis but also defining skeletogenic neural crest cell fate.
Title: Deciphering the cellular and molecular roles of cellular nucleic acid binding protein during cranial neural crest development.

The following CNBPB gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the CNBPB cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
ODa16601	NM_001326405.1 Latest version!	Danio rerio CCHC-type zinc finger, nucleic acid binding protein b (cnbpb), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$104.30 $149.00
ODa16601	XM_001922848.6 Latest version!	Danio rerio CCHC-type zinc finger, nucleic acid binding protein b (cnbpb), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$104.30 $149.00
View Old Accession Versions >>
ODa16601	XM_001922848.5	Danio rerio CCHC-type zinc finger, nucleic acid binding protein b (cnbpb), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$104.30 $149.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

CNBPB ( NM_001326405.1 ) cDNA ORF clone, Danio rerio(Zebrafish) -> NP_001313334.1 Danio rerio CCHC-type zinc finger, nucleic acid binding protein b (cnbpb), mRNA.

Price & Availability↑

CloneID	ODa16601
Clone ID Related Accession (Same CDS sequence)	XM_001922848.6 , NM_001326405.1 , XM_001922848.5
Accession Version	NM_001326405.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 486bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-11-23
Organism	Danio rerio(zebrafish)
Product	zinc finger protein 9
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from CR855375.8. On May 17, 2016 this sequence version replaced XM_003199398.3. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. ##Evidence-Data-START## Transcript exon combination :: GFIL01006418.1, EH999841.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505370, SAMEA3505377 [ECO:0000348] ##Evidence-Data-END##

ATGAGCAGCA ACGAGTGTTT TGGTTGTGGC CGTACGGGTC ATTGGATCAA GAACTGTCCC 
AATGCTGGAC GTGGACGTGG GAAGGGCCGC GGCAGAGGAA AAGATCTTTT CTGCTATCGC 
TGTGGAGAAC CAGGTCATGT TGCGAGAGAT TGTGAGAGGA CTGAAGATGC GTGCTACAAC 
TGCGGCAGAG GCGGCCACAT CTCCAGGGAC TGCAAGGAGC CCAAGAAGGA GCGCGAGCAG 
GTGTGCTATA ACTGCGGTAA AGCCGGACAC ATGGCGCGCG ACTGCGACCA CGCCAATGAG 
CAAAAGTGCT ACTCCTGCGG CGGATTCGGA CACATCCAGA AGGGCTGCGA AAAAGTCAAG 
TGCTACAGGT GTGGAGAGAT CGGTCACGTG GCTGTTCAGT GCAGCAAGGC CAGCGAAGTC 
AACTGCTACA ACTGCGGCAA ATCGGGCCAC GTGGCGAAGG AGTGCACCAT CGAGGCCACC 
GCTTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001313334.1
CDS	132..617
Translation	MSSNECFGCGRTGHWIKNCPNAGRGRGKGRGRGKDLFCYRCGEPGHVARDCERTEDACYNCGRGGHISRDCKEPKKEREQVCYNCGKAGHMARDCDHANEQKCYSCGGFGHIQKGCEKVKCYRCGEIGHVAVQCSKASEVNCYNCGKSGHVAKECTIEATA

Target ORF information:

RefSeq Version	NM_001326405.1
Organism	Danio rerio(zebrafish)
Definition	Danio rerio CCHC-type zinc finger, nucleic acid binding protein b (cnbpb), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001326405.1

ORF Insert Sequence:

ATGAGCAGCA ACGAGTGTTT TGGTTGTGGC CGTACGGGTC ATTGGATCAA GAACTGTCCC 
AATGCTGGAC GTGGACGTGG GAAGGGCCGC GGCAGAGGAA AAGATCTTTT CTGCTATCGC 
TGTGGAGAAC CAGGTCATGT TGCGAGAGAT TGTGAGAGGA CTGAAGATGC GTGCTACAAC 
TGCGGCAGAG GCGGCCACAT CTCCAGGGAC TGCAAGGAGC CCAAGAAGGA GCGCGAGCAG 
GTGTGCTATA ACTGCGGTAA AGCCGGACAC ATGGCGCGCG ACTGCGACCA CGCCAATGAG 
CAAAAGTGCT ACTCCTGCGG CGGATTCGGA CACATCCAGA AGGGCTGCGA AAAAGTCAAG 
TGCTACAGGT GTGGAGAGAT CGGTCACGTG GCTGTTCAGT GCAGCAAGGC CAGCGAAGTC 
AACTGCTACA ACTGCGGCAA ATCGGGCCAC GTGGCGAAGG AGTGCACCAT CGAGGCCACC 
GCTTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

CNBPB ( XM_001922848.6 ) cDNA ORF clone, Danio rerio(Zebrafish) -> XP_001922883.1 Danio rerio CCHC-type zinc finger, nucleic acid binding protein b (cnbpb), transcript variant X1, mRNA.

