DNM1 cDNA ORF clone, Canis lupus familiaris(dog)

Gene
Clones
gRNAs

Summary

Gene Symbol	DNM1
Entrez Gene ID	491319
Full Name	dynamin 1
Gene Type	protein-coding
Organism	Canis lupus familiaris(dog)

mRNA and Protein(s)

mRNA	Protein	Name
NM_001131049.1	NP_001124521.1	dynamin-1

Pathways from BioSystems

Homologies

Mus musculus (house mouse)	Dnm1	NP_034195.2
Caenorhabditis elegans (roundworm)	dyn-1	NP_001024332.1
Pan troglodytes (chimpanzee)	DNM1	XP_520289.3
	DNM1	XP_002808141.1
Bos taurus (cattle)	DNM1	NP_001070288.1
Rattus norvegicus (Norway rat)	Dnm1	NP_542420.1
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP003018	XP_003436355.1
Canis lupus familiaris (dog)	DNM1	NP_001124521.1
Gallus gallus (chicken)	DNM1	XP_001233250.1
Homo sapiens (human)	DNM1	NP_001275668.1
Drosophila melanogaster (fruit fly)	shi	NP_001162767.1
Danio rerio (zebrafish)	dnm1b	NP_001243747.1

Gene Ontology
Bibliography

Related articles in PubMed

Relationship between dynamin 1 mutation status and characteristics of recurrent episodes of exercise-induced collapse in Labrador Retrievers.
Furrow E, Minor KM, Taylor SM, Mickelson JR, Patterson EE
Journal of the American Veterinary Medical Association242(6)786-91(2013 Mar)

Presence and impact of the exercise-induced collapse associated DNM1 mutation in Labrador retrievers and other breeds.
Minor KM, Patterson EE, Keating MK, Gross SD, Ekenstedt KJ, Taylor SM, Mickelson JR
Veterinary journal (London, England : 1997)189(2)214-9(2011 Aug)

A canine DNM1 mutation is highly associated with the syndrome of exercise-induced collapse.
Patterson EE, Minor KM, Tchernatynskaia AV, Taylor SM, Shelton GD, Ekenstedt KJ, Mickelson JR
Nature genetics40(10)1235-9(2008 Oct)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Characteristics of exercised-induced collapse in Labrador Retrievers with various DNM1 genotypes were identified in this study; findings may help distinguish homozygous dogs from those with other types of collapse conditions.
Title: Relationship between dynamin 1 mutation status and characteristics of recurrent episodes of exercise-induced collapse in Labrador Retrievers.

The frequency of DNM1 mutant allele carriers in Labrador retrievers ranged from 17.9%-38.0% and the frequency of homozygous mutant (EE genotype) individuals ranged from 1.8%-13.6%; 83.6% of EE Labradors were reported to have collapsed by age 4 years.
Title: Presence and impact of the exercise-induced collapse associated DNM1 mutation in Labrador retrievers and other breeds.

DNM1 mutation is highly associated with the syndrome of exercise-induced collapse.
Title: A canine DNM1 mutation is highly associated with the syndrome of exercise-induced collapse.

The following DNM1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the DNM1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OCe33983	NM_001131049.1 Latest version!	Canis lupus familiaris dynamin 1 (DNM1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	TBD	Quote Price

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

DNM1 ( NM_001131049.1 ) cDNA ORF clone, Canis lupus familiaris(dog) -> NP_001124521.1 Canis lupus familiaris dynamin 1 (DNM1), mRNA.

