CLDN2 cDNA ORF clone, Canis lupus familiaris(dog)

Gene
Clones
gRNAs

Summary

Gene Symbol	CLDN2
Entrez Gene ID	403649
Full Name	claudin 2
General protein information	Preferred Names claudin 2 Names claudin-2 integral membrane protein claudin-2
Gene Type	protein-coding
Organism	Canis lupus familiaris(dog)

mRNA and Protein(s)

mRNA	Protein	Name
XM_022415488.1	XP_022271196.1	claudin-2 isoform X1
XM_014111313.1	XP_013966788.1	claudin-2 isoform X1
XM_005640981.2	XP_005641038.1	claudin-2 isoform X3
NM_001003089.1	NP_001003089.1	claudin-2
XM_005640980.2	XP_005641037.1	claudin-2 isoform X2
XM_014111313.2	XP_013966788.1	claudin-2 isoform X1
XM_022415489.1	XP_022271197.1	claudin-2 isoform X2

Pathways from BioSystems

Homologies

Homo sapiens (human)	CLDN2	NP_065117.1
Gallus gallus (chicken)	CLDN2	NP_001264551.1
Bos taurus (cattle)	CLDN2	NP_991350.1
Mus musculus (house mouse)	Cldn2	NP_057884.1
Rattus norvegicus (Norway rat)	Cldn2	NP_001100316.1
Xenopus tropicalis (tropical clawed frog)	LOC100489170	XP_004916813.1
	CLDN2	XP_001094444.1
Canis lupus familiaris (dog)	CLDN2	NP_001003089.1

Gene Ontology
Bibliography

Related articles in PubMed

Hypotonic Stress-induced Down-regulation of Claudin-1 and -2 Mediated by Dephosphorylation and Clathrin-dependent Endocytosis in Renal Tubular Epithelial Cells.
Fujii N, Matsuo Y, Matsunaga T, Endo S, Sakai H, Yamaguchi M, Yamazaki Y, Sugatani J, Ikari A
The Journal of biological chemistry291(47)24787-24799(2016 Nov)

Hyperosmolarity-Induced Down-Regulation of Claudin-2 Mediated by Decrease in PKC?-Dependent GATA-2 in MDCK Cells.
Ikari A, Fujii N, Hahakabe S, Hayashi H, Yamaguchi M, Yamazaki Y, Endo S, Matsunaga T, Sugatani J
Journal of cellular physiology230(11)2776-87(2015 Nov)

PKC? interacts with Rab14 and modulates epithelial barrier function through regulation of claudin-2 levels.
Lu R, Dalgalan D, Mandell EK, Parker SS, Ghosh S, Wilson JM
Molecular biology of the cell26(8)1523-31(2015 Apr)

IQGAP1 controls tight junction formation through differential regulation of claudin recruitment.
Tanos BE, Perez Bay AE, Salvarezza S, Vivanco I, Mellinghoff I, Osman M, Sacks DB, Rodriguez-Boulan E
Journal of cell science128(5)853-62(2015 Mar)

Claudin-2 knockout by TALEN-mediated gene targeting in MDCK cells: claudin-2 independently determines the leaky property of tight junctions in MDCK cells.
Tokuda S, Furuse M
PloS one10(3)e0119869(2015)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

hypotonic stress induces dephosphorylation, clathrin-dependent endocytosis, and degradation of claudin-1 and -2 in lysosomes, resulting in disruption of the TJ barrier in renal tubular epithelial cells.
Title: Hypotonic Stress-induced Down-regulation of Claudin-1 and -2 Mediated by Dephosphorylation and Clathrin-dependent Endocytosis in Renal Tubular Epithelial Cells.

These results suggest that hyperosmolarity decreases the expression level of claudin-2 via a decrease in PKCbeta-dependent GATA-2 transcriptional activity in renal tubular epithelial cells
Title: Hyperosmolarity-Induced Down-Regulation of Claudin-2 Mediated by Decrease in PKC?-Dependent GATA-2 in MDCK Cells.

PKCiota binds to Rab14 and that PKCiota requires Rab14 for its correct distribution in cells. As with Rab14, PKCiota protects claudin-2 from lysosomal degradation and, in consequence, modulates epithelial barrier.
Title: PKC? interacts with Rab14 and modulates epithelial barrier function through regulation of claudin-2 levels.

IQGAP1 modulates TJ formation by a twofold mechanism: (1) controlling the expression and recruitment of claudin 2 and recruitment of claudin 4 to the TJ, and (2) transient inhibition of the CDC42-JNK pathway.
Title: IQGAP1 controls tight junction formation through differential regulation of claudin recruitment.

Claudin-2 independently determines the 'leaky' property of Tight Junctions in MDCK II cells.
Title: Claudin-2 knockout by TALEN-mediated gene targeting in MDCK cells: claudin-2 independently determines the leaky property of tight junctions in MDCK cells.

The following CLDN2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the CLDN2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OCe00088	NM_001003089.1 Latest version!	Canis lupus familiaris claudin 2 (CLDN2), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$174.30 $249.00
OCe00088	XM_022415489.1 Latest version!	Canis lupus familiaris claudin 2 (CLDN2), transcript variant X3, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$174.30 $249.00
OCe31930	XM_005640980.2 Latest version!	Canis lupus familiaris claudin 2 (CLDN2), transcript variant X2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$174.30 $249.00
OCe31931	XM_005640981.2 Latest version!	Canis lupus familiaris claudin 2 (CLDN2), transcript variant X3, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$174.30 $249.00
OCe45401	XM_014111313.2 Latest version!	Canis lupus familiaris claudin 2 (CLDN2), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$174.30 $249.00
OCe45401	XM_022415488.1 Latest version!	Canis lupus familiaris claudin 2 (CLDN2), transcript variant X2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$174.30 $249.00
View Old Accession Versions >>
OCe45401	XM_014111313.1	Canis lupus familiaris claudin 2 (CLDN2), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$174.30 $249.00
Hide Old Accession Versions >>

ORF Online Only Promotion

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

CLDN2 ( NM_001003089.1 ) cDNA ORF clone, Canis lupus familiaris(dog) -> NP_001003089.1 Canis lupus familiaris claudin 2 (CLDN2), mRNA.

