mab21l2 cDNA ORF clone, Danio rerio(zebrafish)

Gene
Clones
gRNAs

Summary

Gene Symbol	mab21l2
Entrez Gene ID	117234
Full Name	mab-21-like 2
Synonyms	id:ibd3414
General protein information	Preferred Names mab-21-like 2 Names protein mab-21-like 2 unm_au10
Gene Type	protein-coding
Organism	Danio rerio(zebrafish)

mRNA and Protein(s)

mRNA	Protein	Name
NM_152975.2	NP_694507.1	protein mab-21-like 2

Pathways from BioSystems

Homologies

	MAB21L2	XP_001082398.1
Xenopus tropicalis (tropical clawed frog)	mab21l2	NP_001096455.1
Anopheles gambiae (African malaria mosquito)	MB21L_ANOGA	XP_309230.3
Homo sapiens (human)	MAB21L2	NP_006430.1
Pan troglodytes (chimpanzee)	MAB21L2	XP_001151747.1
Bos taurus (cattle)	MAB21L2	XP_002694365.1
Mus musculus (house mouse)	Mab21l2	NP_035969.2
Canis lupus familiaris (dog)	MAB21L2	XP_867530.2
Rattus norvegicus (Norway rat)	Mab21l2	NP_001102861.1
Danio rerio (zebrafish)	mab21l2	NP_694507.1
Drosophila melanogaster (fruit fly)	CG4766	NP_572287.1

Gene Ontology
Bibliography

Related articles in PubMed

RFX transcription factors are essential for hearing in mice.
Elkon R, Milon B, Morrison L, Shah M, Vijayakumar S, Racherla M, Leitch CC, Silipino L, Hadi S, Weiss-Gayet M, Barras E, Schmid CD, Ait-Lounis A, Barnes A, Song Y, Eisenman DJ, Eliyahu E, Frolenkov GI, Strome SE, Durand B, Zaghloul NA, Jones SM, Reith W, Hertzano R
Nature communications68549(2015 Oct)

Mutations in MAB21L2 result in ocular Coloboma, microcornea and cataracts.
Deml B, Kariminejad A, Borujerdi RH, Muheisen S, Reis LM, Semina EV
PLoS genetics11(2)e1005002(2015)

In vivo analysis of hyaloid vasculature morphogenesis in zebrafish: A role for the lens in maturation and maintenance of the hyaloid.
Hartsock A, Lee C, Arnold V, Gross JM
Developmental biology394(2)327-39(2014 Oct)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

These findings support the identification of MAB21L2 as a novel factor involved in human coloboma and highlight the power of genome editing manipulation in model organisms for analysis of the effects of whole exome variation in humans.
Title: Mutations in MAB21L2 result in ocular Coloboma, microcornea and cataracts.

Despite the absence of conserved non-coding elements, a 4.9-kb mab21l2 promoter is sufficient to recapitulate expression in tissues unique to mab21l1 or mab21l2.
Title: mab21l2 transgenics reveal novel expression patterns of mab21l1 and mab21l2, and conserved promoter regulation without sequence conservation.

mab21l2 is an early downstream effector of rx3 and is critical for survival of eye progenitors.
Title: Zebrafish rx3 and mab21l2 are required during eye morphogenesis.

mab21 genes play a role in differentiation of the early differentiating olfactory bulbs, eye primordia, midbrain and subsequently the branchial pouches and neural tube
Title: Expression of zebrafish mab21 genes marks the differentiating eye, midbrain and neural tube.

The following mab21l2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the mab21l2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ODa37473	NM_152975.2 Latest version!	Danio rerio mab-21-like 2 (mab21l2), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$258.30 $369.00

ORF Online Only Promotion

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

mab21l2 ( NM_152975.2 ) cDNA ORF clone, Danio rerio(zebrafish) -> NP_694507.1 Danio rerio mab-21-like 2 (mab21l2), mRNA.