Price & Availability↑

CloneID	OCe33983
Clone ID Related Accession (Same CDS sequence)	NM_001131049.1
Accession Version	NM_001131049.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2595bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2018-02-24
Organism	Canis lupus familiaris(dog)
Product	dynamin-1
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from EU682271.1. On or before Aug 19, 2008 this sequence version replaced XM_857171.1, XM_845685.1. ##Evidence-Data-START## RNAseq introns :: mixed/partial sample support SAMEA103936001, SAMEA103936002 [ECO:0000350] ##Evidence-Data-END##

ATGGGCAACC GCGGCATGGA GGATCTCATC CCGCTAGTCA ACCGGCTGCA GGACGCCTTC 
TCCGCTATCG GCCAGAACGC GGACCTCGAC CTACCGCAGA TCGCGGTGGT GGGCGGCCAG 
AGCGCCGGCA AGAGCTCGGT GCTCGAGAAT TTCGTAGGCA GGGACTTCCT GCCCCGAGGG 
TCAGGCATTG TCACCCGACG GCCCCTGGTC CTGCAGCTGG TCAATGCCAC CACAGAATAT 
GCCGAATTCC TGCACTGCAA GGGGAAGAAA TTCACTGACT TCGAGGAGGT ACGCCTGGAG 
ATCGAGGCTG AGACCGACCG GGTCACTGGC ACCAACAAGG GCATCTCGCC GGTGCCCATC 
AACCTCCGCG TCTACTCGCC TCAGGTCCTG AATCTGACAC TGGTGGACCT ACCCGGAATG 
ACCAAGGTCC CAGTGGGGGA CCAACCTCCT GACATCGAGT TCCAGATCCG GGACATGCTT 
ATGCAGTTCG TCACCAAAGA GAACTGCCTC ATCCTGGCTG TGTCCCCCGC CAACTCCGAC 
CTGGCCAACT CTGATGCTCT CAAGGTTGCC AAGGAGGTGG ACCCCCAGGG TCAGCGCACC 
ATYGGGGTCA TCACCAAGCT AGATCTGATG GAYGAGGGCA CAGATGCCCG AGATGTGCTA 
GAGAATAAGC TCCTTCCCCT GCGCAGAGGC TACATAGGGG TGGTAAACCG AAGCCAGAAG 
GACATTGATG GCAAGAAGGA CATCTCAGCT GCCTTGGCYG CTGAACKCAA GTTCTTTCTC 
TCCCACCCAT CCTACCGCCA CTTGGCGGAC CGCATGGGCA CACCCTACCT ACAGAAGGTC 
CTCAACCAGC AACTGACCAA CCACATCCGG GACACACTGC CGGGGCTCCG GAACAGGCTG 
CAGAGCCAGC TACTGTCCAT TGAGAAGGAG GTGGAGGAGT ACAAGAACTT CCGACCTGAT 
GACCCAGCAC GCAAGACCAA GGCCCTGCTG CAGATGGTCC AGCAGTTTGC TGTGGACTTT 
GAGAAGCGCA TTGAGGGCTC CGGGGACCAG ATTGACACCT ATGAACTGTC AGGGGGAGCC 
CGCATCAACC GGATCTTCCA TGAGCGCTTC CCCTTTGAGC TAGTCAAGAT GGAGTTTGAT 
GAGAAGGAGC TCCGGAGAGA GATCAGCTAC GCCATCAAGA ACATCCATGG CATTAGAACG 
GGGCTCTTTA CCCCAGACAT GGCTTTTGAG ACCATTGTGA AAAAGCAGGT GAAGAAGATC 
CGAGAACCGT GTCTCAAGTG TGTGGACATG GTTATCTCGG AACTAATCAG CACGGTTAGA 
CAGTGCACCA AGAAGCTGCA GCAGTACCCC CGGCTGCGGG AGGAGATGGA GCGCATCGTG 
ACCACCCACA TCCGGGAGCG TGAGGGTCGC ACCAAGGAGC AGGTTATGCT CCTCATCGAT 
