ADORA2A cDNA ORF clone, Canis lupus familiaris(dog)

Gene
Clones
gRNAs

Summary

Gene Symbol	ADORA2A
Entrez Gene ID	403960
Full Name	adenosine A2a receptor
General protein information	Preferred Names adenosine A2a receptor Names adenosine receptor A2a
Gene Type	protein-coding
Organism	Canis lupus familiaris(dog)

mRNA and Protein(s)

mRNA	Protein	Name
NM_001003278.1	NP_001003278.1	adenosine receptor A2a

Pathways from BioSystems

Homologies

Danio rerio (zebrafish)	adora2ab	NP_001035125.1
Homo sapiens (human)	ADORA2A	NP_000666.2
Rattus norvegicus (Norway rat)	Adora2a	NP_445746.3
Xenopus tropicalis (tropical clawed frog)	adora2a	NP_001106398.1
Canis lupus familiaris (dog)	ADORA2A	NP_001003278.1
Bos taurus (cattle)	ADORA2A	XP_005218339.1
Mus musculus (house mouse)	Adora2a	NP_033760.2
Pan troglodytes (chimpanzee)	ADORA2A	XP_003953896.1
	ADORA2A	XP_001095636.1
Gallus gallus (chicken)	ADORA2A	XP_425280.2
Danio rerio (zebrafish)	adora2aa	NP_001034904.1

Gene Ontology
Bibliography

Related articles in PubMed

Contribution of adenosine A(2A) and A(2B) receptors to ischemic coronary dilation: role of K(V) and K(ATP) channels.
Berwick ZC, Payne GA, Lynch B, Dick GM, Sturek M, Tune JD
Microcirculation (New York, N.Y. : 1994)17(8)600-7(2010 Nov)

Effects of adenosine and a selective A2A adenosine receptor agonist on hemodynamic and thallium-201 and technetium-99m-sestaMIBI biodistribution and kinetics.
Mekkaoui C, Jadbabaie F, Dione DP, Meoli DF, Purushothaman K, Belardinelli L, Sinusas AJ
JACC. Cardiovascular imaging2(10)1198-208(2009 Oct)

The allosteric enhancer PD81,723 increases chimaeric A1/A2A adenosine receptor coupling with Gs.
Bhattacharya S, Youkey RL, Ghartey K, Leonard M, Linden J, Tucker AL
The Biochemical journal396(1)139-46(2006 May)

Trafficking of adenosine A2A and dopamine D2 receptors.
Torvinen M, Torri C, Tombesi A, Marcellino D, Watson S, Lluis C, Franco R, Fuxe K, Agnati LF
Journal of molecular neuroscience : MN25(2)191-200(2005)

Selective amplification and cloning of four new members of the G protein-coupled receptor family.
Libert F, Parmentier M, Lefort A, Dinsart C, Van Sande J, Maenhaut C, Simons MJ, Dumont JE, Vassart G
Science (New York, N.Y.)244(4904)569-72(1989 May)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

A(2A) receptors contribute to coronary vasodilation in response to cardiac ischemia via activation of K(V) and K(ATP) channels.
Title: Contribution of adenosine A(2A) and A(2B) receptors to ischemic coronary dilation: role of K(V) and K(ATP) channels.

Report effects of adenosine and a selective A2A adenosine receptor agonist on hemodynamic and thallium-201 and technetium-99m-sestaMIBI biodistribution and kinetics.
Title: Effects of adenosine and a selective A2A adenosine receptor agonist on hemodynamic and thallium-201 and technetium-99m-sestaMIBI biodistribution and kinetics.

The allosteric effect of PD81,723 is maintained in an A1/A2A AR chimaera in which the predominant G-protein-coupling domain of the A1 receptor, the 3ICL, is replaced by A2A sequence, but not in chimaeric receptors with an A1 sequence in the 3ICL.
Title: The allosteric enhancer PD81,723 increases chimaeric A1/A2A adenosine receptor coupling with Gs.

an activation of either A2A and D2 receptor or blockade of D2 receptors will cause long-lasting changes in A2A and D2 receptor trafficking
Title: Trafficking of adenosine A2A and dopamine D2 receptors.

The following ADORA2A gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the ADORA2A cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OCe00053	NM_001003278.1 Latest version!	Canis lupus familiaris adenosine A2a receptor (ADORA2A), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$258.30 $369.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

ADORA2A ( NM_001003278.1 ) cDNA ORF clone, Canis lupus familiaris(dog) -> NP_001003278.1 Canis lupus familiaris adenosine A2a receptor (ADORA2A), mRNA.

