CYP3A26 cDNA ORF clone, Canis lupus familiaris(dog)

Gene
Clones
gRNAs

Summary

Gene Symbol	CYP3A26
Entrez Gene ID	415127
Full Name	cytochrome P450 3A26
Gene Type	protein-coding
Organism	Canis lupus familiaris(dog)

mRNA and Protein(s)

mRNA	Protein	Name
NM_001003338.1	NP_001003338.1	cytochrome P450 3A26

Pathways from BioSystems

Homologies

Canis lupus familiaris (dog)	CYP3A26	NP_001003338.1
Canis lupus familiaris (dog)	LOC489851	XP_546969.2
Gallus gallus (chicken)	CYP3A4	XP_414782.2
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP012296	XP_551896.3
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP012292	XP_001238280.1
Caenorhabditis elegans (roundworm)	cyp-25A2	NP_497776.2
Bos taurus (cattle)	CYP3A5	NP_001069356.1
Drosophila melanogaster (fruit fly)	Cyp9f2	NP_650189.1
Xenopus tropicalis (tropical clawed frog)	LOC100487846	XP_002937898.2
Homo sapiens (human)	CYP3A4	NP_059488.2
	CYP3A4	NP_001035504.1
Canis lupus familiaris (dog)	CYP3A4	XP_536868.2
Anopheles gambiae (African malaria mosquito)	CYP9L1	XP_320243.1
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP000818	XP_316781.2
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP012850	XP_561320.5
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP012293	XP_001689238.1
Caenorhabditis elegans (roundworm)	cyp-25A3	NP_001040850.1
Caenorhabditis elegans (roundworm)	cyp-25A4	NP_497779.1
Caenorhabditis elegans (roundworm)	cyp-25A6	NP_500512.1
Xenopus tropicalis (tropical clawed frog)	LOC100487054	XP_002937893.2
Canis lupus familiaris (dog)	CYP3A12	NP_001003340.1
Caenorhabditis elegans (roundworm)	cyp-25A1	NP_497775.3
Magnaporthe oryzae (rice blast fungus)	MGG_04911	XP_003712400.1
Pan troglodytes (chimpanzee)	CYP3A4	NP_001116247.1
Bos taurus (cattle)	CYP3A4	NP_001092837.1
Rattus norvegicus (Norway rat)	Cyp3a2	NP_695224.2
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP012294	XP_001238278.2
Caenorhabditis elegans (roundworm)	cyp-25A5	NP_500322.1

Gene Ontology
Bibliography

Related articles in PubMed

Differential expression of CYP3A12 and CYP3A26 mRNAs in canine liver and intestine.
Mealey KL, Jabbes M, Spencer E, Akey JM
Xenobiotica; the fate of foreign compounds in biological systems38(10)1305-12(2008 Oct)

Importance of amino acid residue 474 for substrate specificity of canine and human cytochrome p450 3A enzymes.
He YQ, Roussel F, Halpert JR
Archives of biochemistry and biophysics389(2)264-70(2001 May)

Use of chimeric enzymes and site-directed mutagenesis for identification of three key residues responsible for differences in steroid hydroxylation between canine cytochromes P-450 3A12 and 3A26.
Fraser DJ, He YQ, Harlow GR, Halpert JR
Molecular pharmacology55(2)241-7(1999 Feb)

Isolation, heterologous expression and functional characterization of a novel cytochrome P450 3A enzyme from a canine liver cDNA library.
Fraser DJ, Feyereisen R, Harlow GR, Halpert JR
The Journal of pharmacology and experimental therapeutics283(3)1425-32(1997 Dec)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

In summary, these results represent an important step toward the systematic comparison of human and canine CYP3A enzymes, particularly in relation to oral bioavailability of substrate drugs.
Title: Differential expression of CYP3A12 and CYP3A26 mRNAs in canine liver and intestine.

The following CYP3A26 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the CYP3A26 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OCe34104	NM_001003338.1 Latest version!	Canis lupus familiaris cytochrome P450 3A26 (CYP3A26), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$342.30 $489.00

ORF Online Only Promotion

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

CYP3A26 ( NM_001003338.1 ) cDNA ORF clone, Canis lupus familiaris(dog) -> NP_001003338.1 Canis lupus familiaris cytochrome P450 3A26 (CYP3A26), mRNA.

