PLG cDNA ORF clone, Canis lupus familiaris(dog)

Gene
Clones
gRNAs

Summary

Gene Symbol	PLG
Entrez Gene ID	403602
Full Name	plasminogen
Gene Type	protein-coding
Organism	Canis lupus familiaris(dog)

mRNA and Protein(s)

mRNA	Protein	Name
NM_001286960.1	NP_001273889.1	plasminogen precursor

Pathways from BioSystems

Homologies

Bos taurus (cattle)	PLG	NP_776376.1
Mus musculus (house mouse)	Plg	NP_032903.3
Danio rerio (zebrafish)	plg	NP_958880.1
Pan troglodytes (chimpanzee)	PLG	XP_001152889.1
	PLG	NP_001036540.1
Canis lupus familiaris (dog)	PLG	XP_005615617.1
Rattus norvegicus (Norway rat)	Plg	NP_445943.1
Caenorhabditis elegans (roundworm)	try-1	NP_494910.2
Xenopus tropicalis (tropical clawed frog)	LOC100496227	XP_002938616.2
Homo sapiens (human)	PLG	NP_000292.1
Gallus gallus (chicken)	PLG	XP_419618.2

Gene Ontology
Bibliography

Related articles in PubMed

Ligneous membranitis in Scottish Terriers is associated with a single nucleotide polymorphism in the plasminogen (PLG) gene.
Ainsworth S, Carter S, Fisher C, Dawson J, Makrides L, Nuttall T, Mason SL
Animal genetics46(6)707-10(2015 Dec)

The interaction of streptococcal enolase with canine plasminogen: the role of surfaces in complex formation.
Balhara V, Deshmukh SS, K?lm?n L, Kornblatt JA
PloS one9(2)e88395(2014)

The interaction of canine plasminogen with Streptococcus pyogenes enolase: they bind to one another but what is the nature of the structures involved?
Kornblatt MJ, Kornblatt JA, Hancock MA
PloS one6(12)e28481(2011)

Plasmin activates epithelial Na+ channels by cleaving the gamma subunit.
Passero CJ, Mueller GM, Rondon-Berrios H, Tofovic SP, Hughey RP, Kleyman TR
The Journal of biological chemistry283(52)36586-91(2008 Dec)

Influence of temperature on the conformation of canine plasminogen: an analytical ultracentrifugation and dynamic light scattering study.
Kornblatt JA, Schuck P
Biochemistry44(39)13122-31(2005 Oct)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

mutation in PLG is associated with ligneous membranitis in Scottish Terriers
Title: Ligneous membranitis in Scottish Terriers is associated with a single nucleotide polymorphism in the plasminogen (PLG) gene.

The critical condition for forming stable complexes of streptococcal enolase with canine plasminogen involves Str enolase binding to a surface.
Title: The interaction of streptococcal enolase with canine plasminogen: the role of surfaces in complex formation.

This work examines the interaction between canine plasminogen (dPgn) and Streptococcus pyogenes enolase (Str enolase).
Title: The interaction of canine plasminogen with Streptococcus pyogenes enolase: they bind to one another but what is the nature of the structures involved?

Plasmin activates epithelial Na+ channels by cleaving the gamma subunit
Title: Plasmin activates epithelial Na+ channels by cleaving the gamma subunit.

Temperature changes induce large structural changes, as though the packing density of the protein increases as the temperature is raised
Title: Influence of temperature on the conformation of canine plasminogen: an analytical ultracentrifugation and dynamic light scattering study.

The following PLG gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the PLG cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OCe00444	NM_001286960.1 Latest version!	Canis lupus familiaris plasminogen (PLG), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	12-14	$426.30 $609.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

PLG ( NM_001286960.1 ) cDNA ORF clone, Canis lupus familiaris(dog) -> NP_001273889.1 Canis lupus familiaris plasminogen (PLG), mRNA.