Price & Availability↑

CloneID	OCe00088
Clone ID Related Accession (Same CDS sequence)	NM_001003089.1 , XM_022415489.1
Accession Version	NM_001003089.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 693bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-24
Organism	Canis lupus familiaris(dog)
Product	claudin-2
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AF358907.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AF358907.1 [ECO:0000332] ##Evidence-Data-END##

ATGGCCTCTC TCGGCCTCCA ACTTGTAGGC TACATCCTAG GCCTCCTGGG GCTGTTGGGC 
ACCCTGGTGG CCATGCTGCT TCCCAGCTGG CGAACAAGCT CCTACGTTGG TACCAGCATC 
GTGACGGCGG TCGGCTTCTC CAAGGGCCTC TGGATGGAGT GCGCCACACA CAGCACAGGC 
ATAACCCAGT GTGACATCTA CAGCACCCTC CTAGGCCTGC CTGCTGACAT CCAGGCTGCC 
CAGGCCATGA TGGTGACATC CAGTGCGATC TCTTCGTTGG CCTGCATTGT CTCTGTGGTG 
GGCATGAGAT GCACTGTCTT CTGCCAGGAC TCCCGAGCCA AAGACAGACT GGCGGTGGTG 
GGTGGAGTCT TCTTCATCAT TGGAGGCCTC CTGGGCTTCA TCCCCGTTGC CTGGAACCTT 
CACGGGATCC TGCGGGACTT CTACTCCCCG CTGGTACCCG ATAGCATGAA GTTCGAGATC 
GGAGAAGCTC TCTACCTGGG CATTATTTCC TCCTTGTTCT CCCTGGTAGC TGGCATCATC 
CTCTGCTTTT CCTGCCCACT CCAGGGAAAT CGCTCCGACT ACTATGACTC CTACCAGGCC 
CAGCCCCTTG CAACTAGAGG CTCTCCAAGG CCGGGTCAAC CGCCCAAAGC CAAGAGCGAG 
TTTAACTCCT ACAGCCTGAC AGGGTATGTG TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001003089.1
CDS	59..751
Translation	MASLGLQLVGYILGLLGLLGTLVAMLLPSWRTSSYVGTSIVTAVGFSKGLWMECATHSTGITQCDIYSTLLGLPADIQAAQAMMVTSSAISSLACIVSVVGMRCTVFCQDSRAKDRLAVVGGVFFIIGGLLGFIPVAWNLHGILRDFYSPLVPDSMKFEIGEALYLGIISSLFSLVAGIILCFSCPLQGNRSDYYDSYQAQPLATRGSPRPGQPPKAKSEFNSYSLTGYV

Target ORF information:

RefSeq Version	NM_001003089.1
Organism	Canis lupus familiaris(dog)
Definition	Canis lupus familiaris claudin 2 (CLDN2), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001003089.1

ORF Insert Sequence:

ATGGCCTCTC TCGGCCTCCA ACTTGTAGGC TACATCCTAG GCCTCCTGGG GCTGTTGGGC 
ACCCTGGTGG CCATGCTGCT TCCCAGCTGG CGAACAAGCT CCTACGTTGG TACCAGCATC 
GTGACGGCGG TCGGCTTCTC CAAGGGCCTC TGGATGGAGT GCGCCACACA CAGCACAGGC 
ATAACCCAGT GTGACATCTA CAGCACCCTC CTAGGCCTGC CTGCTGACAT CCAGGCTGCC 
CAGGCCATGA TGGTGACATC CAGTGCGATC TCTTCGTTGG CCTGCATTGT CTCTGTGGTG 
GGCATGAGAT GCACTGTCTT CTGCCAGGAC TCCCGAGCCA AAGACAGACT GGCGGTGGTG 
GGTGGAGTCT TCTTCATCAT TGGAGGCCTC CTGGGCTTCA TCCCCGTTGC CTGGAACCTT 
CACGGGATCC TGCGGGACTT CTACTCCCCG CTGGTACCCG ATAGCATGAA GTTCGAGATC 
GGAGAAGCTC TCTACCTGGG CATTATTTCC TCCTTGTTCT CCCTGGTAGC TGGCATCATC 
CTCTGCTTTT CCTGCCCACT CCAGGGAAAT CGCTCCGACT ACTATGACTC CTACCAGGCC 
CAGCCCCTTG CAACTAGAGG CTCTCCAAGG CCGGGTCAAC CGCCCAAAGC CAAGAGCGAG 
TTTAACTCCT ACAGCCTGAC AGGGTATGTG TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

CLDN2 ( XM_022415489.1 ) cDNA ORF clone, Canis lupus familiaris(dog) -> XP_022271197.1 Canis lupus familiaris claudin 2 (CLDN2), transcript variant X3, mRNA.

