PDCD1 cDNA ORF clone, Canis lupus familiaris(dog)

Gene
Clones
gRNAs

Summary

Gene Symbol	PDCD1
Entrez Gene ID	486213
Full Name	programmed cell death 1
Synonyms	PD-1
General protein information	Preferred Names programmed cell death 1 Names programmed cell death protein 1 programmed death 1
Gene Type	protein-coding
Organism	Canis lupus familiaris(dog)

mRNA and Protein(s)

mRNA	Protein	Name
NM_001314097.1	NP_001301026.1	programmed cell death protein 1 precursor
XM_022409577.1	XP_022265285.1	programmed cell death protein 1 isoform X1

Pathways from BioSystems

Homologies

Pan troglodytes (chimpanzee)	PDCD1	XP_003950066.1
Mus musculus (house mouse)	Pdcd1	NP_032824.1
	PDCD1	NP_001107830.1
Homo sapiens (human)	PDCD1	NP_005009.2
Bos taurus (cattle)	PDCD1	NP_001076975.1
Rattus norvegicus (Norway rat)	LOC102550808	XP_006245633.1
Canis lupus familiaris (dog)	PDCD1	XP_543338.3
Rattus norvegicus (Norway rat)	Pdcd1	NP_001100397.1
Gallus gallus (chicken)	PDCD1	XP_422723.3

Gene Ontology
Bibliography

Related articles in PubMed

PD-1 function in apoptosis of T lymphocytes in canine visceral leishmaniasis.
Chiku VM, Silva KL, de Almeida BF, Venturin GL, Leal AA, de Martini CC, de Rezende Eug?nio F, Dos Santos PS, de Lima VM
Immunobiology221(8)879-88(2016 08)

Programmed Cell Death Ligand 1 Expression in Canine Cancer.
Shosu K, Sakurai M, Inoue K, Nakagawa T, Sakai H, Morimoto M, Okuda M, Noguchi S, Mizuno T
In vivo (Athens, Greece)30(3)195-204(2016 May-Jun)

Immunohistochemical Analysis of PD-L1 Expression in Canine Malignant Cancers and PD-1 Expression on Lymphocytes in Canine Oral Melanoma.
Maekawa N, Konnai S, Okagawa T, Nishimori A, Ikebuchi R, Izumi Y, Takagi S, Kagawa Y, Nakajima C, Suzuki Y, Kato Y, Murata S, Ohashi K
PloS one11(6)e0157176(2016)

Programmed death 1-mediated T cell exhaustion during visceral leishmaniasis impairs phagocyte function.
Esch KJ, Juelsgaard R, Martinez PA, Jones DE, Petersen CA
Journal of immunology (Baltimore, Md. : 1950)191(11)5542-50(2013 Dec)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

in canine visceral leishmaniasis, PD-1 and its ligands are involved in the induction of T lymphocyte apoptosis and in regulating the production of nitric oxide, TNF-alpha, and IL-4, as well as the parasitic load.
Title: PD-1 function in apoptosis of T lymphocytes in canine visceral leishmaniasis.

Data indicate that programmed cell death-ligand 1 (PD-L1) was found in the cells of most tumor cell lines, but programmed cell death-1 (PD-1) was not detected in all of the cell lines, only in two mast cell tumor and two lymphoma cell lines.
Title: Programmed Cell Death Ligand 1 Expression in Canine Cancer.

PD-1 was highly expressed on tumor-infiltrating lymphocytes obtained from oral melanoma, showing that lymphocytes in this cancer type might have been functionally exhausted.
Title: Immunohistochemical Analysis of PD-L1 Expression in Canine Malignant Cancers and PD-1 Expression on Lymphocytes in Canine Oral Melanoma.

this study demonstrates for the first time that pan-T cell, PD-1-mediated, exhaustion during visceral leishmaniasis influenced macrophage-reactive oxygen intermediate production.
Title: Programmed death 1-mediated T cell exhaustion during visceral leishmaniasis impairs phagocyte function.

The following PDCD1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the PDCD1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OCe45915	NM_001314097.1 Latest version!	Canis lupus familiaris programmed cell death 1 (PDCD1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$174.30 $249.00
OCe297019	XM_022409577.1 Latest version!	Canis lupus familiaris programmed cell death 1 (PDCD1), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$174.30 $249.00

ORF Online Only Promotion

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

PDCD1 ( NM_001314097.1 ) cDNA ORF clone, Canis lupus familiaris(dog) -> NP_001301026.1 Canis lupus familiaris programmed cell death 1 (PDCD1), mRNA.

