Gene Symbol | CDKN2B |
Entrez Gene ID | 481563 |
Full Name | cyclin dependent kinase inhibitor 2B |
Synonyms | p15INK4B |
Gene Type | protein-coding |
Organism | Canis lupus familiaris(dog) |
ORF » Species Summary » Canis lupus familiaris » CDKN2B cDNA ORF clone
Gene Symbol | CDKN2B |
Entrez Gene ID | 481563 |
Full Name | cyclin dependent kinase inhibitor 2B |
Synonyms | p15INK4B |
Gene Type | protein-coding |
Organism | Canis lupus familiaris(dog) |
mRNA | Protein | Name |
---|---|---|
XM_005626410.2 | XP_005626467.1 | cyclin-dependent kinase 4 inhibitor B isoform X1 |
NM_001146269.1 | NP_001139741.1 | cyclin-dependent kinase 4 inhibitor B |
XM_005626410.3 | XP_005626467.1 | cyclin-dependent kinase 4 inhibitor B isoform X1 |
Canis lupus familiaris (dog) | CDKN2B | NP_001139741.1 |
Mus musculus (house mouse) | Cdkn2b | NP_031696.1 |
Rattus norvegicus (Norway rat) | Cdkn2b | NP_570825.1 |
Bos taurus (cattle) | CDKN2B | NP_001069362.1 |
Homo sapiens (human) | CDKN2B | NP_004927.2 |
Pan troglodytes (chimpanzee) | CDKN2B | XP_003312069.1 |
CDKN2B | XP_001107263.1 | |
Gallus gallus (chicken) | CDKN2B | NP_989764.1 |
Genome-wide analyses implicate 33 loci in heritable dog osteosarcoma, including regulatory variants near CDKN2A/B.
Karlsson EK, Sigurdsson S, Ivansson E, Thomas R, Elvers I, Wright J, Howald C, Tonomura N, Perloski M, Swofford R, Biagi T, Fryc S, Anderson N, Courtay-Cahen C, Youell L, Ricketts SL, Mandlebaum S, Rivera P, von Euler H, Kisseberth WC, London CA, Lander ES, Couto G, Comstock K, Starkey MP, Modiano JF, Breen M, Lindblad-Toh K
Genome biology14(12)R132(2013 Dec)
Simultaneous inactivation of the p16, p15 and p14 genes encoding cyclin-dependent kinase inhibitors in canine T-lymphoid tumor cells.
Fujiwara-Igarashi A, Goto-Koshino Y, Mochizuki H, Maeda S, Fujino Y, Ohno K, Tsujimoto H
The Journal of veterinary medical science75(6)733-42(2013)
Disruption of chromosome 11 in canine fibrosarcomas highlights an unusual variability of CDKN2B in dogs.
Aguirre-Hern?ndez J, Milne BS, Queen C, O'Brien PC, Hoather T, Haugland S, Ferguson-Smith MA, Dobson JM, Sargan DR
BMC veterinary research527(2009 Jul)
Inactivation of the p16 cyclin-dependent kinase inhibitor in high-grade canine non-Hodgkin's T-cell lymphoma.
Fosmire SP, Thomas R, Jubala CM, Wojcieszyn JW, Valli VE, Getzy DM, Smith TL, Gardner LA, Ritt MG, Bell JS, Freeman KP, Greenfield BE, Lana SE, Kisseberth WC, Helfand SC, Cutter GR, Breen M, Modiano JF
Veterinary pathology44(4)467-78(2007 Jul)
GeneRIFs: Gene References Into Functions What's a GeneRIF?
The greyhound locus exhibiting the strongest association, located 150 kilobases upstream of the genes CDKN2A/B, is also the most rearranged locus in canine osteosarcoma tumors.
Title: Genome-wide analyses implicate 33 loci in heritable dog osteosarcoma, including regulatory variants near CDKN2A/B.
In this study, the full-length complementary DNA (cDNA) of the canine p16 gene was cloned using the 5' and 3' rapid amplification of cDNA ends methods.
Title: Simultaneous inactivation of the p16, p15 and p14 genes encoding cyclin-dependent kinase inhibitors in canine T-lymphoid tumor cells.