Price & Availability↑

CloneID	OCe00088
Clone ID Related Accession (Same CDS sequence)	NM_001003089.1 , XM_022415489.1
Accession Version	XM_022415489.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 693bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-09-04
Organism	Canis lupus familiaris(dog)
Product	claudin-2 isoform X2
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_006621.3) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Canis lupus familiaris Annotation Release 105 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.4 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGGCCTCTC TCGGCCTCCA ACTTGTAGGC TACATCCTAG GCCTCCTGGG GCTGTTGGGC 
ACCCTGGTGG CCATGCTGCT TCCCAGCTGG CGAACAAGCT CCTACGTTGG TACCAGCATC 
GTGACGGCGG TCGGCTTCTC CAAGGGCCTC TGGATGGAGT GCGCCACACA CAGCACAGGC 
ATAACCCAGT GTGACATCTA CAGCACCCTC CTAGGCCTGC CTGCTGACAT CCAGGCTGCC 
CAGGCCATGA TGGTGACATC CAGTGCGATC TCTTCGTTGG CCTGCATTGT CTCTGTGGTG 
GGCATGAGAT GCACTGTCTT CTGCCAGGAC TCCCGAGCCA AAGACAGACT GGCGGTGGTG 
GGTGGAGTCT TCTTCATCAT TGGAGGCCTC CTGGGCTTCA TCCCCGTTGC CTGGAACCTT 
CACGGGATCC TGCGGGACTT CTACTCCCCG CTGGTACCCG ATAGCATGAA GTTCGAGATC 
GGAGAAGCTC TCTACCTGGG CATTATTTCC TCCTTGTTCT CCCTGGTAGC TGGCATCATC 
CTCTGCTTTT CCTGCCCACT CCAGGGAAAT CGCTCCGACT ACTATGACTC CTACCAGGCC 
CAGCCCCTTG CAACTAGAGG CTCTCCAAGG CCGGGTCAAC CGCCCAAAGC CAAGAGCGAG 
TTTAACTCCT ACAGCCTGAC AGGGTATGTG TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_022271197.1
CDS	352..1044
Translation	MASLGLQLVGYILGLLGLLGTLVAMLLPSWRTSSYVGTSIVTAVGFSKGLWMECATHSTGITQCDIYSTLLGLPADIQAAQAMMVTSSAISSLACIVSVVGMRCTVFCQDSRAKDRLAVVGGVFFIIGGLLGFIPVAWNLHGILRDFYSPLVPDSMKFEIGEALYLGIISSLFSLVAGIILCFSCPLQGNRSDYYDSYQAQPLATRGSPRPGQPPKAKSEFNSYSLTGYV

Target ORF information:

RefSeq Version	XM_022415489.1
Organism	Canis lupus familiaris(dog)
Definition	Canis lupus familiaris claudin 2 (CLDN2), transcript variant X3, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_022415489.1

ORF Insert Sequence:

ATGGCCTCTC TCGGCCTCCA ACTTGTAGGC TACATCCTAG GCCTCCTGGG GCTGTTGGGC 
ACCCTGGTGG CCATGCTGCT TCCCAGCTGG CGAACAAGCT CCTACGTTGG TACCAGCATC 
GTGACGGCGG TCGGCTTCTC CAAGGGCCTC TGGATGGAGT GCGCCACACA CAGCACAGGC 
ATAACCCAGT GTGACATCTA CAGCACCCTC CTAGGCCTGC CTGCTGACAT CCAGGCTGCC 
CAGGCCATGA TGGTGACATC CAGTGCGATC TCTTCGTTGG CCTGCATTGT CTCTGTGGTG 
GGCATGAGAT GCACTGTCTT CTGCCAGGAC TCCCGAGCCA AAGACAGACT GGCGGTGGTG 
GGTGGAGTCT TCTTCATCAT TGGAGGCCTC CTGGGCTTCA TCCCCGTTGC CTGGAACCTT 
CACGGGATCC TGCGGGACTT CTACTCCCCG CTGGTACCCG ATAGCATGAA GTTCGAGATC 
GGAGAAGCTC TCTACCTGGG CATTATTTCC TCCTTGTTCT CCCTGGTAGC TGGCATCATC 
CTCTGCTTTT CCTGCCCACT CCAGGGAAAT CGCTCCGACT ACTATGACTC CTACCAGGCC 
CAGCCCCTTG CAACTAGAGG CTCTCCAAGG CCGGGTCAAC CGCCCAAAGC CAAGAGCGAG 
TTTAACTCCT ACAGCCTGAC AGGGTATGTG TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

CLDN2 ( XM_005640980.2 ) cDNA ORF clone, Canis lupus familiaris(dog) -> XP_005641037.1 Canis lupus familiaris claudin 2 (CLDN2), transcript variant X2, mRNA.

Price & Availability↑

CloneID	OCe31930
Clone ID Related Accession (Same CDS sequence)	XM_005640980.2
Accession Version	XM_005640980.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 741bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2015-09-16
Organism	Canis lupus familiaris(Dog)
Product	claudin-2 isoform X2
Comment	MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NW_003726126.1) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Sep 17, 2015 this sequence version replaced XM_005640980.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Canis lupus familiaris Annotation Release 104 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 6.4 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGGCCTCTC TCGGCCTCCA ACTTGTAGGC TACATCCTAG GCCTCCTGGG GCTGTTGGGC 
ACCCTGGTGG CCATGCTGCT TCCCAGCTGG CGAACAAGCT CCTACGTTGG TACCAGCATC 
GTGACGGCGG TCGGCTTCTC CAAGGGCCTC TGGATGGAGT GCGCCACACA CAGCACAGGC 
ATAACCCAGT GTGACATCTA CAGCACCCTC CTAGGCCTGC CTGCTGACAT CCAGGCTGCC 
CAGGCCATGA TGGTGACATC CAGTGCGATC TCTTCGTTGG CCTGCATTGT CTCTGTGGTG 
GGCATGAGAT GCACTGTCTT CTGCCAGGAC TCCCGAGCCA AAGACAGACT GGCGGTGGTG 
GGTGGAGTCT TCTTCATCAT TGGAGGCCTC CTGGGCTTCA TCCCCGTTGC CTGGAACCTT 
CACGGGATCC TGCGGGACTT CTACTCCCCG CTGGTACCCG ATAGCATGAA GTTCGAGATC 
GGAGAAGCTC TCTACCTGGG CATTATTTCC TCCTTGTTCT CCCTGGTAGC TGGCATCATC 
CTCTGCTTTT CCTGCCCACT CCAGGGAAAT CGCTCCGACT ACTATGACTC CTACCAGGCC 
CAGCCCCTTG CAACTAGAGG CTCTCCAAGG CCGGGTCAAC CGCCCAAAGC CAAGAGCGAG 
TTTAACTCCT ACAGCCTGAC AGGCTACCTG GAAAATGCAT TCAGTAAAGC TCCTGGATTA 
ATTAACACCG GTGAAGAATG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_005641037.1
CDS	181..921
Translation	MASLGLQLVGYILGLLGLLGTLVAMLLPSWRTSSYVGTSIVTAVGFSKGLWMECATHSTGITQCDIYSTLLGLPADIQAAQAMMVTSSAISSLACIVSVVGMRCTVFCQDSRAKDRLAVVGGVFFIIGGLLGFIPVAWNLHGILRDFYSPLVPDSMKFEIGEALYLGIISSLFSLVAGIILCFSCPLQGNRSDYYDSYQAQPLATRGSPRPGQPPKAKSEFNSYSLTGYLENAFSKAPGLINTGEE

