Gene Symbol | aak-2 |
Entrez Gene ID | 181727 |
Full Name | 5'-AMP-activated protein kinase catalytic subunit alpha-2 |
Gene Type | protein-coding |
Organism | Caenorhabditis elegans |
ORF » Species Summary » Caenorhabditis elegans » aak-2 cDNA ORF clone
Gene Symbol | aak-2 |
Entrez Gene ID | 181727 |
Full Name | 5'-AMP-activated protein kinase catalytic subunit alpha-2 |
Gene Type | protein-coding |
Organism | Caenorhabditis elegans |
mRNA | Protein | Name |
---|---|---|
NM_001029697.3 | NP_001024868.1 | 5'-AMP-activated protein kinase catalytic subunit alpha-2 |
NM_078310.7 | NP_510711.2 | 5'-AMP-activated protein kinase catalytic subunit alpha-2 |
NM_078309.4 | NP_510710.2 | 5'-AMP-activated protein kinase catalytic subunit alpha-2 |
NM_078309.6 | NP_510710.2 | 5'-AMP-activated protein kinase catalytic subunit alpha-2 |
NM_078310.5 | NP_510711.2 | 5'-AMP-activated protein kinase catalytic subunit alpha-2 |
NM_001029697.4 | NP_001024868.1 | 5'-AMP-activated protein kinase catalytic subunit alpha-2 |
Pan troglodytes (chimpanzee) | PRKAA2 | XP_001144587.1 |
Mus musculus (house mouse) | Prkaa2 | NP_835279.2 |
Anopheles gambiae (African malaria mosquito) | AgaP_AGAP002686 | XP_312237.4 |
Caenorhabditis elegans (roundworm) | aak-2 | NP_510710.2 |
Neurospora crassa | NCU04566 | XP_958665.2 |
PRKAA2 | XP_002801614.1 | |
Bos taurus (cattle) | PRKAA2 | NP_001192534.1 |
Rattus norvegicus (Norway rat) | Prkaa2 | NP_076481.1 |
Danio rerio (zebrafish) | prkaa2 | XP_700831.4 |
Drosophila melanogaster (fruit fly) | SNF1A | NP_477313.1 |
Saccharomyces cerevisiae (baker's yeast) | SNF1 | NP_010765.3 |
Schizosaccharomyces pombe (fission yeast) | ssp2 | NP_588376.1 |
Kluyveromyces lactis | KLLA0A03806g | XP_451166.1 |
Oryza sativa (rice) | Os03g0289100 | NP_001049790.1 |
Canis lupus familiaris (dog) | PRKAA2 | XP_005620393.1 |
Gallus gallus (chicken) | PRKAA2 | NP_001034694.1 |
Eremothecium gossypii | AGOS_AEL230W | NP_984631.1 |
Oryza sativa (rice) | Os08g0484600 | NP_001062083.1 |
Homo sapiens (human) | PRKAA2 | NP_006243.2 |
Magnaporthe oryzae (rice blast fungus) | MGG_00803 | XP_003718181.1 |
Xenopus tropicalis (tropical clawed frog) | prkaa2 | NP_001135554.1 |
Genome sequence of the nematode C. elegans: a platform for investigating biology.
Science (New York, N.Y.)282(5396)2012-8(1998 Dec)
GeneRIFs: Gene References Into Functions What's a GeneRIF?
Transcription factors CEP-1 and CEH-23 collaborate with AAK-2 to modulate longevity in Caenorhabditis elegans.
Title: Transcription factors CEP-1/p53 and CEH-23 collaborate with AAK-2/AMPK to modulate longevity in Caenorhabditis elegans.
he results revealed that RNAi-mediated inactivation of several genes restores gonad elongation, including aak-2, which encodes the catalytic subunit of AMP-activated protein kinase (AMPK). We then generated triple mutant worms for cnnm-1; cnnm-3; aak-2 and confirmed that the aak-2 mutation also suppressed the defective gonadal elongation in cnnm-1; cnnm-3 mutant worms.
Title: Mg2+ Extrusion from Intestinal Epithelia by CNNM Proteins Is Essential for Gonadogenesis via AMPK-TORC1 Signaling in Caenorhabditis elegans.
AAK-2 regulates oxidative metabolism in Caenorhabditis elegans through the NHR-49 and MDT-15 transcriptional regulators.
Title: AMP-Activated Protein Kinase Regulates Oxidative Metabolism in Caenorhabditis elegans through the NHR-49 and MDT-15 Transcriptional Regulators.
Knockdown of Indy/CeNAC2 increased life span by 22+/-3 % compared to controls, together with a decrease in whole body fat content by ~50%. Indy/CeNAC2 reduction also increased the activation of the intracellular energy sensor AMPK/aak2.
Title: Knockdown of Indy/CeNac2 extends Caenorhabditis elegans life span by inducing AMPK/aak-2.
AMPK and HIF-1 may control immunity and longevity tightly by acting as feedback regulators of ROS
Title: Feedback regulation via AMPK and HIF-1 mediates ROS-dependent longevity in Caenorhabditis elegans.
