rpe65b cDNA ORF clone, Danio rerio(zebrafish)

Gene
Clones
gRNAs

Summary

Gene Symbol	rpe65b
Entrez Gene ID	100002865
Full Name	retinal pigment epithelium-specific protein 65b
Synonyms	RPE56b,rpepb,si:ch211-198n5.5,wu:fc74c09,zgc:110538
General protein information	Preferred Names retinal pigment epithelium-specific protein 65b Names all-trans-retinyl ester 13-cis isomerohydrolase 13cIMH meso-zeaxanthin isomerase retinal pigment epithelium 65b retinal pigment epithelium-specific 65 kDa protein homolog B retinal pigment epithelium-specific protein b
Gene Type	protein-coding
Organism	Danio rerio(zebrafish)

mRNA and Protein(s)

mRNA	Protein	Name
XM_021478150.1	XP_021333825.1	all-trans-retinyl ester 13-cis isomerohydrolase isoform X1
NM_001089433.2	NP_001082902.2	all-trans-retinyl ester 13-cis isomerohydrolase

Pathways from BioSystems

Homologies

Mus musculus (house mouse)	Rpe65	NP_084263.2
	RPE65	XP_001095946.1
Danio rerio (zebrafish)	rpe65c	NP_001107125.1
Xenopus tropicalis (tropical clawed frog)	rpe65	NP_001120538.1
Pan troglodytes (chimpanzee)	RPE65	XP_001165086.1
Canis lupus familiaris (dog)	RPE65	NP_001003176.1
Gallus gallus (chicken)	RPE65	NP_990215.1
Homo sapiens (human)	RPE65	NP_000320.1
Bos taurus (cattle)	RPE65	NP_776878.1
Rattus norvegicus (Norway rat)	Rpe65	NP_446014.2
Danio rerio (zebrafish)	rpe65b	NP_001082902.2
Danio rerio (zebrafish)	rpe65a	NP_957045.1

Gene Ontology
Bibliography

Related articles in PubMed

Regulation of posterior body and epidermal morphogenesis in zebrafish by localized Yap1 and Wwtr1.
Kimelman D, Smith NL, Lai JKH, Stainier DY
eLife6(2017 Dec)

GUCA1A mutation causes maculopathy in a five-generation family with a wide spectrum of severity.
Chen X, Sheng X, Zhuang W, Sun X, Liu G, Shi X, Huang G, Mei Y, Li Y, Pan X, Liu Y, Li Z, Zhao Q, Yan B, Zhao C
Genetics in medicine : official journal of the American College of Medical Genetics19(8)945-954(2017 Aug)

Evolution of complexity in the zebrafish synapse proteome.
Bay?s ?, Collins MO, Reig-Viader R, Gou G, Goulding D, Izquierdo A, Choudhary JS, Emes RD, Grant SG
Nature communications814613(2017 Mar)

MicroRNA-184 promotes differentiation of the retinal pigment epithelium by targeting the AKT2/mTOR signaling pathway.
Jiang C, Qin B, Liu G, Sun X, Shi H, Ding S, Liu Y, Zhu M, Chen X, Zhao C
Oncotarget7(32)52340-52353(2016 Aug)

Identification of the key residues determining the product specificity of isomerohydrolase.
Takahashi Y, Moiseyev G, Nikolaeva O, Ma JX
Biochemistry51(20)4217-25(2012 May)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The following rpe65b gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the rpe65b cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ODa39024	NM_001089433.2 Latest version!	Danio rerio retinoid isomerohydrolase RPE65 b (rpe65b), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$342.30 $489.00
ODa143635	XM_021478150.1 Latest version!	Danio rerio retinal pigment epithelium-specific protein 65b (rpe65b), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$258.30 $369.00

ORF Online Only Promotion

Next-day Shipping ORF Clones ( in default vector with tag)
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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

rpe65b ( NM_001089433.2 ) cDNA ORF clone, Danio rerio(zebrafish) -> NP_001082902.2 Danio rerio retinoid isomerohydrolase RPE65 b (rpe65b), mRNA.