Price & Availability↑

CloneID	OCe45915
Clone ID Related Accession (Same CDS sequence)	NM_001314097.1
Accession Version	NM_001314097.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 867bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-12-05
Organism	Canis lupus familiaris(dog)
Product	programmed cell death protein 1 precursor
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AB850882.1. On Oct 6, 2015 this sequence version replaced XM_543338.5. ##Evidence-Data-START## Transcript exon combination :: AB850882.1, AB898677.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA4547743 [ECO:0000348] ##Evidence-Data-END##

ATGGGGAGCC GGCGGGGGCC CTGGCCGCTC GTCTGGGCCG TGCTGCAGCT GGGCTGGTGG 
CCAGGATGGC TCCTAGACTC CCCTGACAGG CCCTGGAGCC CGCTCACCTT CTCCCCGGCG 
CAGCTCACGG TGCAGGAGGG AGAGAACGCC ACGTTCACCT GCAGCCTGGC CGACATCCCC 
GACAGCTTCG TGCTCAACTG GTACCGCCTG AGCCCCCGCA ACCAGACGGA CAAGCTGGCC 
GCCTTCCAGG AGGACCGCAT CGAGCCGGGC CGGGACAGGC GCTTCCGCGT CACGCGGCTG 
CCCAACGGGC GGGACTTCCA CATGAGCATC GTCGCTGCGC GCCTCAACGA CAGCGGCATC 
TACCTGTGCG GGGCCATCTA CCTGCCCCCC AACACACAGA TCAACGAGAG TCCCCGCGCA 
GAGCTCTCCG TGACGGAGAG AACCCTGGAG CCCCCCACAC AGAGCCCCAG CCCCCCACCC 
AGACTCAGCG GCCAGTTGCA GGGGCTGGTC ATCGGCGTCA CGAGCGTGCT GGTGGGTGTC 
CTGCTACTGC TGCTGCTGAC CTGGGTCCTG GCCGCTGTCT TCCCCAGGGC CACCCGAGGT 
GCCTGTGTGT GCGGGAGCGA GGACGAGCCT CTGAAGGAGG GCCCCGATGC AGCGCCCGTC 
TTCACCCTGG ACTACGGGGA GCTGGACTTC CAGTGGCGAG AGAAGACGCC GGAGCCCCCG 
GCGCCCTGTG CCCCGGAGCA GACCGAGTAT GCCACCATCG TCTTCCCGGG CAGGCCGGCG 
TCCCCGGGCC GCAGGGCCTC GGCCAGCAGC CTGCAGGGAG CCCAGCCTCC GAGCCCCGAG 
GACGGACCCG GCCTGTGGCC CCCCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001301026.1
CDS	47..913
Translation	MGSRRGPWPLVWAVLQLGWWPGWLLDSPDRPWSPLTFSPAQLTVQEGENATFTCSLADIPDSFVLNWYRLSPRNQTDKLAAFQEDRIEPGRDRRFRVTRLPNGRDFHMSIVAARLNDSGIYLCGAIYLPPNTQINESPRAELSVTERTLEPPTQSPSPPPRLSGQLQGLVIGVTSVLVGVLLLLLLTWVLAAVFPRATRGACVCGSEDEPLKEGPDAAPVFTLDYGELDFQWREKTPEPPAPCAPEQTEYATIVFPGRPASPGRRASASSLQGAQPPSPEDGPGLWPP

Target ORF information:

RefSeq Version	NM_001314097.1
Organism	Canis lupus familiaris(dog)
Definition	Canis lupus familiaris programmed cell death 1 (PDCD1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001314097.1

ORF Insert Sequence:

ATGGGGAGCC GGCGGGGGCC CTGGCCGCTC GTCTGGGCCG TGCTGCAGCT GGGCTGGTGG 
CCAGGATGGC TCCTAGACTC CCCTGACAGG CCCTGGAGCC CGCTCACCTT CTCCCCGGCG 
CAGCTCACGG TGCAGGAGGG AGAGAACGCC ACGTTCACCT GCAGCCTGGC CGACATCCCC 
GACAGCTTCG TGCTCAACTG GTACCGCCTG AGCCCCCGCA ACCAGACGGA CAAGCTGGCC 
GCCTTCCAGG AGGACCGCAT CGAGCCGGGC CGGGACAGGC GCTTCCGCGT CACGCGGCTG 
CCCAACGGGC GGGACTTCCA CATGAGCATC GTCGCTGCGC GCCTCAACGA CAGCGGCATC 
TACCTGTGCG GGGCCATCTA CCTGCCCCCC AACACACAGA TCAACGAGAG TCCCCGCGCA 
GAGCTCTCCG TGACGGAGAG AACCCTGGAG CCCCCCACAC AGAGCCCCAG CCCCCCACCC 
AGACTCAGCG GCCAGTTGCA GGGGCTGGTC ATCGGCGTCA CGAGCGTGCT GGTGGGTGTC 
CTGCTACTGC TGCTGCTGAC CTGGGTCCTG GCCGCTGTCT TCCCCAGGGC CACCCGAGGT 
GCCTGTGTGT GCGGGAGCGA GGACGAGCCT CTGAAGGAGG GCCCCGATGC AGCGCCCGTC 
TTCACCCTGG ACTACGGGGA GCTGGACTTC CAGTGGCGAG AGAAGACGCC GGAGCCCCCG 
GCGCCCTGTG CCCCGGAGCA GACCGAGTAT GCCACCATCG TCTTCCCGGG CAGGCCGGCG 
TCCCCGGGCC GCAGGGCCTC GGCCAGCAGC CTGCAGGGAG CCCAGCCTCC GAGCCCCGAG 
GACGGACCCG GCCTGTGGCC CCCCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PDCD1 ( XM_022409577.1 ) cDNA ORF clone, Canis lupus familiaris(dog) -> XP_022265285.1 Canis lupus familiaris programmed cell death 1 (PDCD1), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OCe297019
Clone ID Related Accession (Same CDS sequence)	XM_022409577.1
Accession Version	XM_022409577.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 864bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-09-04
Organism	Canis lupus familiaris(dog)
Product	programmed cell death protein 1 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_006607.3) annotated using gene prediction method: Gnomon. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Canis lupus familiaris Annotation Release 105 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.4 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGGGGAGCC GGCGGGGGCC CTGGCCGCTC GTCTGGGCCG TGCTGCAGCT GGGCTGGTGG 
CCAGGATGGC TCCTAGACTC CCCTGACAGG CCCTGGAGCC CGCTCACCTT CTCCCCGGCG 
CAGCTCACGG TGCAGGAGGG AGAGAACGCC ACGTTCACCT GCAGCCTGGC CGACATCCCC 
GACAGCTTCG TGCTCAACTG GTACCGCCTG AGCCCCCGCA ACCAGACGGA CAAGCTGGCC 
GCCTTCCAGG AGGACCGCAT CGAGCCGGGC CGGGACAGGC GCTTCCGCGT CATGCGGCTG 
CCCAACGGGC GGGACTTCCA CATGAGCATC GTCGCTGCGC GCCTCAACGA CAGCGGCATC 
TACCTGTGCG GGGCCATCTA CCTGCCCCCC AACACACAGA TCAACGAGAG TCCCCGCGCA 
GAGCTCTCCG TGACGGAGAG AACCCTGGAG CCCCCCACAC AGAGCCCCAG CCCCCCACCC 
AGACTCAGCG GCCAGTTGCA GGGGCTGGTC ATCGGCGTCA CGAGCGTGCT GGTGGGTGTC 
CTGCTACTGC TGCTGCTGAC CTGGGTCCTG GCCGCTGTCT TCCCCAGGGC CACCCGAGGT 
GCCTGTGTGT GCGGGAGCGA GGACGAGCCT CTGGAGGGCC CCGATGCAGC GCCCGTCTTC 
ACCCTGGACT ACGGGGAGCT GGACTTCCAG TGGCGAGAGA AGACGCCGGA GCCCCCGGCG 
CCCTGTGCCC CGGAGCAGAC CGAGTATGCC ACCATCGTCT TCCCGGGCAG GCCGGCGTCC 
CCGGGCCGCA GGGCCTCGGC CAGCAGCCTG CAGGGAGCCC AGCCTCCGAG CCCCGAGGAC 
GGACCCGGCC TGTGGCCCCT CTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_022265285.1
CDS	235..1098
Translation	MGSRRGPWPLVWAVLQLGWWPGWLLDSPDRPWSPLTFSPAQLTVQEGENATFTCSLADIPDSFVLNWYRLSPRNQTDKLAAFQEDRIEPGRDRRFRVMRLPNGRDFHMSIVAARLNDSGIYLCGAIYLPPNTQINESPRAELSVTERTLEPPTQSPSPPPRLSGQLQGLVIGVTSVLVGVLLLLLLTWVLAAVFPRATRGACVCGSEDEPLEGPDAAPVFTLDYGELDFQWREKTPEPPAPCAPEQTEYATIVFPGRPASPGRRASASSLQGAQPPSPEDGPGLWPL