Price & Availability↑

CloneID	OCe00444
Clone ID Related Accession (Same CDS sequence)	NM_001286960.1
Accession Version	NM_001286960.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2439bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2018-09-22
Organism	Canis lupus familiaris(dog)
Product	plasminogen precursor
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AAEX03000327.1. On Nov 21, 2013 this sequence version replaced XM_533468.4. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments and orthologous data. ##Evidence-Data-START## RNAseq introns :: single sample supports all introns SAMN07419785 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## inferred exon combination :: based on alignments, homology ##RefSeq-Attributes-END##

ATGGAACATA AGGAAGTGGT CCTTCTACTT CTTTTATTCC TGAAATCAGG TCATGGAAGC 
CTCCTGGATG ACTATGTGAA CACGCAGGGG GCTTCAGTGT TCAGCCTCAC TAAGAAGCAG 
TTATCAGTAG GAAGCATAGA AGAATGTGCA GCCAAGTGTG AGGAGGAAAC GGGGTTCATT 
TGCAGGTCAT TCCAATATCA CAGTAAAGAG CAACAATGTG TGATCATGCC TGAAAACAGC 
AAGTCTTCTA TAGTCTTCAG GATGAGAGAT GTGTTTTTAT TCGAAAAGAG AATATATCTT 
TCAGAGTGCA AGACTGGAAA TGGGAAAACC TACAGGGGGA CCATGGCCAA AACGAAGAAT 
GACGTTGCCT GTCAAAAATG GAGTGACAAT TCTCCGCACA AACCTAACTA TACGCCTGAG 
AAGCACCCCT TGGAGGGGCT GGAGGAGAAC TATTGCAGGA ACCCTGACAA CGACGAGAAC 
GGGCCCTGGT GCTACACCAC AAACCCAGAC GTGAGGTTCG ACTACTGCAA CATTCCAGAA 
TGTGAAGAGG AATGTATGCA TTGCAGTGGG GAAAATTATG AGGGCAAAAT TTCCAAGACA 
AAGTCTGGAC TCGAGTGCCA AGCCTGGAAC TCTCAAACCC CACATGCTCA TGGATATATT 
CCTTCCAAAT TTCCAAGCAA GAACTTGAAG ATGAATTACT GCCGTAACCC TGATGGGGAG 
CCCCGCCCAT GGTGTTTCAC CATGGATCCC AACAAACGCT GGGAATTCTG TGACATTCCC 
CGCTGTACAA CACCACCACC CCCTTCGGGC CCAACGTACC AGTGTCTGAA GGGCAGAGGG 
GAGAGCTACC GAGGGAAGGT GTCCGTCACT GTCTCTGGAC ATACATGTCA GCACTGGAGT 
GAACAGACCC CTCACAAGCA CAACAGGACC CCAGAAAACT TCCCTTGCAA AAATTTGGAT 
GAAAACTACT GTCGCAACCC TGATGGAGAA ACAGCTCCAT GGTGCTACAC AACCAACAGT 
GAGGTGAGGT GGGAACACTG CCAGATTCCG TCCTGTGAGT CCTCTCCAAT AACCACAGAA 
TATTTGGATG CCCCAGCTTC AGTGCCACCT GAACAAACTC CTGTGGTCCA GGAGTGCTAC 
CACGGCAATG GGCAGAGTTA TCGAGGCACA TCATCCACTA CTATCACAGG AAGAAAATGT 
CAGTCTTGGT CATCTATGAC ACCACACCGA CATGAGAAGA CCCCAGAACA CTTCCCGGAG 
