CYP2C18 cDNA ORF clone, Canis lupus familiaris(dog)

Gene
Clones
gRNAs

Summary

Gene Symbol	CYP2C18
Entrez Gene ID	415122
Full Name	cytochrome P450 2C21
Synonyms	CYP2C19,CYP2C21,CYPIIC21
Gene Type	protein-coding
Organism	Canis lupus familiaris(dog)

mRNA and Protein(s)

mRNA	Protein	Name
NM_001197044.1	NP_001183973.1	cytochrome P450 2C21

Pathways from BioSystems

Homologies

	CYP2C75	NP_001035301.1
Bos taurus (cattle)	LOC522146	XP_002698447.1
Bos taurus (cattle)	LOC785540	XP_005225701.1
Homo sapiens (human)	CYP2C19	NP_000760.1
Pan troglodytes (chimpanzee)	LOC740956	XP_001152464.1
Bos taurus (cattle)	CYP2C19	NP_001103262.1
Rattus norvegicus (Norway rat)	Cyp2c6v1	NP_001013926.1
Canis lupus familiaris (dog)	CYP2C18	NP_001183973.1

Gene Ontology
Bibliography

Related articles in PubMed

A non-acidic sulfaphenazole analog demonstrating high intrinsic clearance and selectivity by canine CYP2C21.
Locuson CW, Alfaro JF, Zaya MJ, Billen D, White JA, Jones JP
Drug metabolism letters5(4)253-8(2011 Dec)

Genetic variants in ABCB1 and CYP2C19 and cardiovascular outcomes after treatment with clopidogrel and prasugrel in the TRITON-TIMI 38 trial: a pharmacogenetic analysis.
Mega JL, Close SL, Wiviott SD, Shen L, Walker JR, Simon T, Antman EM, Braunwald E, Sabatine MS
Lancet (London, England)376(9749)1312-9(2010 Oct)

Substrate specificity and kinetic properties of seven heterologously expressed dog cytochromes p450.
Shou M, Norcross R, Sandig G, Lu P, Li Y, Lin Y, Mei Q, Rodrigues AD, Rushmore TH
Drug metabolism and disposition: the biological fate of chemicals31(9)1161-9(2003 Sep)

Isolation of a new canine cytochrome P450 CDNA from the cytochrome P450 2C subfamily (CYP2C41) and evidence for polymorphic differences in its expression.
Blaisdell J, Goldstein JA, Bai SA
Drug metabolism and disposition: the biological fate of chemicals26(3)278-83(1998 Mar)

Isolation of cDNAs coding for three different forms of liver microsomal cytochrome P-450 from polychlorinated biphenyl-treated beagle dogs.
Uchida T, Komori M, Kitada M, Kamataki T
Molecular pharmacology38(5)644-51(1990 Nov)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Report a non-acidic sulfaphenazole analog demonstrating high intrinsic clearance and selectivity by canine CYP2C21.
Title: A non-acidic sulfaphenazole analog demonstrating high intrinsic clearance and selectivity by canine CYP2C21.

In acute coronary syndromes who have percutaneous intervention, when both ABCB1 and CYP2C19 are taken into account this genotype associated with increased risk of major adverse cardiovascular events while on standard doses of clopidogrel.
Title: Genetic variants in ABCB1 and CYP2C19 and cardiovascular outcomes after treatment with clopidogrel and prasugrel in the TRITON-TIMI 38 trial: a pharmacogenetic analysis.

The following CYP2C18 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the CYP2C18 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OCe00408	NM_001197044.1 Latest version!	Canis lupus familiaris cytochrome P450 2C21 (CYP2C18), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$258.30 $369.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

CYP2C18 ( NM_001197044.1 ) cDNA ORF clone, Canis lupus familiaris(dog) -> NP_001183973.1 Canis lupus familiaris cytochrome P450 2C21 (CYP2C18), mRNA.

