NDRG1 cDNA ORF clone, Canis lupus familiaris(dog)

Gene
Clones
gRNAs

Summary

Gene Symbol	NDRG1
Entrez Gene ID	482049
Full Name	N-myc downstream regulated 1
Gene Type	protein-coding
Organism	Canis lupus familiaris(dog)

mRNA and Protein(s)

mRNA	Protein	Name
NM_001284434.1	NP_001271363.1	protein NDRG1
XM_005627974.2	XP_005628031.1	protein NDRG1 isoform X1
XM_005627974.3	XP_005628031.1	protein NDRG1 isoform X1

Pathways from BioSystems

Homologies

Mus musculus (house mouse)	Ndrg1	NP_032707.2
Rattus norvegicus (Norway rat)	Ndrg1	NP_001011991.1
Xenopus tropicalis (tropical clawed frog)	ndrg1	NP_001008146.1
Bos taurus (cattle)	NDRG1	NP_001030181.1
Pan troglodytes (chimpanzee)	NDRG1	XP_001140704.1
Canis lupus familiaris (dog)	NDRG1	XP_005628031.1
Danio rerio (zebrafish)	ndrg1a	NP_998513.2
Homo sapiens (human)	NDRG1	NP_001128714.1
	NDRG1	XP_001088640.1
Gallus gallus (chicken)	NDRG1	XP_418430.2

Gene Ontology
Bibliography

Related articles in PubMed

Re-emergence of hereditary polyneuropathy in Scandinavian Alaskan malamute dogs-old enemy or new entity? A case series.
J?derlund KH, Rohdin C, Berendt M, Stigen ?, Fredholm M, Espenes A, Bjerk?s I, Moe L
Acta veterinaria Scandinavica59(1)26(2017 May)

A Gly98Val mutation in the N-Myc downstream regulated gene 1 (NDRG1) in Alaskan Malamutes with polyneuropathy.
Bruun CS, J?derlund KH, Berendt M, Jensen KB, Spodsberg EH, Gredal H, Shelton GD, Mickelson JR, Minor KM, Lohi H, Bjerk?s I, Stigen O, Espenes A, Rohdin C, Edlund R, Ohlsson J, Cizinauskas S, Leifsson PS, Dr?gem?ller C, Moe L, Cirera S, Fredholm M
PloS one8(2)e54547(2013)

A deletion in the N-myc downstream regulated gene 1 (NDRG1) gene in Greyhounds with polyneuropathy.
Dr?gem?ller C, Becker D, Kessler B, Kemter E, Tetens J, Jurina K, J?derlund KH, Flagstad A, Perloski M, Lindblad-Toh K, Matiasek K
PloS one5(6)e11258(2010 Jun)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

This study concluded that historical and recent phenotypic polyneuropathy cases were carrying the same NDRG1-mutation due to silent transmission of recessive disease.
Title: Re-emergence of hereditary polyneuropathy in Scandinavian Alaskan malamute dogs-old enemy or new entity? A case series.

Data conclude that the G>T substitution in NDRG1 is most likely the mutation that causes polyneuropathy in Alaskan Malamutes
Title: A Gly98Val mutation in the N-Myc downstream regulated gene 1 (NDRG1) in Alaskan Malamutes with polyneuropathy.

identified the first genetically characterized canine Charcot-Marie-Tooth (CMT) model which offers an opportunity to gain further insights into the pathobiology and therapy of human NDRG1 associated CMT disease
Title: A deletion in the N-myc downstream regulated gene 1 (NDRG1) gene in Greyhounds with polyneuropathy.

The following NDRG1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the NDRG1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OCe33833	NM_001284434.1 Latest version!	Canis lupus familiaris N-myc downstream regulated 1 (NDRG1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	TBD	$258.30 $369.00
OCe16045	XM_005627974.3 Latest version!	Canis lupus familiaris N-myc downstream regulated 1 (NDRG1), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	TBD	$258.30 $369.00
View Old Accession Versions >>
OCe16045	XM_005627974.2	Canis lupus familiaris N-myc downstream regulated 1 (NDRG1), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	TBD	$258.30 $369.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

NDRG1 ( NM_001284434.1 ) cDNA ORF clone, Canis lupus familiaris(dog) -> NP_001271363.1 Canis lupus familiaris N-myc downstream regulated 1 (NDRG1), mRNA.