GCTGGCCTGA CGATGAACTA CTGCAGGAAC CCCGACGCCG ACAAAAGCCC TTGGTGTTAC 
ACCACCGACC CCTCTGTGCG CTGGGAGTTC TGTAACTTGA GAAAATGCTT AGACCCGGAG 
GCGAGCGCCA CCAACTCCCC TGCTGTGCCC CAAGTTCCCA GCGGACAGGA GCCTTCTGCA 
TCAGACTGCA TGTTTGGGAA CGGCAAAGGA TACCGGGGCA AGAAGGCAAC CACTGTGATG 
GGCATCCCAT GCCAGGAGTG GGCTGCCCAG GAGCCCCACA GACACAGTAT TTTCACTCCA 
GAGACAAATC CACAGGCTGG TCTGGAAAAA AACTACTGCC GTAATCCTGA TGGTGATGTC 
AATGGTCCTT GGTGCTACAC AATGAATCAA AGAAAACTTT TTGACTACTG TGATGTGCCT 
CAGTGTGTGT CCACTTCATT CGATTGCGGA AAGCCCCAGG TGGAGCCAAA GAAATGTCCT 
GGAAGGGTCG TAGGTGGGTG CGTGGCCAAC CCACATTCCT GGCCCTGGCA AATCAGTCTT 
AGAACAAGAT ATGGAAAGCA CTTCTGTGGA GGGACTTTAA TATCCCCAGA GTGGGTGCTG 
ACGGCAGCCC ATTGCCTGGA GAGATCCTCG AGGCCTGCAT CATATAAGGT CATCCTGGGT 
GCACATAAAG AAGTCAATCT TGAATCAGAT GTTCAGGAGA TAGAGGTGTA CAAGCTGTTC 
TTGGAGCCCA CACGTGCAGA CATCGCCTTG TTGAAGCTGA GCAGCCCTGC TGTCATCACC 
TCAAAGGTAA TCCCAGCTTG TCTGCCACCC CCAAATTATG TGGTTGCTGA CCGGACATTA 
TGTTACATCA CTGGCTGGGG AGAAACCCAA GGCACGTATG GTGCGGGGCT CCTCAAGGAA 
GCCCAGCTGC CTGTGATTGA GAACAAAGTG TGTAATCGCT ATGAGTATCT GAATGGAAGA 
GTCAAATCGA CAGAGCTTTG CGCGGGGAAT TTGGCTGGAG GCACAGACAG TTGTCAGGGT 
GACAGTGGAG GACCTCTGGT TTGCTTCGAG AAGGACAAGT ACATTTTACA AGGAGTCACT 
TCTTGGGGTC TTGGCTGTGC CCGTCCCAAT AAGCCTGGTG TCTATGTTCG TGTGTCAAGG 
TTTGTTACTT GGATTGAAGG AATAATGAGA AATAATTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001273889.1
CDS	41..2479
Translation	MEHKEVVLLLLLFLKSGHGSLLDDYVNTQGASVFSLTKKQLSVGSIEECAAKCEEETGFICRSFQYHSKEQQCVIMPENSKSSIVFRMRDVFLFEKRIYLSECKTGNGKTYRGTMAKTKNDVACQKWSDNSPHKPNYTPEKHPLEGLEENYCRNPDNDENGPWCYTTNPDVRFDYCNIPECEEECMHCSGENYEGKISKTKSGLECQAWNSQTPHAHGYIPSKFPSKNLKMNYCRNPDGEPRPWCFTMDPNKRWEFCDIPRCTTPPPPSGPTYQCLKGRGESYRGKVSVTVSGHTCQHWSEQTPHKHNRTPENFPCKNLDENYCRNPDGETAPWCYTTNSEVRWEHCQIPSCESSPITTEYLDAPASVPPEQTPVVQECYHGNGQSYRGTSSTTITGRKCQSWSSMTPHRHEKTPEHFPEAGLTMNYCRNPDADKSPWCYTTDPSVRWEFCNLRKCLDPEASATNSPAVPQVPSGQEPSASDCMFGNGKGYRGKKATTVMGIPCQEWAAQEPHRHSIFTPETNPQAGLEKNYCRNPDGDVNGPWCYTMNQRKLFDYCDVPQCVSTSFDCGKPQVEPKKCPGRVVGGCVANPHSWPWQISLRTRYGKHFCGGTLISPEWVLTAAHCLERSSRPASYKVILGAHKEVNLESDVQEIEVYKLFLEPTRADIALLKLSSPAVITSKVIPACLPPPNYVVADRTLCYITGWGETQGTYGAGLLKEAQLPVIENKVCNRYEYLNGRVKSTELCAGNLAGGTDSCQGDSGGPLVCFEKDKYILQGVTSWGLGCARPNKPGVYVRVSRFVTWIEGIMRNN

