aldh1l1 cDNA ORF clone, Danio rerio(zebrafish)

Gene
Clones
gRNAs

Summary

Gene Symbol	aldh1l1
Entrez Gene ID	100526683
Full Name	aldehyde dehydrogenase 1 family, member L1
General protein information	Preferred Names aldehyde dehydrogenase 1 family, member L1 Names cytosolic 10-formyltetrahydrofolate dehydrogenase 10-formyltetrahydrofolate dehydrogenase FDH
Gene Type	protein-coding
Organism	Danio rerio(zebrafish)

mRNA and Protein(s)

mRNA	Protein	Name
NM_001198772.1	NP_001185701.1	cytosolic 10-formyltetrahydrofolate dehydrogenase

Pathways from BioSystems

Homologies

	ALDH1L1	XP_002802729.1
Mus musculus (house mouse)	Aldh1l1	NP_081682.1
Homo sapiens (human)	ALDH1L1	NP_001257293.1
Bos taurus (cattle)	ALDH1L1	NP_001096557.1
Pan troglodytes (chimpanzee)	ALDH1L1	XP_516714.4
Rattus norvegicus (Norway rat)	Aldh1l1	NP_071992.1
Danio rerio (zebrafish)	aldh1l1	NP_001185701.1
Caenorhabditis elegans (roundworm)	alh-3	NP_502054.2
Xenopus tropicalis (tropical clawed frog)	aldh1l1	NP_001011027.1

Gene Ontology
Bibliography

Related articles in PubMed

The Retinol Binding Protein Receptor 2 (Rbpr2) is required for Photoreceptor Outer Segment Morphogenesis and Visual Function in Zebrafish.
Shi Y, Obert E, Rahman B, Rohrer B, Lobo GP
Scientific reports7(1)16207(2017 Nov)

A novel perivascular cell population in the zebrafish brain.
Venero Galanternik M, Castranova D, Gore AV, Blewett NH, Jung HM, Stratman AN, Kirby MR, Iben J, Miller MF, Kawakami K, Maraia RJ, Weinstein BM
eLife6(2017 04)

Evolution of complexity in the zebrafish synapse proteome.
Bay?s ?, Collins MO, Reig-Viader R, Gou G, Goulding D, Izquierdo A, Choudhary JS, Emes RD, Grant SG
Nature communications814613(2017 Mar)

Transcriptomic, proteomic, and metabolomic landscape of positional memory in the caudal fin of zebrafish.
Rabinowitz JS, Robitaille AM, Wang Y, Ray CA, Thummel R, Gu H, Djukovic D, Raftery D, Berndt JD, Moon RT
Proceedings of the National Academy of Sciences of the United States of America114(5)E717-E726(2017 Jan)

Structures of the hydrolase domain of zebrafish 10-formyltetrahydrofolate dehydrogenase and its complexes reveal a complete set of key residues for hydrolysis and product inhibition.
Lin CC, Chuankhayan P, Chang WN, Kao TT, Guan HH, Fun HK, Nakagawa A, Fu TF, Chen CJ
Acta crystallographica. Section D, Biological crystallography71(Pt 4)1006-21(2015 Apr)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The crystal structures of apo-form N-terminal domain - FDH and its complexes with the substrate analogue 10-formyl-5,8-dideazafolate (10-FDDF) and with the products tetrahydrofolate and formate have been determined.
Title: Structures of the hydrolase domain of zebrafish 10-formyltetrahydrofolate dehydrogenase and its complexes reveal a complete set of key residues for hydrolysis and product inhibition.

Knock-down of the fdh(10-Formyltetrahydrofolate dehydrogenase) gene impeded morphogenetic movement and caused incorrect cardiac positioning, defective hematopoiesis, notochord malformation and ultimate death of morphants
Title: Knocking down 10-Formyltetrahydrofolate dehydrogenase increased oxidative stress and impeded zebrafish embryogenesis by obstructing morphogenetic movement.

The following aldh1l1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the aldh1l1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ODa00727	NM_001198772.1 Latest version!	Danio rerio aldehyde dehydrogenase 1 family, member L1 (aldh1l1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	12-14	$510.30 $729.00

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

aldh1l1 ( NM_001198772.1 ) cDNA ORF clone, Danio rerio(zebrafish) -> NP_001185701.1 Danio rerio aldehyde dehydrogenase 1 family, member L1 (aldh1l1), mRNA.