Price & Availability↑

CloneID	ODa16601
Clone ID Related Accession (Same CDS sequence)	XM_001922848.6 , NM_001326405.1 , XM_001922848.5
Accession Version	XM_001922848.6 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 486bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-06-14
Organism	Danio rerio(zebrafish)
Product	zinc finger protein 9 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_007122.7) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Jun 15, 2017 this sequence version replaced XM_001922848.5. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Danio rerio Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.4 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGAGCAGCA ACGAGTGTTT TGGTTGTGGC CGTACGGGTC ATTGGATCAA GAACTGTCCC 
AATGCTGGAC GTGGACGTGG GAAGGGCCGC GGCAGAGGAA AAGATCTTTT CTGCTATCGC 
TGTGGAGAAC CAGGTCATGT TGCGAGAGAT TGTGAGAGGA CTGAAGATGC GTGCTACAAC 
TGCGGCAGAG GCGGCCACAT CTCCAGGGAC TGCAAGGAGC CCAAGAAGGA GCGCGAGCAG 
GTGTGCTATA ACTGCGGTAA AGCCGGACAC ATGGCGCGCG ACTGCGACCA CGCCAATGAG 
CAAAAGTGCT ACTCCTGCGG CGGATTCGGA CACATCCAGA AGGGCTGCGA AAAAGTCAAG 
TGCTACAGGT GTGGAGAGAT CGGTCACGTG GCTGTTCAGT GCAGCAAGGC CAGCGAAGTC 
AACTGCTACA ACTGCGGCAA ATCGGGCCAC GTGGCGAAGG AGTGCACCAT CGAGGCCACC 
GCTTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_001922883.1
CDS	357..842
Translation	MSSNECFGCGRTGHWIKNCPNAGRGRGKGRGRGKDLFCYRCGEPGHVARDCERTEDACYNCGRGGHISRDCKEPKKEREQVCYNCGKAGHMARDCDHANEQKCYSCGGFGHIQKGCEKVKCYRCGEIGHVAVQCSKASEVNCYNCGKSGHVAKECTIEATA

Target ORF information:

RefSeq Version	XM_001922848.6
Organism	Danio rerio(zebrafish)
Definition	Danio rerio CCHC-type zinc finger, nucleic acid binding protein b (cnbpb), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_001922848.6

ORF Insert Sequence:

ATGAGCAGCA ACGAGTGTTT TGGTTGTGGC CGTACGGGTC ATTGGATCAA GAACTGTCCC 
AATGCTGGAC GTGGACGTGG GAAGGGCCGC GGCAGAGGAA AAGATCTTTT CTGCTATCGC 
TGTGGAGAAC CAGGTCATGT TGCGAGAGAT TGTGAGAGGA CTGAAGATGC GTGCTACAAC 
TGCGGCAGAG GCGGCCACAT CTCCAGGGAC TGCAAGGAGC CCAAGAAGGA GCGCGAGCAG 
GTGTGCTATA ACTGCGGTAA AGCCGGACAC ATGGCGCGCG ACTGCGACCA CGCCAATGAG 
CAAAAGTGCT ACTCCTGCGG CGGATTCGGA CACATCCAGA AGGGCTGCGA AAAAGTCAAG 
TGCTACAGGT GTGGAGAGAT CGGTCACGTG GCTGTTCAGT GCAGCAAGGC CAGCGAAGTC 
AACTGCTACA ACTGCGGCAA ATCGGGCCAC GTGGCGAAGG AGTGCACCAT CGAGGCCACC 
GCTTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

CNBPB ( XM_001922848.5 ) cDNA ORF clone, Danio rerio(Zebrafish) -> XP_001922883.1 Danio rerio CCHC-type zinc finger, nucleic acid binding protein b (cnbpb), transcript variant X1, mRNA.