Price & Availability↑

CloneID	OCe33833
Clone ID Related Accession (Same CDS sequence)	NM_001284434.1
Accession Version	NM_001284434.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1155bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-05-20
Organism	Canis lupus familiaris(dog)
Product	protein NDRG1
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from JX987297.1. ##Evidence-Data-START## Transcript exon combination :: JX987297.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA103936001, SAMEA103936002 [ECO:0000350] ##Evidence-Data-END##

ATGTCTCGGG AGCTGCAGGA CGTGGACCTC GCCGAGGTGA AGCCTTTGGT AGAGAAAGGG 
GAGACCATCA CCGGCCTCCT GCAAGAGTTT GATGTTCAGG AGCAGGACAT CGAGACCGTG 
CATGGCTCCA TCCACGTCAC GCTGTGTGGG ACCCCCAAGG GCAACCGGCC CGTCATCCTC 
ACCTACCACG ACATTGGCAT GAACCACAAA ACCTGCTACA ACCCCCTCTT CAACTCTGAG 
GACATGCAGG AGATCACACA GCACTTCGCC GTCTGCCATG TGGATGCCCC TGGCCAGCAG 
GACGGCGCTG CCTCCTTCCC TGTGGGGTAC ATGTACCCCT CCATGGACCA GCTGGCCGAG 
ATGCTTCCTG GAGTCCTCCA CCAGTTTGGG CTGAAAAGCA TCATTGGCAT GGGAACTGGA 
GCAGGCGCCT ACATCCTCAC TCGGTTTGCT CTGAACAACC CCGAGATGGT GGAGGGCCTC 
GTCCTTATCA ACGTGAACCC TTGTGCAGAA GGCTGGATGG ATTGGGCTGC ATCCAAGATC 
TCCGGGTGGA CCCAAGCCCT TCCAGACATG GTGGTGTCCC ATCTCTTTGG GAAGGAGGAA 
ATGCAGAACA ACGTGGAGGT GGTCCACACT TACCGCCAGC ACATCGTGAA TGACATGAAC 
CCCGGCAACC TGCACCTGTT CATCAACGCC TACAACAGCC GACGGGACCT GGAGATCGAG 
CGGCCGATGC CCGGAGCCCA CACAGTCACC CTGCAGTGTC CTGCTTTGTT GGTGGTTGGG 
GACAGTTCTC CTGCTGTGGA TGCTGTGGTG GAGTGCAACT CAAAATTGGA CCCAACCAAG 
ACCACTCTCC TCAAGATGGC AGATTGTGGT GGCCTCCCGC AGATCTCCCA GCCAGCCAAG 
CTTGCCGAGG CCTTCAAGTA CTTCGTGCAG GGCATGGGAT ACATGCCCTC AGCCAGCATG 
ACCCGCCTGA TGCGCTCCCG CACGGCCTCT GGCTCCAGCG TCACATCCCT GGAGGGTGCC 
CGCAGCCGCT CCCACACCAG CGAGGGCACC CGCAGCCGCT CCCACACCAG TGAGGGTGCT 
CGCCTGGACA TCACCCCCAA CTCTGGAGCC ACCGGCAACA ATGCCGGGCC CAAGTCCATG 
GAGGTGTCCT GCTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001271363.1
CDS	9..1163
Translation	MSRELQDVDLAEVKPLVEKGETITGLLQEFDVQEQDIETVHGSIHVTLCGTPKGNRPVILTYHDIGMNHKTCYNPLFNSEDMQEITQHFAVCHVDAPGQQDGAASFPVGYMYPSMDQLAEMLPGVLHQFGLKSIIGMGTGAGAYILTRFALNNPEMVEGLVLINVNPCAEGWMDWAASKISGWTQALPDMVVSHLFGKEEMQNNVEVVHTYRQHIVNDMNPGNLHLFINAYNSRRDLEIERPMPGAHTVTLQCPALLVVGDSSPAVDAVVECNSKLDPTKTTLLKMADCGGLPQISQPAKLAEAFKYFVQGMGYMPSASMTRLMRSRTASGSSVTSLEGARSRSHTSEGTRSRSHTSEGARLDITPNSGATGNNAGPKSMEVSC

