RPGR cDNA ORF clone, Canis lupus familiaris(dog)

Gene
Clones
gRNAs

Summary

Gene Symbol	RPGR
Entrez Gene ID	403726
Full Name	retinitis pigmentosa GTPase regulator
Gene Type	protein-coding
Organism	Canis lupus familiaris(dog)

mRNA and Protein(s)

mRNA	Protein	Name
NM_001003126.1	NP_001003126.1	X-linked retinitis pigmentosa GTPase regulator

Pathways from BioSystems

Homologies

Pan troglodytes (chimpanzee)	RPGR	XP_003954016.1
Mus musculus (house mouse)	Rpgr	NP_001171421.1
Rattus norvegicus (Norway rat)	Rpgr	XP_006256751.1
Xenopus tropicalis (tropical clawed frog)	rpgr	NP_001037872.1
Danio rerio (zebrafish)	rpgrb	XP_005169406.1
Canis lupus familiaris (dog)	RPGR	NP_001003126.1
Homo sapiens (human)	RPGR	NP_000319.1

Gene Ontology
Bibliography

Related articles in PubMed

Molecular studies of phenotype variation in canine RPGR-XLPRA1.
Appelbaum T, Becker D, Santana E, Aguirre GD
Molecular vision22319-31(2016)

Muscular dystrophy in the Japanese Spitz: an inversion disrupts the DMD and RPGR genes.
Atencia-Fernandez S, Shiel RE, Mooney CT, Nolan CM
Animal genetics46(2)175-84(2015 Apr)

Different RPGR exon ORF15 mutations in Canids provide insights into photoreceptor cell degeneration.
Zhang Q, Acland GM, Wu WX, Johnson JL, Pearce-Kelling S, Tulloch B, Vervoort R, Wright AF, Aguirre GD
Human molecular genetics11(9)993-1003(2002 May)

Mapping of X-linked progressive retinal atrophy (XLPRA), the canine homolog of retinitis pigmentosa 3 (RP3).
Zeiss CJ, Ray K, Acland GM, Aguirre GD
Human molecular genetics9(4)531-7(2000 Mar)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Lack of association between haplotypes and the disease phenotype suggests that these genes are not genetic modifiers of XLPRA1
Title: Molecular studies of phenotype variation in canine RPGR-XLPRA1.

a chromosome inversion disrupting the DMD and RPGR genes is the causative mutation for X-linked muscular dystrophy in the Japanese Spitz breed
Title: Muscular dystrophy in the Japanese Spitz: an inversion disrupts the DMD and RPGR genes.

The following RPGR gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the RPGR cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OCe00104	NM_001003126.1 Latest version!	Canis lupus familiaris retinitis pigmentosa GTPase regulator (RPGR), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	20	$629.30 $899.00

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

RPGR ( NM_001003126.1 ) cDNA ORF clone, Canis lupus familiaris(dog) -> NP_001003126.1 Canis lupus familiaris retinitis pigmentosa GTPase regulator (RPGR), mRNA.