Price & Availability↑

CloneID	ODa00727
Clone ID Related Accession (Same CDS sequence)	NM_001198772.1
Accession Version	NM_001198772.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2712bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-01-26
Organism	Danio rerio(zebrafish)
Product	cytosolic 10-formyltetrahydrofolate dehydrogenase
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from EU686693.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: EU686693.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA708828, SAMEA708836 [ECO:0000348] ##Evidence-Data-END##

ATGAAAATTG CAGTGATTGG CCAGAGTCTC TTTGGACAGG AGGTATACAA AGAATTGAAG 
AATGAAGGCC ACATGATTGT TGGTGTATTC ACAATCCCTG ACAAAGATGG AAAAGTAGAC 
CCACTTGCGA TTGAGGCAGA GAAGGATGGT GTGCCAGTGT TTAAGTTTCC CCGCTGGAGG 
CTGAAGGGAA AGGCCATTAC AGAAGTGGTA GACCAGTACA AAGCAGTTGG TGCGGAACTG 
AATGTTCTAC CTTTCTGCTC TCAGTTCATC CCAATGGAAG TGATAGATCA CCCAAAACAT 
GGTTCCATCA TTTACCATCC TTCCCTGCTG CCCAGACACA GAGGTGCCTC TGCCATTAAC 
TGGACCCTCA TTCATGGTGA TAAGAAGGGA GGGTTTACTG TTTTCTGGGC AGATGATGGA 
CTGGACACAG GACCAATTCT TTTGCAAAGA GAATGTGATG TTGAGCCAAA TGACAACGTA 
AACAGCATCT ACAAGCGCTT CCTGTTTCCA GAGGGAGTCA AGGGCATGGT AGAGGCAGTC 
AGGTTGATTG CAACAGGGAA AGCTCCAAGA ATCAAGCAAC CCGAAGAAGG AGCCACATAT 
GAGTGTATTC AGAAGAAAGA AAATTCAAAG ATTGACTGGA ATCAACCAGC AGAAGCCATT 
CATAACTGGA TCAGAGGAAA TGACAGAGTA CCTGGAGCCT GGGCAGAGAT AGATGGCAAA 
AGTGTGTCAT TTTATGGATC CACTCTGTTG GAAAATGATC ATTTTTCAAG TAATGGTCAA 
CCTTTGGAAA TCCCTGGAGC AAGTCGAGCT GCCCTAGTTA CCAAAAATGG CCTTGTTCTC 
TTTGGGAATG ATGGAAAGAT GTTGCTTGTG AAAAACCTGC AGTTTGAGGA TGGGAAGATG 
ATTCCTGGCT CCCAATATTT TAAAGCTGGT GTCACGTCTA CAGTGGAGCT CTCTGAGGAT 
GAAAATCGAT TCGCTGAGCA GATGAGGGTG GTGTGGAAGA GTATTTTAAC TAACGTAGAG 
AAGATTGAAG ACACTACTGA CTTCTTTAAG TCTGGCGCTG CATCAATGGA CGTAGTCAGG 
CTGGTGGAAG AGGTCAAGTT GAGGGCAGCA CAGTTGCAGT TGCAGAATGA GGACGTTTAC 
ATGGCGACAA GCTTTCAAGA GTTCATTCAA ATGTGTGTGA GGAAGTTAAG AGGAGAGGAT 
GAGGAAGAAG AGTTCAACGT AGACTATGTA GAAAAGAAAC TGAACAATAT GACAATTCAC 
ATCCCCCACC AGCTTTTTAT AAATGGGGAA TTTGTGGATG CGGAAGGAGG AAAAACCTAT 
AAGAGCATTA ACCCTACTGA CGGACAAGCA ATCTGTGACG TGTCTTTAGC TCAGATCTCT 
GATGTGGAAA AAGCAGTCGC TGCAGCTAAA GAAGCTTTTG AGGAAGGAGA GTGGGGGAAG 
ATGAACCCCA GAGACAGAGG CAAGCTGCTT TACAAACTGG CAGATCTGAT GGAGCAGCAT 
CAAGAAGAGT TGGCTACCAT TGAAAGCATA GACTCGGGAG CAGTCTATAC CCTTGCCCTC 