Price & Availability↑

CloneID	ODa16601
Clone ID Related Accession (Same CDS sequence)	XM_001922848.6 , NM_001326405.1 , XM_001922848.5
Accession Version	XM_001922848.5	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 486bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-06-23
Organism	Danio rerio(Zebrafish)
Product	zinc finger protein 9 isoform X1
Comment	MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_007122.6) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Jun 24, 2016 this sequence version replaced XM_001922848.4. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Danio rerio Annotation Release 105 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGAGCAGCA ACGAGTGTTT TGGTTGTGGC CGTACGGGTC ATTGGATCAA GAACTGTCCC 
AATGCTGGAC GTGGACGTGG GAAGGGCCGC GGCAGAGGAA AAGATCTTTT CTGCTATCGC 
TGTGGAGAAC CAGGTCATGT TGCGAGAGAT TGTGAGAGGA CTGAAGATGC GTGCTACAAC 
TGCGGCAGAG GCGGCCACAT CTCCAGGGAC TGCAAGGAGC CCAAGAAGGA GCGCGAGCAG 
GTGTGCTATA ACTGCGGTAA AGCCGGACAC ATGGCGCGCG ACTGCGACCA CGCCAATGAG 
CAAAAGTGCT ACTCCTGCGG CGGATTCGGA CACATCCAGA AGGGCTGCGA AAAAGTCAAG 
TGCTACAGGT GTGGAGAGAT CGGTCACGTG GCTGTTCAGT GCAGCAAGGC CAGCGAAGTC 
AACTGCTACA ACTGCGGCAA ATCGGGCCAC GTGGCGAAGG AGTGCACCAT CGAGGCCACC 
GCTTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_001922883.1
CDS	357..842
Translation	MSSNECFGCGRTGHWIKNCPNAGRGRGKGRGRGKDLFCYRCGEPGHVARDCERTEDACYNCGRGGHISRDCKEPKKEREQVCYNCGKAGHMARDCDHANEQKCYSCGGFGHIQKGCEKVKCYRCGEIGHVAVQCSKASEVNCYNCGKSGHVAKECTIEATA

Target ORF information:

RefSeq Version	XM_001922848.5
Organism	Danio rerio(Zebrafish)
Definition	Danio rerio CCHC-type zinc finger, nucleic acid binding protein b (cnbpb), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_001922848.5

ORF Insert Sequence:

ATGAGCAGCA ACGAGTGTTT TGGTTGTGGC CGTACGGGTC ATTGGATCAA GAACTGTCCC 
AATGCTGGAC GTGGACGTGG GAAGGGCCGC GGCAGAGGAA AAGATCTTTT CTGCTATCGC 
TGTGGAGAAC CAGGTCATGT TGCGAGAGAT TGTGAGAGGA CTGAAGATGC GTGCTACAAC 
TGCGGCAGAG GCGGCCACAT CTCCAGGGAC TGCAAGGAGC CCAAGAAGGA GCGCGAGCAG 
GTGTGCTATA ACTGCGGTAA AGCCGGACAC ATGGCGCGCG ACTGCGACCA CGCCAATGAG 
CAAAAGTGCT ACTCCTGCGG CGGATTCGGA CACATCCAGA AGGGCTGCGA AAAAGTCAAG 
TGCTACAGGT GTGGAGAGAT CGGTCACGTG GCTGTTCAGT GCAGCAAGGC CAGCGAAGTC 
AACTGCTACA ACTGCGGCAA ATCGGGCCAC GTGGCGAAGG AGTGCACCAT CGAGGCCACC 
GCTTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

CNBP acts as a key transcriptional regulator of sustained expression of interleukin-6.
Nucleic acids research45(6)3280-3296(2017 Apr)
Lee E,Lee TA,Kim JH,Park A,Ra EA,Kang S,Choi HJ,Choi JL,Huh HD,Lee JE,Lee S,Park B

Evolution of complexity in the zebrafish synapse proteome.
Nature communications814613(2017 Mar)
Bay?s ?,Collins MO,Reig-Viader R,Gou G,Goulding D,Izquierdo A,Choudhary JS,Emes RD,Grant SG

Cnbp ameliorates Treacher Collins Syndrome craniofacial anomalies through a pathway that involves redox-responsive genes.
Cell death & disease7(10)e2397(2016 Oct)
de Peralta MS,Mouguelar VS,Sdrigotti MA,Ishiy FA,Fanganiello RD,Passos-Bueno MR,Coux G,Calcaterra NB

Gene evolution and gene expression after whole genome duplication in fish: the PhyloFish database.
BMC genomics17368(2016 05)
Pasquier J,Cabau C,Nguyen T,Jouanno E,Severac D,Braasch I,Journot L,Pontarotti P,Klopp C,Postlethwait JH,Guiguen Y,Bobe J

RFX transcription factors are essential for hearing in mice.
Nature communications68549(2015 Oct)
Elkon R,Milon B,Morrison L,Shah M,Vijayakumar S,Racherla M,Leitch CC,Silipino L,Hadi S,Weiss-Gayet M,Barras E,Schmid CD,Ait-Lounis A,Barnes A,Song Y,Eisenman DJ,Eliyahu E,Frolenkov GI,Strome SE,Durand B,Zaghloul NA,Jones SM,Reith W,Hertzano R

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CNBPB cDNA ORF clone, Danio rerio(Zebrafish)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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