Price & Availability↑

CloneID	ODa37473
Clone ID Related Accession (Same CDS sequence)	NM_152975.2
Accession Version	NM_152975.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1080bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-23
Organism	Danio rerio(zebrafish)
Product	protein mab-21-like 2
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC065628.1. On Feb 22, 2004 this sequence version replaced NM_152975.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC065628.1 [ECO:0000332] ##Evidence-Data-END##

ATGATTGCAA CGCAAGCAAA GCTGGTTTAC CAGCTTAATA AATATTACAA CGAAAGATGC 
CAGGCGCGCA AAGCGGCCAT CGCCAAGACC ATACGAGAGG TGTGTAAGGT GGTGTCGGAT 
GTGCTGAAGG AGGTGGAGGT CCAAGAGCCC CGTTTCATCA GCTCCCTGAG CGAGATAGAC 
GCGCGCTATG AGGGCATGGA GGTCATCGCA CCCAACGAGT TTGAGGTCGT ACTTTACCTG 
AACCAGATGG GGGTGTTCAA CTTTGTGGAC GATGGCTCTC TGCCGGGCTG CGCGGTGCTC 
AAGCTCAGCG ACGGCCGCAA GAGGAGCATG TCCCTGTGGG TGGAGTTCAT CACCGCCTCC 
GGTTATCTAT CGGCACGAAA GATTCGCTCC CGCTTTCAGA CGCTGGTTGC CCAGGCCGTG 
GATAAATGCA GCTACCGGGA CGTGGTTAAG ATGGTGGCGG ACACGAGCGA AGTGAAACTG 
CGCATTCGGG AGAGATACGT CGTGCAAATC ACCCCGGCCT TCAAGTGCAC GGGCATCTGG 
CCTAGGAGTG CCGCTCAGTG GCCCATGCCT CACATCCCGT GGCCCGGGCC GAACCGGGTG 
GCGGAGGTAA AAGCGGAGGG GTTTAACCTG CTCTCTAAAG AGTGCTACTC GTTGACGGGC 
AAGCAGAGCT CGGCAGAAAG CGACGCCTGG GTCTTGCAGT TCGCCGAGGC CGAGAACAGG 
CTTCTGATGT CGGGCTGTAG GAAGAAATGC CTCTCTGTTC TAAAGACTCT CCGTGACCGA 
CACCTCGAGC TGCCGGGACA GCCGCTTAAT AACTACCACA TGAAGACCCT ACTGCTATAC 
GAGTGCGAGA AACACCCGCG GGAGACTGAC TGGGACGAGT CGTGCCTCGG CGACCGACTG 
AACGGTATTC TGCTGCAGCT CATCTCCTGC CTGCAGTGCC GCCGGTGCCC ACATTACTTC 
TTACCCAATC TAGACCTGTT TCAGGGTAAA CCACACTCGG CTCTGGAGAC AGCGGCCAAA 
CAGACCTGGA GACTGGCAAG AGAAATCCTT ACCAACGCTA AAAGTTTGGA TAAACTGTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_694507.1
CDS	340..1419
Translation	MIATQAKLVYQLNKYYNERCQARKAAIAKTIREVCKVVSDVLKEVEVQEPRFISSLSEIDARYEGMEVIAPNEFEVVLYLNQMGVFNFVDDGSLPGCAVLKLSDGRKRSMSLWVEFITASGYLSARKIRSRFQTLVAQAVDKCSYRDVVKMVADTSEVKLRIRERYVVQITPAFKCTGIWPRSAAQWPMPHIPWPGPNRVAEVKAEGFNLLSKECYSLTGKQSSAESDAWVLQFAEAENRLLMSGCRKKCLSVLKTLRDRHLELPGQPLNNYHMKTLLLYECEKHPRETDWDESCLGDRLNGILLQLISCLQCRRCPHYFLPNLDLFQGKPHSALETAAKQTWRLAREILTNAKSLDKL

