SLC11A1 cDNA ORF clone, Canis lupus familiaris(dog)

Gene
Clones
gRNAs

Summary

Gene Symbol	SLC11A1
Entrez Gene ID	478909
Full Name	solute carrier family 11 member 1
Synonyms	NRAMP1
General protein information	Preferred Names solute carrier family 11 member 1 Names natural resistance-associated macrophage protein 1 NRAMP 1 solute carrier family 11 (proton-coupled divalent metal ion transporters), member 1
Gene Type	protein-coding
Organism	Canis lupus familiaris(dog)

mRNA and Protein(s)

mRNA	Protein	Name
NM_001013851.1	NP_001013873.1	natural resistance-associated macrophage protein 1

Pathways from BioSystems

Homologies

Pan troglodytes (chimpanzee)	SLC11A1	XP_001156701.1
Bos taurus (cattle)	SLC11A1	NP_777077.1
Rattus norvegicus (Norway rat)	Slc11a1	NP_001026828.1
Oryza sativa (rice)	Os03g0208500	NP_001049330.1
Homo sapiens (human)	SLC11A1	NP_000569.3
Xenopus tropicalis (tropical clawed frog)	slc11a1	XP_002933999.2
Canis lupus familiaris (dog)	SLC11A1	NP_001013873.1
Arabidopsis thaliana (thale cress)	NRAMP2	NP_175157.1
	SLC11A1	XP_001089328.1
Mus musculus (house mouse)	Slc11a1	NP_038640.2
Arabidopsis thaliana (thale cress)	NRAMP4	NP_201534.1
Gallus gallus (chicken)	SLC11A1	NP_990295.1
Arabidopsis thaliana (thale cress)	NRAMP3	NP_179896.1

Gene Ontology
Bibliography

Related articles in PubMed

cDNA sequencing and expression of Nramp1 (Slc11a1) in dogs phenotypically resistant or susceptible to visceral leishmaniasis.
Bueno R, Carvalho Neta AV, Xavier MN, Oliveira RG, Diniz SA, Melo MN, Santos RL
Veterinary immunology and immunopathology127(3-4)332-9(2009 Feb)

Slc11a1 (formerly Nramp1) and susceptibility to canine visceral leishmaniasis.
Sanchez-Robert E, Altet L, Utzet-Sadurni M, Giger U, Sanchez A, Francino O
Veterinary research39(3)36(2008 May-Jun)

Polymorphism of Slc11a1 (Nramp1) gene and canine leishmaniasis in a case-control study.
Sanchez-Robert E, Altet L, Sanchez A, Francino O
The Journal of heredity96(7)755-8(2005)

Mapping and sequencing of the canine NRAMP1 gene and identification of mutations in leishmaniasis-susceptible dogs.
Altet L, Francino O, Solano-Gallego L, Renier C, S?nchez A
Infection and immunity70(6)2763-71(2002 Jun)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The base sequence of Nramp1 and its expression in dogs that were susceptible or resistant to visceral leishmaniasis was found to be identical, and expression did not differ.
Title: cDNA sequencing and expression of Nramp1 (Slc11a1) in dogs phenotypically resistant or susceptible to visceral leishmaniasis.

These results corroborate that Slc11a1 polymorphisms are associated with increased risk for canine visceral leishmaniasis.
Title: Slc11a1 (formerly Nramp1) and susceptibility to canine visceral leishmaniasis.

The special genotype distribution for the Slc11a1 polymorphism associated with the prevalence of the illness in the boxer breed emphasizes the potential importance that breed genetic background has in canine leishmaniasis susceptibility.
Title: Polymorphism of Slc11a1 (Nramp1) gene and canine leishmaniasis in a case-control study.

The following SLC11A1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the SLC11A1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OCe00068	NM_001013851.1 Latest version!	Canis lupus familiaris solute carrier family 11 member 1 (SLC11A1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$342.30 $489.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

SLC11A1 ( NM_001013851.1 ) cDNA ORF clone, Canis lupus familiaris(dog) -> NP_001013873.1 Canis lupus familiaris solute carrier family 11 member 1 (SLC11A1), mRNA.

Price & Availability↑

CloneID	OCe00068
Clone ID Related Accession (Same CDS sequence)	NM_001013851.1
Accession Version	NM_001013851.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1644bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-25
Organism	Canis lupus familiaris(dog)
Product	natural resistance-associated macrophage protein 1
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AF091049.2. On Apr 1, 2005 this sequence version replaced XM_536068.1. ##Evidence-Data-START## Transcript exon combination :: DQ784645.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA103936001, SAMEA103936002 [ECO:0000350] ##Evidence-Data-END##