Price & Availability↑

CloneID	OCe00104
Clone ID Related Accession (Same CDS sequence)	NM_001003126.1
Accession Version	NM_001003126.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 3012bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-24
Organism	Canis lupus familiaris(dog)
Product	X-linked retinitis pigmentosa GTPase regulator
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AF148801.1. ##Evidence-Data-START## Transcript exon combination :: AF148801.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA103936001, SAMEA103936002 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGGGGAAC CCGAGGAGGT GATGCCCGGT TCAGGTGCTG TGTTTACATT TGGGAAAACT 
CAATTTGCTG AAAATATTCC CAGCAAATTT TGGTTTAGAA ATGATGTACC TACATTTCTT 
TCATGTGGAG ATGAGCATAC TGCTGTTGTT ACAGGAAATA ATAAACTTTA CATGTTTGGC 
AGTAACAACT GGGGCCAGTT GGGATTAGGA TCAAAATCAA CTGTTAGCAA GCCAACGTGT 
GTCAAAGCTT TAAAACCTGA AAAAGTGAAA TTTGCGGCCT GTGGAAGGAA CCACACCCTA 
GTTTCAACAG AAGGAGGCAA AGTATATGCA GCTGGAGGAA ATAATGAAGG ACAGCTGGGA 
CTTGGTGACA CTGAAGAGAG AAGCACTTTT CATCTAATTA GTTTTTTTAC TTCCCAGCGT 
AAGATTAAGC AGCTTTCTGC TGGATCTAAT ACTTCAGCTG CACTAACTGA GGATGGAGAG 
CTTTTCATGT GGGGTGATAA TTCTGAAGGG CAAATTGGTT TAGAAAATGT AACCAATGTG 
TGTGTCCCTC AACAAGTGAC TGTTGGAAAA CCTATCTCCT GGATCTCTTG TGGATATTAC 
CATTCAGCTT TTGTAACAAC AGAGGGACAA CTGTACACAT TTGGAGAACC GGAGTGTGGA 
AAGTTAGGTC TTCCCAATCA GCTGCTGGTC AACCACAGAA TGCCCCAGCC GGTACCTGGA 
ATTCCCGGGA AGGTGGTCCA AGTAGCTTGT GGTGGAGGGC ACACAGTGGT TCTTACAGAG 
AAAGCCGTGT ATACCTTTGG GCTGGGACAG TTTGGTCAGC TGGGTCTTGG CACTTTTCTT 
TTTGAAACCT CAGTGCCCAA AGCCATTGAG CATATTAAGG ATCAGAAAAT AAGTTTTATT 
GCCTGTGGAG AAAATCACAC AGCTCTGATA ACAGATATGG GTCTCATGTA TACTTTTGGA 
GATGGTCGAC ATGGAAAATT AGGACTTGGA CTGGAGAATT CTACCAATCA GTTCATTCCC 
ACTCTGTGCT CTAATTTTTT GAGGTTTATA GTTCAATTGG TGTCTTGTGG TGGATGTCAC 
ACACTAGTTT TTGCCACTCC ACGACTTGGT GGGACAGAAG AAATGGAGTT AAAAGAAATA 
AACAAATCTT GCTTCTCTGC AGCAACTTCT CTGTCCCTCA GCAATCTGAG CTCAGGAATT 
GTACTGCATC AAACTCTATC AGCACGTGTG CGGCGGAGAG AGAGGGAAAA ATCACCTGAT 
TCTTTTCAAA TGACACGAAC ACTACCTCCA ATTGATGGGA TTCCTATGCC ACCTGTTTGC 
TTTTCCCCCA GTCCAATTCC TTTCTATATG GCTGCAAGTA ATTGGTCAGG GAAAATGACA 
CCTGAAAAGG AGGGCCTCAC GCAGCCAGAA CCAGATTATT TTCGAGATAA CATGGCCAAA 
GGGAAAGAAA CAGATAATTC TTCGGCAACA GATTCAGAAA GCCTTGGAGA AACTACCGAT 
GTCTTAAACA TGACACATAT GATGAGCCTG AATTCCAATG ACAAGTCCCT AAAATTATCA 
CCAATTGATA AACAAAAGAA ACAAGAAACA ATTGAGAAAC TGAAGCAGCA TACAGCTCAC 
TTTGGAAATG ATGATAGTAA AGGATGTGCA AGTGAAGAGA TGTCCAAAAC AGTGAAAGAG 
GGGAAAGCAT ATAAACAACT TTTGGCAAAA GGAATATACA TGACGCAAGC AGCTATGACT 
