MSTN cDNA ORF clone, Canis lupus familiaris(dog)

Gene
Clones
gRNAs

Summary

Gene Symbol	MSTN
Entrez Gene ID	403433
Full Name	myostatin
Synonyms	GDF8
General protein information	Preferred Names myostatin Names growth/differentiation factor 8 GDF-8
Gene Type	protein-coding
Organism	Canis lupus familiaris(dog)

mRNA and Protein(s)

mRNA	Protein	Name
NM_001002959.1	NP_001002959.1	growth/differentiation factor 8 precursor

Pathways from BioSystems

Homologies

Gallus gallus (chicken)	MSTN	NP_001001461.1
Xenopus tropicalis (tropical clawed frog)	LOC100496408	XP_002931568.1
Homo sapiens (human)	MSTN	NP_005250.1
	MSTN	NP_001073588.1
Pan troglodytes (chimpanzee)	MSTN	NP_001073388.1
Canis lupus familiaris (dog)	MSTN	NP_001002959.1
Bos taurus (cattle)	MSTN	NP_001001525.1
Mus musculus (house mouse)	Mstn	NP_034964.1
Danio rerio (zebrafish)	mstnb	NP_571094.1
Rattus norvegicus (Norway rat)	Mstn	NP_062024.1
Drosophila melanogaster (fruit fly)	myo	NP_726604.1

Gene Ontology
Bibliography

Related articles in PubMed

Dystrophin-deficient dogs with reduced myostatin have unequal muscle growth and greater joint contractures.
Kornegay JN, Bogan DJ, Bogan JR, Dow JL, Wang J, Fan Z, Liu N, Warsing LC, Grange RW, Ahn M, Balog-Alvarez CJ, Cotten SW, Willis MS, Brinkmeyer-Langford C, Zhu H, Palandra J, Morris CA, Styner MA, Wagner KR
Skeletal muscle614(2016)

Gross muscle hypertrophy in whippet dogs is caused by a mutation in the myostatin gene.
Shelton GD, Engvall E
Neuromuscular disorders : NMD17(9-10)721-2(2007 Oct)

A mutation in the myostatin gene increases muscle mass and enhances racing performance in heterozygote dogs.
Mosher DS, Quignon P, Bustamante CD, Sutter NB, Mellersh CS, Parker HG, Ostrander EA
PLoS genetics3(5)e79(2007 May)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Partial myostatin loss may exaggerate selective muscle hypertrophy or atrophy/hypoplasia in dystrophin-deficient dogs and worsen contractures.
Title: Dystrophin-deficient dogs with reduced myostatin have unequal muscle growth and greater joint contractures.

Gross muscle hypertrophy in whippet dogs is caused by a mutation in the myostatin gene.
Title: Gross muscle hypertrophy in whippet dogs is caused by a mutation in the myostatin gene.

These results highlight the utility of performance-enhancing polymorphisms, marking the first time a mutation in MSTN has been quantitatively linked to increased athletic performance.
Title: A mutation in the myostatin gene increases muscle mass and enhances racing performance in heterozygote dogs.

The following MSTN gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the MSTN cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OCe00094	NM_001002959.1 Latest version!	Canis lupus familiaris myostatin (MSTN), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$258.30 $369.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

MSTN ( NM_001002959.1 ) cDNA ORF clone, Canis lupus familiaris(dog) -> NP_001002959.1 Canis lupus familiaris myostatin (MSTN), mRNA.

Price & Availability↑

CloneID	OCe00094
Clone ID Related Accession (Same CDS sequence)	NM_001002959.1
Accession Version	NM_001002959.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1128bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-02-15
Organism	Canis lupus familiaris(dog)
Product	growth/differentiation factor 8 precursor
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AY367768.1. ##Evidence-Data-START## Transcript exon combination :: AY367768.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA103936001, SAMEA103936002 [ECO:0000348] ##Evidence-Data-END##

ATGCAGAGAC TGCAAATCTG TGTTTATATT TACCTGTTTG TGCTGATTGT TGCTGGCCCA 
GTCGATCTAA GTGAGAACAG TGAGCAAAAA GAAAATGTGG AAAAGGAGGG GCTGTGTAAT 
GCATGTATGT GGAGGCAAAA CACTAAGTCT TCAAGGATAG AAGCCATAAA AATTCAAATC 
CTCAGCAAAC TTCGCCTGGA AACGGCTCCC AACATCAGCA GAGATGCTGT CAGACAACTC 
TTGCCGCGGG CTCCTCCGCT GCGGGAGCTG ATCGACCAGT ACGACGTCCA GAGGGATGAC 
AGCAGCGACG GCTCCCTGGA GGACGACGAC TACCACGCCA CCACCGAGAC GGTCATTGCC 
ATGCCCGCCG AGACTGATCT TCTCATGCAA GTGGAAGGAA AACCCAAATG TTGTTTCTTT 
AAGTTTAGCT CTAAAATACA ATATAATAAA GTAGTAAAGG CCCAACTGTG GATATATCTG 
AGACCCGTCA AGACTCCTAC AACAGTGTTT GTGCAAATCC TGAGACTCAT CAAACCCATG 
AAAGACGGTA CAAGATATAC TGGAATCCGA TCTCTGAAAC TTGACATGAA CCCAGGCACT 
GGTATTTGGC AGAGCATTGA TGTGAAGACA GTGTTGCAAA ATTGGCTCAA ACAGCCTGAA 
TCCAACTTAG GCATTGAAAT CAAAGCTTTA GATGAGAATG GTCATGATCT TGCGGTAACC 
TTCCCAGGAC CCGGAGAAGA TGGGCTGAAT CCCTTTTTAG AAGTCAAGGT GACAGACACA 
CCAAAAAGAT CCAGAAGAGA TTTCGGGCTT GACTGTGATG AGCACTCAAC AGAATCTCGG 
TGCTGTCGTT ACCCTCTAAC TGTGGACTTT GAAGCTTTTG GATGGGATTG GATTATTGCA 
CCCAAAAGAT ATAAGGCCAA TTACTGCTCT GGAGAGTGTG AATTTGTGTT TTTACAAAAG 
TATCCTCATA CCCATCTCGT ACACCAAGCA AACCCCAGGG GCTCAGCGGG CCCCTGCTGT 
ACTCCCACAA AGATGTCTCC CATTAATATG CTATATTTTA ATGGCAAAGA ACAAATAATA 
TATGGGAAAA TTCCAGCCAT GGTAGTAGAT CGCTGTGGGT GCTCATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001002959.1
CDS	1..1128
Translation	MQRLQICVYIYLFVLIVAGPVDLSENSEQKENVEKEGLCNACMWRQNTKSSRIEAIKIQILSKLRLETAPNISRDAVRQLLPRAPPLRELIDQYDVQRDDSSDGSLEDDDYHATTETVIAMPAETDLLMQVEGKPKCCFFKFSSKIQYNKVVKAQLWIYLRPVKTPTTVFVQILRLIKPMKDGTRYTGIRSLKLDMNPGTGIWQSIDVKTVLQNWLKQPESNLGIEIKALDENGHDLAVTFPGPGEDGLNPFLEVKVTDTPKRSRRDFGLDCDEHSTESRCCRYPLTVDFEAFGWDWIIAPKRYKANYCSGECEFVFLQKYPHTHLVHQANPRGSAGPCCTPTKMSPINMLYFNGKEQIIYGKIPAMVVDRCGCS