Price & Availability↑

CloneID	ODa39024
Clone ID Related Accession (Same CDS sequence)	NM_001089433.2
Accession Version	NM_001089433.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1599bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-06-08
Organism	Danio rerio(zebrafish)
Product	all-trans-retinyl ester 13-cis isomerohydrolase
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from CR759968.6. On or before Jun 4, 2009 this sequence version replaced NM_001029975.1, NM_001089433.1. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. ##Evidence-Data-START## Transcript exon combination :: AY646887.1, BC133985.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA2168446, SAMEA2168447 [ECO:0000350] ##Evidence-Data-END##

ATGGTCAGTC GTCTTGAACA CCCAGCCGGT GGATATAAGA AAGTCTTTGA GTCGTGTGAA 
GAGTTAGCGG AGCCCATTCC TGCTCATGTC TCAGGTAAAA TCCCAGCATG GCTGTCTGGA 
AGTCTGCTCC GCATGGGCCC TGGGCTTTTC GAGATTGGAG ATGAACCATT TAACCATCTT 
TTTGATGGCC AGGCTCTCAT TCACAAGTTT GACCTGAAGG ACGGACGTGT AACCTATCAT 
CGCAAGTTTA TCAGAACTGA TGCTTATGTG AGAGCCATGA CAGAGAAAAG GGTTGTGATT 
ACAGAACTCG GCACCGCTGC ATATCCAGAT CCATGCAAAA ACATCTTTTC CAGGTTTTTC 
ACTTACTTCC AAGGCACTGA GGTTACAGAC AACTGTTCTG TAAACATTTA CCCCATCGGT 
GAAGACTTCT ATGCCTGCAC TGAAACCAAC TTCATTACCA AAGTCAATCC TGATACCCTG 
GAAACAATAA AAAAGGTGGA CCTCTGCAAT TATCTGTCGG TTAATGGTTT AACAGCACAT 
CCACACATTG AAGCAGACGG TACTGTATAT AACATTGGAA ACTGCTTTGG GAAGAACATG 
TCCCTGGCCT ACAACATTGT CAAGATCCCG CCACTACAAG AAGAAAAATC TGATCCACTT 
GCGATGTCAA AGGTTTTGGT CCAGTTTCCA AGCAGTGAAA GGTTCAAACC ATCCTACGTT 
CACAGCTTTG GCATGACAGA GAACCATTTT GTGTTTGTTG AAACTCCGGT GAAGATCAAT 
CTGCTGAAAT TTCTCACTTC CTGGAGCATC AGAGGGTCAA ATTATATGGA CTGCTTTGAA 
TCTAATGACA GAATGGGAAC ATGGTTTCAT CTGGCAGCCA AAAATCCCGG CAAATACATC 
GACCACAAAT TCAGAACATC TGCCTTCAAT ATTTTTCACC ACATTAACTG TTTTGAAGAC 
CAAGGCTTTA TTGTTGTTGA CCTGTGCACA TGGAAAGGCC ATGAATTTGT GTACAATTAT 
CTATATTTGG CAAATCTGAG GCAAAACTGG GAGGAAGTCA AAAAAGCAGC CCTGAGAGCT 
CCACAGCCGG AGGTGCGCAG ATACGTGCTT CCACTGGACA TCCACAGGGA AGAGCAAGGG 
AAGAACTTGG TTTCTCTTCC ATACACCACA GCCACTGCTG TCATGTGCAG TGATGGAACT 
GTTTGGCTCG AACCCGAGGT TCTTTTCTCT GGACCACGTC AGGCTTTTGA GTTTCCTCAG 
ATAAACTACA GCAAATTCAA CGGGAAAGAT TACACCTTTG CCTATGGACT CGGACTGAAC 
CACTTTGTTC CAGACCGGAT TTGCAAGCTG AATGTGAAAA GTAAAGAAAC CTGGATCTGG 
CAGGAGCCGG ACGCCTATCC TTCTGAACCA CTGTTTGTAC AAAGCCCTGA TGCTGAAGAT 
GAAGACGATG GTGTTCTGTT GAGTATTGTA GTGAAACCTG GAGTTTCTCA GAGGCCGGCG 
TTTCTCCTCA TTCTCAAGGC CACTGACCTG ACAGAAATAG CACGTGCGGA GGTTGACGTC 
CTCATTCCTC TTACTCTCCA CGGCATCTAC AAACCTTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001082902.2
CDS	31..1629
Translation	MVSRLEHPAGGYKKVFESCEELAEPIPAHVSGKIPAWLSGSLLRMGPGLFEIGDEPFNHLFDGQALIHKFDLKDGRVTYHRKFIRTDAYVRAMTEKRVVITELGTAAYPDPCKNIFSRFFTYFQGTEVTDNCSVNIYPIGEDFYACTETNFITKVNPDTLETIKKVDLCNYLSVNGLTAHPHIEADGTVYNIGNCFGKNMSLAYNIVKIPPLQEEKSDPLAMSKVLVQFPSSERFKPSYVHSFGMTENHFVFVETPVKINLLKFLTSWSIRGSNYMDCFESNDRMGTWFHLAAKNPGKYIDHKFRTSAFNIFHHINCFEDQGFIVVDLCTWKGHEFVYNYLYLANLRQNWEEVKKAALRAPQPEVRRYVLPLDIHREEQGKNLVSLPYTTATAVMCSDGTVWLEPEVLFSGPRQAFEFPQINYSKFNGKDYTFAYGLGLNHFVPDRICKLNVKSKETWIWQEPDAYPSEPLFVQSPDAEDEDDGVLLSIVVKPGVSQRPAFLLILKATDLTEIARAEVDVLIPLTLHGIYKP