Target ORF information:

RefSeq Version	XM_005640980.2
Organism	Canis lupus familiaris(Dog)
Definition	Canis lupus familiaris claudin 2 (CLDN2), transcript variant X2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_005640980.2

ORF Insert Sequence:

ATGGCCTCTC TCGGCCTCCA ACTTGTAGGC TACATCCTAG GCCTCCTGGG GCTGTTGGGC 
ACCCTGGTGG CCATGCTGCT TCCCAGCTGG CGAACAAGCT CCTACGTTGG TACCAGCATC 
GTGACGGCGG TCGGCTTCTC CAAGGGCCTC TGGATGGAGT GCGCCACACA CAGCACAGGC 
ATAACCCAGT GTGACATCTA CAGCACCCTC CTAGGCCTGC CTGCTGACAT CCAGGCTGCC 
CAGGCCATGA TGGTGACATC CAGTGCGATC TCTTCGTTGG CCTGCATTGT CTCTGTGGTG 
GGCATGAGAT GCACTGTCTT CTGCCAGGAC TCCCGAGCCA AAGACAGACT GGCGGTGGTG 
GGTGGAGTCT TCTTCATCAT TGGAGGCCTC CTGGGCTTCA TCCCCGTTGC CTGGAACCTT 
CACGGGATCC TGCGGGACTT CTACTCCCCG CTGGTACCCG ATAGCATGAA GTTCGAGATC 
GGAGAAGCTC TCTACCTGGG CATTATTTCC TCCTTGTTCT CCCTGGTAGC TGGCATCATC 
CTCTGCTTTT CCTGCCCACT CCAGGGAAAT CGCTCCGACT ACTATGACTC CTACCAGGCC 
CAGCCCCTTG CAACTAGAGG CTCTCCAAGG CCGGGTCAAC CGCCCAAAGC CAAGAGCGAG 
TTTAACTCCT ACAGCCTGAC AGGCTACCTG GAAAATGCAT TCAGTAAAGC TCCTGGATTA 
ATTAACACCG GTGAAGAATG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

CLDN2 ( XM_005640981.2 ) cDNA ORF clone, Canis lupus familiaris(dog) -> XP_005641038.1 Canis lupus familiaris claudin 2 (CLDN2), transcript variant X3, mRNA.

Price & Availability↑

CloneID	OCe31931
Clone ID Related Accession (Same CDS sequence)	XM_005640981.2
Accession Version	XM_005640981.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 702bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2015-09-16
Organism	Canis lupus familiaris(Dog)
Product	claudin-2 isoform X3
Comment	MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NW_003726126.1) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Sep 17, 2015 this sequence version replaced XM_005640981.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Canis lupus familiaris Annotation Release 104 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 6.4 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGGCCTCTC TCGGCCTCCA ACTTGTAGGC TACATCCTAG GCCTCCTGGG GCTGTTGGGC 
ACCCTGGTGG CCATGCTGCT TCCCAGCTGG CGAACAAGCT CCTACGTTGG TACCAGCATC 
GTGACGGCGG TCGGCTTCTC CAAGGGCCTC TGGATGGAGT GCGCCACACA CAGCACAGGC 
ATAACCCAGT GTGACATCTA CAGCACCCTC CTAGGCCTGC CTGCTGACAT CCAGGCTGCC 
CAGGCCATGA TGGTGACATC CAGTGCGATC TCTTCGTTGG CCTGCATTGT CTCTGTGGTG 
GGCATGAGAT GCACTGTCTT CTGCCAGGAC TCCCGAGCCA AAGACAGACT GGCGGTGGTG 
GGTGGAGTCT TCTTCATCAT TGGAGGCCTC CTGGGCTTCA TCCCCGTTGC CTGGAACCTT 
CACGGGATCC TGCGGGACTT CTACTCCCCG CTGGTACCCG ATAGCATGAA GTTCGAGATC 
GGAGAAGCTC TCTACCTGGG CATTATTTCC TCCTTGTTCT CCCTGGTAGC TGGCATCATC 
CTCTGCTTTT CCTGCCCACT CCAGGGAAAT CGCTCCGACT ACTATGACTC CTACCAGGCC 
CAGCCCCTTG CAACTAGAGG CTCTCCAAGG CCGGGTCAAC CGCCCAAAGC CAAGAGCGAG 
TTTAACTCCT ACAGCCTGAC AGGCTCACAA CCCCTTCTAT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_005641038.1
CDS	180..881
Translation	MASLGLQLVGYILGLLGLLGTLVAMLLPSWRTSSYVGTSIVTAVGFSKGLWMECATHSTGITQCDIYSTLLGLPADIQAAQAMMVTSSAISSLACIVSVVGMRCTVFCQDSRAKDRLAVVGGVFFIIGGLLGFIPVAWNLHGILRDFYSPLVPDSMKFEIGEALYLGIISSLFSLVAGIILCFSCPLQGNRSDYYDSYQAQPLATRGSPRPGQPPKAKSEFNSYSLTGSQPLL

