slc26a5 cDNA ORF clone, Danio rerio(zebrafish)

Gene
Clones
gRNAs

Summary

Gene Symbol	slc26a5
Entrez Gene ID	322846
Full Name	solute carrier family 26 (anion exchanger), member 5
Synonyms	fb73d12,fb74g12,pres,wu:fb73d12,wu:fb74g12
General protein information	Preferred Names solute carrier family 26 (anion exchanger), member 5 Names prestin solute carrier family 26, member 5 zprestin
Gene Type	protein-coding
Organism	Danio rerio(zebrafish)

mRNA and Protein(s)

mRNA	Protein	Name
NM_201473.1	NP_958881.1	prestin

Pathways from BioSystems

Homologies

Homo sapiens (human)	SLC26A5	NP_945350.1
Canis lupus familiaris (dog)	SLC26A5	XP_540393.2
Drosophila melanogaster (fruit fly)	Prestin	NP_649024.1
Caenorhabditis elegans (roundworm)	sulp-7	NP_001033571.1
Caenorhabditis elegans (roundworm)	sulp-4	NP_505989.1
Caenorhabditis elegans (roundworm)	sulp-3	NP_509424.2
Rattus norvegicus (Norway rat)	Slc26a5	NP_110467.1
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP010389	XP_559067.3
Caenorhabditis elegans (roundworm)	sulp-8	NP_001256129.1
Xenopus tropicalis (tropical clawed frog)	slc26a5	XP_002933151.2
Gallus gallus (chicken)	SLC26A5	NP_001072945.1
Oryza sativa (rice)	Os04g0652400	NP_001054098.1
Pan troglodytes (chimpanzee)	SLC26A5	XP_003339466.1
Bos taurus (cattle)	SLC26A5	NP_001179807.1
Mus musculus (house mouse)	Slc26a5	NP_109652.3
Danio rerio (zebrafish)	slc26a5	NP_958881.1
Caenorhabditis elegans (roundworm)	sulp-5	NP_505990.2
Arabidopsis thaliana (thale cress)	AST91	NP_173722.1

Gene Ontology
Bibliography

Related articles in PubMed

Gene evolution and gene expression after whole genome duplication in fish: the PhyloFish database.
Pasquier J, Cabau C, Nguyen T, Jouanno E, Severac D, Braasch I, Journot L, Pontarotti P, Klopp C, Postlethwait JH, Guiguen Y, Bobe J
BMC genomics17368(2016 05)

RFX transcription factors are essential for hearing in mice.
Elkon R, Milon B, Morrison L, Shah M, Vijayakumar S, Racherla M, Leitch CC, Silipino L, Hadi S, Weiss-Gayet M, Barras E, Schmid CD, Ait-Lounis A, Barnes A, Song Y, Eisenman DJ, Eliyahu E, Frolenkov GI, Strome SE, Durand B, Zaghloul NA, Jones SM, Reith W, Hertzano R
Nature communications68549(2015 Oct)

High-throughput gene targeting and phenotyping in zebrafish using CRISPR/Cas9.
Varshney GK, Pei W, LaFave MC, Idol J, Xu L, Gallardo V, Carrington B, Bishop K, Jones M, Li M, Harper U, Huang SC, Prakash A, Chen W, Sood R, Ledin J, Burgess SM
Genome research25(7)1030-42(2015 Jul)

Solute Carrier Family 26 Member a2 (slc26a2) Regulates Otic Development and Hair Cell Survival in Zebrafish.
Liu F, Xia W, Hu J, Wang Y, Yang F, Sun S, Zhang J, Jiang N, Wang H, Tian W, Wang X, Ma D
PloS one10(9)e0136832(2015)

A motif of eleven amino acids is a structural adaptation that facilitates motor capability of eutherian prestin.
Tan X, Pecka JL, Tang J, Lovas S, Beisel KW, He DZ
Journal of cell science125(Pt 4)1039-47(2012 Feb)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

results show, for the first time, that the substitution of a span of 11 amino acid residues confers the electrogenic anion transporters of zebrafish and chicken prestins with motor-like function
Title: A motif of eleven amino acids is a structural adaptation that facilitates motor capability of eutherian prestin.

