PTEN cDNA ORF clone, Canis lupus familiaris(dog)

Gene
Clones
gRNAs

Summary

Gene Symbol	PTEN
Entrez Gene ID	403832
Full Name	phosphatase and tensin homolog
Synonyms	MMAC1
General protein information	Preferred Names phosphatase and tensin homolog Names phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN homolog of human mutated in multiple advanced cancers mutated in multiple advanced cancers 1
Gene Type	protein-coding
Organism	Canis lupus familiaris(dog)

mRNA and Protein(s)

mRNA	Protein	Name
NM_001003192.1	NP_001003192.1	phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN

Pathways from BioSystems

Homologies

Mus musculus (house mouse)	Pten	NP_032986.1
Gallus gallus (chicken)	PTEN	XP_421555.2
Drosophila melanogaster (fruit fly)	Pten	NP_001162933.1
	PTEN	XP_001102542.1
Bos taurus (cattle)	PTEN	XP_002698416.1
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP009628	XP_553421.2
Pan troglodytes (chimpanzee)	PTEN	XP_521544.3
Danio rerio (zebrafish)	ptenb	NP_001001822.1
Homo sapiens (human)	PTEN	NP_000305.3
Rattus norvegicus (Norway rat)	Pten	NP_113794.1
Canis lupus familiaris (dog)	PTEN	NP_001003192.1
Xenopus tropicalis (tropical clawed frog)	pten	NP_001116943.1

Gene Ontology
Bibliography

Related articles in PubMed

Is STAT3 and PTEN Expression Altered in Canine Prostate Cancer?
Lin HY, Palmieri C
Journal of comparative pathology155(2-3)185-189(2016 Aug-Oct)

The 5-lipoxygenase inhibitor tepoxalin induces oxidative damage and altered PTEN status prior to apoptosis in canine osteosarcoma cell lines.
Loftus JP, Cavatorta D, Bushey JJ, Levine CB, Sevier CS, Wakshlag JJ
Veterinary and comparative oncology14(2)e17-30(2016 Jun)

Co-localization of PTEN and E-cadherin in canine mammary hyperplasias and benign and malignant mammary tumors.
Asproni P, Ressel L, Millanta F, Vannozzi I, Poli A
Research in veterinary science103113-8(2015 Dec)

PTEN contributes to profound PI3K/Akt signaling pathway deregulation in dystrophin-deficient dog muscle.
Feron M, Guevel L, Rouger K, Dubreil L, Arnaud MC, Ledevin M, Megeney LA, Cherel Y, Sakanyan V
The American journal of pathology174(4)1459-70(2009 Apr)

Expression and significance of PTEN and VEGF in canine mammary gland tumours.
Qiu CW, Lin DG, Wang JQ, Li CY, Deng GZ
Veterinary research communications32(6)463-72(2008 Aug)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The data suggest that overexpression of STAT3 and downregulation of PTEN may be an important step in canine prostate carcinogenesis
Title: Is STAT3 and PTEN Expression Altered in Canine Prostate Cancer?

These data suggest that inhibition of lipoxygenases and off target oxidation in osteosarcoma cells play roles in the apoptotic response.
Title: The 5-lipoxygenase inhibitor tepoxalin induces oxidative damage and altered PTEN status prior to apoptosis in canine osteosarcoma cell lines.

All the hyperplastic samples stained positive for both markers, 100% of adenomas were positive for PTEN and 86% for E-cadherin, and 69% and 34% of carcinomas were positive for PTEN and E-cadherin, respectively.
Title: Co-localization of PTEN and E-cadherin in canine mammary hyperplasias and benign and malignant mammary tumors.

increased PTEN expression and activity play a central role in PI3K/Akt/GSK3beta and p70S6K pathway modulation, which could exacerbate the consequences of dystrophin deficiency.
Title: PTEN contributes to profound PI3K/Akt signaling pathway deregulation in dystrophin-deficient dog muscle.

The relationship between the expression of the PTEN and VEGF and the clinicopathological features in canine mammary gland tumours are reported.
Title: Expression and significance of PTEN and VEGF in canine mammary gland tumours.

The following PTEN gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the PTEN cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OCe00090	NM_001003192.1 Latest version!	Canis lupus familiaris phosphatase and tensin homolog (PTEN), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$258.30 $369.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

PTEN ( NM_001003192.1 ) cDNA ORF clone, Canis lupus familiaris(dog) -> NP_001003192.1 Canis lupus familiaris phosphatase and tensin homolog (PTEN), mRNA.