The following aak-2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the aak-2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
CloneID | OCa349683 | |
Clone ID Related Accession (Same CDS sequence) | NM_078310.7 , NM_078310.5 | |
Accession Version | NM_078310.7 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 1875bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-10-17 | |
Organism | Caenorhabditis elegans | |
Product | 5'-AMP-activated protein kinase catalytic subunit alpha-2 | |
Comment | Comment: REVIEWED REFSEQ: This record has been curated by WormBase. This record is derived from an annotated genomic sequence (NC_003284). On Oct 18, 2019 this sequence version replaced NM_078310.6. |
1 | ATGTTTTCTC ATCAAGATCG AGACCGCGAT AGGAAGGAGG ACGGTGGTGG AGACGGTACT |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_510711.2 |
CDS | 3..1877 |
Translation |
Target ORF information:
Target ORF information:
|
NM_078310.7 |
1 | ATGTTTTCTC ATCAAGATCG AGACCGCGAT AGGAAGGAGG ACGGTGGTGG AGACGGTACT |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OCa349683 | |
Clone ID Related Accession (Same CDS sequence) | NM_078310.7 , NM_078310.5 | |
Accession Version | NM_078310.5 | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 1875bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-04-08 | |
Organism | Caenorhabditis elegans | |
Product | 5'-AMP-activated protein kinase catalytic subunit alpha-2 | |
Comment | Comment: REVIEWED REFSEQ: This record has been curated by WormBase. This record is derived from an annotated genomic sequence (NC_003284). On Jun 26, 2012 this sequence version replaced NM_078310.4. COMPLETENESS: incomplete on both ends. |
1 | ATGTTTTCTC ATCAAGATCG AGACCGCGAT AGGAAGGAGG ACGGTGGTGG AGACGGTACT |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_510711.2 |
CDS | 1..1875 |
Translation |
Target ORF information:
Target ORF information:
|
NM_078310.5 |
1 | ATGTTTTCTC ATCAAGATCG AGACCGCGAT AGGAAGGAGG ACGGTGGTGG AGACGGTACT |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OCa349684 | |
Clone ID Related Accession (Same CDS sequence) | NM_078309.4 , NM_078309.6 | |
Accession Version | NM_078309.4 | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 1881bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-04-08 | |
Organism | Caenorhabditis elegans | |
Product | 5'-AMP-activated protein kinase catalytic subunit alpha-2 | |
Comment | Comment: REVIEWED REFSEQ: This record has been curated by WormBase. This record is derived from an annotated genomic sequence (NC_003284). On Jun 26, 2012 this sequence version replaced NM_078309.3. COMPLETENESS: incomplete on both ends. |
1 | ATGTTTTCTC ATCAAGATCG AGACCGCGAT AGGAAGGAGG ACGGTGGTGG AGACGGTACT |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_510710.2 |
CDS | 1..1881 |
Translation |
Target ORF information:
Target ORF information:
|
NM_078309.4 |
1 | ATGTTTTCTC ATCAAGATCG AGACCGCGAT AGGAAGGAGG ACGGTGGTGG AGACGGTACT |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OCa349684 | |
Clone ID Related Accession (Same CDS sequence) | NM_078309.4 , NM_078309.6 | |
Accession Version | NM_078309.6 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 1881bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-10-17 | |
Organism | Caenorhabditis elegans | |
Product | 5'-AMP-activated protein kinase catalytic subunit alpha-2 | |
Comment | Comment: REVIEWED REFSEQ: This record has been curated by WormBase. This record is derived from an annotated genomic sequence (NC_003284). On Oct 18, 2019 this sequence version replaced NM_078309.5. |
1 | ATGTTTTCTC ATCAAGATCG AGACCGCGAT AGGAAGGAGG ACGGTGGTGG AGACGGTACT |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_510710.2 |
CDS | 3..1883 |
Translation |
Target ORF information:
Target ORF information:
|
NM_078309.6 |
1 | ATGTTTTCTC ATCAAGATCG AGACCGCGAT AGGAAGGAGG ACGGTGGTGG AGACGGTACT |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OCa349685 | |
Clone ID Related Accession (Same CDS sequence) | NM_001029697.3 , NM_001029697.4 | |
Accession Version | NM_001029697.3 | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 1689bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-04-08 | |
Organism | Caenorhabditis elegans | |
Product | 5'-AMP-activated protein kinase catalytic subunit alpha-2 | |
Comment | Comment: REVIEWED REFSEQ: This record has been curated by WormBase. This record is derived from an annotated genomic sequence (NC_003284). On Jun 26, 2012 this sequence version replaced NM_001029697.2. COMPLETENESS: incomplete on both ends. |
1 | ATGTCGTCTC CAGGAGGAGA AACGTCGACG AAGCAGCAAC AAGAGCTCAA AGCTCAAATC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_001024868.1 |
CDS | 1..1689 |
Translation |
Target ORF information:
Target ORF information:
|
NM_001029697.3 |
1 | ATGTCGTCTC CAGGAGGAGA AACGTCGACG AAGCAGCAAC AAGAGCTCAA AGCTCAAATC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OCa349685 | |
Clone ID Related Accession (Same CDS sequence) | NM_001029697.3 , NM_001029697.4 | |
Accession Version | NM_001029697.4 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 1689bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-10-17 | |
Organism | Caenorhabditis elegans | |
Product | 5'-AMP-activated protein kinase catalytic subunit alpha-2 | |
Comment | Comment: REVIEWED REFSEQ: This record has been curated by WormBase. This record is derived from an annotated genomic sequence (NC_003284). On Sep 4, 2019 this sequence version replaced NM_001029697.3. |
1 | ATGTCGTCTC CAGGAGGAGA AACGTCGACG AAGCAGCAAC AAGAGCTCAA AGCTCAAATC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_001024868.1 |
CDS | 44..1732 |
Translation |
Target ORF information:
Target ORF information:
|
NM_001029697.4 |
1 | ATGTCGTCTC CAGGAGGAGA AACGTCGACG AAGCAGCAAC AAGAGCTCAA AGCTCAAATC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
Genome sequence of the nematode C. elegans: a platform for investigating biology. |