Price & Availability↑

CloneID	OCe34104
Clone ID Related Accession (Same CDS sequence)	NM_001003338.1
Accession Version	NM_001003338.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1512bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-10-21
Organism	Canis lupus familiaris(dog)
Product	cytochrome P450 3A26
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AF547269.1. ##Evidence-Data-START## Transcript exon combination :: AF547269.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA4547745, SAMN00013515 [ECO:0000348] ##Evidence-Data-END##

ATGGACTTGA TCCCAAGCTT TTCCACAGAA ACCTGGCTTC TTCTGGCTAT CAGCCTGGTG 
CTCCTCTATC TGTATGGGAC CTACACACAT GGGATTTTTA GGAAGCTGGG AATTCCTGGG 
CCAACACCTC TGCCTTTTGT GGGAACTGCT CTGGGCTACC GTAATGGTTT TTATGTTTTT 
GACATGAAAT GTTTTAGTAA GTATGGAAGA ATGTGGGGGT TTTATGATGG GCGACAGCCT 
GTGCTGGCTA TCACAGATCC GGACATGATC AAAACAGTAC TAGTGAAAGA ATGTTATTCT 
GTCTTCACAA ACCGGCGGAC TCTTGGTCCA GTGGGATTTA TGAAAAGTGC GATCTCTCTG 
TCTGAGGATG AAGAGTGGAA GAGAATACGA ACTTTGCTGT CTCCAACCTT CACCACTGGA 
AAGCTCAAGG AGATGTTCCC CATCATTGGC CAGTATGGAG ATGTGTTGGT GAACAACCTG 
AGGAAGGAGG CAGAGAAAGG CAAGGCCATC AACTTGAAAG ATGTCTTTGG AGCCTACAGC 
ATGGATGTGA TTACCAGCAT ATCGTTTGGA GTGAACATTG ATTCCCTCAA CCACCCACAA 
GATCCGTTTG TGGAAAATAC CAAGAATCTC TTAAAATTTG ATTTCCTTGA CCCATTTTTA 
TTCTCCATAT TACTGTTTCC ATTCCTTACT CCGGTTTTTG AAATATTAAA TATCTGGCTA 
TTTCCAAAGA AAGTTACTGA TTTTTTCAGA AAATCTGTAG AGAGAATGAA GGAAAGTCGC 
CTAAAAGATA AACAAAAGCA CCGAGTGGAC TTTCTTCAGC TGATGATTAA CTCCCAGAAT 
TCCAAAGAAA TGGACACTCA TAAAGCTCTA TCTGATTTGG AGCTGGTGGC CCAATCTATT 
GTCTTTATTT TTGCTGGCTA TGAGACCACT AGCAGTTGTC TTTCCTTTCT TATGTATGAA 
TTGGCCACTC ACCGTGATGT CCAGCAGAAA CTGCAGGAGG AGATTGATGC GACTTTCCCC 
AATAAGGCAG CACCCACTTA TGAGGCCCTT GTACAGATGG AGTATCTGGA CATGGTATTG 
AATGAAACTC TCCGATTATA CTCAGTCGCT GGTAGACTTG AGAGGGTCTG TAAGAAAGAT 
GTGGAAATCA GTGGTGTGTT CATTCCCAAA GGGACAGTGG TGATGGTGCC AACCTTTATT 
CTTCATCGAG ACCAGAATCT CTGGCCAGAG CCTGAGGAAT TCCGACCTGA AAGGTTCAGT 
AGGAAGAACA AGGACAGCAT AAATCCTTAT ACATACCTGC CTTTTGGAAC TGGACCCCGA 
AACTGCATTG GAATGAGGTT TGCAATCATG AACATGAAAC TTGCCCTTGT CAGGGTCCTG 
CAGAACTTCT CCTTCAAATC TTGTAAAGAA ACACAGATCT CCCTGAGAAT AAATACTCGA 
GGGATTATTC AACCTGAAAA ACCCGTTGTT CTCAAGGTTG AGCCAAGAGA TGGGAGTGTA 
AGTGGAGCCT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001003338.1
CDS	82..1593
Translation	MDLIPSFSTETWLLLAISLVLLYLYGTYTHGIFRKLGIPGPTPLPFVGTALGYRNGFYVFDMKCFSKYGRMWGFYDGRQPVLAITDPDMIKTVLVKECYSVFTNRRTLGPVGFMKSAISLSEDEEWKRIRTLLSPTFTTGKLKEMFPIIGQYGDVLVNNLRKEAEKGKAINLKDVFGAYSMDVITSISFGVNIDSLNHPQDPFVENTKNLLKFDFLDPFLFSILLFPFLTPVFEILNIWLFPKKVTDFFRKSVERMKESRLKDKQKHRVDFLQLMINSQNSKEMDTHKALSDLELVAQSIVFIFAGYETTSSCLSFLMYELATHRDVQQKLQEEIDATFPNKAAPTYEALVQMEYLDMVLNETLRLYSVAGRLERVCKKDVEISGVFIPKGTVVMVPTFILHRDQNLWPEPEEFRPERFSRKNKDSINPYTYLPFGTGPRNCIGMRFAIMNMKLALVRVLQNFSFKSCKETQISLRINTRGIIQPEKPVVLKVEPRDGSVSGA

Target ORF information:

RefSeq Version	NM_001003338.1
Organism	Canis lupus familiaris(dog)
Definition	Canis lupus familiaris cytochrome P450 3A26 (CYP3A26), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001003338.1