Target ORF information:

RefSeq Version	XM_005640981.2
Organism	Canis lupus familiaris(Dog)
Definition	Canis lupus familiaris claudin 2 (CLDN2), transcript variant X3, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_005640981.2

ORF Insert Sequence:

ATGGCCTCTC TCGGCCTCCA ACTTGTAGGC TACATCCTAG GCCTCCTGGG GCTGTTGGGC 
ACCCTGGTGG CCATGCTGCT TCCCAGCTGG CGAACAAGCT CCTACGTTGG TACCAGCATC 
GTGACGGCGG TCGGCTTCTC CAAGGGCCTC TGGATGGAGT GCGCCACACA CAGCACAGGC 
ATAACCCAGT GTGACATCTA CAGCACCCTC CTAGGCCTGC CTGCTGACAT CCAGGCTGCC 
CAGGCCATGA TGGTGACATC CAGTGCGATC TCTTCGTTGG CCTGCATTGT CTCTGTGGTG 
GGCATGAGAT GCACTGTCTT CTGCCAGGAC TCCCGAGCCA AAGACAGACT GGCGGTGGTG 
GGTGGAGTCT TCTTCATCAT TGGAGGCCTC CTGGGCTTCA TCCCCGTTGC CTGGAACCTT 
CACGGGATCC TGCGGGACTT CTACTCCCCG CTGGTACCCG ATAGCATGAA GTTCGAGATC 
GGAGAAGCTC TCTACCTGGG CATTATTTCC TCCTTGTTCT CCCTGGTAGC TGGCATCATC 
CTCTGCTTTT CCTGCCCACT CCAGGGAAAT CGCTCCGACT ACTATGACTC CTACCAGGCC 
CAGCCCCTTG CAACTAGAGG CTCTCCAAGG CCGGGTCAAC CGCCCAAAGC CAAGAGCGAG 
TTTAACTCCT ACAGCCTGAC AGGCTCACAA CCCCTTCTAT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

CLDN2 ( XM_022415488.1 ) cDNA ORF clone, Canis lupus familiaris(dog) -> XP_022271196.1 Canis lupus familiaris claudin 2 (CLDN2), transcript variant X2, mRNA.

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CloneID	OCe45401
Clone ID Related Accession (Same CDS sequence)	XM_022415488.1 , XM_014111313.1 , XM_014111313.2
Accession Version	XM_022415488.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 969bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-09-04
Organism	Canis lupus familiaris(dog)
Product	claudin-2 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_006621.3) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Canis lupus familiaris Annotation Release 105 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.4 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGGCCTCTC TCGGCCTCCA ACTTGTAGGC TACATCCTAG GCCTCCTGGG GCTGTTGGGC 
ACCCTGGTGG CCATGCTGCT TCCCAGCTGG CGAACAAGCT CCTACGTTGG TACCAGCATC 
GTGACGGCGG TCGGCTTCTC CAAGGGCCTC TGGATGGAGT GCGCCACACA CAGCACAGGC 
ATAACCCAGT GTGACATCTA CAGCACCCTC CTAGGCCTGC CTGCTGACAT CCAGGCTGCC 
CAGGCCATGA TGGTGACATC CAGTGCGATC TCTTCGTTGG CCTGCATTGT CTCTGTGGTG 
GGCATGAGAT GCACTGTCTT CTGCCAGGAC TCCCGAGCCA AAGACAGACT GGCGGTGGTG 
GGTGGAGTCT TCTTCATCAT TGGAGGCCTC CTGGGCTTCA TCCCCGTTGC CTGGAACCTT 
CACGGGATCC TGCGGGACTT CTACTCCCCG CTGGTACCCG ATAGCATGAA GTTCGAGATC 
GGAGAAGCTC TCTACCTGGG CATTATTTCC TCCTTGTTCT CCCTGGTAGC TGGCATCATC 
CTCTGCTTTT CCTGCCCACT CCAGGGAAAT CGCTCCGACT ACTATGACTC CTACCAGGCC 
CAGCCCCTTG CAACTAGAGG CTCTCCAAGG CCGGGTCAAC CGCCCAAAGC CAAGAGCGAG 
TTTAACTCCT ACAGCCTGAC AGGATCTGAA TCTACACCAG CAAGGGATAC TTTCTTGGGT 
CAAAACTCCT CAAGATTCTT CCCAAAAGTC AAAATACCTT GGAGACCTTG GGTGGATTTC 
GGCTCATCAG ATTCCATTGA CAGAGGCCAG AGGAAGAGCA GATTTGAGAA GGTAGAGAAG 
AAAGGAGGGG TGATGGCTCT TTGCCCTTCA TCCAGATCTG CAAAAAATCT GAGGCGGAAC 
AGAACCATGA TCAATCAGGA CCTACTTCTA GAGAAAATCT TATTCCAAGG GGACTGCAAT 
CTGAGTTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_022271196.1
CDS	828..1796
Translation	MASLGLQLVGYILGLLGLLGTLVAMLLPSWRTSSYVGTSIVTAVGFSKGLWMECATHSTGITQCDIYSTLLGLPADIQAAQAMMVTSSAISSLACIVSVVGMRCTVFCQDSRAKDRLAVVGGVFFIIGGLLGFIPVAWNLHGILRDFYSPLVPDSMKFEIGEALYLGIISSLFSLVAGIILCFSCPLQGNRSDYYDSYQAQPLATRGSPRPGQPPKAKSEFNSYSLTGSESTPARDTFLGQNSSRFFPKVKIPWRPWVDFGSSDSIDRGQRKSRFEKVEKKGGVMALCPSSRSAKNLRRNRTMINQDLLLEKILFQGDCNLS