Target ORF information:

RefSeq Version	NM_001284434.1
Organism	Canis lupus familiaris(dog)
Definition	Canis lupus familiaris N-myc downstream regulated 1 (NDRG1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001284434.1

ORF Insert Sequence:

ATGTCTCGGG AGCTGCAGGA CGTGGACCTC GCCGAGGTGA AGCCTTTGGT AGAGAAAGGG 
GAGACCATCA CCGGCCTCCT GCAAGAGTTT GATGTTCAGG AGCAGGACAT CGAGACCGTG 
CATGGCTCCA TCCACGTCAC GCTGTGTGGG ACCCCCAAGG GCAACCGGCC CGTCATCCTC 
ACCTACCACG ACATTGGCAT GAACCACAAA ACCTGCTACA ACCCCCTCTT CAACTCTGAG 
GACATGCAGG AGATCACACA GCACTTCGCC GTCTGCCATG TGGATGCCCC TGGCCAGCAG 
GACGGCGCTG CCTCCTTCCC TGTGGGGTAC ATGTACCCCT CCATGGACCA GCTGGCCGAG 
ATGCTTCCTG GAGTCCTCCA CCAGTTTGGG CTGAAAAGCA TCATTGGCAT GGGAACTGGA 
GCAGGCGCCT ACATCCTCAC TCGGTTTGCT CTGAACAACC CCGAGATGGT GGAGGGCCTC 
GTCCTTATCA ACGTGAACCC TTGTGCAGAA GGCTGGATGG ATTGGGCTGC ATCCAAGATC 
TCCGGGTGGA CCCAAGCCCT TCCAGACATG GTGGTGTCCC ATCTCTTTGG GAAGGAGGAA 
ATGCAGAACA ACGTGGAGGT GGTCCACACT TACCGCCAGC ACATCGTGAA TGACATGAAC 
CCCGGCAACC TGCACCTGTT CATCAACGCC TACAACAGCC GACGGGACCT GGAGATCGAG 
CGGCCGATGC CCGGAGCCCA CACAGTCACC CTGCAGTGTC CTGCTTTGTT GGTGGTTGGG 
GACAGTTCTC CTGCTGTGGA TGCTGTGGTG GAGTGCAACT CAAAATTGGA CCCAACCAAG 
ACCACTCTCC TCAAGATGGC AGATTGTGGT GGCCTCCCGC AGATCTCCCA GCCAGCCAAG 
CTTGCCGAGG CCTTCAAGTA CTTCGTGCAG GGCATGGGAT ACATGCCCTC AGCCAGCATG 
ACCCGCCTGA TGCGCTCCCG CACGGCCTCT GGCTCCAGCG TCACATCCCT GGAGGGTGCC 
CGCAGCCGCT CCCACACCAG CGAGGGCACC CGCAGCCGCT CCCACACCAG TGAGGGTGCT 
CGCCTGGACA TCACCCCCAA CTCTGGAGCC ACCGGCAACA ATGCCGGGCC CAAGTCCATG 
GAGGTGTCCT GCTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