Motor function is an innovation of therian prestin and is concurrent with diminished transporter capabilities.
Title: From zebrafish to mammal: functional evolution of prestin, the motor protein of cochlear outer hair cells.

sequence conservation between mammalian and nonmammalian prestin together with a common pharmacology of electromotility and divalent antiport
Title: Nonmammalian orthologs of prestin (SLC26A5) are electrogenic divalent/chloride anion exchangers.

Compared with mammalian prestin, charge movements mediated by zprestin display a weaker voltage dependence and slower kinetics; they occur at more positive membrane voltages, and are not associated with electromotile responses.
Title: Voltage-sensitive prestin orthologue expressed in zebrafish hair cells.

The following slc26a5 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the slc26a5 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ODa03319	NM_201473.1 Latest version!	Danio rerio solute carrier family 26 member 5 (slc26a5), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	12-14	$426.30 $609.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

slc26a5 ( NM_201473.1 ) cDNA ORF clone, Danio rerio(zebrafish) -> NP_958881.1 Danio rerio solute carrier family 26 member 5 (slc26a5), mRNA.

Price & Availability↑

CloneID	ODa03319
Clone ID Related Accession (Same CDS sequence)	NM_201473.1
Accession Version	NM_201473.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2220bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-04-07
Organism	Danio rerio(zebrafish)
Product	prestin
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC054604.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC054604.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA2168446, SAMEA2168447 [ECO:0000350] ##Evidence-Data-END##