Target ORF information:

RefSeq Version	XM_022409577.1
Organism	Canis lupus familiaris(dog)
Definition	Canis lupus familiaris programmed cell death 1 (PDCD1), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_022409577.1

ORF Insert Sequence:

ATGGGGAGCC GGCGGGGGCC CTGGCCGCTC GTCTGGGCCG TGCTGCAGCT GGGCTGGTGG 
CCAGGATGGC TCCTAGACTC CCCTGACAGG CCCTGGAGCC CGCTCACCTT CTCCCCGGCG 
CAGCTCACGG TGCAGGAGGG AGAGAACGCC ACGTTCACCT GCAGCCTGGC CGACATCCCC 
GACAGCTTCG TGCTCAACTG GTACCGCCTG AGCCCCCGCA ACCAGACGGA CAAGCTGGCC 
GCCTTCCAGG AGGACCGCAT CGAGCCGGGC CGGGACAGGC GCTTCCGCGT CATGCGGCTG 
CCCAACGGGC GGGACTTCCA CATGAGCATC GTCGCTGCGC GCCTCAACGA CAGCGGCATC 
TACCTGTGCG GGGCCATCTA CCTGCCCCCC AACACACAGA TCAACGAGAG TCCCCGCGCA 
GAGCTCTCCG TGACGGAGAG AACCCTGGAG CCCCCCACAC AGAGCCCCAG CCCCCCACCC 
AGACTCAGCG GCCAGTTGCA GGGGCTGGTC ATCGGCGTCA CGAGCGTGCT GGTGGGTGTC 
CTGCTACTGC TGCTGCTGAC CTGGGTCCTG GCCGCTGTCT TCCCCAGGGC CACCCGAGGT 
GCCTGTGTGT GCGGGAGCGA GGACGAGCCT CTGGAGGGCC CCGATGCAGC GCCCGTCTTC 
ACCCTGGACT ACGGGGAGCT GGACTTCCAG TGGCGAGAGA AGACGCCGGA GCCCCCGGCG 
CCCTGTGCCC CGGAGCAGAC CGAGTATGCC ACCATCGTCT TCCCGGGCAG GCCGGCGTCC 
CCGGGCCGCA GGGCCTCGGC CAGCAGCCTG CAGGGAGCCC AGCCTCCGAG CCCCGAGGAC 
GGACCCGGCC TGTGGCCCCT CTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

PD-1 function in apoptosis of T lymphocytes in canine visceral leishmaniasis.
Immunobiology221(8)879-88(2016 08)
Chiku VM,Silva KL,de Almeida BF,Venturin GL,Leal AA,de Martini CC,de Rezende Eug?nio F,Dos Santos PS,de Lima VM

Programmed Cell Death Ligand 1 Expression in Canine Cancer.
In vivo (Athens, Greece)30(3)195-204(2016 May-Jun)
Shosu K,Sakurai M,Inoue K,Nakagawa T,Sakai H,Morimoto M,Okuda M,Noguchi S,Mizuno T

Immunohistochemical Analysis of PD-L1 Expression in Canine Malignant Cancers and PD-1 Expression on Lymphocytes in Canine Oral Melanoma.
PloS one11(6)e0157176(2016)
Maekawa N,Konnai S,Okagawa T,Nishimori A,Ikebuchi R,Izumi Y,Takagi S,Kagawa Y,Nakajima C,Suzuki Y,Kato Y,Murata S,Ohashi K

Programmed death 1-mediated T cell exhaustion during visceral leishmaniasis impairs phagocyte function.
Journal of immunology (Baltimore, Md. : 1950)191(11)5542-50(2013 Dec)
Esch KJ,Juelsgaard R,Martinez PA,Jones DE,Petersen CA

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PDCD1 cDNA ORF clone, Canis lupus familiaris(dog)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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