AAAACACACA TTGGCATGTC TATCCAGACA TTCAGATACT TTGCTGGCTG GTGTGACAAG 
ATTCAGGGCT GCACTATTCC CATAAACCAG GCTCGACCTA ATCGAAACCT TACCTTTACC 
AAGAAAGAGC CCATTGGTGT GTGCGGCATT GTAATTCCAT GGAATTATCC ACTGATGATG 
CTGGCTTGGA AGACTGCGGC CTGCCTGGCT GCTGGAAACA CTGTAGTTCT TAAACCTGCC 
CAGGTCACAC CTTTGACTGC TCTCAAATTT GCTGAATTAA CTGCTCTGGC AAAATTTCCA 
AAAGGAGTGG TGAACATACT ACCTGGATCA GGGTCTTTGG TTGGTCAGCG ACTTTCTGAT 
CACCCTGATG TCCGAAAACT GGGCTTCACT GGCTCTACTG AGATTGGCAA ACATATCATG 
AAAAGTTGCG CAGTCAGCAA TGTGAAAAAG GTTTCTCTTG AGCTCGGAGG GAAATCTCCT 
CTCATCATCT TTAATGACTG TGATCTGGAC AAGGCAGTCA GAATGGGCAT GAGCTCTGTG 
TTCTTCAATA AGGGGGAGAA CTGCATTGCA GCAGGGAGAC TATTCATTGA GGAGTCCATC 
CATGACATTT TTCTGGAAAG AGTGGTTAGC GAAATAAGGA AGATGAAGAT TGGTGATCCT 
CTGGACCGTT CCACAGACCA CGGTCCCCAA AACCACAAAG CTCATCTGGA CAAACTGGTG 
GAATACTGCG AAAAGGGGGT CAAAGAAGGA GCAAAATTAG TGTGTGGAGG AAAACAAGTG 
GAGCGTCCAG GTTTCTTCTT TGAACCAACT GTTTTCACTG ATGTGCAGGA TCACATGTAT 
ATCGCTGTCG AGGAGTCTTT TGGGCCTGTC ATGATCATCT CCAAATTCAG CAATGGAGAA 
GTTGACAAGG TGCTGCAGAG GGCTAATGCT ACAGAATTTG GCTTAGCATC AGGTGTGTTT 
ACACGTGACA TTAGTAAGGC TCTCTATGTG AGTGAAAAGC TTCAGGCTGG CACTGTGTTC 
ATCAACACGT ACAACAAGAC GGATGTGGCA GCTCCTTTTG GTGGCTTCAA ACAATCTGGC 
TTTGGCAAAG ATTTGGGTCA AGAAGCTCTG AATGAGTATC TGAAGACTAA ATGTGTCACA 
GTGGAATACT AA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001185701.1
CDS	59..2770
Translation	MKIAVIGQSLFGQEVYKELKNEGHMIVGVFTIPDKDGKVDPLAIEAEKDGVPVFKFPRWRLKGKAITEVVDQYKAVGAELNVLPFCSQFIPMEVIDHPKHGSIIYHPSLLPRHRGASAINWTLIHGDKKGGFTVFWADDGLDTGPILLQRECDVEPNDNVNSIYKRFLFPEGVKGMVEAVRLIATGKAPRIKQPEEGATYECIQKKENSKIDWNQPAEAIHNWIRGNDRVPGAWAEIDGKSVSFYGSTLLENDHFSSNGQPLEIPGASRAALVTKNGLVLFGNDGKMLLVKNLQFEDGKMIPGSQYFKAGVTSTVELSEDENRFAEQMRVVWKSILTNVEKIEDTTDFFKSGAASMDVVRLVEEVKLRAAQLQLQNEDVYMATSFQEFIQMCVRKLRGEDEEEEFNVDYVEKKLNNMTIHIPHQLFINGEFVDAEGGKTYKSINPTDGQAICDVSLAQISDVEKAVAAAKEAFEEGEWGKMNPRDRGKLLYKLADLMEQHQEELATIESIDSGAVYTLALKTHIGMSIQTFRYFAGWCDKIQGCTIPINQARPNRNLTFTKKEPIGVCGIVIPWNYPLMMLAWKTAACLAAGNTVVLKPAQVTPLTALKFAELTALAKFPKGVVNILPGSGSLVGQRLSDHPDVRKLGFTGSTEIGKHIMKSCAVSNVKKVSLELGGKSPLIIFNDCDLDKAVRMGMSSVFFNKGENCIAAGRLFIEESIHDIFLERVVSEIRKMKIGDPLDRSTDHGPQNHKAHLDKLVEYCEKGVKEGAKLVCGGKQVERPGFFFEPTVFTDVQDHMYIAVEESFGPVMIISKFSNGEVDKVLQRANATEFGLASGVFTRDISKALYVSEKLQAGTVFINTYNKTDVAAPFGGFKQSGFGKDLGQEALNEYLKTKCVTVEY