ATGGAAGCAT TTTCAGATGA GGACATAGGT AATGACTCAG GCCAGCCTGG GCCTCGGGCT 
GACACCCACG CAGAGGGTGT GCAAAGAAAG ATATTTAGTT GTGAAAGTAA GCATGGTCTC 
TATCCACCTG ACTTTAAGGC GATAGCAAAG GAAAGTGATG GAGGCCAAAG TCAGAAGGAT 
CCAGAAGCAG AAGAAACAGT CTCTGAGAAG GAAAACGAGC TGGCGGAAAT GGCAGGTCTG 
CAGGCTAGGA GACAAAGTGA AGAGAATTTA AGAAATATTA ATATGTTCTT TGACGACTTA 
CCAAATAGAG ACGTGAATAT TGAGGATGAA GAAAGTAAAG ATTTTGTTAA GGACAGTAGG 
AGGAACAAAC AAGATGTGAT CTTTGACAGT GAAAGAGAAT CTATAGAGGA GCCAGACAGT 
TACTTGGAAG GTGAAAGCGA AAGTCAGCAA GGTACCACTG ATGGCTTCGA GCAGCCTGAG 
TCAGTAGAAT TTAGTAGTGG AGAGAAAGAG GATGATGATG AAGTGGAAAC TGACCAAAAC 
TTGTGGTATA GCAGAAAATT TATCGAACAA GGACACAAGG AAGAGACCGA ACACATACTG 
TCCAAATTCA TGGCAAAATA TGATTTTAAG TGTGACCACT TGTCAGAGAT TCCAGAGGAG 
CAGGAAGGAG CAGAGGATTC AGAAGGAAGT GGAATAGAGG AGCAAGAGGT AGAGGCAAAT 
GAGAATGTGG AGGTGCCTGC AGGAAAAGAG GAGAAGGAAA TAGAGATCCT GTCAGATGAC 
CTGACAGACA GAGCAGAGGA TCATGAGTTT TCAGAAGATG AAGAACCAGA GGATATGGCT 
GAGGAACTTG ATGAAGATCT GGAAAGCAAG AAGAATGTTC CAGCAGATGT GGCCAGTGAC 
AACTCCCTTA AAAAGGACGA GACAACCAAA CAAGAAAAAC GAGCTATTTG TGAATACAAT 
GAAAATCCAA AAGGAAACAT GCATTATCAT GCAAAGAGCA GTTCTTCAGA AGTCCTGAAT 
GATAGTGAAT CAACACCAAA TAAAGATGTG AAAAAATCAA AGAAGATTTT CCTCTTTAAA 
AGGATGTCAT TGATGAGTCA GAAAAGTATG CAGAGTAATA ATGAGCCACT CCCAGAGATA 
AAACCAATAG GAGATCAAAT AGCTTTTAAA GGCAATAAGA AAGATGCCAA CCAGAACCAC 
ATGGGGCAAA ACCATCAGGA TACTTCACCC CCAGATATGG AGAGAAGATC AAAATCTTGT 
ACAATACTAT AA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001003126.1
CDS	81..3092
Translation	MGEPEEVMPGSGAVFTFGKTQFAENIPSKFWFRNDVPTFLSCGDEHTAVVTGNNKLYMFGSNNWGQLGLGSKSTVSKPTCVKALKPEKVKFAACGRNHTLVSTEGGKVYAAGGNNEGQLGLGDTEERSTFHLISFFTSQRKIKQLSAGSNTSAALTEDGELFMWGDNSEGQIGLENVTNVCVPQQVTVGKPISWISCGYYHSAFVTTEGQLYTFGEPECGKLGLPNQLLVNHRMPQPVPGIPGKVVQVACGGGHTVVLTEKAVYTFGLGQFGQLGLGTFLFETSVPKAIEHIKDQKISFIACGENHTALITDMGLMYTFGDGRHGKLGLGLENSTNQFIPTLCSNFLRFIVQLVSCGGCHTLVFATPRLGGTEEMELKEINKSCFSAATSLSLSNLSSGIVLHQTLSARVRRREREKSPDSFQMTRTLPPIDGIPMPPVCFSPSPIPFYMAASNWSGKMTPEKEGLTQPEPDYFRDNMAKGKETDNSSATDSESLGETTDVLNMTHMMSLNSNDKSLKLSPIDKQKKQETIEKLKQHTAHFGNDDSKGCASEEMSKTVKEGKAYKQLLAKGIYMTQAAMTMEAFSDEDIGNDSGQPGPRADTHAEGVQRKIFSCESKHGLYPPDFKAIAKESDGGQSQKDPEAEETVSEKENELAEMAGLQARRQSEENLRNINMFFDDLPNRDVNIEDEESKDFVKDSRRNKQDVIFDSERESIEEPDSYLEGESESQQGTTDGFEQPESVEFSSGEKEDDDEVETDQNLWYSRKFIEQGHKEETEHILSKFMAKYDFKCDHLSEIPEEQEGAEDSEGSGIEEQEVEANENVEVPAGKEEKEIEILSDDLTDRAEDHEFSEDEEPEDMAEELDEDLESKKNVPADVASDNSLKKDETTKQEKRAICEYNENPKGNMHYHAKSSSSEVLNDSESTPNKDVKKSKKIFLFKRMSLMSQKSMQSNNEPLPEIKPIGDQIAFKGNKKDANQNHMGQNHQDTSPPDMERRSKSCTIL