ATGGAGCACG TAACTGTTAG CGAGGAGCCG TCCGCTACAC TAATGTACCA TGTGGAACGA 
CCCATATTCA GTGAAGCTTA TATTGACTCA GAGCTTCTGC ACAAGAGGAA GAAGACACCC 
AAACCCTATA AACTGAGAGT AGCAGAGCAT CTCTGCTGTT CGTCTGAGAA AGTCAAGTCT 
GTTGTTTTTG GTTTTCTACC CATTTTAACA TGGCTGCCAT CATATCCACT AAAGGAATAT 
CTTTTTGGGG ACATTGTCTC AGGAATCAGC ACAGGTGTAA TGCAGCTACC TCAAGGTCTT 
GCTTATGCAA TGCTGGCAGC TGTCCCTCCA GTGTTTGGCT TATATTCATC ATTTTATCCC 
GTCCTGTTAT ACACATTCTT TGGTACCTCC AAACATATAT CAATAGGCAC ATTTGCTGTA 
ATCAGTCTGA TGATTGGTGG GGTTGCTGTA AGAGAGGCCC CAGACTCCAT GTTTATGGTC 
AATGGGACCA ATTCTTCACT GGTTGTGAAT ATTGAGGCCC GTGATTCCAG AAGAGTGGAG 
GTGGTTGTAG CTCTGACAAC TCTAGTAGGA ATCATCCAGT TTGTACTGGG TCTGCTGAGG 
TTTGGTTTCC TGGCGATTTA TCTGACTGAG CCGCTGGTGC GAGGTTTCAC CACTGCCGCG 
GCTGTGCACG TCTCAGTGTC GCAACTCAAG TACCTGCTGG GAGTGAAGAC TGCACGCTTC 
AATGGGCCTC TTTCTGTAGT GTATAGTCTC GATGCTGTCC TCAGGAACAT TGCAGACACT 
AATATTGTCA CTCTAATTAT TGGGCTGGGG TGTACTGTGT TCCTGTACAT CATCAAACAG 
CTCAACGAAC GCTTCAAGAA GAAGCTACTT ATCCCCATCC CTGGAGAAAT CATAGTGGTA 
ATTGTGTCCA CTGGTATCTC ATACGGGATG CTTATGTCTG AAAACTATGG TGTGGACGTT 
GTGGGTAAAA TTCCTACTGG GTTGCTGCCA CCCAAGGTTC CAGACTTCTC AGTCTTTCCA 
AACCTCTTTG CAGACGCCGT CCCTATAGCT GTTGTTGGAT TTTCCATTAC AATCTCATTA 
GCCAAAACCT TTGCTCTAAA GTATGGCTAC AGTGTTGATG GAAATCAGGA GCTCATCGCG 
CTGGGACTTT GTAACTTTGT CAGTTCGTTC TTCCACACGT TTGTCGTCAC CGCCTCAATG 
TCTCGCAGCC TGGTACAGGA GAGCACTGGA GGACATACTG AAATTGCAGG TCTCTTGGCG 
TCCCTACTTG TGCTACTGGT GGTGGTGGCC ATTGGATTTG TCTTTCAGCC ATTACCCACG 
ACGGTGTTGG CTGCTATCAT CATGGTTAAT CTCCTGGGGA TGTTTAAGCA AACAAGGGAT 
ATTCCAGTTT TATGGAGAAA AAGCAAGATT GAACTGGCAA TTTGGCTGGT GTCTTTTTTT 
GCATCGGTTC TCCTGGGCCT GGATTATGGT TTGGCGGTTG CCATGGCTTT TGCTATACTC 
ACCGTGATTT ACAGAACACA ACGCCCCAAG AATGTCGTTC TTGGACAAAT CCCAGATACA 
GGATTGTACT TTGATGTGGA TGAATATGAA GAGGCTGAGG AATGCTCAGG GATTAAGATT 
TTTCAGTCCA ATTCCTCCAT CTACTTCGCA AACAGTGAGC TGTATGTCAA GGCCCTCAAG 
GCAAAGACTG GAATTGACCC GGAAAAACTG CTTGATGCCA AGAAATTACA GCTCAAATAT 
GCCAAAAGAG ACACAGAGGG TACAAAGACT GTAAACCAAG GCTCTTTGCT GAAGAAAAAT 
GCAGTCGTCT TATTGGACAT GGAGCTGGGC GTCACTCATG AAGTCCTGAA CGGGCCACAA 
AAACCAAAGC ATGTACACAC CAATGGCCAG ATGACCGAGA AACACATCGA ATCTGAATCT 
GAGGATGAAT TCTTTCTGCA GCGTCTCACC CCCATTCACT CCGTCATCCT GGACTTTACT 
CCTGTTAACT TTATTGACTC TGTAGGAGCC AAAACCATTA AATCAGTGAT CAAAGAGTAT 
GCAACAGTTG ACGTGAAGGT TGTACTTGCT GGATGTAGCA GGACCCTTCT GTCTGAACTC 
AGGACGCTCC AGTTCTTCAG TGAGCCTGTG ACCCCTGACC TCATTTTCCC CACCATTCAT 
GACGCAGTAC TGCAGTGTAA ACGTTGGAGG GATCTTCCCG TCCACCCAAA CATCCACTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_958881.1
CDS	184..2403
Translation	MEHVTVSEEPSATLMYHVERPIFSEAYIDSELLHKRKKTPKPYKLRVAEHLCCSSEKVKSVVFGFLPILTWLPSYPLKEYLFGDIVSGISTGVMQLPQGLAYAMLAAVPPVFGLYSSFYPVLLYTFFGTSKHISIGTFAVISLMIGGVAVREAPDSMFMVNGTNSSLVVNIEARDSRRVEVVVALTTLVGIIQFVLGLLRFGFLAIYLTEPLVRGFTTAAAVHVSVSQLKYLLGVKTARFNGPLSVVYSLDAVLRNIADTNIVTLIIGLGCTVFLYIIKQLNERFKKKLLIPIPGEIIVVIVSTGISYGMLMSENYGVDVVGKIPTGLLPPKVPDFSVFPNLFADAVPIAVVGFSITISLAKTFALKYGYSVDGNQELIALGLCNFVSSFFHTFVVTASMSRSLVQESTGGHTEIAGLLASLLVLLVVVAIGFVFQPLPTTVLAAIIMVNLLGMFKQTRDIPVLWRKSKIELAIWLVSFFASVLLGLDYGLAVAMAFAILTVIYRTQRPKNVVLGQIPDTGLYFDVDEYEEAEECSGIKIFQSNSSIYFANSELYVKALKAKTGIDPEKLLDAKKLQLKYAKRDTEGTKTVNQGSLLKKNAVVLLDMELGVTHEVLNGPQKPKHVHTNGQMTEKHIESESEDEFFLQRLTPIHSVILDFTPVNFIDSVGAKTIKSVIKEYATVDVKVVLAGCSRTLLSELRTLQFFSEPVTPDLIFPTIHDAVLQCKRWRDLPVHPNIH