Target ORF information:

RefSeq Version	NM_001089433.2
Organism	Danio rerio(zebrafish)
Definition	Danio rerio retinoid isomerohydrolase RPE65 b (rpe65b), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001089433.2

ORF Insert Sequence:

ATGGTCAGTC GTCTTGAACA CCCAGCCGGT GGATATAAGA AAGTCTTTGA GTCGTGTGAA 
GAGTTAGCGG AGCCCATTCC TGCTCATGTC TCAGGTAAAA TCCCAGCATG GCTGTCTGGA 
AGTCTGCTCC GCATGGGCCC TGGGCTTTTC GAGATTGGAG ATGAACCATT TAACCATCTT 
TTTGATGGCC AGGCTCTCAT TCACAAGTTT GACCTGAAGG ACGGACGTGT AACCTATCAT 
CGCAAGTTTA TCAGAACTGA TGCTTATGTG AGAGCCATGA CAGAGAAAAG GGTTGTGATT 
ACAGAACTCG GCACCGCTGC ATATCCAGAT CCATGCAAAA ACATCTTTTC CAGGTTTTTC 
ACTTACTTCC AAGGCACTGA GGTTACAGAC AACTGTTCTG TAAACATTTA CCCCATCGGT 
GAAGACTTCT ATGCCTGCAC TGAAACCAAC TTCATTACCA AAGTCAATCC TGATACCCTG 
GAAACAATAA AAAAGGTGGA CCTCTGCAAT TATCTGTCGG TTAATGGTTT AACAGCACAT 
CCACACATTG AAGCAGACGG TACTGTATAT AACATTGGAA ACTGCTTTGG GAAGAACATG 
TCCCTGGCCT ACAACATTGT CAAGATCCCG CCACTACAAG AAGAAAAATC TGATCCACTT 
GCGATGTCAA AGGTTTTGGT CCAGTTTCCA AGCAGTGAAA GGTTCAAACC ATCCTACGTT 
CACAGCTTTG GCATGACAGA GAACCATTTT GTGTTTGTTG AAACTCCGGT GAAGATCAAT 
CTGCTGAAAT TTCTCACTTC CTGGAGCATC AGAGGGTCAA ATTATATGGA CTGCTTTGAA 
TCTAATGACA GAATGGGAAC ATGGTTTCAT CTGGCAGCCA AAAATCCCGG CAAATACATC 
GACCACAAAT TCAGAACATC TGCCTTCAAT ATTTTTCACC ACATTAACTG TTTTGAAGAC 
CAAGGCTTTA TTGTTGTTGA CCTGTGCACA TGGAAAGGCC ATGAATTTGT GTACAATTAT 
CTATATTTGG CAAATCTGAG GCAAAACTGG GAGGAAGTCA AAAAAGCAGC CCTGAGAGCT 
CCACAGCCGG AGGTGCGCAG ATACGTGCTT CCACTGGACA TCCACAGGGA AGAGCAAGGG 
AAGAACTTGG TTTCTCTTCC ATACACCACA GCCACTGCTG TCATGTGCAG TGATGGAACT 
GTTTGGCTCG AACCCGAGGT TCTTTTCTCT GGACCACGTC AGGCTTTTGA GTTTCCTCAG 
ATAAACTACA GCAAATTCAA CGGGAAAGAT TACACCTTTG CCTATGGACT CGGACTGAAC 
CACTTTGTTC CAGACCGGAT TTGCAAGCTG AATGTGAAAA GTAAAGAAAC CTGGATCTGG 
CAGGAGCCGG ACGCCTATCC TTCTGAACCA CTGTTTGTAC AAAGCCCTGA TGCTGAAGAT 
GAAGACGATG GTGTTCTGTT GAGTATTGTA GTGAAACCTG GAGTTTCTCA GAGGCCGGCG 
TTTCTCCTCA TTCTCAAGGC CACTGACCTG ACAGAAATAG CACGTGCGGA GGTTGACGTC 
CTCATTCCTC TTACTCTCCA CGGCATCTAC AAACCTTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