Target ORF information:

RefSeq Version	NM_001003126.1
Organism	Canis lupus familiaris(dog)
Definition	Canis lupus familiaris retinitis pigmentosa GTPase regulator (RPGR), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001003126.1

ORF Insert Sequence:

ATGGGGGAAC CCGAGGAGGT GATGCCCGGT TCAGGTGCTG TGTTTACATT TGGGAAAACT 
CAATTTGCTG AAAATATTCC CAGCAAATTT TGGTTTAGAA ATGATGTACC TACATTTCTT 
TCATGTGGAG ATGAGCATAC TGCTGTTGTT ACAGGAAATA ATAAACTTTA CATGTTTGGC 
AGTAACAACT GGGGCCAGTT GGGATTAGGA TCAAAATCAA CTGTTAGCAA GCCAACGTGT 
GTCAAAGCTT TAAAACCTGA AAAAGTGAAA TTTGCGGCCT GTGGAAGGAA CCACACCCTA 
GTTTCAACAG AAGGAGGCAA AGTATATGCA GCTGGAGGAA ATAATGAAGG ACAGCTGGGA 
CTTGGTGACA CTGAAGAGAG AAGCACTTTT CATCTAATTA GTTTTTTTAC TTCCCAGCGT 
AAGATTAAGC AGCTTTCTGC TGGATCTAAT ACTTCAGCTG CACTAACTGA GGATGGAGAG 
CTTTTCATGT GGGGTGATAA TTCTGAAGGG CAAATTGGTT TAGAAAATGT AACCAATGTG 
TGTGTCCCTC AACAAGTGAC TGTTGGAAAA CCTATCTCCT GGATCTCTTG TGGATATTAC 
CATTCAGCTT TTGTAACAAC AGAGGGACAA CTGTACACAT TTGGAGAACC GGAGTGTGGA 
AAGTTAGGTC TTCCCAATCA GCTGCTGGTC AACCACAGAA TGCCCCAGCC GGTACCTGGA 
ATTCCCGGGA AGGTGGTCCA AGTAGCTTGT GGTGGAGGGC ACACAGTGGT TCTTACAGAG 
AAAGCCGTGT ATACCTTTGG GCTGGGACAG TTTGGTCAGC TGGGTCTTGG CACTTTTCTT 
TTTGAAACCT CAGTGCCCAA AGCCATTGAG CATATTAAGG ATCAGAAAAT AAGTTTTATT 
GCCTGTGGAG AAAATCACAC AGCTCTGATA ACAGATATGG GTCTCATGTA TACTTTTGGA 
GATGGTCGAC ATGGAAAATT AGGACTTGGA CTGGAGAATT CTACCAATCA GTTCATTCCC 
ACTCTGTGCT CTAATTTTTT GAGGTTTATA GTTCAATTGG TGTCTTGTGG TGGATGTCAC 
ACACTAGTTT TTGCCACTCC ACGACTTGGT GGGACAGAAG AAATGGAGTT AAAAGAAATA 
AACAAATCTT GCTTCTCTGC AGCAACTTCT CTGTCCCTCA GCAATCTGAG CTCAGGAATT 
GTACTGCATC AAACTCTATC AGCACGTGTG CGGCGGAGAG AGAGGGAAAA ATCACCTGAT 
TCTTTTCAAA TGACACGAAC ACTACCTCCA ATTGATGGGA TTCCTATGCC ACCTGTTTGC 
TTTTCCCCCA GTCCAATTCC TTTCTATATG GCTGCAAGTA ATTGGTCAGG GAAAATGACA 
CCTGAAAAGG AGGGCCTCAC GCAGCCAGAA CCAGATTATT TTCGAGATAA CATGGCCAAA 
GGGAAAGAAA CAGATAATTC TTCGGCAACA GATTCAGAAA GCCTTGGAGA AACTACCGAT 
GTCTTAAACA TGACACATAT GATGAGCCTG AATTCCAATG ACAAGTCCCT AAAATTATCA 
CCAATTGATA AACAAAAGAA ACAAGAAACA ATTGAGAAAC TGAAGCAGCA TACAGCTCAC 
TTTGGAAATG ATGATAGTAA AGGATGTGCA AGTGAAGAGA TGTCCAAAAC AGTGAAAGAG 
GGGAAAGCAT ATAAACAACT TTTGGCAAAA GGAATATACA TGACGCAAGC AGCTATGACT 
ATGGAAGCAT TTTCAGATGA GGACATAGGT AATGACTCAG GCCAGCCTGG GCCTCGGGCT 
GACACCCACG CAGAGGGTGT GCAAAGAAAG ATATTTAGTT GTGAAAGTAA GCATGGTCTC 