Target ORF information:

RefSeq Version	XM_022415488.1
Organism	Canis lupus familiaris(dog)
Definition	Canis lupus familiaris claudin 2 (CLDN2), transcript variant X2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_022415488.1

ORF Insert Sequence:

ATGGCCTCTC TCGGCCTCCA ACTTGTAGGC TACATCCTAG GCCTCCTGGG GCTGTTGGGC 
ACCCTGGTGG CCATGCTGCT TCCCAGCTGG CGAACAAGCT CCTACGTTGG TACCAGCATC 
GTGACGGCGG TCGGCTTCTC CAAGGGCCTC TGGATGGAGT GCGCCACACA CAGCACAGGC 
ATAACCCAGT GTGACATCTA CAGCACCCTC CTAGGCCTGC CTGCTGACAT CCAGGCTGCC 
CAGGCCATGA TGGTGACATC CAGTGCGATC TCTTCGTTGG CCTGCATTGT CTCTGTGGTG 
GGCATGAGAT GCACTGTCTT CTGCCAGGAC TCCCGAGCCA AAGACAGACT GGCGGTGGTG 
GGTGGAGTCT TCTTCATCAT TGGAGGCCTC CTGGGCTTCA TCCCCGTTGC CTGGAACCTT 
CACGGGATCC TGCGGGACTT CTACTCCCCG CTGGTACCCG ATAGCATGAA GTTCGAGATC 
GGAGAAGCTC TCTACCTGGG CATTATTTCC TCCTTGTTCT CCCTGGTAGC TGGCATCATC 
CTCTGCTTTT CCTGCCCACT CCAGGGAAAT CGCTCCGACT ACTATGACTC CTACCAGGCC 
CAGCCCCTTG CAACTAGAGG CTCTCCAAGG CCGGGTCAAC CGCCCAAAGC CAAGAGCGAG 
TTTAACTCCT ACAGCCTGAC AGGATCTGAA TCTACACCAG CAAGGGATAC TTTCTTGGGT 
CAAAACTCCT CAAGATTCTT CCCAAAAGTC AAAATACCTT GGAGACCTTG GGTGGATTTC 
GGCTCATCAG ATTCCATTGA CAGAGGCCAG AGGAAGAGCA GATTTGAGAA GGTAGAGAAG 
AAAGGAGGGG TGATGGCTCT TTGCCCTTCA TCCAGATCTG CAAAAAATCT GAGGCGGAAC 
AGAACCATGA TCAATCAGGA CCTACTTCTA GAGAAAATCT TATTCCAAGG GGACTGCAAT 
CTGAGTTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

CLDN2 ( XM_014111313.1 ) cDNA ORF clone, Canis lupus familiaris(dog) -> XP_013966788.1 Canis lupus familiaris claudin 2 (CLDN2), transcript variant X1, mRNA.

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CloneID	OCe45401
Clone ID Related Accession (Same CDS sequence)	XM_022415488.1 , XM_014111313.1 , XM_014111313.2
Accession Version	XM_014111313.1	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 969bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2015-09-16
Organism	Canis lupus familiaris(Dog)
Product	claudin-2 isoform X1
Comment	MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NW_003726126.1) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Canis lupus familiaris Annotation Release 104 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 6.4 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGGCCTCTC TCGGCCTCCA ACTTGTAGGC TACATCCTAG GCCTCCTGGG GCTGTTGGGC 
ACCCTGGTGG CCATGCTGCT TCCCAGCTGG CGAACAAGCT CCTACGTTGG TACCAGCATC 
GTGACGGCGG TCGGCTTCTC CAAGGGCCTC TGGATGGAGT GCGCCACACA CAGCACAGGC 
ATAACCCAGT GTGACATCTA CAGCACCCTC CTAGGCCTGC CTGCTGACAT CCAGGCTGCC 
CAGGCCATGA TGGTGACATC CAGTGCGATC TCTTCGTTGG CCTGCATTGT CTCTGTGGTG 
GGCATGAGAT GCACTGTCTT CTGCCAGGAC TCCCGAGCCA AAGACAGACT GGCGGTGGTG 
GGTGGAGTCT TCTTCATCAT TGGAGGCCTC CTGGGCTTCA TCCCCGTTGC CTGGAACCTT 
CACGGGATCC TGCGGGACTT CTACTCCCCG CTGGTACCCG ATAGCATGAA GTTCGAGATC 
GGAGAAGCTC TCTACCTGGG CATTATTTCC TCCTTGTTCT CCCTGGTAGC TGGCATCATC 
CTCTGCTTTT CCTGCCCACT CCAGGGAAAT CGCTCCGACT ACTATGACTC CTACCAGGCC 
CAGCCCCTTG CAACTAGAGG CTCTCCAAGG CCGGGTCAAC CGCCCAAAGC CAAGAGCGAG 
TTTAACTCCT ACAGCCTGAC AGGATCTGAA TCTACACCAG CAAGGGATAC TTTCTTGGGT 
CAAAACTCCT CAAGATTCTT CCCAAAAGTC AAAATACCTT GGAGACCTTG GGTGGATTTC 
GGCTCATCAG ATTCCATTGA CAGAGGCCAG AGGAAGAGCA GATTTGAGAA GGTAGAGAAG 
AAAGGAGGGG TGATGGCTCT TTGCCCTTCA TCCAGATCTG CAAAAAATCT GAGGCGGAAC 
AGAACCATGA TCAATCAGGA CCTACTTCTA GAGAAAATCT TATTCCAAGG GGACTGCAAT 
CTGAGTTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_013966788.1
CDS	183..1151
Translation	MASLGLQLVGYILGLLGLLGTLVAMLLPSWRTSSYVGTSIVTAVGFSKGLWMECATHSTGITQCDIYSTLLGLPADIQAAQAMMVTSSAISSLACIVSVVGMRCTVFCQDSRAKDRLAVVGGVFFIIGGLLGFIPVAWNLHGILRDFYSPLVPDSMKFEIGEALYLGIISSLFSLVAGIILCFSCPLQGNRSDYYDSYQAQPLATRGSPRPGQPPKAKSEFNSYSLTGSESTPARDTFLGQNSSRFFPKVKIPWRPWVDFGSSDSIDRGQRKSRFEKVEKKGGVMALCPSSRSAKNLRRNRTMINQDLLLEKILFQGDCNLS