ATTGAGCTGG CGTACATGAA TACCAATCAT GAGGACTTCA TAGGCTTTGC CAATGCTCAG 
CAGAGGAGCA ACCAGATGAA CAAGAAGAAG GCTTCAGGGA ACCAGGATGA GATTCTGGTC 
ATCCGGAAGG GCTGGCTGAC CATCAACAAT ATTGGCATCA TGAAGGGGGG CTCCAAGGAG 
TACTGGTTTG TCCTGACCGC TGAGAATCTG TCCTGGTACA AGGATGACGA GGAGAAAGAG 
AAGAAATACA TGCTCTCCGT GGACAATCTG AAGCTACGGG ACGTGGAGAA AGGTTTCATG 
TCAAGCAAGC ACATCTTTGC CCTCTTTAAC ACTGAGCAGA GGAATGTCTA CAAGGATTAT 
CGGCAGCTGG AACTGGCCTG TGAGACRCAA GAGGAGGTGG ATAGCTGGAA GGCCTCTTTC 
CTGCGGGCTG GCGTATATCC TGAACGCGTT GGGGACAAGG AGAAAGCCAG CGAAACAGAG 
GAGAATGGCT CAGACAGCTT CATGCACTCC ATGGACCCAC AGCTAGAGCG GCAGGTGGAG 
ACCATCCGGA ACCTGGTAGA CTCATACATG GCCATCGTGA ACAAGACCGT GCGTGACCTC 
ATGCCGAAGA CCATCATGCA CCTCATGATC AACAATACGA AGGAATTCAT CTTCTCGGAG 
CTGCTCGCCA ACCTGTACTC GTGCGGGGAC CAGAACACAC TGATGGAGGA GTCGGCGGAG 
CAGGCGCAAC GGCGCGACGA GATGCTGCGC ATGTACCACG CACTGAAGGA GGCGCTCAGC 
ATCATCGGCG ATATCAACAC GACCACCGTC AGCACGCCCA TGCCCCCGCC CGTGGACGAC 
TCCTGGCTGC AGGTGCAGAG CGTACCGGCC GGACGCAGGT CACCCACGTC CAGCCCCACG 
CCGCAGCGCC GAGCCCCCGC CGTGCCCCCA GCCCGGCCCG GGTCGCGGGG CCCTGCTCCT 
GGGCCTCCGC CTGCTGGGTC CGCCCTGGGG GGGGCGCCCC CCGTGCCCTC CAGGCCGGGG 
GCTTCCCCTG ACCCCTTCGG TCCTCCCCCC CAGGTGCCCT CGCGCCCCAA CCGCGCCCCG 
CCCGGGGTCC CCAGCCGATC GGGTCAGGCA AGTCCGTCCC GTCCTGAGAG CCCCAGGCCC 
CCCTTCGACC TCTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001124521.1
CDS	117..2711
Translation	MGNRGMEDLIPLVNRLQDAFSAIGQNADLDLPQIAVVGGQSAGKSSVLENFVGRDFLPRGSGIVTRRPLVLQLVNATTEYAEFLHCKGKKFTDFEEVRLEIEAETDRVTGTNKGISPVPINLRVYSPQVLNLTLVDLPGMTKVPVGDQPPDIEFQIRDMLMQFVTKENCLILAVSPANSDLANSDALKVAKEVDPQGQRTnullGVITKLDLMnullEGTDARDVLENKLLPLRRGYIGVVNRSQKDIDGKKDISAALnullAEnullKFFLSHPSYRHLADRMGTPYLQKVLNQQLTNHIRDTLPGLRNRLQSQLLSIEKEVEEYKNFRPDDPARKTKALLQMVQQFAVDFEKRIEGSGDQIDTYELSGGARINRIFHERFPFELVKMEFDEKELRREISYAIKNIHGIRTGLFTPDMAFETIVKKQVKKIREPCLKCVDMVISELISTVRQCTKKLQQYPRLREEMERIVTTHIREREGRTKEQVMLLIDIELAYMNTNHEDFIGFANAQQRSNQMNKKKASGNQDEILVIRKGWLTINNIGIMKGGSKEYWFVLTAENLSWYKDDEEKEKKYMLSVDNLKLRDVEKGFMSSKHIFALFNTEQRNVYKDYRQLELACEnullQEEVDSWKASFLRAGVYPERVGDKEKASETEENGSDSFMHSMDPQLERQVETIRNLVDSYMAIVNKTVRDLMPKTIMHLMINNTKEFIFSELLANLYSCGDQNTLMEESAEQAQRRDEMLRMYHALKEALSIIGDINTTTVSTPMPPPVDDSWLQVQSVPAGRRSPTSSPTPQRRAPAVPPARPGSRGPAPGPPPAGSALGGAPPVPSRPGASPDPFGPPPQVPSRPNRAPPGVPSRSGQASPSRPESPRPPFDL

