Gene Symbol | MC1R |
Entrez Gene ID | 489652 |
Full Name | melanocortin 1 receptor |
Synonyms | MC1-R,MSH-R |
Gene Type | protein-coding |
Organism | Canis lupus familiaris(dog) |
ORF » Species Summary » Canis lupus familiaris » MC1R cDNA ORF clone
Gene Symbol | MC1R |
Entrez Gene ID | 489652 |
Full Name | melanocortin 1 receptor |
Synonyms | MC1-R,MSH-R |
Gene Type | protein-coding |
Organism | Canis lupus familiaris(dog) |
mRNA | Protein | Name |
---|---|---|
NM_001014282.2 | NP_001014304.2 | melanocyte-stimulating hormone receptor |
Homo sapiens (human) | MC1R | NP_002377.4 |
Bos taurus (cattle) | MC1R | NP_776533.1 |
Pan troglodytes (chimpanzee) | MC1R | NP_001009152.1 |
Mus musculus (house mouse) | Mc1r | NP_032585.2 |
Canis lupus familiaris (dog) | MC1R | NP_001014304.1 |
Rattus norvegicus (Norway rat) | Mc1r | XP_006255857.1 |
Xenopus tropicalis (tropical clawed frog) | mc1r | XP_002937630.2 |
Gallus gallus (chicken) | MC1R | NP_001026633.1 |
Danio rerio (zebrafish) | mc1r | NP_851301.1 |
Relationship between the melanocortin-1 receptor (MC1R) variant R306ter and physiological responses to mechanical or thermal stimuli in Labrador Retriever dogs.
Perez TE, Mealey KL, Burke NS, Grubb TL, Court MH, Greene SA
Veterinary anaesthesia and analgesia44(2)370-374(2017 Mar)
Characterization of different 5'-untranslated exons of the ASIP gene in black-and-tan Doberman Pinscher and brindle Boxer dogs.
Ciampolini R, Cecchi F, Spaterna A, Bramante A, Bardet SM, Oulmouden A
Animal genetics44(1)114-7(2013 Feb)
Signature of balancing selection at the MC1R gene in Kunming dog populations.
Wang GD, Cheng LG, Fan RX, Irwin DM, Tang SS, Peng JG, Zhang YP
PloS one8(2)e55469(2013)
Mutations in the melanocortin 1 receptor, ?-defensin103 and agouti signaling protein genes, and their association with coat color phenotypes in Akita-inu dogs.
Oguro-Okano M, Honda M, Yamazaki K, Okano K
The Journal of veterinary medical science73(7)853-8(2011 Jul)
GeneRIFs: Gene References Into Functions What's a GeneRIF?
The results of this study suggest that differential expression of ASIP determine pigment-type switching in a MC1R and K allele-dependent manner in dogs.
Title: Characterization of different 5'-untranslated exons of the ASIP gene in black-and-tan Doberman Pinscher and brindle Boxer dogs.
high heterozygosity and allelic differences at the MC1R locus may explain both the mixed color coat, of yellow and black, and the difference in coat colors in both Kunming dog populations
Title: Signature of balancing selection at the MC1R gene in Kunming dog populations.
2 key mutations in the MC1R gene and the CBD103 gene are associated with the phenotypic discriminations among brindle, red/sesame, and white coats.
Title: Mutations in the melanocortin 1 receptor, ?-defensin103 and agouti signaling protein genes, and their association with coat color phenotypes in Akita-inu dogs.
This new allele is dominant to the E and e (p.Arg306ter) alleles at MC1R but recessive to the E(M) (p.Met264Val) allele.
Title: A new mutation in MC1R explains a coat color phenotype in 2 "old" breeds: Saluki and Afghan hound.
Comparative linkage analysis of chromosome showed that "ZFP276-MC1R-GAS8" linkage group was conservative in human, chimpanzee, chicken and dog.
Title: [Analysis on molecular evolution of MC1R gene in dog].
The following MC1R gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the MC1R cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
CloneID | OCe45903 | |
Clone ID Related Accession (Same CDS sequence) | NM_001014282.2 | |
Accession Version | NM_001014282.2 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 954bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-12-22 | |
Organism | Canis lupus familiaris(dog) | |
Product | melanocyte-stimulating hormone receptor | |
Comment | Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AAEX03003947.1. On Sep 1, 2015 this sequence version replaced NM_001014282.1. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. ##RefSeq-Attributes-START## inferred exon combination :: based on alignments, homology ##RefSeq-Attributes-END## |
1 | ATGTCTGGGC AGGGCCCCCA GAGAAGGCTG CTGGGCTCTC TCAATGGCAC CTCCCCAGCC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_001014304.2 |
CDS | 1..954 |
Translation |
Target ORF information:
Target ORF information:
|
NM_001014282.2 |
1 | ATGTCTGGGC AGGGCCCCCA GAGAAGGCTG CTGGGCTCTC TCAATGGCAC CTCCCCAGCC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
Relationship between the melanocortin-1 receptor (MC1R) variant R306ter and physiological responses to mechanical or thermal stimuli in Labrador Retriever dogs. |
Characterization of different 5'-untranslated exons of the ASIP gene in black-and-tan Doberman Pinscher and brindle Boxer dogs. |
Signature of balancing selection at the MC1R gene in Kunming dog populations. |
Mutations in the melanocortin 1 receptor, ?-defensin103 and agouti signaling protein genes, and their association with coat color phenotypes in Akita-inu dogs. |