BAC hybridisations on metaphases of two fibrosarcomas showed loss of heterozygosity on chromosome 11 in the CDKN2B-CDKN2A tumour suppressor gene cluster region
Title: Disruption of chromosome 11 in canine fibrosarcomas highlights an unusual variability of CDKN2B in dogs.
The data show that p16 deletion or inactivation occurs almost exclusively in high-grade T-cell non-Hodgkin's lymphoma(NHL); alternative pathways can generate functional phenotypes of Rb deficiency in low-grade T-cell NHL and in high-grade B-cell NHL.
Title: Inactivation of the p16 cyclin-dependent kinase inhibitor in high-grade canine non-Hodgkin's T-cell lymphoma.
The following CDKN2B gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the CDKN2B cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
CloneID | OCe34321 | |
Clone ID Related Accession (Same CDS sequence) | NM_001146269.1 | |
Accession Version | NM_001146269.1 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 417bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2017-10-22 | |
Organism | Canis lupus familiaris(dog) | |
Product | cyclin-dependent kinase 4 inhibitor B | |
Comment | Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AAEX03007905.1. On Apr 4, 2009 this sequence version replaced XM_538685.2. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. ##Evidence-Data-START## RNAseq introns :: mixed/partial sample support SAMEA103936001, SAMEA103936002 [ECO:0000350] ##Evidence-Data-END## |
1 | ATGCGCGAGG AGGCCACGGG CTTGCTCGGC GGGGACGGCG GCGACGCGGG CCTGGCCAGC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_001139741.1 |
CDS | 1..417 |
Translation |
Target ORF information:
Target ORF information:
|
NM_001146269.1 |
1 | ATGCGCGAGG AGGCCACGGG CTTGCTCGGC GGGGACGGCG GCGACGCGGG CCTGGCCAGC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OCe14144 | |
Clone ID Related Accession (Same CDS sequence) | XM_005626410.2 , XM_005626410.3 | |
Accession Version | XM_005626410.2 | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 465bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2015-09-16 | |
Organism | Canis lupus familiaris(Dog) | |
Product | cyclin-dependent kinase 4 inhibitor B isoform X1 | |
Comment | MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NW_003726080.1) annotated using gene prediction method: Gnomon. Also see: Documentation of NCBI's Annotation Process On Sep 17, 2015 this sequence version replaced XM_005626410.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Canis lupus familiaris Annotation Release 104 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 6.4 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## |
1 | ATGCGCGAGG AGGCCACGGG CTTGCTCGGC GGCGGCGGCG GCGGGGACGG CGGCGGGGAC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | XP_005626467.1 |
CDS | 454..918 |
Translation |
Target ORF information:
Target ORF information:
|
XM_005626410.2 |
1 | ATGCGCGAGG AGGCCACGGG CTTGCTCGGC GGCGGCGGCG GCGGGGACGG CGGCGGGGAC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OCe14144 | |
Clone ID Related Accession (Same CDS sequence) | XM_005626410.2 , XM_005626410.3 | |
Accession Version | XM_005626410.3 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 465bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2017-09-04 | |
Organism | Canis lupus familiaris(dog) | |
Product | cyclin-dependent kinase 4 inhibitor B isoform X1 | |
Comment | Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_006593.3) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Sep 5, 2017 this sequence version replaced XM_005626410.2. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Canis lupus familiaris Annotation Release 105 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.4 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## |
1 | ATGCGCGAGG AGGCCACGGG CTTGCTCGGC GGCGGCGGCG GCGGGGACGG CGGCGGGGAC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | XP_005626467.1 |
CDS | 454..918 |
Translation |
Target ORF information:
Target ORF information:
|
XM_005626410.3 |
1 | ATGCGCGAGG AGGCCACGGG CTTGCTCGGC GGCGGCGGCG GCGGGGACGG CGGCGGGGAC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
Genome-wide analyses implicate 33 loci in heritable dog osteosarcoma, including regulatory variants near CDKN2A/B. |
Simultaneous inactivation of the p16, p15 and p14 genes encoding cyclin-dependent kinase inhibitors in canine T-lymphoid tumor cells. |
Disruption of chromosome 11 in canine fibrosarcomas highlights an unusual variability of CDKN2B in dogs. |
Inactivation of the p16 cyclin-dependent kinase inhibitor in high-grade canine non-Hodgkin's T-cell lymphoma. |