NDRG1 ( XM_005627974.2 ) cDNA ORF clone, Canis lupus familiaris(dog) -> XP_005628031.1 Canis lupus familiaris N-myc downstream regulated 1 (NDRG1), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OCe16045
Clone ID Related Accession (Same CDS sequence)	XM_005627974.2 , XM_005627974.3
Accession Version	XM_005627974.2	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1155bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2015-09-16
Organism	Canis lupus familiaris(Dog)
Product	protein NDRG1 isoform X1
Comment	MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NW_003726083.1) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Sep 17, 2015 this sequence version replaced XM_005627974.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Canis lupus familiaris Annotation Release 104 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 6.4 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGTCTCGGG AGCTGCAGGA CGTGGACCTC GCCGAGGTGA AGCCTTTGGT GGAGAAAGGG 
GAGACCATCA CCGGCCTCCT GCAAGAGTTT GATGTTCAGG AGCAGGACAT CGAGACCGTG 
CATGGCTCCA TCCACGTCAC GCTGTGTGGG ACCCCCAAGG GCAACCGGCC CGTCATCCTC 
ACCTACCACG ACATTGGCAT GAACCACAAA ACCTGCTACA ACCCCCTCTT CAACTCTGAG 
GACATGCAGG AGATCACACA GCACTTCGCC GTCTGCCATG TGGATGCCCC TGGCCAGCAG 
GACGGCGCTG CCTCCTTCCC TGTGGGGTAC ATGTACCCCT CCATGGACCA GCTGGCCGAG 
ATGCTTCCTG GAGTCCTCCA CCAGTTTGGG CTGAAAAGCA TCATTGGCAT GGGAACTGGA 
GCAGGCGCCT ACATCCTCAC TCGGTTTGCT CTGAACAACC CCGAGATGGT GGAGGGCCTC 
GTCCTTATCA ACGTGAACCC TTGTGCAGAA GGCTGGATGG ATTGGGCTGC ATCCAAGATC 
TCCGGGTGGA CCCAAGCCCT TCCAGACATG GTGGTGTCCC ATCTCTTTGG GAAGGAGGAA 
ATGCAGAACA ACGTGGAGGT GGTCCACACT TACCGCCAGC ACATCGTGAA TGACATGAAC 
CCCGGCAACC TGCATCTGTT CATCAACGCC TACAACAGCC GACGGGACCT GGAGATCGAG 
CGGCCGATGC CCGGAGCCCA CACAGTCACC CTGCAGTGTC CTGCTTTGTT GGTGGTTGGG 
GACAGTTCTC CTGCTGTGGA TGCTGTGGTG GAGTGCAACT CAAAATTGGA CCCAACCAAG 
ACCACTCTCC TCAAGATGGC AGATTGTGGT GGCCTCCCGC AGATCTCCCA GCCAGCCAAG 
CTTGCCGAGG CCTTCAAGTA CTTCGTGCAG GGCATGGGAT ACATGCCCTC AGCCAGCATG 
ACCCGCCTGA TGCGCTCCCG CACGGCCTCT GGCTCCAGCG TCACATCCCT GGAGGGTGCC 
CGCAGCCGCT CCCACACCAG CGAGGGCACC CGCAGCCGCT CCCACACCAG TGAGGGTGCT 
CGCCTGGACA TCACCCCCAA CTCTGGAGCC ACCGGCAACA ATGCCGGGCC CAAGTCCATG 
GAGGTGTCCT GCTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_005628031.1
CDS	121..1275
Translation	MSRELQDVDLAEVKPLVEKGETITGLLQEFDVQEQDIETVHGSIHVTLCGTPKGNRPVILTYHDIGMNHKTCYNPLFNSEDMQEITQHFAVCHVDAPGQQDGAASFPVGYMYPSMDQLAEMLPGVLHQFGLKSIIGMGTGAGAYILTRFALNNPEMVEGLVLINVNPCAEGWMDWAASKISGWTQALPDMVVSHLFGKEEMQNNVEVVHTYRQHIVNDMNPGNLHLFINAYNSRRDLEIERPMPGAHTVTLQCPALLVVGDSSPAVDAVVECNSKLDPTKTTLLKMADCGGLPQISQPAKLAEAFKYFVQGMGYMPSASMTRLMRSRTASGSSVTSLEGARSRSHTSEGTRSRSHTSEGARLDITPNSGATGNNAGPKSMEVSC