Target ORF information:

RefSeq Version	NM_001131049.1
Organism	Canis lupus familiaris(dog)
Definition	Canis lupus familiaris dynamin 1 (DNM1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001131049.1

ORF Insert Sequence:

ATGGGCAACC GCGGCATGGA GGATCTCATC CCGCTAGTCA ACCGGCTGCA GGACGCCTTC 
TCCGCTATCG GCCAGAACGC GGACCTCGAC CTACCGCAGA TCGCGGTGGT GGGCGGCCAG 
AGCGCCGGCA AGAGCTCGGT GCTCGAGAAT TTCGTAGGCA GGGACTTCCT GCCCCGAGGG 
TCAGGCATTG TCACCCGACG GCCCCTGGTC CTGCAGCTGG TCAATGCCAC CACAGAATAT 
GCCGAATTCC TGCACTGCAA GGGGAAGAAA TTCACTGACT TCGAGGAGGT ACGCCTGGAG 
ATCGAGGCTG AGACCGACCG GGTCACTGGC ACCAACAAGG GCATCTCGCC GGTGCCCATC 
AACCTCCGCG TCTACTCGCC TCAGGTCCTG AATCTGACAC TGGTGGACCT ACCCGGAATG 
ACCAAGGTCC CAGTGGGGGA CCAACCTCCT GACATCGAGT TCCAGATCCG GGACATGCTT 
ATGCAGTTCG TCACCAAAGA GAACTGCCTC ATCCTGGCTG TGTCCCCCGC CAACTCCGAC 
CTGGCCAACT CTGATGCTCT CAAGGTTGCC AAGGAGGTGG ACCCCCAGGG TCAGCGCACC 
ATYGGGGTCA TCACCAAGCT AGATCTGATG GAYGAGGGCA CAGATGCCCG AGATGTGCTA 
GAGAATAAGC TCCTTCCCCT GCGCAGAGGC TACATAGGGG TGGTAAACCG AAGCCAGAAG 
GACATTGATG GCAAGAAGGA CATCTCAGCT GCCTTGGCYG CTGAACKCAA GTTCTTTCTC 
TCCCACCCAT CCTACCGCCA CTTGGCGGAC CGCATGGGCA CACCCTACCT ACAGAAGGTC 
CTCAACCAGC AACTGACCAA CCACATCCGG GACACACTGC CGGGGCTCCG GAACAGGCTG 
CAGAGCCAGC TACTGTCCAT TGAGAAGGAG GTGGAGGAGT ACAAGAACTT CCGACCTGAT 
GACCCAGCAC GCAAGACCAA GGCCCTGCTG CAGATGGTCC AGCAGTTTGC TGTGGACTTT 
GAGAAGCGCA TTGAGGGCTC CGGGGACCAG ATTGACACCT ATGAACTGTC AGGGGGAGCC 
CGCATCAACC GGATCTTCCA TGAGCGCTTC CCCTTTGAGC TAGTCAAGAT GGAGTTTGAT 
GAGAAGGAGC TCCGGAGAGA GATCAGCTAC GCCATCAAGA ACATCCATGG CATTAGAACG 
GGGCTCTTTA CCCCAGACAT GGCTTTTGAG ACCATTGTGA AAAAGCAGGT GAAGAAGATC 
CGAGAACCGT GTCTCAAGTG TGTGGACATG GTTATCTCGG AACTAATCAG CACGGTTAGA 
CAGTGCACCA AGAAGCTGCA GCAGTACCCC CGGCTGCGGG AGGAGATGGA GCGCATCGTG 
ACCACCCACA TCCGGGAGCG TGAGGGTCGC ACCAAGGAGC AGGTTATGCT CCTCATCGAT 
ATTGAGCTGG CGTACATGAA TACCAATCAT GAGGACTTCA TAGGCTTTGC CAATGCTCAG 
CAGAGGAGCA ACCAGATGAA CAAGAAGAAG GCTTCAGGGA ACCAGGATGA GATTCTGGTC 
ATCCGGAAGG GCTGGCTGAC CATCAACAAT ATTGGCATCA TGAAGGGGGG CTCCAAGGAG 