ATGACAGGTG ACAAGGACCC CCAAAGTGTA AGCAGGCCCA ACTATGGCTC CATCTCCCAC 
CCACCCAGCT CAGAGCCACA GCAAGAACCT CTCAGAACAA CCTACCTGAG TGAGAAGATC 
CCCATCCCGG ACACAGAACC GGGCACATTC AGCCTGAGGA AGCTGTGGGC CTTCACCGGG 
CCTGGCTTCC TCATGAGCAT CGCTTTCCTG GACCCAGGAA ACATCGAGTC AGATCTTCAG 
GCTGGCGCCG TGGCTGGATT CAAACTGCTC TGGGTGCTGC TATGGGCCAC GGTGCTGGGC 
TTGCTCTGCC AGCGCCTGGC TGCCCGGCTG GGTGTGGTGA CAGGCAAGGA CTTGGGCGAG 
ATCTGTCATC TCTACTACCC TAAGGTGCCC CGCACCCTCC TCTGGCTGAC CATCGAGCTA 
GCCATCGTGG GCTCGGACAT GCAGGAGGTC ATCGGCACGG CCATCGCGTT CAGCCTGCTG 
TCAGCCGGCC GAATCCCACT CTGGGGTGGC GTCCTCATCA CCATCGTGGA CACCTTCTTC 
TTCCTCTTCC TTGACAACTA CGGGTTGCGG AAGCTGGAAG CCTTTTTCGG AATCCTTATT 
ACAATTATGG CCTTGACCTT CGGCTACGAG TACGTGGTGG CACGTCCCGC CCAGGTAGCG 
CTTCTCCAGG GCCTGCTCCT GCCCTCGTGC CCCGGCTGCG GCCGGCCGGA GCTGCTGCAG 
GCCGTGGGCA TCGTCGGCGC CATCATCATG CCCCACAACA TCTACCTGCA CTCGGCCCTG 
GTCAAGTCTC GAGAGATAGA CCGGTCCCGC CGGCCGGACA TCCGAGAAGC CAACATGTAC 
TTCCTGATTG AGGCCAGCAT CGCCCTGTCT GTCTCCTTCT TCATCAATCT CTTTGTTGTA 
GCGGTGTTCG GGCAGGCCTT CTACCAGCAA ACCAACGAGG CTGCGTTCAA CGTCTGCGCC 
AACAGCAGCC TCCACGACTA CGCCAAGATC TTCCCCAGGA ACAACCTTAC GGTGGAGGTG 
GACATCTACC AGGGAGGCGT GATGCTGGGC TGCGTCTTCG GGCCCGCGGC GCTCTACATC 
TGGGCCGTGG GCCTCCTGGC GGCGGGACAG AGCTCCACCA TGACCGGCAC CTACGCGGGA 
CAGTTTGTGA TGGAGGGCTT CCTGCGGCTG CGGTGGTCAC GCTTCGCGCG GGTGCTCCTC 
ACTCGCTCCT GCGCCATCCT GCCCACCGTG CTCGTGGTAG TCTTCAGGGA CCTGAAAGAC 
CTGTCAGGTC TCAACGACCT GCTCAACGTG CTGCAGAGCC TGCTGCTTCC CTTTGCGGTG 
CTGCCTATCC TTACGTTCAC CAGCATGCCA GCCCTCATGC AGGAGTTTGC CAATGGCCGG 
CTGAGCAAGG CCATCACATC CTTCATCATG GCCCTGGTCT GTGCCATCAA CCTCTACTTC 
GTGGTCATCT ACCTGCCCAG CCTCCCACAC CCTGCCTACT TCATCCTCGT AGCCCTTCTG 
GCTATAGTCT ACCTGGGCCT CACCACCTAT CTGGTCTGGA CCTGTTTCAT TGCCCATGGA 
GTCACCCTTC TGGCCCACAG CTCCCATCAA CACTTCCTGT ATGGGCTCCC TGATGTGGAG 
GAGAAAGGGA AGATCTCTGG GTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001013873.1
CDS	1..1644
Translation	MTGDKDPQSVSRPNYGSISHPPSSEPQQEPLRTTYLSEKIPIPDTEPGTFSLRKLWAFTGPGFLMSIAFLDPGNIESDLQAGAVAGFKLLWVLLWATVLGLLCQRLAARLGVVTGKDLGEICHLYYPKVPRTLLWLTIELAIVGSDMQEVIGTAIAFSLLSAGRIPLWGGVLITIVDTFFFLFLDNYGLRKLEAFFGILITIMALTFGYEYVVARPAQVALLQGLLLPSCPGCGRPELLQAVGIVGAIIMPHNIYLHSALVKSREIDRSRRPDIREANMYFLIEASIALSVSFFINLFVVAVFGQAFYQQTNEAAFNVCANSSLHDYAKIFPRNNLTVEVDIYQGGVMLGCVFGPAALYIWAVGLLAAGQSSTMTGTYAGQFVMEGFLRLRWSRFARVLLTRSCAILPTVLVVVFRDLKDLSGLNDLLNVLQSLLLPFAVLPILTFTSMPALMQEFANGRLSKAITSFIMALVCAINLYFVVIYLPSLPHPAYFILVALLAIVYLGLTTYLVWTCFIAHGVTLLAHSSHQHFLYGLPDVEEKGKISG

Target ORF information:

RefSeq Version	NM_001013851.1
Organism	Canis lupus familiaris(dog)
Definition	Canis lupus familiaris solute carrier family 11 member 1 (SLC11A1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001013851.1

ORF Insert Sequence:

ATGACAGGTG ACAAGGACCC CCAAAGTGTA AGCAGGCCCA ACTATGGCTC CATCTCCCAC 
CCACCCAGCT CAGAGCCACA GCAAGAACCT CTCAGAACAA CCTACCTGAG TGAGAAGATC 
CCCATCCCGG ACACAGAACC GGGCACATTC AGCCTGAGGA AGCTGTGGGC CTTCACCGGG 
CCTGGCTTCC TCATGAGCAT CGCTTTCCTG GACCCAGGAA ACATCGAGTC AGATCTTCAG 
GCTGGCGCCG TGGCTGGATT CAAACTGCTC TGGGTGCTGC TATGGGCCAC GGTGCTGGGC 
TTGCTCTGCC AGCGCCTGGC TGCCCGGCTG GGTGTGGTGA CAGGCAAGGA CTTGGGCGAG 
ATCTGTCATC TCTACTACCC TAAGGTGCCC CGCACCCTCC TCTGGCTGAC CATCGAGCTA 
GCCATCGTGG GCTCGGACAT GCAGGAGGTC ATCGGCACGG CCATCGCGTT CAGCCTGCTG 
TCAGCCGGCC GAATCCCACT CTGGGGTGGC GTCCTCATCA CCATCGTGGA CACCTTCTTC 
TTCCTCTTCC TTGACAACTA CGGGTTGCGG AAGCTGGAAG CCTTTTTCGG AATCCTTATT 
ACAATTATGG CCTTGACCTT CGGCTACGAG TACGTGGTGG CACGTCCCGC CCAGGTAGCG 
CTTCTCCAGG GCCTGCTCCT GCCCTCGTGC CCCGGCTGCG GCCGGCCGGA GCTGCTGCAG 
GCCGTGGGCA TCGTCGGCGC CATCATCATG CCCCACAACA TCTACCTGCA CTCGGCCCTG 
GTCAAGTCTC GAGAGATAGA CCGGTCCCGC CGGCCGGACA TCCGAGAAGC CAACATGTAC 
TTCCTGATTG AGGCCAGCAT CGCCCTGTCT GTCTCCTTCT TCATCAATCT CTTTGTTGTA 
GCGGTGTTCG GGCAGGCCTT CTACCAGCAA ACCAACGAGG CTGCGTTCAA CGTCTGCGCC 
AACAGCAGCC TCCACGACTA CGCCAAGATC TTCCCCAGGA ACAACCTTAC GGTGGAGGTG 
GACATCTACC AGGGAGGCGT GATGCTGGGC TGCGTCTTCG GGCCCGCGGC GCTCTACATC 
TGGGCCGTGG GCCTCCTGGC GGCGGGACAG AGCTCCACCA TGACCGGCAC CTACGCGGGA 
CAGTTTGTGA TGGAGGGCTT CCTGCGGCTG CGGTGGTCAC GCTTCGCGCG GGTGCTCCTC 
ACTCGCTCCT GCGCCATCCT GCCCACCGTG CTCGTGGTAG TCTTCAGGGA CCTGAAAGAC 
CTGTCAGGTC TCAACGACCT GCTCAACGTG CTGCAGAGCC TGCTGCTTCC CTTTGCGGTG 
CTGCCTATCC TTACGTTCAC CAGCATGCCA GCCCTCATGC AGGAGTTTGC CAATGGCCGG 
CTGAGCAAGG CCATCACATC CTTCATCATG GCCCTGGTCT GTGCCATCAA CCTCTACTTC 
GTGGTCATCT ACCTGCCCAG CCTCCCACAC CCTGCCTACT TCATCCTCGT AGCCCTTCTG 
GCTATAGTCT ACCTGGGCCT CACCACCTAT CTGGTCTGGA CCTGTTTCAT TGCCCATGGA 
GTCACCCTTC TGGCCCACAG CTCCCATCAA CACTTCCTGT ATGGGCTCCC TGATGTGGAG 
GAGAAAGGGA AGATCTCTGG GTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

cDNA sequencing and expression of Nramp1 (Slc11a1) in dogs phenotypically resistant or susceptible to visceral leishmaniasis.
Veterinary immunology and immunopathology127(3-4)332-9(2009 Feb)
Bueno R,Carvalho Neta AV,Xavier MN,Oliveira RG,Diniz SA,Melo MN,Santos RL

Slc11a1 (formerly Nramp1) and susceptibility to canine visceral leishmaniasis.
Veterinary research39(3)36(2008 May-Jun)
Sanchez-Robert E,Altet L,Utzet-Sadurni M,Giger U,Sanchez A,Francino O

Polymorphism of Slc11a1 (Nramp1) gene and canine leishmaniasis in a case-control study.
The Journal of heredity96(7)755-8(2005)
Sanchez-Robert E,Altet L,Sanchez A,Francino O

Mapping and sequencing of the canine NRAMP1 gene and identification of mutations in leishmaniasis-susceptible dogs.
Infection and immunity70(6)2763-71(2002 Jun)
Altet L,Francino O,Solano-Gallego L,Renier C,S?nchez A

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SLC11A1 cDNA ORF clone, Canis lupus familiaris(dog)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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