Price & Availability↑

CloneID	OCe00053
Clone ID Related Accession (Same CDS sequence)	NM_001003278.1
Accession Version	NM_001003278.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1239bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-25
Organism	Canis lupus familiaris(dog)
Product	adenosine receptor A2a
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from X14052.1. ##Evidence-Data-START## Transcript exon combination :: X14052.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA103936001, SAMEA103936002 [ECO:0000348] ##Evidence-Data-END##

ATGTCCACCA TGGGCTCCTG GGTGTACATC ACGGTGGAGC TGGCCATCGC TGTGCTGGCC 
ATCCTGGGCA ATGTGCTGGT GTGCTGGGCT GTGTGGCTGA ACAGCAACCT GCAGAACGTC 
ACCAACTACT TCGTGGTGTC ACTGGCGGCA GCCGACATTG CCGTGGGAGT CCTCGCGATC 
CCCTTCGCCA TCACCATCAG CACAGGGTTC TGTGCTGCCT GCCACAACTG CCTCTTCTTT 
GCCTGCTTTG TCCTGGTCCT CACTCAGAGC TCCATCTTCA GCCTCCTGGC CATCGCCATT 
GACCGCTACA TCGCCATCCG CATCCCACTC CGGTACAATG GCTTGGTGAC TGGCACAAGG 
GCCAAGGGCA TCATTGCGGT CTGCTGGGTG CTGTCGTTTG CCATTGGCTT GACTCCCATG 
CTGGGCTGGA ACAACTGCAG TCAGCCAAAG GAGGGCAGAA ACTACTCACA GGGCTGCGGG 
GAGGGCCAGG TGGCCTGTCT CTTTGAGGAT GTGGTGCCCA TGAACTACAT GGTGTACTAC 
AACTTCTTTG CTTTTGTCCT GGTGCCGCTG CTGCTCATGC TGGGTGTCTA CTTGCGGATC 
TTCCTAGCAG CTCGGCGACA GCTGAAGCAG ATGGAGAGCC AGCCTCTGCC TGGGGAGCGG 
GCTCGGTCCA CGCTGCAGAA GGAGGTCCAC GCTGCCAAGT CACTGGCCAT CATTGTGGGG 
CTCTTCGCCC TCTGCTGGCT GCCCCTGCAT ATCATCAACT GCTTTACCTT CTTTTGCCCA 
GAGTGTAGCC ATGCCCCACT CTGGCTCATG TACCTGACCA TCGTCCTCTC CCACACCAAT 
TCTGTTGTGA ATCCCTTCAT CTATGCCTAC CGCATCCGTG AGTTTCGCCA GACCTTCCGC 
AAGATCATTC GCAGCCACGT CCTGAGGCGG CGGGAGCCCT TCAAAGCAGG TGGCACCAGT 
GCCCGCGCCT TGGCAGCTCA TGGCAGTGAT GGAGAGCAGA TCAGCCTCCG CCTCAATGGC 
CATCCTCCTG GGGTGTGGGC CAATGGCAGC GCCCCCCATC CTGAGCGGCG GCCCAATGGC 
TACACCCTGG GGCTGGTGAG TGGAGGGATT GCCCCTGAGT CCCATGGCGA CATGGGCCTC 
CCAGATGTGG AGCTCCTCAG CCATGAGCTC AAGGGAGCAT GCCCAGAGTC CCCTGGCCTT 
GAAGGTCCCC TGGCCCAGGA TGGAGCAGGA GTGTCCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001003278.1
CDS	295..1533
Translation	MSTMGSWVYITVELAIAVLAILGNVLVCWAVWLNSNLQNVTNYFVVSLAAADIAVGVLAIPFAITISTGFCAACHNCLFFACFVLVLTQSSIFSLLAIAIDRYIAIRIPLRYNGLVTGTRAKGIIAVCWVLSFAIGLTPMLGWNNCSQPKEGRNYSQGCGEGQVACLFEDVVPMNYMVYYNFFAFVLVPLLLMLGVYLRIFLAARRQLKQMESQPLPGERARSTLQKEVHAAKSLAIIVGLFALCWLPLHIINCFTFFCPECSHAPLWLMYLTIVLSHTNSVVNPFIYAYRIREFRQTFRKIIRSHVLRRREPFKAGGTSARALAAHGSDGEQISLRLNGHPPGVWANGSAPHPERRPNGYTLGLVSGGIAPESHGDMGLPDVELLSHELKGACPESPGLEGPLAQDGAGVS

Target ORF information:

RefSeq Version	NM_001003278.1
Organism	Canis lupus familiaris(dog)
Definition	Canis lupus familiaris adenosine A2a receptor (ADORA2A), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001003278.1

ORF Insert Sequence:

ATGTCCACCA TGGGCTCCTG GGTGTACATC ACGGTGGAGC TGGCCATCGC TGTGCTGGCC 
ATCCTGGGCA ATGTGCTGGT GTGCTGGGCT GTGTGGCTGA ACAGCAACCT GCAGAACGTC 
ACCAACTACT TCGTGGTGTC ACTGGCGGCA GCCGACATTG CCGTGGGAGT CCTCGCGATC 
CCCTTCGCCA TCACCATCAG CACAGGGTTC TGTGCTGCCT GCCACAACTG CCTCTTCTTT 
GCCTGCTTTG TCCTGGTCCT CACTCAGAGC TCCATCTTCA GCCTCCTGGC CATCGCCATT 
GACCGCTACA TCGCCATCCG CATCCCACTC CGGTACAATG GCTTGGTGAC TGGCACAAGG 
GCCAAGGGCA TCATTGCGGT CTGCTGGGTG CTGTCGTTTG CCATTGGCTT GACTCCCATG 
CTGGGCTGGA ACAACTGCAG TCAGCCAAAG GAGGGCAGAA ACTACTCACA GGGCTGCGGG 
GAGGGCCAGG TGGCCTGTCT CTTTGAGGAT GTGGTGCCCA TGAACTACAT GGTGTACTAC 
AACTTCTTTG CTTTTGTCCT GGTGCCGCTG CTGCTCATGC TGGGTGTCTA CTTGCGGATC 
TTCCTAGCAG CTCGGCGACA GCTGAAGCAG ATGGAGAGCC AGCCTCTGCC TGGGGAGCGG 
GCTCGGTCCA CGCTGCAGAA GGAGGTCCAC GCTGCCAAGT CACTGGCCAT CATTGTGGGG 
CTCTTCGCCC TCTGCTGGCT GCCCCTGCAT ATCATCAACT GCTTTACCTT CTTTTGCCCA 
GAGTGTAGCC ATGCCCCACT CTGGCTCATG TACCTGACCA TCGTCCTCTC CCACACCAAT 
TCTGTTGTGA ATCCCTTCAT CTATGCCTAC CGCATCCGTG AGTTTCGCCA GACCTTCCGC 
AAGATCATTC GCAGCCACGT CCTGAGGCGG CGGGAGCCCT TCAAAGCAGG TGGCACCAGT 
GCCCGCGCCT TGGCAGCTCA TGGCAGTGAT GGAGAGCAGA TCAGCCTCCG CCTCAATGGC 
CATCCTCCTG GGGTGTGGGC CAATGGCAGC GCCCCCCATC CTGAGCGGCG GCCCAATGGC 
TACACCCTGG GGCTGGTGAG TGGAGGGATT GCCCCTGAGT CCCATGGCGA CATGGGCCTC 
CCAGATGTGG AGCTCCTCAG CCATGAGCTC AAGGGAGCAT GCCCAGAGTC CCCTGGCCTT 
GAAGGTCCCC TGGCCCAGGA TGGAGCAGGA GTGTCCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Contribution of adenosine A(2A) and A(2B) receptors to ischemic coronary dilation: role of K(V) and K(ATP) channels.
Microcirculation (New York, N.Y. : 1994)17(8)600-7(2010 Nov)
Berwick ZC,Payne GA,Lynch B,Dick GM,Sturek M,Tune JD

Effects of adenosine and a selective A2A adenosine receptor agonist on hemodynamic and thallium-201 and technetium-99m-sestaMIBI biodistribution and kinetics.
JACC. Cardiovascular imaging2(10)1198-208(2009 Oct)
Mekkaoui C,Jadbabaie F,Dione DP,Meoli DF,Purushothaman K,Belardinelli L,Sinusas AJ

The allosteric enhancer PD81,723 increases chimaeric A1/A2A adenosine receptor coupling with Gs.
The Biochemical journal396(1)139-46(2006 May)
Bhattacharya S,Youkey RL,Ghartey K,Leonard M,Linden J,Tucker AL

Trafficking of adenosine A2A and dopamine D2 receptors.
Journal of molecular neuroscience : MN25(2)191-200(2005)
Torvinen M,Torri C,Tombesi A,Marcellino D,Watson S,Lluis C,Franco R,Fuxe K,Agnati LF

Selective amplification and cloning of four new members of the G protein-coupled receptor family.
Science (New York, N.Y.)244(4904)569-72(1989 May)
Libert F,Parmentier M,Lefort A,Dinsart C,Van Sande J,Maenhaut C,Simons MJ,Dumont JE,Vassart G

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ADORA2A cDNA ORF clone, Canis lupus familiaris(dog)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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