ORF Insert Sequence:

ATGGACTTGA TCCCAAGCTT TTCCACAGAA ACCTGGCTTC TTCTGGCTAT CAGCCTGGTG 
CTCCTCTATC TGTATGGGAC CTACACACAT GGGATTTTTA GGAAGCTGGG AATTCCTGGG 
CCAACACCTC TGCCTTTTGT GGGAACTGCT CTGGGCTACC GTAATGGTTT TTATGTTTTT 
GACATGAAAT GTTTTAGTAA GTATGGAAGA ATGTGGGGGT TTTATGATGG GCGACAGCCT 
GTGCTGGCTA TCACAGATCC GGACATGATC AAAACAGTAC TAGTGAAAGA ATGTTATTCT 
GTCTTCACAA ACCGGCGGAC TCTTGGTCCA GTGGGATTTA TGAAAAGTGC GATCTCTCTG 
TCTGAGGATG AAGAGTGGAA GAGAATACGA ACTTTGCTGT CTCCAACCTT CACCACTGGA 
AAGCTCAAGG AGATGTTCCC CATCATTGGC CAGTATGGAG ATGTGTTGGT GAACAACCTG 
AGGAAGGAGG CAGAGAAAGG CAAGGCCATC AACTTGAAAG ATGTCTTTGG AGCCTACAGC 
ATGGATGTGA TTACCAGCAT ATCGTTTGGA GTGAACATTG ATTCCCTCAA CCACCCACAA 
GATCCGTTTG TGGAAAATAC CAAGAATCTC TTAAAATTTG ATTTCCTTGA CCCATTTTTA 
TTCTCCATAT TACTGTTTCC ATTCCTTACT CCGGTTTTTG AAATATTAAA TATCTGGCTA 
TTTCCAAAGA AAGTTACTGA TTTTTTCAGA AAATCTGTAG AGAGAATGAA GGAAAGTCGC 
CTAAAAGATA AACAAAAGCA CCGAGTGGAC TTTCTTCAGC TGATGATTAA CTCCCAGAAT 
TCCAAAGAAA TGGACACTCA TAAAGCTCTA TCTGATTTGG AGCTGGTGGC CCAATCTATT 
GTCTTTATTT TTGCTGGCTA TGAGACCACT AGCAGTTGTC TTTCCTTTCT TATGTATGAA 
TTGGCCACTC ACCGTGATGT CCAGCAGAAA CTGCAGGAGG AGATTGATGC GACTTTCCCC 
AATAAGGCAG CACCCACTTA TGAGGCCCTT GTACAGATGG AGTATCTGGA CATGGTATTG 
AATGAAACTC TCCGATTATA CTCAGTCGCT GGTAGACTTG AGAGGGTCTG TAAGAAAGAT 
GTGGAAATCA GTGGTGTGTT CATTCCCAAA GGGACAGTGG TGATGGTGCC AACCTTTATT 
CTTCATCGAG ACCAGAATCT CTGGCCAGAG CCTGAGGAAT TCCGACCTGA AAGGTTCAGT 
AGGAAGAACA AGGACAGCAT AAATCCTTAT ACATACCTGC CTTTTGGAAC TGGACCCCGA 
AACTGCATTG GAATGAGGTT TGCAATCATG AACATGAAAC TTGCCCTTGT CAGGGTCCTG 
CAGAACTTCT CCTTCAAATC TTGTAAAGAA ACACAGATCT CCCTGAGAAT AAATACTCGA 
GGGATTATTC AACCTGAAAA ACCCGTTGTT CTCAAGGTTG AGCCAAGAGA TGGGAGTGTA 
AGTGGAGCCT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Differential expression of CYP3A12 and CYP3A26 mRNAs in canine liver and intestine.
Xenobiotica; the fate of foreign compounds in biological systems38(10)1305-12(2008 Oct)
Mealey KL,Jabbes M,Spencer E,Akey JM

Importance of amino acid residue 474 for substrate specificity of canine and human cytochrome p450 3A enzymes.
Archives of biochemistry and biophysics389(2)264-70(2001 May)
He YQ,Roussel F,Halpert JR

Use of chimeric enzymes and site-directed mutagenesis for identification of three key residues responsible for differences in steroid hydroxylation between canine cytochromes P-450 3A12 and 3A26.
Molecular pharmacology55(2)241-7(1999 Feb)
Fraser DJ,He YQ,Harlow GR,Halpert JR

Isolation, heterologous expression and functional characterization of a novel cytochrome P450 3A enzyme from a canine liver cDNA library.
The Journal of pharmacology and experimental therapeutics283(3)1425-32(1997 Dec)
Fraser DJ,Feyereisen R,Harlow GR,Halpert JR

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CYP3A26 cDNA ORF clone, Canis lupus familiaris(dog)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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オンラインフォーム

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