Target ORF information:

RefSeq Version	NM_001198772.1
Organism	Danio rerio(zebrafish)
Definition	Danio rerio aldehyde dehydrogenase 1 family, member L1 (aldh1l1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001198772.1

ORF Insert Sequence:

ATGAAAATTG CAGTGATTGG CCAGAGTCTC TTTGGACAGG AGGTATACAA AGAATTGAAG 
AATGAAGGCC ACATGATTGT TGGTGTATTC ACAATCCCTG ACAAAGATGG AAAAGTAGAC 
CCACTTGCGA TTGAGGCAGA GAAGGATGGT GTGCCAGTGT TTAAGTTTCC CCGCTGGAGG 
CTGAAGGGAA AGGCCATTAC AGAAGTGGTA GACCAGTACA AAGCAGTTGG TGCGGAACTG 
AATGTTCTAC CTTTCTGCTC TCAGTTCATC CCAATGGAAG TGATAGATCA CCCAAAACAT 
GGTTCCATCA TTTACCATCC TTCCCTGCTG CCCAGACACA GAGGTGCCTC TGCCATTAAC 
TGGACCCTCA TTCATGGTGA TAAGAAGGGA GGGTTTACTG TTTTCTGGGC AGATGATGGA 
CTGGACACAG GACCAATTCT TTTGCAAAGA GAATGTGATG TTGAGCCAAA TGACAACGTA 
AACAGCATCT ACAAGCGCTT CCTGTTTCCA GAGGGAGTCA AGGGCATGGT AGAGGCAGTC 
AGGTTGATTG CAACAGGGAA AGCTCCAAGA ATCAAGCAAC CCGAAGAAGG AGCCACATAT 
GAGTGTATTC AGAAGAAAGA AAATTCAAAG ATTGACTGGA ATCAACCAGC AGAAGCCATT 
CATAACTGGA TCAGAGGAAA TGACAGAGTA CCTGGAGCCT GGGCAGAGAT AGATGGCAAA 
AGTGTGTCAT TTTATGGATC CACTCTGTTG GAAAATGATC ATTTTTCAAG TAATGGTCAA 
CCTTTGGAAA TCCCTGGAGC AAGTCGAGCT GCCCTAGTTA CCAAAAATGG CCTTGTTCTC 
TTTGGGAATG ATGGAAAGAT GTTGCTTGTG AAAAACCTGC AGTTTGAGGA TGGGAAGATG 
ATTCCTGGCT CCCAATATTT TAAAGCTGGT GTCACGTCTA CAGTGGAGCT CTCTGAGGAT 
GAAAATCGAT TCGCTGAGCA GATGAGGGTG GTGTGGAAGA GTATTTTAAC TAACGTAGAG 
AAGATTGAAG ACACTACTGA CTTCTTTAAG TCTGGCGCTG CATCAATGGA CGTAGTCAGG 
CTGGTGGAAG AGGTCAAGTT GAGGGCAGCA CAGTTGCAGT TGCAGAATGA GGACGTTTAC 
ATGGCGACAA GCTTTCAAGA GTTCATTCAA ATGTGTGTGA GGAAGTTAAG AGGAGAGGAT 
GAGGAAGAAG AGTTCAACGT AGACTATGTA GAAAAGAAAC TGAACAATAT GACAATTCAC 
ATCCCCCACC AGCTTTTTAT AAATGGGGAA TTTGTGGATG CGGAAGGAGG AAAAACCTAT 
AAGAGCATTA ACCCTACTGA CGGACAAGCA ATCTGTGACG TGTCTTTAGC TCAGATCTCT 
GATGTGGAAA AAGCAGTCGC TGCAGCTAAA GAAGCTTTTG AGGAAGGAGA GTGGGGGAAG 
ATGAACCCCA GAGACAGAGG CAAGCTGCTT TACAAACTGG CAGATCTGAT GGAGCAGCAT 
CAAGAAGAGT TGGCTACCAT TGAAAGCATA GACTCGGGAG CAGTCTATAC CCTTGCCCTC 
AAAACACACA TTGGCATGTC TATCCAGACA TTCAGATACT TTGCTGGCTG GTGTGACAAG 
ATTCAGGGCT GCACTATTCC CATAAACCAG GCTCGACCTA ATCGAAACCT TACCTTTACC 
AAGAAAGAGC CCATTGGTGT GTGCGGCATT GTAATTCCAT GGAATTATCC ACTGATGATG 
CTGGCTTGGA AGACTGCGGC CTGCCTGGCT GCTGGAAACA CTGTAGTTCT TAAACCTGCC 
CAGGTCACAC CTTTGACTGC TCTCAAATTT GCTGAATTAA CTGCTCTGGC AAAATTTCCA 
AAAGGAGTGG TGAACATACT ACCTGGATCA GGGTCTTTGG TTGGTCAGCG ACTTTCTGAT 
CACCCTGATG TCCGAAAACT GGGCTTCACT GGCTCTACTG AGATTGGCAA ACATATCATG 
AAAAGTTGCG CAGTCAGCAA TGTGAAAAAG GTTTCTCTTG AGCTCGGAGG GAAATCTCCT 
CTCATCATCT TTAATGACTG TGATCTGGAC AAGGCAGTCA GAATGGGCAT GAGCTCTGTG 
TTCTTCAATA AGGGGGAGAA CTGCATTGCA GCAGGGAGAC TATTCATTGA GGAGTCCATC 
CATGACATTT TTCTGGAAAG AGTGGTTAGC GAAATAAGGA AGATGAAGAT TGGTGATCCT 
CTGGACCGTT CCACAGACCA CGGTCCCCAA AACCACAAAG CTCATCTGGA CAAACTGGTG 
GAATACTGCG AAAAGGGGGT CAAAGAAGGA GCAAAATTAG TGTGTGGAGG AAAACAAGTG 
GAGCGTCCAG GTTTCTTCTT TGAACCAACT GTTTTCACTG ATGTGCAGGA TCACATGTAT 
ATCGCTGTCG AGGAGTCTTT TGGGCCTGTC ATGATCATCT CCAAATTCAG CAATGGAGAA 
GTTGACAAGG TGCTGCAGAG GGCTAATGCT ACAGAATTTG GCTTAGCATC AGGTGTGTTT 
ACACGTGACA TTAGTAAGGC TCTCTATGTG AGTGAAAAGC TTCAGGCTGG CACTGTGTTC 
ATCAACACGT ACAACAAGAC GGATGTGGCA GCTCCTTTTG GTGGCTTCAA ACAATCTGGC 
TTTGGCAAAG ATTTGGGTCA AGAAGCTCTG AATGAGTATC TGAAGACTAA ATGTGTCACA 
GTGGAATACT AA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