Target ORF information:

RefSeq Version	NM_001002959.1
Organism	Canis lupus familiaris(dog)
Definition	Canis lupus familiaris myostatin (MSTN), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001002959.1

ORF Insert Sequence:

ATGCAGAGAC TGCAAATCTG TGTTTATATT TACCTGTTTG TGCTGATTGT TGCTGGCCCA 
GTCGATCTAA GTGAGAACAG TGAGCAAAAA GAAAATGTGG AAAAGGAGGG GCTGTGTAAT 
GCATGTATGT GGAGGCAAAA CACTAAGTCT TCAAGGATAG AAGCCATAAA AATTCAAATC 
CTCAGCAAAC TTCGCCTGGA AACGGCTCCC AACATCAGCA GAGATGCTGT CAGACAACTC 
TTGCCGCGGG CTCCTCCGCT GCGGGAGCTG ATCGACCAGT ACGACGTCCA GAGGGATGAC 
AGCAGCGACG GCTCCCTGGA GGACGACGAC TACCACGCCA CCACCGAGAC GGTCATTGCC 
ATGCCCGCCG AGACTGATCT TCTCATGCAA GTGGAAGGAA AACCCAAATG TTGTTTCTTT 
AAGTTTAGCT CTAAAATACA ATATAATAAA GTAGTAAAGG CCCAACTGTG GATATATCTG 
AGACCCGTCA AGACTCCTAC AACAGTGTTT GTGCAAATCC TGAGACTCAT CAAACCCATG 
AAAGACGGTA CAAGATATAC TGGAATCCGA TCTCTGAAAC TTGACATGAA CCCAGGCACT 
GGTATTTGGC AGAGCATTGA TGTGAAGACA GTGTTGCAAA ATTGGCTCAA ACAGCCTGAA 
TCCAACTTAG GCATTGAAAT CAAAGCTTTA GATGAGAATG GTCATGATCT TGCGGTAACC 
TTCCCAGGAC CCGGAGAAGA TGGGCTGAAT CCCTTTTTAG AAGTCAAGGT GACAGACACA 
CCAAAAAGAT CCAGAAGAGA TTTCGGGCTT GACTGTGATG AGCACTCAAC AGAATCTCGG 
TGCTGTCGTT ACCCTCTAAC TGTGGACTTT GAAGCTTTTG GATGGGATTG GATTATTGCA 
CCCAAAAGAT ATAAGGCCAA TTACTGCTCT GGAGAGTGTG AATTTGTGTT TTTACAAAAG 
TATCCTCATA CCCATCTCGT ACACCAAGCA AACCCCAGGG GCTCAGCGGG CCCCTGCTGT 
ACTCCCACAA AGATGTCTCC CATTAATATG CTATATTTTA ATGGCAAAGA ACAAATAATA 
TATGGGAAAA TTCCAGCCAT GGTAGTAGAT CGCTGTGGGT GCTCATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Dystrophin-deficient dogs with reduced myostatin have unequal muscle growth and greater joint contractures.
Skeletal muscle614(2016)
Kornegay JN,Bogan DJ,Bogan JR,Dow JL,Wang J,Fan Z,Liu N,Warsing LC,Grange RW,Ahn M,Balog-Alvarez CJ,Cotten SW,Willis MS,Brinkmeyer-Langford C,Zhu H,Palandra J,Morris CA,Styner MA,Wagner KR

Gross muscle hypertrophy in whippet dogs is caused by a mutation in the myostatin gene.
Neuromuscular disorders : NMD17(9-10)721-2(2007 Oct)
Shelton GD,Engvall E

A mutation in the myostatin gene increases muscle mass and enhances racing performance in heterozygote dogs.
PLoS genetics3(5)e79(2007 May)
Mosher DS,Quignon P,Bustamante CD,Sutter NB,Mellersh CS,Parker HG,Ostrander EA

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MSTN cDNA ORF clone, Canis lupus familiaris(dog)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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