Target ORF information:

RefSeq Version	XM_005627974.2
Organism	Canis lupus familiaris(Dog)
Definition	Canis lupus familiaris N-myc downstream regulated 1 (NDRG1), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_005627974.2

ORF Insert Sequence:

ATGTCTCGGG AGCTGCAGGA CGTGGACCTC GCCGAGGTGA AGCCTTTGGT GGAGAAAGGG 
GAGACCATCA CCGGCCTCCT GCAAGAGTTT GATGTTCAGG AGCAGGACAT CGAGACCGTG 
CATGGCTCCA TCCACGTCAC GCTGTGTGGG ACCCCCAAGG GCAACCGGCC CGTCATCCTC 
ACCTACCACG ACATTGGCAT GAACCACAAA ACCTGCTACA ACCCCCTCTT CAACTCTGAG 
GACATGCAGG AGATCACACA GCACTTCGCC GTCTGCCATG TGGATGCCCC TGGCCAGCAG 
GACGGCGCTG CCTCCTTCCC TGTGGGGTAC ATGTACCCCT CCATGGACCA GCTGGCCGAG 
ATGCTTCCTG GAGTCCTCCA CCAGTTTGGG CTGAAAAGCA TCATTGGCAT GGGAACTGGA 
GCAGGCGCCT ACATCCTCAC TCGGTTTGCT CTGAACAACC CCGAGATGGT GGAGGGCCTC 
GTCCTTATCA ACGTGAACCC TTGTGCAGAA GGCTGGATGG ATTGGGCTGC ATCCAAGATC 
TCCGGGTGGA CCCAAGCCCT TCCAGACATG GTGGTGTCCC ATCTCTTTGG GAAGGAGGAA 
ATGCAGAACA ACGTGGAGGT GGTCCACACT TACCGCCAGC ACATCGTGAA TGACATGAAC 
CCCGGCAACC TGCATCTGTT CATCAACGCC TACAACAGCC GACGGGACCT GGAGATCGAG 
CGGCCGATGC CCGGAGCCCA CACAGTCACC CTGCAGTGTC CTGCTTTGTT GGTGGTTGGG 
GACAGTTCTC CTGCTGTGGA TGCTGTGGTG GAGTGCAACT CAAAATTGGA CCCAACCAAG 
ACCACTCTCC TCAAGATGGC AGATTGTGGT GGCCTCCCGC AGATCTCCCA GCCAGCCAAG 
CTTGCCGAGG CCTTCAAGTA CTTCGTGCAG GGCATGGGAT ACATGCCCTC AGCCAGCATG 
ACCCGCCTGA TGCGCTCCCG CACGGCCTCT GGCTCCAGCG TCACATCCCT GGAGGGTGCC 
CGCAGCCGCT CCCACACCAG CGAGGGCACC CGCAGCCGCT CCCACACCAG TGAGGGTGCT 
CGCCTGGACA TCACCCCCAA CTCTGGAGCC ACCGGCAACA ATGCCGGGCC CAAGTCCATG 
GAGGTGTCCT GCTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