Price & Availability↑

CloneID	OCe00408
Clone ID Related Accession (Same CDS sequence)	NM_001197044.1
Accession Version	NM_001197044.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1473bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-24
Organism	Canis lupus familiaris(dog)
Product	cytochrome P450 2C21
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AAEX03015430.1. On or before Oct 3, 2010 this sequence version replaced XM_854406.1, XM_854444.1, XM_534973.2. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. ##Evidence-Data-START## Transcript exon combination :: AF049909.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00013515, SAMN07419817 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGATCTCT TCATAGTTCT GGTGATATGT CTTTCTTGTT TGATTTCTTT CTTTCTGTGG 
AATCAAAATC GTGCCAAAGG GAAGCTGCCA CCTGGCCCCA CTCCTCTCCC AATCATTGGA 
AATATTCTAC AGATAAATAC TAAGAATGTC AGCAAATCCC TAAGCAAGCT AGCAGAGAAT 
TATGGCCCTG TGTTCACTGT GTATTTTGGC ATGAAGCCTA CCGTGGTGTT GTACGGGTAT 
GAAGCGGTGA AGGAAGCTCT AATTGATCGG AGTGAAGAGT TTTCAGGCAG AGGCCATTTC 
CCATTGTTGG ACTGGACCAT ACAGGGATTA GGAATTGTTT TCAGCAACGG AGAAAAATGG 
AAGCAAACCC GGCGTTTTTC CCTGACAGTT TTGCGGAATA TGGGGATGGG AAAGAAGACT 
GTTGAAGACA GAATTCAAGA AGAGGCCTTG TATCTAGTGG AAGCATTAAA AAAAACCAAC 
GCATCTCCCT GTGATCCTAC TTTCCTTCTG GGCTGTGCTC CCTGCAATGT GATTTGCTCC 
ATTATTTTCC AGAATCGTTT TGAGTATGAT GATAAAGATT TTTTAACCTT GTTAGAGTAT 
TTTCATGAAA ACCTTCTAAT TTCAAGCACC TCCTGGATAC AGCTCTACAA TGCTTTCCCT 
CTTTTAATAC ATTACCTTCC AGGAAGTCAT CATGTGTTAT TTAAAAACAT TGCTAACCAA 
TTTAAGTTTA TTTCGGAAAA AATAAAAGAA CACGAAGAAT CTCTAAACTT TAGTAACCCT 
CGGGACTTTA TTGACTACTT CCTGATCAAA ATAGAAAAGG AAAAACACAA CAAACAGTCT 
GAATTTACCA TGGACAACTT GATCATTACC ATATGGGATG TGTTTAGTGC GGGAACAGAG 
ACAACGAGCA CCACCCTGAG ATACGGACTA TTGGTGCTAT TAAAGCACCC AGATGTCACA 
GCTAAAGTCC AGGAAGAGAT TCATCGTGTA GTTGGCAGAC ATCGGAGCCC CTGCATGCAA 
GATAGGAGCT GCATGCCCTA CACAGATGCT GTGGTACATG AGATCCAGAG ATACATTGAT 
CTTGTCCCCA ACAATCTGCC CCATTCAGTG ACTCAGGACA TCAAGTTTAG AGAATACCTT 
ATTCCCAAGG GCACAACCAT ATTAACATCT CTGACTTCTG TCCTGCATGA TGAGAAAGGA 
TTCCCCAACC CAGATCAGTT TGATCCTGGC CACTTCCTGG ATGAAAATGG CAGCTTTAAG 
AAGAGTGACT ACTTCATGGC CTTCTCAGCA GGGAAGAGAG TTTGTGTTGG AGAAGGCCTG 
GCCCGCATGG AGCTGTTTTT GCTACTGACC AATATTTTAC AGCATTTCAC CTTGAAACCT 
CTGGTTGATC CAAAGGACAT TGACACCACC CCAATTGCCA ATGGGTTGGG TGCTACACCA 
CCTTCCTATA AGCTCTGTTT TGTTCCAGTC TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001183973.1
CDS	12..1484
Translation	MDLFIVLVICLSCLISFFLWNQNRAKGKLPPGPTPLPIIGNILQINTKNVSKSLSKLAENYGPVFTVYFGMKPTVVLYGYEAVKEALIDRSEEFSGRGHFPLLDWTIQGLGIVFSNGEKWKQTRRFSLTVLRNMGMGKKTVEDRIQEEALYLVEALKKTNASPCDPTFLLGCAPCNVICSIIFQNRFEYDDKDFLTLLEYFHENLLISSTSWIQLYNAFPLLIHYLPGSHHVLFKNIANQFKFISEKIKEHEESLNFSNPRDFIDYFLIKIEKEKHNKQSEFTMDNLIITIWDVFSAGTETTSTTLRYGLLVLLKHPDVTAKVQEEIHRVVGRHRSPCMQDRSCMPYTDAVVHEIQRYIDLVPNNLPHSVTQDIKFREYLIPKGTTILTSLTSVLHDEKGFPNPDQFDPGHFLDENGSFKKSDYFMAFSAGKRVCVGEGLARMELFLLLTNILQHFTLKPLVDPKDIDTTPIANGLGATPPSYKLCFVPV

Target ORF information:

RefSeq Version	NM_001197044.1
Organism	Canis lupus familiaris(dog)
Definition	Canis lupus familiaris cytochrome P450 2C21 (CYP2C18), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001197044.1

ORF Insert Sequence:

ATGGATCTCT TCATAGTTCT GGTGATATGT CTTTCTTGTT TGATTTCTTT CTTTCTGTGG 
AATCAAAATC GTGCCAAAGG GAAGCTGCCA CCTGGCCCCA CTCCTCTCCC AATCATTGGA 
AATATTCTAC AGATAAATAC TAAGAATGTC AGCAAATCCC TAAGCAAGCT AGCAGAGAAT 
TATGGCCCTG TGTTCACTGT GTATTTTGGC ATGAAGCCTA CCGTGGTGTT GTACGGGTAT 
GAAGCGGTGA AGGAAGCTCT AATTGATCGG AGTGAAGAGT TTTCAGGCAG AGGCCATTTC 
CCATTGTTGG ACTGGACCAT ACAGGGATTA GGAATTGTTT TCAGCAACGG AGAAAAATGG 
AAGCAAACCC GGCGTTTTTC CCTGACAGTT TTGCGGAATA TGGGGATGGG AAAGAAGACT 
GTTGAAGACA GAATTCAAGA AGAGGCCTTG TATCTAGTGG AAGCATTAAA AAAAACCAAC 
GCATCTCCCT GTGATCCTAC TTTCCTTCTG GGCTGTGCTC CCTGCAATGT GATTTGCTCC 
ATTATTTTCC AGAATCGTTT TGAGTATGAT GATAAAGATT TTTTAACCTT GTTAGAGTAT 
TTTCATGAAA ACCTTCTAAT TTCAAGCACC TCCTGGATAC AGCTCTACAA TGCTTTCCCT 
CTTTTAATAC ATTACCTTCC AGGAAGTCAT CATGTGTTAT TTAAAAACAT TGCTAACCAA 
TTTAAGTTTA TTTCGGAAAA AATAAAAGAA CACGAAGAAT CTCTAAACTT TAGTAACCCT 
CGGGACTTTA TTGACTACTT CCTGATCAAA ATAGAAAAGG AAAAACACAA CAAACAGTCT 
GAATTTACCA TGGACAACTT GATCATTACC ATATGGGATG TGTTTAGTGC GGGAACAGAG 
ACAACGAGCA CCACCCTGAG ATACGGACTA TTGGTGCTAT TAAAGCACCC AGATGTCACA 
GCTAAAGTCC AGGAAGAGAT TCATCGTGTA GTTGGCAGAC ATCGGAGCCC CTGCATGCAA 
GATAGGAGCT GCATGCCCTA CACAGATGCT GTGGTACATG AGATCCAGAG ATACATTGAT 
CTTGTCCCCA ACAATCTGCC CCATTCAGTG ACTCAGGACA TCAAGTTTAG AGAATACCTT 
ATTCCCAAGG GCACAACCAT ATTAACATCT CTGACTTCTG TCCTGCATGA TGAGAAAGGA 
TTCCCCAACC CAGATCAGTT TGATCCTGGC CACTTCCTGG ATGAAAATGG CAGCTTTAAG 
AAGAGTGACT ACTTCATGGC CTTCTCAGCA GGGAAGAGAG TTTGTGTTGG AGAAGGCCTG 
GCCCGCATGG AGCTGTTTTT GCTACTGACC AATATTTTAC AGCATTTCAC CTTGAAACCT 
CTGGTTGATC CAAAGGACAT TGACACCACC CCAATTGCCA ATGGGTTGGG TGCTACACCA 
CCTTCCTATA AGCTCTGTTT TGTTCCAGTC TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

A non-acidic sulfaphenazole analog demonstrating high intrinsic clearance and selectivity by canine CYP2C21.
Drug metabolism letters5(4)253-8(2011 Dec)
Locuson CW,Alfaro JF,Zaya MJ,Billen D,White JA,Jones JP

Genetic variants in ABCB1 and CYP2C19 and cardiovascular outcomes after treatment with clopidogrel and prasugrel in the TRITON-TIMI 38 trial: a pharmacogenetic analysis.
Lancet (London, England)376(9749)1312-9(2010 Oct)
Mega JL,Close SL,Wiviott SD,Shen L,Walker JR,Simon T,Antman EM,Braunwald E,Sabatine MS

Substrate specificity and kinetic properties of seven heterologously expressed dog cytochromes p450.
Drug metabolism and disposition: the biological fate of chemicals31(9)1161-9(2003 Sep)
Shou M,Norcross R,Sandig G,Lu P,Li Y,Lin Y,Mei Q,Rodrigues AD,Rushmore TH

Isolation of a new canine cytochrome P450 CDNA from the cytochrome P450 2C subfamily (CYP2C41) and evidence for polymorphic differences in its expression.
Drug metabolism and disposition: the biological fate of chemicals26(3)278-83(1998 Mar)
Blaisdell J,Goldstein JA,Bai SA

Isolation of cDNAs coding for three different forms of liver microsomal cytochrome P-450 from polychlorinated biphenyl-treated beagle dogs.
Molecular pharmacology38(5)644-51(1990 Nov)
Uchida T,Komori M,Kitada M,Kamataki T

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CYP2C18 cDNA ORF clone, Canis lupus familiaris(dog)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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