rpe65b ( XM_021478150.1 ) cDNA ORF clone, Danio rerio(zebrafish) -> XP_021333825.1 Danio rerio retinal pigment epithelium-specific protein 65b (rpe65b), transcript variant X1, mRNA.

Price & Availability↑

CloneID	ODa143635
Clone ID Related Accession (Same CDS sequence)	XM_021478150.1
Accession Version	XM_021478150.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1002bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-06-14
Organism	Danio rerio(zebrafish)
Product	all-trans-retinyl ester 13-cis isomerohydrolase isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_007119.7) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Danio rerio Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.4 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGTCCCTGG CCTACAACAT TGTCAAGATC CCGCCACTAC AAGAAGAAAA ATCTGATCCA 
CTTGCGATGT CAAAGGTTTT GGTCCAGTTT CCAAGCAGTG AAAGGTTCAA ACCATCCTAC 
GTTCACAGCT TTGGCATGAC AGAGAACCAT TTTGTGTTTG TTGAAACTCC GGTGAAGATC 
AATCTGCTGA AATTTCTCAC TTCCTGGAGC ATCAGAGGGT CAAATTATAT GGACTGCTTT 
GAATCTAATG ACAGAATGGG AACATGGTTT CATCTGGCAG CCAAAAATCC CGGCAAATAC 
ATCGACCACA AATTCAGAAC ATCTGCCTTC AATATTTTTC ACCACATTAA CTGTTTTGAA 
GACCAAGGCT TTATTGTTGT TGACCTGTGC ACATGGAAAG GCCATGAATT TGTGTACAAT 
TATCTATATT TGGCAAATCT GAGGCAAAAC TGGGAGGAAG TCAAAAAAGC AGCCCTGAGA 
GCTCCACAGC CGGAGGTGCG CAGATACGTG CTTCCACTGG ACATCCACAG GGAAGAGCAA 
GGGAAGAACT TGGTTTCTCT TCCATACACC ACAGCCACTG CTGTCATGTG CAGTGATGGA 
ACTGTTTGGC TCGAACCCGA GGTTCTTTTC TCTGGACCAC GTCAGGCTTT TGAGTTTCCT 
CAGATAAACT ACAGCAAATT CAACGGGAAA GATTACACCT TTGCCTATGG ACTCGGACTG 
AACCACTTTG TTCCAGACCG GATTTGCAAG CTGAATGTGA AAAGTAAAGA AACCTGGATC 
TGGCAGGAGC CGGACGCCTA TCCTTCTGAA CCACTGTTTG TACAAAGCCC TGATGCTGAA 
GATGAAGACG ATGGTGTTCT GTTGAGTATT GTAGTGAAAC CTGGAGTTTC TCAGAGGCCG 
GCGTTTCTCC TCATTCTCAA GGCCACTGAC CTGACAGAAA TAGCACGTGC GGAGGTTGAC 
GTCCTCATTC CTCTTACTCT CCACGGCATC TACAAACCTT AG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_021333825.1
CDS	333..1334
Translation	MSLAYNIVKIPPLQEEKSDPLAMSKVLVQFPSSERFKPSYVHSFGMTENHFVFVETPVKINLLKFLTSWSIRGSNYMDCFESNDRMGTWFHLAAKNPGKYIDHKFRTSAFNIFHHINCFEDQGFIVVDLCTWKGHEFVYNYLYLANLRQNWEEVKKAALRAPQPEVRRYVLPLDIHREEQGKNLVSLPYTTATAVMCSDGTVWLEPEVLFSGPRQAFEFPQINYSKFNGKDYTFAYGLGLNHFVPDRICKLNVKSKETWIWQEPDAYPSEPLFVQSPDAEDEDDGVLLSIVVKPGVSQRPAFLLILKATDLTEIARAEVDVLIPLTLHGIYKP