NDRG1 ( XM_005627974.3 ) cDNA ORF clone, Canis lupus familiaris(dog) -> XP_005628031.1 Canis lupus familiaris N-myc downstream regulated 1 (NDRG1), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OCe16045
Clone ID Related Accession (Same CDS sequence)	XM_005627974.2 , XM_005627974.3
Accession Version	XM_005627974.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1155bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-09-04
Organism	Canis lupus familiaris(dog)
Product	protein NDRG1 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_006595.3) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Sep 5, 2017 this sequence version replaced XM_005627974.2. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Canis lupus familiaris Annotation Release 105 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.4 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGTCTCGGG AGCTGCAGGA CGTGGACCTC GCCGAGGTGA AGCCTTTGGT GGAGAAAGGG 
GAGACCATCA CCGGCCTCCT GCAAGAGTTT GATGTTCAGG AGCAGGACAT CGAGACCGTG 
CATGGCTCCA TCCACGTCAC GCTGTGTGGG ACCCCCAAGG GCAACCGGCC CGTCATCCTC 
ACCTACCACG ACATTGGCAT GAACCACAAA ACCTGCTACA ACCCCCTCTT CAACTCTGAG 
GACATGCAGG AGATCACACA GCACTTCGCC GTCTGCCATG TGGATGCCCC TGGCCAGCAG 
GACGGCGCTG CCTCCTTCCC TGTGGGGTAC ATGTACCCCT CCATGGACCA GCTGGCCGAG 
ATGCTTCCTG GAGTCCTCCA CCAGTTTGGG CTGAAAAGCA TCATTGGCAT GGGAACTGGA 
GCAGGCGCCT ACATCCTCAC TCGGTTTGCT CTGAACAACC CCGAGATGGT GGAGGGCCTC 
GTCCTTATCA ACGTGAACCC TTGTGCAGAA GGCTGGATGG ATTGGGCTGC ATCCAAGATC 
TCCGGGTGGA CCCAAGCCCT TCCAGACATG GTGGTGTCCC ATCTCTTTGG GAAGGAGGAA 
ATGCAGAACA ACGTGGAGGT GGTCCACACT TACCGCCAGC ACATCGTGAA TGACATGAAC 
CCCGGCAACC TGCATCTGTT CATCAACGCC TACAACAGCC GACGGGACCT GGAGATCGAG 
CGGCCGATGC CCGGAGCCCA CACAGTCACC CTGCAGTGTC CTGCTTTGTT GGTGGTTGGG 
GACAGTTCTC CTGCTGTGGA TGCTGTGGTG GAGTGCAACT CAAAATTGGA CCCAACCAAG 
ACCACTCTCC TCAAGATGGC AGATTGTGGT GGCCTCCCGC AGATCTCCCA GCCAGCCAAG 
CTTGCCGAGG CCTTCAAGTA CTTCGTGCAG GGCATGGGAT ACATGCCCTC AGCCAGCATG 
ACCCGCCTGA TGCGCTCCCG CACGGCCTCT GGCTCCAGCG TCACATCCCT GGAGGGTGCC 
CGCAGCCGCT CCCACACCAG CGAGGGCACC CGCAGCCGCT CCCACACCAG TGAGGGTGCT 
CGCCTGGACA TCACCCCCAA CTCTGGAGCC ACCGGCAACA ATGCCGGGCC CAAGTCCATG 
GAGGTGTCCT GCTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_005628031.1
CDS	102..1256
Translation	MSRELQDVDLAEVKPLVEKGETITGLLQEFDVQEQDIETVHGSIHVTLCGTPKGNRPVILTYHDIGMNHKTCYNPLFNSEDMQEITQHFAVCHVDAPGQQDGAASFPVGYMYPSMDQLAEMLPGVLHQFGLKSIIGMGTGAGAYILTRFALNNPEMVEGLVLINVNPCAEGWMDWAASKISGWTQALPDMVVSHLFGKEEMQNNVEVVHTYRQHIVNDMNPGNLHLFINAYNSRRDLEIERPMPGAHTVTLQCPALLVVGDSSPAVDAVVECNSKLDPTKTTLLKMADCGGLPQISQPAKLAEAFKYFVQGMGYMPSASMTRLMRSRTASGSSVTSLEGARSRSHTSEGTRSRSHTSEGARLDITPNSGATGNNAGPKSMEVSC

Target ORF information:

RefSeq Version	XM_005627974.3
Organism	Canis lupus familiaris(dog)
Definition	Canis lupus familiaris N-myc downstream regulated 1 (NDRG1), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_005627974.3

ORF Insert Sequence:

ATGTCTCGGG AGCTGCAGGA CGTGGACCTC GCCGAGGTGA AGCCTTTGGT GGAGAAAGGG 
GAGACCATCA CCGGCCTCCT GCAAGAGTTT GATGTTCAGG AGCAGGACAT CGAGACCGTG 
CATGGCTCCA TCCACGTCAC GCTGTGTGGG ACCCCCAAGG GCAACCGGCC CGTCATCCTC 
ACCTACCACG ACATTGGCAT GAACCACAAA ACCTGCTACA ACCCCCTCTT CAACTCTGAG 
GACATGCAGG AGATCACACA GCACTTCGCC GTCTGCCATG TGGATGCCCC TGGCCAGCAG 
GACGGCGCTG CCTCCTTCCC TGTGGGGTAC ATGTACCCCT CCATGGACCA GCTGGCCGAG 
ATGCTTCCTG GAGTCCTCCA CCAGTTTGGG CTGAAAAGCA TCATTGGCAT GGGAACTGGA 
GCAGGCGCCT ACATCCTCAC TCGGTTTGCT CTGAACAACC CCGAGATGGT GGAGGGCCTC 
GTCCTTATCA ACGTGAACCC TTGTGCAGAA GGCTGGATGG ATTGGGCTGC ATCCAAGATC 
TCCGGGTGGA CCCAAGCCCT TCCAGACATG GTGGTGTCCC ATCTCTTTGG GAAGGAGGAA 
ATGCAGAACA ACGTGGAGGT GGTCCACACT TACCGCCAGC ACATCGTGAA TGACATGAAC 
CCCGGCAACC TGCATCTGTT CATCAACGCC TACAACAGCC GACGGGACCT GGAGATCGAG 
CGGCCGATGC CCGGAGCCCA CACAGTCACC CTGCAGTGTC CTGCTTTGTT GGTGGTTGGG 
GACAGTTCTC CTGCTGTGGA TGCTGTGGTG GAGTGCAACT CAAAATTGGA CCCAACCAAG 
ACCACTCTCC TCAAGATGGC AGATTGTGGT GGCCTCCCGC AGATCTCCCA GCCAGCCAAG 
CTTGCCGAGG CCTTCAAGTA CTTCGTGCAG GGCATGGGAT ACATGCCCTC AGCCAGCATG 
ACCCGCCTGA TGCGCTCCCG CACGGCCTCT GGCTCCAGCG TCACATCCCT GGAGGGTGCC 
CGCAGCCGCT CCCACACCAG CGAGGGCACC CGCAGCCGCT CCCACACCAG TGAGGGTGCT 
CGCCTGGACA TCACCCCCAA CTCTGGAGCC ACCGGCAACA ATGCCGGGCC CAAGTCCATG 
GAGGTGTCCT GCTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Re-emergence of hereditary polyneuropathy in Scandinavian Alaskan malamute dogs-old enemy or new entity? A case series.
Acta veterinaria Scandinavica59(1)26(2017 May)
J?derlund KH,Rohdin C,Berendt M,Stigen ?,Fredholm M,Espenes A,Bjerk?s I,Moe L

A Gly98Val mutation in the N-Myc downstream regulated gene 1 (NDRG1) in Alaskan Malamutes with polyneuropathy.
PloS one8(2)e54547(2013)
Bruun CS,J?derlund KH,Berendt M,Jensen KB,Spodsberg EH,Gredal H,Shelton GD,Mickelson JR,Minor KM,Lohi H,Bjerk?s I,Stigen O,Espenes A,Rohdin C,Edlund R,Ohlsson J,Cizinauskas S,Leifsson PS,Dr?gem?ller C,Moe L,Cirera S,Fredholm M

A deletion in the N-myc downstream regulated gene 1 (NDRG1) gene in Greyhounds with polyneuropathy.
PloS one5(6)e11258(2010 Jun)
Dr?gem?ller C,Becker D,Kessler B,Kemter E,Tetens J,Jurina K,J?derlund KH,Flagstad A,Perloski M,Lindblad-Toh K,Matiasek K

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NDRG1 cDNA ORF clone, Canis lupus familiaris(dog)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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