Target ORF information:

RefSeq Version	XM_014111313.1
Organism	Canis lupus familiaris(Dog)
Definition	Canis lupus familiaris claudin 2 (CLDN2), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_014111313.1

ORF Insert Sequence:

ATGGCCTCTC TCGGCCTCCA ACTTGTAGGC TACATCCTAG GCCTCCTGGG GCTGTTGGGC 
ACCCTGGTGG CCATGCTGCT TCCCAGCTGG CGAACAAGCT CCTACGTTGG TACCAGCATC 
GTGACGGCGG TCGGCTTCTC CAAGGGCCTC TGGATGGAGT GCGCCACACA CAGCACAGGC 
ATAACCCAGT GTGACATCTA CAGCACCCTC CTAGGCCTGC CTGCTGACAT CCAGGCTGCC 
CAGGCCATGA TGGTGACATC CAGTGCGATC TCTTCGTTGG CCTGCATTGT CTCTGTGGTG 
GGCATGAGAT GCACTGTCTT CTGCCAGGAC TCCCGAGCCA AAGACAGACT GGCGGTGGTG 
GGTGGAGTCT TCTTCATCAT TGGAGGCCTC CTGGGCTTCA TCCCCGTTGC CTGGAACCTT 
CACGGGATCC TGCGGGACTT CTACTCCCCG CTGGTACCCG ATAGCATGAA GTTCGAGATC 
GGAGAAGCTC TCTACCTGGG CATTATTTCC TCCTTGTTCT CCCTGGTAGC TGGCATCATC 
CTCTGCTTTT CCTGCCCACT CCAGGGAAAT CGCTCCGACT ACTATGACTC CTACCAGGCC 
CAGCCCCTTG CAACTAGAGG CTCTCCAAGG CCGGGTCAAC CGCCCAAAGC CAAGAGCGAG 
TTTAACTCCT ACAGCCTGAC AGGATCTGAA TCTACACCAG CAAGGGATAC TTTCTTGGGT 
CAAAACTCCT CAAGATTCTT CCCAAAAGTC AAAATACCTT GGAGACCTTG GGTGGATTTC 
GGCTCATCAG ATTCCATTGA CAGAGGCCAG AGGAAGAGCA GATTTGAGAA GGTAGAGAAG 
AAAGGAGGGG TGATGGCTCT TTGCCCTTCA TCCAGATCTG CAAAAAATCT GAGGCGGAAC 
AGAACCATGA TCAATCAGGA CCTACTTCTA GAGAAAATCT TATTCCAAGG GGACTGCAAT 
CTGAGTTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

CLDN2 ( XM_014111313.2 ) cDNA ORF clone, Canis lupus familiaris(dog) -> XP_013966788.1 Canis lupus familiaris claudin 2 (CLDN2), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OCe45401
Clone ID Related Accession (Same CDS sequence)	XM_022415488.1 , XM_014111313.1 , XM_014111313.2
Accession Version	XM_014111313.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 969bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-09-04
Organism	Canis lupus familiaris(dog)
Product	claudin-2 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_006621.3) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Sep 5, 2017 this sequence version replaced XM_014111313.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Canis lupus familiaris Annotation Release 105 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.4 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGGCCTCTC TCGGCCTCCA ACTTGTAGGC TACATCCTAG GCCTCCTGGG GCTGTTGGGC 
ACCCTGGTGG CCATGCTGCT TCCCAGCTGG CGAACAAGCT CCTACGTTGG TACCAGCATC 
GTGACGGCGG TCGGCTTCTC CAAGGGCCTC TGGATGGAGT GCGCCACACA CAGCACAGGC 
ATAACCCAGT GTGACATCTA CAGCACCCTC CTAGGCCTGC CTGCTGACAT CCAGGCTGCC 
CAGGCCATGA TGGTGACATC CAGTGCGATC TCTTCGTTGG CCTGCATTGT CTCTGTGGTG 
GGCATGAGAT GCACTGTCTT CTGCCAGGAC TCCCGAGCCA AAGACAGACT GGCGGTGGTG 
GGTGGAGTCT TCTTCATCAT TGGAGGCCTC CTGGGCTTCA TCCCCGTTGC CTGGAACCTT 
CACGGGATCC TGCGGGACTT CTACTCCCCG CTGGTACCCG ATAGCATGAA GTTCGAGATC 
GGAGAAGCTC TCTACCTGGG CATTATTTCC TCCTTGTTCT CCCTGGTAGC TGGCATCATC 
CTCTGCTTTT CCTGCCCACT CCAGGGAAAT CGCTCCGACT ACTATGACTC CTACCAGGCC 
CAGCCCCTTG CAACTAGAGG CTCTCCAAGG CCGGGTCAAC CGCCCAAAGC CAAGAGCGAG 
TTTAACTCCT ACAGCCTGAC AGGATCTGAA TCTACACCAG CAAGGGATAC TTTCTTGGGT 
CAAAACTCCT CAAGATTCTT CCCAAAAGTC AAAATACCTT GGAGACCTTG GGTGGATTTC 
GGCTCATCAG ATTCCATTGA CAGAGGCCAG AGGAAGAGCA GATTTGAGAA GGTAGAGAAG 
AAAGGAGGGG TGATGGCTCT TTGCCCTTCA TCCAGATCTG CAAAAAATCT GAGGCGGAAC 
AGAACCATGA TCAATCAGGA CCTACTTCTA GAGAAAATCT TATTCCAAGG GGACTGCAAT 
CTGAGTTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_013966788.1
CDS	375..1343
Translation	MASLGLQLVGYILGLLGLLGTLVAMLLPSWRTSSYVGTSIVTAVGFSKGLWMECATHSTGITQCDIYSTLLGLPADIQAAQAMMVTSSAISSLACIVSVVGMRCTVFCQDSRAKDRLAVVGGVFFIIGGLLGFIPVAWNLHGILRDFYSPLVPDSMKFEIGEALYLGIISSLFSLVAGIILCFSCPLQGNRSDYYDSYQAQPLATRGSPRPGQPPKAKSEFNSYSLTGSESTPARDTFLGQNSSRFFPKVKIPWRPWVDFGSSDSIDRGQRKSRFEKVEKKGGVMALCPSSRSAKNLRRNRTMINQDLLLEKILFQGDCNLS