TATCCACCTG ACTTTAAGGC GATAGCAAAG GAAAGTGATG GAGGCCAAAG TCAGAAGGAT 
CCAGAAGCAG AAGAAACAGT CTCTGAGAAG GAAAACGAGC TGGCGGAAAT GGCAGGTCTG 
CAGGCTAGGA GACAAAGTGA AGAGAATTTA AGAAATATTA ATATGTTCTT TGACGACTTA 
CCAAATAGAG ACGTGAATAT TGAGGATGAA GAAAGTAAAG ATTTTGTTAA GGACAGTAGG 
AGGAACAAAC AAGATGTGAT CTTTGACAGT GAAAGAGAAT CTATAGAGGA GCCAGACAGT 
TACTTGGAAG GTGAAAGCGA AAGTCAGCAA GGTACCACTG ATGGCTTCGA GCAGCCTGAG 
TCAGTAGAAT TTAGTAGTGG AGAGAAAGAG GATGATGATG AAGTGGAAAC TGACCAAAAC 
TTGTGGTATA GCAGAAAATT TATCGAACAA GGACACAAGG AAGAGACCGA ACACATACTG 
TCCAAATTCA TGGCAAAATA TGATTTTAAG TGTGACCACT TGTCAGAGAT TCCAGAGGAG 
CAGGAAGGAG CAGAGGATTC AGAAGGAAGT GGAATAGAGG AGCAAGAGGT AGAGGCAAAT 
GAGAATGTGG AGGTGCCTGC AGGAAAAGAG GAGAAGGAAA TAGAGATCCT GTCAGATGAC 
CTGACAGACA GAGCAGAGGA TCATGAGTTT TCAGAAGATG AAGAACCAGA GGATATGGCT 
GAGGAACTTG ATGAAGATCT GGAAAGCAAG AAGAATGTTC CAGCAGATGT GGCCAGTGAC 
AACTCCCTTA AAAAGGACGA GACAACCAAA CAAGAAAAAC GAGCTATTTG TGAATACAAT 
GAAAATCCAA AAGGAAACAT GCATTATCAT GCAAAGAGCA GTTCTTCAGA AGTCCTGAAT 
GATAGTGAAT CAACACCAAA TAAAGATGTG AAAAAATCAA AGAAGATTTT CCTCTTTAAA 
AGGATGTCAT TGATGAGTCA GAAAAGTATG CAGAGTAATA ATGAGCCACT CCCAGAGATA 
AAACCAATAG GAGATCAAAT AGCTTTTAAA GGCAATAAGA AAGATGCCAA CCAGAACCAC 
ATGGGGCAAA ACCATCAGGA TACTTCACCC CCAGATATGG AGAGAAGATC AAAATCTTGT 
ACAATACTAT AA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Molecular studies of phenotype variation in canine RPGR-XLPRA1.
Molecular vision22319-31(2016)
Appelbaum T,Becker D,Santana E,Aguirre GD

Muscular dystrophy in the Japanese Spitz: an inversion disrupts the DMD and RPGR genes.
Animal genetics46(2)175-84(2015 Apr)
Atencia-Fernandez S,Shiel RE,Mooney CT,Nolan CM

Different RPGR exon ORF15 mutations in Canids provide insights into photoreceptor cell degeneration.
Human molecular genetics11(9)993-1003(2002 May)
Zhang Q,Acland GM,Wu WX,Johnson JL,Pearce-Kelling S,Tulloch B,Vervoort R,Wright AF,Aguirre GD

Mapping of X-linked progressive retinal atrophy (XLPRA), the canine homolog of retinitis pigmentosa 3 (RP3).
Human molecular genetics9(4)531-7(2000 Mar)
Zeiss CJ,Ray K,Acland GM,Aguirre GD

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RPGR cDNA ORF clone, Canis lupus familiaris(dog)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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