Target ORF information:

RefSeq Version	NM_201473.1
Organism	Danio rerio(zebrafish)
Definition	Danio rerio solute carrier family 26 member 5 (slc26a5), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_201473.1

ORF Insert Sequence:

ATGGAGCACG TAACTGTTAG CGAGGAGCCG TCCGCTACAC TAATGTACCA TGTGGAACGA 
CCCATATTCA GTGAAGCTTA TATTGACTCA GAGCTTCTGC ACAAGAGGAA GAAGACACCC 
AAACCCTATA AACTGAGAGT AGCAGAGCAT CTCTGCTGTT CGTCTGAGAA AGTCAAGTCT 
GTTGTTTTTG GTTTTCTACC CATTTTAACA TGGCTGCCAT CATATCCACT AAAGGAATAT 
CTTTTTGGGG ACATTGTCTC AGGAATCAGC ACAGGTGTAA TGCAGCTACC TCAAGGTCTT 
GCTTATGCAA TGCTGGCAGC TGTCCCTCCA GTGTTTGGCT TATATTCATC ATTTTATCCC 
GTCCTGTTAT ACACATTCTT TGGTACCTCC AAACATATAT CAATAGGCAC ATTTGCTGTA 
ATCAGTCTGA TGATTGGTGG GGTTGCTGTA AGAGAGGCCC CAGACTCCAT GTTTATGGTC 
AATGGGACCA ATTCTTCACT GGTTGTGAAT ATTGAGGCCC GTGATTCCAG AAGAGTGGAG 
GTGGTTGTAG CTCTGACAAC TCTAGTAGGA ATCATCCAGT TTGTACTGGG TCTGCTGAGG 
TTTGGTTTCC TGGCGATTTA TCTGACTGAG CCGCTGGTGC GAGGTTTCAC CACTGCCGCG 
GCTGTGCACG TCTCAGTGTC GCAACTCAAG TACCTGCTGG GAGTGAAGAC TGCACGCTTC 
AATGGGCCTC TTTCTGTAGT GTATAGTCTC GATGCTGTCC TCAGGAACAT TGCAGACACT 
AATATTGTCA CTCTAATTAT TGGGCTGGGG TGTACTGTGT TCCTGTACAT CATCAAACAG 
CTCAACGAAC GCTTCAAGAA GAAGCTACTT ATCCCCATCC CTGGAGAAAT CATAGTGGTA 
ATTGTGTCCA CTGGTATCTC ATACGGGATG CTTATGTCTG AAAACTATGG TGTGGACGTT 
GTGGGTAAAA TTCCTACTGG GTTGCTGCCA CCCAAGGTTC CAGACTTCTC AGTCTTTCCA 
AACCTCTTTG CAGACGCCGT CCCTATAGCT GTTGTTGGAT TTTCCATTAC AATCTCATTA 
GCCAAAACCT TTGCTCTAAA GTATGGCTAC AGTGTTGATG GAAATCAGGA GCTCATCGCG 
CTGGGACTTT GTAACTTTGT CAGTTCGTTC TTCCACACGT TTGTCGTCAC CGCCTCAATG 
TCTCGCAGCC TGGTACAGGA GAGCACTGGA GGACATACTG AAATTGCAGG TCTCTTGGCG 
TCCCTACTTG TGCTACTGGT GGTGGTGGCC ATTGGATTTG TCTTTCAGCC ATTACCCACG 
ACGGTGTTGG CTGCTATCAT CATGGTTAAT CTCCTGGGGA TGTTTAAGCA AACAAGGGAT 
ATTCCAGTTT TATGGAGAAA AAGCAAGATT GAACTGGCAA TTTGGCTGGT GTCTTTTTTT 
GCATCGGTTC TCCTGGGCCT GGATTATGGT TTGGCGGTTG CCATGGCTTT TGCTATACTC 
ACCGTGATTT ACAGAACACA ACGCCCCAAG AATGTCGTTC TTGGACAAAT CCCAGATACA 
GGATTGTACT TTGATGTGGA TGAATATGAA GAGGCTGAGG AATGCTCAGG GATTAAGATT 
TTTCAGTCCA ATTCCTCCAT CTACTTCGCA AACAGTGAGC TGTATGTCAA GGCCCTCAAG 
GCAAAGACTG GAATTGACCC GGAAAAACTG CTTGATGCCA AGAAATTACA GCTCAAATAT 
GCCAAAAGAG ACACAGAGGG TACAAAGACT GTAAACCAAG GCTCTTTGCT GAAGAAAAAT 
GCAGTCGTCT TATTGGACAT GGAGCTGGGC GTCACTCATG AAGTCCTGAA CGGGCCACAA 
AAACCAAAGC ATGTACACAC CAATGGCCAG ATGACCGAGA AACACATCGA ATCTGAATCT 
GAGGATGAAT TCTTTCTGCA GCGTCTCACC CCCATTCACT CCGTCATCCT GGACTTTACT 
CCTGTTAACT TTATTGACTC TGTAGGAGCC AAAACCATTA AATCAGTGAT CAAAGAGTAT 
GCAACAGTTG ACGTGAAGGT TGTACTTGCT GGATGTAGCA GGACCCTTCT GTCTGAACTC 
AGGACGCTCC AGTTCTTCAG TGAGCCTGTG ACCCCTGACC TCATTTTCCC CACCATTCAT 
GACGCAGTAC TGCAGTGTAA ACGTTGGAGG GATCTTCCCG TCCACCCAAA CATCCACTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Gene evolution and gene expression after whole genome duplication in fish: the PhyloFish database.
BMC genomics17368(2016 05)
Pasquier J,Cabau C,Nguyen T,Jouanno E,Severac D,Braasch I,Journot L,Pontarotti P,Klopp C,Postlethwait JH,Guiguen Y,Bobe J