TACTGGTTTG TCCTGACCGC TGAGAATCTG TCCTGGTACA AGGATGACGA GGAGAAAGAG 
AAGAAATACA TGCTCTCCGT GGACAATCTG AAGCTACGGG ACGTGGAGAA AGGTTTCATG 
TCAAGCAAGC ACATCTTTGC CCTCTTTAAC ACTGAGCAGA GGAATGTCTA CAAGGATTAT 
CGGCAGCTGG AACTGGCCTG TGAGACRCAA GAGGAGGTGG ATAGCTGGAA GGCCTCTTTC 
CTGCGGGCTG GCGTATATCC TGAACGCGTT GGGGACAAGG AGAAAGCCAG CGAAACAGAG 
GAGAATGGCT CAGACAGCTT CATGCACTCC ATGGACCCAC AGCTAGAGCG GCAGGTGGAG 
ACCATCCGGA ACCTGGTAGA CTCATACATG GCCATCGTGA ACAAGACCGT GCGTGACCTC 
ATGCCGAAGA CCATCATGCA CCTCATGATC AACAATACGA AGGAATTCAT CTTCTCGGAG 
CTGCTCGCCA ACCTGTACTC GTGCGGGGAC CAGAACACAC TGATGGAGGA GTCGGCGGAG 
CAGGCGCAAC GGCGCGACGA GATGCTGCGC ATGTACCACG CACTGAAGGA GGCGCTCAGC 
ATCATCGGCG ATATCAACAC GACCACCGTC AGCACGCCCA TGCCCCCGCC CGTGGACGAC 
TCCTGGCTGC AGGTGCAGAG CGTACCGGCC GGACGCAGGT CACCCACGTC CAGCCCCACG 
CCGCAGCGCC GAGCCCCCGC CGTGCCCCCA GCCCGGCCCG GGTCGCGGGG CCCTGCTCCT 
GGGCCTCCGC CTGCTGGGTC CGCCCTGGGG GGGGCGCCCC CCGTGCCCTC CAGGCCGGGG 
GCTTCCCCTG ACCCCTTCGG TCCTCCCCCC CAGGTGCCCT CGCGCCCCAA CCGCGCCCCG 
CCCGGGGTCC CCAGCCGATC GGGTCAGGCA AGTCCGTCCC GTCCTGAGAG CCCCAGGCCC 
CCCTTCGACC TCTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Relationship between dynamin 1 mutation status and characteristics of recurrent episodes of exercise-induced collapse in Labrador Retrievers.
Journal of the American Veterinary Medical Association242(6)786-91(2013 Mar)
Furrow E,Minor KM,Taylor SM,Mickelson JR,Patterson EE

Presence and impact of the exercise-induced collapse associated DNM1 mutation in Labrador retrievers and other breeds.
Veterinary journal (London, England : 1997)189(2)214-9(2011 Aug)
Minor KM,Patterson EE,Keating MK,Gross SD,Ekenstedt KJ,Taylor SM,Mickelson JR

A canine DNM1 mutation is highly associated with the syndrome of exercise-induced collapse.
Nature genetics40(10)1235-9(2008 Oct)
Patterson EE,Minor KM,Tchernatynskaia AV,Taylor SM,Shelton GD,Ekenstedt KJ,Mickelson JR

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DNM1 cDNA ORF clone, Canis lupus familiaris(dog)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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