Target ORF information:

RefSeq Version	NM_152975.2
Organism	Danio rerio(zebrafish)
Definition	Danio rerio mab-21-like 2 (mab21l2), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_152975.2

ORF Insert Sequence:

ATGATTGCAA CGCAAGCAAA GCTGGTTTAC CAGCTTAATA AATATTACAA CGAAAGATGC 
CAGGCGCGCA AAGCGGCCAT CGCCAAGACC ATACGAGAGG TGTGTAAGGT GGTGTCGGAT 
GTGCTGAAGG AGGTGGAGGT CCAAGAGCCC CGTTTCATCA GCTCCCTGAG CGAGATAGAC 
GCGCGCTATG AGGGCATGGA GGTCATCGCA CCCAACGAGT TTGAGGTCGT ACTTTACCTG 
AACCAGATGG GGGTGTTCAA CTTTGTGGAC GATGGCTCTC TGCCGGGCTG CGCGGTGCTC 
AAGCTCAGCG ACGGCCGCAA GAGGAGCATG TCCCTGTGGG TGGAGTTCAT CACCGCCTCC 
GGTTATCTAT CGGCACGAAA GATTCGCTCC CGCTTTCAGA CGCTGGTTGC CCAGGCCGTG 
GATAAATGCA GCTACCGGGA CGTGGTTAAG ATGGTGGCGG ACACGAGCGA AGTGAAACTG 
CGCATTCGGG AGAGATACGT CGTGCAAATC ACCCCGGCCT TCAAGTGCAC GGGCATCTGG 
CCTAGGAGTG CCGCTCAGTG GCCCATGCCT CACATCCCGT GGCCCGGGCC GAACCGGGTG 
GCGGAGGTAA AAGCGGAGGG GTTTAACCTG CTCTCTAAAG AGTGCTACTC GTTGACGGGC 
AAGCAGAGCT CGGCAGAAAG CGACGCCTGG GTCTTGCAGT TCGCCGAGGC CGAGAACAGG 
CTTCTGATGT CGGGCTGTAG GAAGAAATGC CTCTCTGTTC TAAAGACTCT CCGTGACCGA 
CACCTCGAGC TGCCGGGACA GCCGCTTAAT AACTACCACA TGAAGACCCT ACTGCTATAC 
GAGTGCGAGA AACACCCGCG GGAGACTGAC TGGGACGAGT CGTGCCTCGG CGACCGACTG 
AACGGTATTC TGCTGCAGCT CATCTCCTGC CTGCAGTGCC GCCGGTGCCC ACATTACTTC 
TTACCCAATC TAGACCTGTT TCAGGGTAAA CCACACTCGG CTCTGGAGAC AGCGGCCAAA 
CAGACCTGGA GACTGGCAAG AGAAATCCTT ACCAACGCTA AAAGTTTGGA TAAACTGTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

RFX transcription factors are essential for hearing in mice.
Nature communications68549(2015 Oct)
Elkon R,Milon B,Morrison L,Shah M,Vijayakumar S,Racherla M,Leitch CC,Silipino L,Hadi S,Weiss-Gayet M,Barras E,Schmid CD,Ait-Lounis A,Barnes A,Song Y,Eisenman DJ,Eliyahu E,Frolenkov GI,Strome SE,Durand B,Zaghloul NA,Jones SM,Reith W,Hertzano R

Mutations in MAB21L2 result in ocular Coloboma, microcornea and cataracts.
PLoS genetics11(2)e1005002(2015)
Deml B,Kariminejad A,Borujerdi RH,Muheisen S,Reis LM,Semina EV

In vivo analysis of hyaloid vasculature morphogenesis in zebrafish: A role for the lens in maturation and maintenance of the hyaloid.
Developmental biology394(2)327-39(2014 Oct)
Hartsock A,Lee C,Arnold V,Gross JM