The Retinol Binding Protein Receptor 2 (Rbpr2) is required for Photoreceptor Outer Segment Morphogenesis and Visual Function in Zebrafish.
Scientific reports7(1)16207(2017 Nov)
Shi Y,Obert E,Rahman B,Rohrer B,Lobo GP

A novel perivascular cell population in the zebrafish brain.
eLife6(2017 04)
Venero Galanternik M,Castranova D,Gore AV,Blewett NH,Jung HM,Stratman AN,Kirby MR,Iben J,Miller MF,Kawakami K,Maraia RJ,Weinstein BM

Evolution of complexity in the zebrafish synapse proteome.
Nature communications814613(2017 Mar)
Bay?s ?,Collins MO,Reig-Viader R,Gou G,Goulding D,Izquierdo A,Choudhary JS,Emes RD,Grant SG

Transcriptomic, proteomic, and metabolomic landscape of positional memory in the caudal fin of zebrafish.
Proceedings of the National Academy of Sciences of the United States of America114(5)E717-E726(2017 Jan)
Rabinowitz JS,Robitaille AM,Wang Y,Ray CA,Thummel R,Gu H,Djukovic D,Raftery D,Berndt JD,Moon RT

Structures of the hydrolase domain of zebrafish 10-formyltetrahydrofolate dehydrogenase and its complexes reveal a complete set of key residues for hydrolysis and product inhibition.
Acta crystallographica. Section D, Biological crystallography71(Pt 4)1006-21(2015 Apr)
Lin CC,Chuankhayan P,Chang WN,Kao TT,Guan HH,Fun HK,Nakagawa A,Fu TF,Chen CJ

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aldh1l1 cDNA ORF clone, Danio rerio(zebrafish)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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