RFX transcription factors are essential for hearing in mice.
Nature communications68549(2015 Oct)
Elkon R,Milon B,Morrison L,Shah M,Vijayakumar S,Racherla M,Leitch CC,Silipino L,Hadi S,Weiss-Gayet M,Barras E,Schmid CD,Ait-Lounis A,Barnes A,Song Y,Eisenman DJ,Eliyahu E,Frolenkov GI,Strome SE,Durand B,Zaghloul NA,Jones SM,Reith W,Hertzano R

High-throughput gene targeting and phenotyping in zebrafish using CRISPR/Cas9.
Genome research25(7)1030-42(2015 Jul)
Varshney GK,Pei W,LaFave MC,Idol J,Xu L,Gallardo V,Carrington B,Bishop K,Jones M,Li M,Harper U,Huang SC,Prakash A,Chen W,Sood R,Ledin J,Burgess SM

Solute Carrier Family 26 Member a2 (slc26a2) Regulates Otic Development and Hair Cell Survival in Zebrafish.
PloS one10(9)e0136832(2015)
Liu F,Xia W,Hu J,Wang Y,Yang F,Sun S,Zhang J,Jiang N,Wang H,Tian W,Wang X,Ma D

A motif of eleven amino acids is a structural adaptation that facilitates motor capability of eutherian prestin.
Journal of cell science125(Pt 4)1039-47(2012 Feb)
Tan X,Pecka JL,Tang J,Lovas S,Beisel KW,He DZ

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slc26a5 cDNA ORF clone, Danio rerio(zebrafish)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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