Target ORF information:

RefSeq Version	XM_014111313.2
Organism	Canis lupus familiaris(dog)
Definition	Canis lupus familiaris claudin 2 (CLDN2), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_014111313.2

ORF Insert Sequence:

ATGGCCTCTC TCGGCCTCCA ACTTGTAGGC TACATCCTAG GCCTCCTGGG GCTGTTGGGC 
ACCCTGGTGG CCATGCTGCT TCCCAGCTGG CGAACAAGCT CCTACGTTGG TACCAGCATC 
GTGACGGCGG TCGGCTTCTC CAAGGGCCTC TGGATGGAGT GCGCCACACA CAGCACAGGC 
ATAACCCAGT GTGACATCTA CAGCACCCTC CTAGGCCTGC CTGCTGACAT CCAGGCTGCC 
CAGGCCATGA TGGTGACATC CAGTGCGATC TCTTCGTTGG CCTGCATTGT CTCTGTGGTG 
GGCATGAGAT GCACTGTCTT CTGCCAGGAC TCCCGAGCCA AAGACAGACT GGCGGTGGTG 
GGTGGAGTCT TCTTCATCAT TGGAGGCCTC CTGGGCTTCA TCCCCGTTGC CTGGAACCTT 
CACGGGATCC TGCGGGACTT CTACTCCCCG CTGGTACCCG ATAGCATGAA GTTCGAGATC 
GGAGAAGCTC TCTACCTGGG CATTATTTCC TCCTTGTTCT CCCTGGTAGC TGGCATCATC 
CTCTGCTTTT CCTGCCCACT CCAGGGAAAT CGCTCCGACT ACTATGACTC CTACCAGGCC 
CAGCCCCTTG CAACTAGAGG CTCTCCAAGG CCGGGTCAAC CGCCCAAAGC CAAGAGCGAG 
TTTAACTCCT ACAGCCTGAC AGGATCTGAA TCTACACCAG CAAGGGATAC TTTCTTGGGT 
CAAAACTCCT CAAGATTCTT CCCAAAAGTC AAAATACCTT GGAGACCTTG GGTGGATTTC 
GGCTCATCAG ATTCCATTGA CAGAGGCCAG AGGAAGAGCA GATTTGAGAA GGTAGAGAAG 
AAAGGAGGGG TGATGGCTCT TTGCCCTTCA TCCAGATCTG CAAAAAATCT GAGGCGGAAC 
AGAACCATGA TCAATCAGGA CCTACTTCTA GAGAAAATCT TATTCCAAGG GGACTGCAAT 
CTGAGTTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Hypotonic Stress-induced Down-regulation of Claudin-1 and -2 Mediated by Dephosphorylation and Clathrin-dependent Endocytosis in Renal Tubular Epithelial Cells.
The Journal of biological chemistry291(47)24787-24799(2016 Nov)
Fujii N,Matsuo Y,Matsunaga T,Endo S,Sakai H,Yamaguchi M,Yamazaki Y,Sugatani J,Ikari A

Hyperosmolarity-Induced Down-Regulation of Claudin-2 Mediated by Decrease in PKC?-Dependent GATA-2 in MDCK Cells.
Journal of cellular physiology230(11)2776-87(2015 Nov)
Ikari A,Fujii N,Hahakabe S,Hayashi H,Yamaguchi M,Yamazaki Y,Endo S,Matsunaga T,Sugatani J

PKC? interacts with Rab14 and modulates epithelial barrier function through regulation of claudin-2 levels.
Molecular biology of the cell26(8)1523-31(2015 Apr)
Lu R,Dalgalan D,Mandell EK,Parker SS,Ghosh S,Wilson JM

IQGAP1 controls tight junction formation through differential regulation of claudin recruitment.
Journal of cell science128(5)853-62(2015 Mar)
Tanos BE,Perez Bay AE,Salvarezza S,Vivanco I,Mellinghoff I,Osman M,Sacks DB,Rodriguez-Boulan E

Claudin-2 knockout by TALEN-mediated gene targeting in MDCK cells: claudin-2 independently determines the leaky property of tight junctions in MDCK cells.
PloS one10(3)e0119869(2015)
Tokuda S,Furuse M

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CLDN2 cDNA ORF clone, Canis lupus familiaris(dog)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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