Gene Symbol | HLA-DRB1 |
Entrez Gene ID | 474860 |
Full Name | MHC class II DLA DRB1 beta chain |
Synonyms | DLA-DRB1,DLA-DRBB1,DRB,DRB1,DRBB1,LA-DRB |
Gene Type | protein-coding |
Organism | Canis lupus familiaris(dog) |
ORF » Species Summary » Canis lupus familiaris » HLA-DRB1 cDNA ORF clone
Gene Symbol | HLA-DRB1 |
Entrez Gene ID | 474860 |
Full Name | MHC class II DLA DRB1 beta chain |
Synonyms | DLA-DRB1,DLA-DRBB1,DRB,DRB1,DRBB1,LA-DRB |
Gene Type | protein-coding |
Organism | Canis lupus familiaris(dog) |
mRNA | Protein | Name |
---|---|---|
NM_001014768.1 | NP_001014768.1 | DLA class II histocompatibility antigen, DR-1 beta chain precursor |
Canis lupus familiaris (dog) | HLA-DRB1 | NP_001014768.1 |
Homo sapiens (human) | HLA-DRB5 | NP_002116.2 |
Pan troglodytes (chimpanzee) | PATR-DRB5 | XP_001165809.3 |
MAMU-DRB1 | NP_001037726.1 | |
Bos taurus (cattle) | LOC101903005 | XP_005201033.1 |
Mus musculus (house mouse) | H2-Eb1 | NP_034512.2 |
Rattus norvegicus (Norway rat) | RT1-Db1 | NP_001008884.1 |
Associations between gastric dilatation-volvulus in Great Danes and specific alleles of the canine immune-system genes DLA88, DRB1, and TLR5.
Harkey MA, Villagran AM, Venkataraman GM, Leisenring WM, Hullar MAJ, Torok-Storb BJ
American journal of veterinary research78(8)934-945(2017 Aug)
Molecular mechanism and cellular function of MHCII ubiquitination.
Oh J, Shin JS
Immunological reviews266(1)134-44(2015 Jul)
A study of the association between chronic superficial keratitis and polymorphisms in the upstream regulatory regions of DLA-DRB1, DLA-DQB1 and DLA-DQA1.
Barrientos LS, Zapata G, Crespi JA, Posik DM, D?az S, It V, Peral-Garc?a P, Giovambattista G
Veterinary immunology and immunopathology156(3-4)205-10(2013 Dec)
MHC class II risk haplotype associated with canine chronic superficial keratitis in German Shepherd dogs.
Jokinen P, Rusanen EM, Kennedy LJ, Lohi H
Veterinary immunology and immunopathology140(1-2)37-41(2011 Mar)
Evaluation of the class II region of the major histocompatibility complex of the greyhound with the genomic matching technique and sequence-based typing.
Fliegner RA, Holloway SA, Lester S, McLure CA, Dawkins RL
Tissue antigens72(2)131-6(2008 Aug)
GeneRIFs: Gene References Into Functions What's a GeneRIF?
associated with gastric dilatation-volvulus in Great Danes
Title: Associations between gastric dilatation-volvulus in Great Danes and specific alleles of the canine immune-system genes DLA88, DRB1, and TLR5.
dogs homozygous at DRB1*69 [C/T] had a risk for developing Canine chronic superficial keratitis disease that was over four times the risk for heterozygotes.
Title: A study of the association between chronic superficial keratitis and polymorphisms in the upstream regulatory regions of DLA-DRB1, DLA-DQB1 and DLA-DQA1.
The haplotype DLADRB1* 01501/DQA1*00601/DQB1*00301 was significantly associated with chronic superficial keratitis (CSK) in German Shepherd dogs, and homozygosity of MHC class II increased risk for CSK.
Title: MHC class II risk haplotype associated with canine chronic superficial keratitis in German Shepherd dogs.
Two new DLA-DRB1 alleles were identified.
Title: Evaluation of the class II region of the major histocompatibility complex of the greyhound with the genomic matching technique and sequence-based typing.
data do not provide evidence for involvement of DLA-DRB1 in degenerative myelopathy
Title: Alleles of DLA-DRB1 are not unique in German Shepherd dogs having degenerative myelopathy.
The following HLA-DRB1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the HLA-DRB1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
CloneID | OCe00139 | |
Clone ID Related Accession (Same CDS sequence) | NM_001014768.1 | |
Accession Version | NM_001014768.1 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 801bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-09-21 | |
Organism | Canis lupus familiaris(dog) | |
Product | DLA class II histocompatibility antigen, DR-1 beta chain precursor | |
Comment | Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from M29611.1. On Apr 8, 2005 this sequence version replaced XM_532095.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: M29611.1, HO774920.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA4547746 [ECO:0000348] ##Evidence-Data-END## |
1 | ATGGTGTGTC TGTGTTTTCT TGGAGGCTCC TGGATGACAG CTCTGATGCT GATACTGATG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_001014768.1 |
CDS | 40..840 |
Translation |
Target ORF information:
Target ORF information:
|
NM_001014768.1 |
1 | ATGGTGTGTC TGTGTTTTCT TGGAGGCTCC TGGATGACAG CTCTGATGCT GATACTGATG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
Associations between gastric dilatation-volvulus in Great Danes and specific alleles of the canine immune-system genes DLA88, DRB1, and TLR5. |
Molecular mechanism and cellular function of MHCII ubiquitination. |
A study of the association between chronic superficial keratitis and polymorphisms in the upstream regulatory regions of DLA-DRB1, DLA-DQB1 and DLA-DQA1. |
MHC class II risk haplotype associated with canine chronic superficial keratitis in German Shepherd dogs. |
Evaluation of the class II region of the major histocompatibility complex of the greyhound with the genomic matching technique and sequence-based typing. |