Target ORF information:

RefSeq Version	NM_001286960.1
Organism	Canis lupus familiaris(dog)
Definition	Canis lupus familiaris plasminogen (PLG), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001286960.1

ORF Insert Sequence:

ATGGAACATA AGGAAGTGGT CCTTCTACTT CTTTTATTCC TGAAATCAGG TCATGGAAGC 
CTCCTGGATG ACTATGTGAA CACGCAGGGG GCTTCAGTGT TCAGCCTCAC TAAGAAGCAG 
TTATCAGTAG GAAGCATAGA AGAATGTGCA GCCAAGTGTG AGGAGGAAAC GGGGTTCATT 
TGCAGGTCAT TCCAATATCA CAGTAAAGAG CAACAATGTG TGATCATGCC TGAAAACAGC 
AAGTCTTCTA TAGTCTTCAG GATGAGAGAT GTGTTTTTAT TCGAAAAGAG AATATATCTT 
TCAGAGTGCA AGACTGGAAA TGGGAAAACC TACAGGGGGA CCATGGCCAA AACGAAGAAT 
GACGTTGCCT GTCAAAAATG GAGTGACAAT TCTCCGCACA AACCTAACTA TACGCCTGAG 
AAGCACCCCT TGGAGGGGCT GGAGGAGAAC TATTGCAGGA ACCCTGACAA CGACGAGAAC 
GGGCCCTGGT GCTACACCAC AAACCCAGAC GTGAGGTTCG ACTACTGCAA CATTCCAGAA 
TGTGAAGAGG AATGTATGCA TTGCAGTGGG GAAAATTATG AGGGCAAAAT TTCCAAGACA 
AAGTCTGGAC TCGAGTGCCA AGCCTGGAAC TCTCAAACCC CACATGCTCA TGGATATATT 
CCTTCCAAAT TTCCAAGCAA GAACTTGAAG ATGAATTACT GCCGTAACCC TGATGGGGAG 
CCCCGCCCAT GGTGTTTCAC CATGGATCCC AACAAACGCT GGGAATTCTG TGACATTCCC 
CGCTGTACAA CACCACCACC CCCTTCGGGC CCAACGTACC AGTGTCTGAA GGGCAGAGGG 
GAGAGCTACC GAGGGAAGGT GTCCGTCACT GTCTCTGGAC ATACATGTCA GCACTGGAGT 
GAACAGACCC CTCACAAGCA CAACAGGACC CCAGAAAACT TCCCTTGCAA AAATTTGGAT 
GAAAACTACT GTCGCAACCC TGATGGAGAA ACAGCTCCAT GGTGCTACAC AACCAACAGT 
GAGGTGAGGT GGGAACACTG CCAGATTCCG TCCTGTGAGT CCTCTCCAAT AACCACAGAA 
TATTTGGATG CCCCAGCTTC AGTGCCACCT GAACAAACTC CTGTGGTCCA GGAGTGCTAC 
CACGGCAATG GGCAGAGTTA TCGAGGCACA TCATCCACTA CTATCACAGG AAGAAAATGT 
CAGTCTTGGT CATCTATGAC ACCACACCGA CATGAGAAGA CCCCAGAACA CTTCCCGGAG 
GCTGGCCTGA CGATGAACTA CTGCAGGAAC CCCGACGCCG ACAAAAGCCC TTGGTGTTAC 
ACCACCGACC CCTCTGTGCG CTGGGAGTTC TGTAACTTGA GAAAATGCTT AGACCCGGAG 
GCGAGCGCCA CCAACTCCCC TGCTGTGCCC CAAGTTCCCA GCGGACAGGA GCCTTCTGCA 
TCAGACTGCA TGTTTGGGAA CGGCAAAGGA TACCGGGGCA AGAAGGCAAC CACTGTGATG 
GGCATCCCAT GCCAGGAGTG GGCTGCCCAG GAGCCCCACA GACACAGTAT TTTCACTCCA 
GAGACAAATC CACAGGCTGG TCTGGAAAAA AACTACTGCC GTAATCCTGA TGGTGATGTC 
AATGGTCCTT GGTGCTACAC AATGAATCAA AGAAAACTTT TTGACTACTG TGATGTGCCT 