Price & Availability↑

CloneID	OCe00090
Clone ID Related Accession (Same CDS sequence)	NM_001003192.1
Accession Version	NM_001003192.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1212bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-24
Organism	Canis lupus familiaris(dog)
Product	phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from U92435.1. ##Evidence-Data-START## Transcript exon combination :: U92435.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA103936001, SAMEA103936002 [ECO:0000348] ##Evidence-Data-END##

ATGACAGCCA TCATCAAGGA GATCGTCAGC AGAAACAAAA GGCGCTACCA GGAGGATGGG 
TTCGACTTGG ACTTGACCTA TATTTATCCC AACATTATTG CTATGGGGTT TCCTGCAGAA 
AGACTTGAAG GCGTATACAG GAACAATATT GATGATGTAG TAAGGTTTTT GGATTCAAAG 
CATAAAAACC ATTACAAGAT ATACAATCTG TGTGCTGAAA GACATTATGA TACCGCCAAA 
TTTAACTGCA GAGTTGCACA GTATCCTTTT GAAGACCATA ATCCACCACA GCTAGAACTT 
ATCAAACCCT TTTGTGAAGA TCTTGACCAA TGGCTAAGTG AAGATGACAA TCATGTTGCA 
GCAATTCACT GTAAAGCTGG AAAGGGACGA ACTGGTGTAA TGATTTGTGC ATATTTATTA 
CATCGGGGCA AATTTCTAAA GGCACAAGAG GCCCTAGATT TCTATGGGGA AGTAAGGACC 
AGAGACAAAA AGGGAGTAAC TATTCCCAGT CAGAGGCGCT ATGTGTATTA TTATAGCTAC 
CTGTTAAAGA ATCATCTGGA TTATAGACCA GTGGCACTGT TGTTTCACAA GATGATGTTT 
GAAACTATTC CAATGTTCAG TGGCGGAACT TGCAATCCTC AGTTTGTGGT CTGCCAGCTA 
AAGGTGAAGA TCTATTCCTC CAATTCAGGA CCCACACGAC GGGAAGACAA GTTCATGTAC 
TTTGAGTTCC CTCAGCCATT GCCTGTGTGC GGTGACATCA AAGTAGAGTT CTTCCACAAA 
CAGAACAAGA TGCTAAAAAA GGACAAAATG TTTCACTTTT GGGTAAACAC ATTCTTCATA 
CCAGGACCAG AGGAAACCTC AGAAAAAGTA GAAAATGGAA GTCTATGTGA TCAAGAAATT 
GATAGTATTT GCAGTATAGA ACGTGCAGAT AATGACAAGG AATATCTAGT ACTCACTTTA 
ACAAAAAATG ATCTCGACAA AGCAAATAAA GACAAGGCCA ACCGATATTT TTCTCCAAAT 
TTTAAGGTGA AGCTGTACTT CACAAAAACT GTAGAGGAGC CATCAAACCC GGAGGCTAGC 
AGTTCAACTT CTGTGACGCC AGATGTTAGT GACAATGAAC CTGATCATTA TAGATATTCT 
GACACCACTG ACTCTGACCC AGAGAATGAA CCCTTTGATG AAGATCAGCA CACACAAATC 
ACAAAAGTCT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001003192.1
CDS	109..1320
Translation	MTAIIKEIVSRNKRRYQEDGFDLDLTYIYPNIIAMGFPAERLEGVYRNNIDDVVRFLDSKHKNHYKIYNLCAERHYDTAKFNCRVAQYPFEDHNPPQLELIKPFCEDLDQWLSEDDNHVAAIHCKAGKGRTGVMICAYLLHRGKFLKAQEALDFYGEVRTRDKKGVTIPSQRRYVYYYSYLLKNHLDYRPVALLFHKMMFETIPMFSGGTCNPQFVVCQLKVKIYSSNSGPTRREDKFMYFEFPQPLPVCGDIKVEFFHKQNKMLKKDKMFHFWVNTFFIPGPEETSEKVENGSLCDQEIDSICSIERADNDKEYLVLTLTKNDLDKANKDKANRYFSPNFKVKLYFTKTVEEPSNPEASSSTSVTPDVSDNEPDHYRYSDTTDSDPENEPFDEDQHTQITKV

Target ORF information:

RefSeq Version	NM_001003192.1
Organism	Canis lupus familiaris(dog)
Definition	Canis lupus familiaris phosphatase and tensin homolog (PTEN), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001003192.1

ORF Insert Sequence:

ATGACAGCCA TCATCAAGGA GATCGTCAGC AGAAACAAAA GGCGCTACCA GGAGGATGGG 
TTCGACTTGG ACTTGACCTA TATTTATCCC AACATTATTG CTATGGGGTT TCCTGCAGAA 
AGACTTGAAG GCGTATACAG GAACAATATT GATGATGTAG TAAGGTTTTT GGATTCAAAG 
CATAAAAACC ATTACAAGAT ATACAATCTG TGTGCTGAAA GACATTATGA TACCGCCAAA 
TTTAACTGCA GAGTTGCACA GTATCCTTTT GAAGACCATA ATCCACCACA GCTAGAACTT 
ATCAAACCCT TTTGTGAAGA TCTTGACCAA TGGCTAAGTG AAGATGACAA TCATGTTGCA 
GCAATTCACT GTAAAGCTGG AAAGGGACGA ACTGGTGTAA TGATTTGTGC ATATTTATTA 
CATCGGGGCA AATTTCTAAA GGCACAAGAG GCCCTAGATT TCTATGGGGA AGTAAGGACC 
AGAGACAAAA AGGGAGTAAC TATTCCCAGT CAGAGGCGCT ATGTGTATTA TTATAGCTAC 
CTGTTAAAGA ATCATCTGGA TTATAGACCA GTGGCACTGT TGTTTCACAA GATGATGTTT 
GAAACTATTC CAATGTTCAG TGGCGGAACT TGCAATCCTC AGTTTGTGGT CTGCCAGCTA 
AAGGTGAAGA TCTATTCCTC CAATTCAGGA CCCACACGAC GGGAAGACAA GTTCATGTAC 
TTTGAGTTCC CTCAGCCATT GCCTGTGTGC GGTGACATCA AAGTAGAGTT CTTCCACAAA 
CAGAACAAGA TGCTAAAAAA GGACAAAATG TTTCACTTTT GGGTAAACAC ATTCTTCATA 
CCAGGACCAG AGGAAACCTC AGAAAAAGTA GAAAATGGAA GTCTATGTGA TCAAGAAATT 
GATAGTATTT GCAGTATAGA ACGTGCAGAT AATGACAAGG AATATCTAGT ACTCACTTTA 
ACAAAAAATG ATCTCGACAA AGCAAATAAA GACAAGGCCA ACCGATATTT TTCTCCAAAT 
TTTAAGGTGA AGCTGTACTT CACAAAAACT GTAGAGGAGC CATCAAACCC GGAGGCTAGC 
AGTTCAACTT CTGTGACGCC AGATGTTAGT GACAATGAAC CTGATCATTA TAGATATTCT 
GACACCACTG ACTCTGACCC AGAGAATGAA CCCTTTGATG AAGATCAGCA CACACAAATC 
ACAAAAGTCT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Is STAT3 and PTEN Expression Altered in Canine Prostate Cancer?
Journal of comparative pathology155(2-3)185-189(2016 Aug-Oct)
Lin HY,Palmieri C

The 5-lipoxygenase inhibitor tepoxalin induces oxidative damage and altered PTEN status prior to apoptosis in canine osteosarcoma cell lines.
Veterinary and comparative oncology14(2)e17-30(2016 Jun)
Loftus JP,Cavatorta D,Bushey JJ,Levine CB,Sevier CS,Wakshlag JJ

Co-localization of PTEN and E-cadherin in canine mammary hyperplasias and benign and malignant mammary tumors.
Research in veterinary science103113-8(2015 Dec)
Asproni P,Ressel L,Millanta F,Vannozzi I,Poli A

PTEN contributes to profound PI3K/Akt signaling pathway deregulation in dystrophin-deficient dog muscle.
The American journal of pathology174(4)1459-70(2009 Apr)
Feron M,Guevel L,Rouger K,Dubreil L,Arnaud MC,Ledevin M,Megeney LA,Cherel Y,Sakanyan V

Expression and significance of PTEN and VEGF in canine mammary gland tumours.
Veterinary research communications32(6)463-72(2008 Aug)
Qiu CW,Lin DG,Wang JQ,Li CY,Deng GZ

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PTEN cDNA ORF clone, Canis lupus familiaris(dog)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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