Target ORF information:

RefSeq Version	XM_021478150.1
Organism	Danio rerio(zebrafish)
Definition	Danio rerio retinal pigment epithelium-specific protein 65b (rpe65b), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_021478150.1

ORF Insert Sequence:

ATGTCCCTGG CCTACAACAT TGTCAAGATC CCGCCACTAC AAGAAGAAAA ATCTGATCCA 
CTTGCGATGT CAAAGGTTTT GGTCCAGTTT CCAAGCAGTG AAAGGTTCAA ACCATCCTAC 
GTTCACAGCT TTGGCATGAC AGAGAACCAT TTTGTGTTTG TTGAAACTCC GGTGAAGATC 
AATCTGCTGA AATTTCTCAC TTCCTGGAGC ATCAGAGGGT CAAATTATAT GGACTGCTTT 
GAATCTAATG ACAGAATGGG AACATGGTTT CATCTGGCAG CCAAAAATCC CGGCAAATAC 
ATCGACCACA AATTCAGAAC ATCTGCCTTC AATATTTTTC ACCACATTAA CTGTTTTGAA 
GACCAAGGCT TTATTGTTGT TGACCTGTGC ACATGGAAAG GCCATGAATT TGTGTACAAT 
TATCTATATT TGGCAAATCT GAGGCAAAAC TGGGAGGAAG TCAAAAAAGC AGCCCTGAGA 
GCTCCACAGC CGGAGGTGCG CAGATACGTG CTTCCACTGG ACATCCACAG GGAAGAGCAA 
GGGAAGAACT TGGTTTCTCT TCCATACACC ACAGCCACTG CTGTCATGTG CAGTGATGGA 
ACTGTTTGGC TCGAACCCGA GGTTCTTTTC TCTGGACCAC GTCAGGCTTT TGAGTTTCCT 
CAGATAAACT ACAGCAAATT CAACGGGAAA GATTACACCT TTGCCTATGG ACTCGGACTG 
AACCACTTTG TTCCAGACCG GATTTGCAAG CTGAATGTGA AAAGTAAAGA AACCTGGATC 
TGGCAGGAGC CGGACGCCTA TCCTTCTGAA CCACTGTTTG TACAAAGCCC TGATGCTGAA 
GATGAAGACG ATGGTGTTCT GTTGAGTATT GTAGTGAAAC CTGGAGTTTC TCAGAGGCCG 
GCGTTTCTCC TCATTCTCAA GGCCACTGAC CTGACAGAAA TAGCACGTGC GGAGGTTGAC 
GTCCTCATTC CTCTTACTCT CCACGGCATC TACAAACCTT AG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Regulation of posterior body and epidermal morphogenesis in zebrafish by localized Yap1 and Wwtr1.
eLife6(2017 Dec)
Kimelman D,Smith NL,Lai JKH,Stainier DY

GUCA1A mutation causes maculopathy in a five-generation family with a wide spectrum of severity.
Genetics in medicine : official journal of the American College of Medical Genetics19(8)945-954(2017 Aug)
Chen X,Sheng X,Zhuang W,Sun X,Liu G,Shi X,Huang G,Mei Y,Li Y,Pan X,Liu Y,Li Z,Zhao Q,Yan B,Zhao C

Evolution of complexity in the zebrafish synapse proteome.
Nature communications814613(2017 Mar)
Bay?s ?,Collins MO,Reig-Viader R,Gou G,Goulding D,Izquierdo A,Choudhary JS,Emes RD,Grant SG

MicroRNA-184 promotes differentiation of the retinal pigment epithelium by targeting the AKT2/mTOR signaling pathway.
Oncotarget7(32)52340-52353(2016 Aug)
Jiang C,Qin B,Liu G,Sun X,Shi H,Ding S,Liu Y,Zhu M,Chen X,Zhao C

Identification of the key residues determining the product specificity of isomerohydrolase.
Biochemistry51(20)4217-25(2012 May)
Takahashi Y,Moiseyev G,Nikolaeva O,Ma JX