CAGTGTGTGT CCACTTCATT CGATTGCGGA AAGCCCCAGG TGGAGCCAAA GAAATGTCCT 
GGAAGGGTCG TAGGTGGGTG CGTGGCCAAC CCACATTCCT GGCCCTGGCA AATCAGTCTT 
AGAACAAGAT ATGGAAAGCA CTTCTGTGGA GGGACTTTAA TATCCCCAGA GTGGGTGCTG 
ACGGCAGCCC ATTGCCTGGA GAGATCCTCG AGGCCTGCAT CATATAAGGT CATCCTGGGT 
GCACATAAAG AAGTCAATCT TGAATCAGAT GTTCAGGAGA TAGAGGTGTA CAAGCTGTTC 
TTGGAGCCCA CACGTGCAGA CATCGCCTTG TTGAAGCTGA GCAGCCCTGC TGTCATCACC 
TCAAAGGTAA TCCCAGCTTG TCTGCCACCC CCAAATTATG TGGTTGCTGA CCGGACATTA 
TGTTACATCA CTGGCTGGGG AGAAACCCAA GGCACGTATG GTGCGGGGCT CCTCAAGGAA 
GCCCAGCTGC CTGTGATTGA GAACAAAGTG TGTAATCGCT ATGAGTATCT GAATGGAAGA 
GTCAAATCGA CAGAGCTTTG CGCGGGGAAT TTGGCTGGAG GCACAGACAG TTGTCAGGGT 
GACAGTGGAG GACCTCTGGT TTGCTTCGAG AAGGACAAGT ACATTTTACA AGGAGTCACT 
TCTTGGGGTC TTGGCTGTGC CCGTCCCAAT AAGCCTGGTG TCTATGTTCG TGTGTCAAGG 
TTTGTTACTT GGATTGAAGG AATAATGAGA AATAATTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Ligneous membranitis in Scottish Terriers is associated with a single nucleotide polymorphism in the plasminogen (PLG) gene.
Animal genetics46(6)707-10(2015 Dec)
Ainsworth S,Carter S,Fisher C,Dawson J,Makrides L,Nuttall T,Mason SL

The interaction of streptococcal enolase with canine plasminogen: the role of surfaces in complex formation.
PloS one9(2)e88395(2014)
Balhara V,Deshmukh SS,K?lm?n L,Kornblatt JA

The interaction of canine plasminogen with Streptococcus pyogenes enolase: they bind to one another but what is the nature of the structures involved?
PloS one6(12)e28481(2011)
Kornblatt MJ,Kornblatt JA,Hancock MA

Plasmin activates epithelial Na+ channels by cleaving the gamma subunit.
The Journal of biological chemistry283(52)36586-91(2008 Dec)
Passero CJ,Mueller GM,Rondon-Berrios H,Tofovic SP,Hughey RP,Kleyman TR

Influence of temperature on the conformation of canine plasminogen: an analytical ultracentrifugation and dynamic light scattering study.
Biochemistry44(39)13122-31(2005 Oct)
Kornblatt JA,Schuck P

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PLG cDNA ORF clone, Canis lupus familiaris(dog)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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